scholarly journals Assessment of the level of serum uric acid in patients of pre-eclampsia and their comparison with levels in normotensive pregnancy

2018 ◽  
Vol 7 (12) ◽  
pp. 4900
Author(s):  
Hemant G. Deshpande ◽  
Chandrakant S. Madkar ◽  
Madhukar Shinde ◽  
Vilisha S. Kothari
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Economic Status ◽  
Venous Blood ◽  
Perinatal Morbidity ◽  
Third Trimester ◽  
Socio Economic Status ◽  
Geographical Variations ◽  
Study Population ◽  
Normotensive Pregnancy

Background: Pre-eclampsia is one of the major causes of maternal and perinatal morbidity and mortality. There are various parameters to evaluate pre-eclampsia. S.uric acid levels is one of the important biochemical markers in pre-eclampsia. The objective of current study is to compare the levels of S.uric acid in pre-eclamptic patients and normotensive patients.Methods: A total of 256 antenatal patients, consisting of two groups, 128 patients in each group diagnosed with pre-eclampsia (either earlier or during examination) and 128 control antenatal patients in their third trimester were considered. Both the groups were compared in relation to age, parity, socio economic status and geographical variations. Blood sample (venous blood) of about 5ml was drawn from the ante cubital vein of the patient under all aseptic precautions to estimate S.uric acid levels.Results: The observation of present study shows that the level of serum uric acid is significantly higher in the cases of pre-eclampsia. The value of S.uric acid increases with the severity of pre-eclampsia.Conclusions: It is concluded from this study that high levels of uric acid are found in the serum of pre-eclamptic cases as compared to normotensive cases of the study population. The levels of uric acid are higher in severe cases as compared to the levels in mild and moderate cases.

Socio-economic factors and the sex ratio at birth

1971 ◽  
Vol 3 (1) ◽  
pp. 23-42 ◽  
Author(s):  
Michael S. Teitelbaum ◽  
Nathan Mantel
Keyword(s):  
Sex Ratio ◽  
Birth Order ◽  
Economic Status ◽  
Economic Effect ◽  
Economic Variables ◽  
Socio Economic Status ◽  
Significant Difference ◽  
Study Population ◽  
Socio Economic Variables ◽  
The Relationship

Using a large special study population and refined indicators of socio-economic status, the relationship of the live birth sex ratio to socio economic variables is examined. The analyses provide control for the possible confounding effects of race and birth order.The sex ratio is shown to be significantly and positively associated with socio-economic variables. The relationship is not linear, however, but instead is characterized by an apparent ‘diminishing returns’ curve. The major increase in sex ratio is detected as socio-economic status increases from low to moderate. No significant change occurs between moderate and higher socio-economic levels.Even after controlling for the significant socio-economic effect, the analyses detect a significant difference between the sex ratios of Whites on the one hand and Negroes and Puerto Ricans on the other.No significant association between birth order and the sex ratio can be detected in the study population.

scholarly journals Systemic diseases and their association with open-angle glaucoma in the population of Stockholm

2021 ◽  
Author(s):  
Per Wändell ◽  
Axel C. Carlsson ◽  
Gunnar Ljunggren
Keyword(s):  
Total Population ◽  
Open Angle Glaucoma ◽  
Economic Status ◽  
Open Angle ◽  
Socio Economic Status ◽  
Chronic Lung Diseases ◽  
Somatic Comorbidities ◽  
Study Population ◽  
Hospital Stays ◽  
Somatic Diseases

Abstract Objective We aimed to study open-angle glaucoma in association with somatic comorbidities in the total population of adults in Region Stockholm. Methods The study population included all living persons aged 19 years and above who resided in Stockholm County, Sweden, on 1 January 2017 (N = 1 703 675). Subjects with specified diseases were identified with data from all registered consultations and hospital stays during 2008–2019. As outcome, the risk of being associated with a diagnosis of open-angle glaucoma was identified during 2012–2018. Analyses were performed by gender, controlling for age and socio-economic status. Age-adjusted odds ratios (ORs) with 95% confidence intervals (95% CI) for women and men with open-angle glaucoma, using individuals without this as referents, were calculated. Socio-economic status was assessed based on the neighbourhood the subjects lived in. Results In total, 16,299 cases of open-angle glaucoma were identified during 2012–2018, 9204 women and 7095 men. Higher fully adjusted OR (95% CI) for risk of being associated with open-angle glaucoma was for women and men with diabetes 1.138 (1.074–1.207) and 1.216 (1.148–1.289), cancer 1.175 (1.120–1.233) and 1.106 (1.048–1.166), hypertension 1.372 (1.306–1.440) and 1.243 (1.179–1.311); and for women with thyroid diseases 1.086 (1.030–1.146), chronic lung diseases 1.153 (1.093–1.216), and inflammatory arthropathies 1.132 (1.006–1.275). Higher glaucoma incidence was observed in individuals residing in high socio-economic status neighbourhoods. Conclusion The risk of glaucoma is increased in some somatic diseases, especially in individuals with diabetes, hypertension and cancer; and in higher socio-economic neighbourhoods as compared to lower socio-economic neighbourhoods.

scholarly journals Assessment of serum uric acid levels in patients with cervical intraepithelial neoplasia in Benin City

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Kenneth Atoe ◽  
Augustine Onovuakpo Eguvbe
Keyword(s):  
Uric Acid ◽  
Cervical Intraepithelial Neoplasia ◽  
Serum Uric Acid ◽  
Venous Blood ◽  
High Sensitivity ◽  
Intraepithelial Neoplasia ◽  
Control Group ◽  
Benin City ◽  
Malignant Lesions ◽  
Edo State

Elevated Uric acid levels in humans have been associated with cancer, though the pathogenic mechanism is still unclear. The present study attempts to investigate if elevated uric acid levels could be used to investigate the pre-malignant lesions leading to cervical cancer. The study which was carried out at the Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital Benin City and Department of Chemical Pathology, Edo University Iyamho, Edo state Nigeria, between August, 2017 and January 2019, examined the capacity of detecting Cervical Intraepithelial Neoplasia (CIN) early with serum uric acid in order to increase the chances of survival of women at risk. A total of 197 female participants were recruited for the study. Based on histological diagnosis, they were grouped as CIN 1, CIN 2 and CIN 3. The control group were negative for CIN. Venous blood was obtained from participants and serum uric acid levels were determined using standard laboratory methods. The benchmark for serum uric acid levels in diagnosing CIN presented in this study was at 6.55 mg/dL. The probability that uric acid level higher than 6.55 mg/dL indicate the disease probabilty was 93.1%. The age category within the CIN group with the highest level of uric acid was 31-40 years (10.86 mg/dL). The use of serum uric acid as an excellent biomarker for the diagnosis of CIN is therefore suggested due to its high sensitivity.

scholarly journals Serum uric acid is no more a by-stander for risk of cardiovascular diseases in metabolic syndrome: a prospective study

2021 ◽  
Vol 8 (6) ◽  
pp. 788
Author(s):  
Anirudh Kumar Allam ◽  
Chandrakant Chavan ◽  
Rahul Mandole ◽  
Jagdish Hiremath ◽  
Vikrant Khese
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Worldwide Population ◽  
Study Population ◽  
A Prospective Study

Background: Cardiovascular diseases have become the fastest growing health issue in India and worldwide. Population with metabolic syndrome is known to be pre-disposed to several chronic disorders along with higher risk of experiencing cardiovascular events. The role of uric acid as a cardiovascular risk factor in metabolic syndrome was not well studied in the literature, which made us to undertake the present study.Methods: All the patients aged between 18 to 75 years (both gender) who approached Madhavbaug cardiac care clinics located in Maharashtra, India for assessing risk of heart disease from January 2015 to January 2017 were screened. Risk factors for metabolic syndrome have been evaluated among the study population and categorised into metabolic syndrome positive (³3 risk factors) and negative groups (<3 risk factors). Statistical analysis was done using SPSS software version: 21.0.Results: Our study includes 2294 subjects who met the inclusion and exclusion criteria. Males outnumbered the females and sex ratio was 2.89:1. Females had lower serum uric acid levels compared to males irrespective of metabolic component. Gender and serum uric acid levels (high and low) were used stratification of the subjects. Serum uric acid is an independent predictor of cardiovascular diseases with an Odds ratio of 1.13 (95% confidence interval).Conclusions: Serum uric acid level is one of the important predictor for cardiovascular risk in metabolic syndrome. Raised uric acid is not an innocent by-stander and one of the major contributors in development of cardiovascular diseases.

scholarly journals PENGARUH STATUS SOSIAL EKONOMI ORANG TUA, LITERASI EKONOMI DAN PERCAYA DIRI TERHADAP MINAT WIRAUSAHA SISWA SMP NEGERI DI KECAMATAN TENGGILIS MEJOYO SURABAYA

2017 ◽  
Vol 4 (2) ◽  
pp. 149
Author(s):  
Muhammad Thohir ◽  
Yoyok Soesatyo ◽  
Harti Harti
Keyword(s):  
Regression Analysis ◽  
Random Sampling ◽  
Economic Status ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Economic Literacy ◽  
Socio Economic Status ◽  
Self Confidence ◽  
Student Interests ◽  
Study Population

This analysis to know the determine the effect of Socioeconomic Status of Parents of the students 'entrepreneurial interest, Effect of Economic Literacy for students' entrepreneurial interest, Effect on Interest Entrepreneurial Confidence Students and the Effect of Socio economic Status of Parents, Economic Literacy and self Confidence toEntrepreneurial Student Interests with partial and collectively - together/simultaneously in SMP at Mejoyo Tenggilis Subdistrict Surabaya. This study is using multiple linear regression analysis with a quantitative approach.The study population of 686 students and a sample of 253 students was taken by random sampling propotional.Based on the results of research and discussion of the results of this study concluded that the results the Socio-Economic Status of Parents, Economic Literacy, and Self Confidence influence the Entrepreneurial Interests with significant

scholarly journals Council tax valuation band predicts breast feeding and socio-economic status in the ALSPAC study population

2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Norman Beale ◽  
◽  
Gill Kane ◽  
Mark Gwynne ◽  
Carole Peart ◽  
...  
Keyword(s):  
Breast Feeding ◽  
Economic Status ◽  
Socio Economic Status ◽  
Study Population

scholarly journals Hyperuricemia in Systemic Hypertension and its correlation with systolic and diastolic blood pressure.

2020 ◽  
Vol 27 (01) ◽  
pp. 89-93
Author(s):  
Haji Khan Khoharo ◽  
Ali Akbar Shah ◽  
Fatima Qureshi ◽  
Sajjad Ali Almani
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Diastolic Blood Pressure ◽  
Serum Uric Acid ◽  
Study Design ◽  
Venous Blood ◽  
University Hospital ◽  
Systemic Hypertension ◽  
Cross Sectional ◽  
Positive Correlation

Objectives: To determine the serum uric acid (SUA) in systemic hypertension and its correlation with systolic (SBP) and diastolic blood pressure (DBP). Study Design: Cross sectional study design. Setting: Department of Medicine, Isra University Hospital. Period: From April 2016 – February 2017. Material and Methods: A sample of 100 cases of systemic hypertension and 100 age, gender, body weight and BMI controls were selected through non-probability purposive sampling. Volunteers were asked for history, physical examination, and blood sampling. Systemic BP was measured with a mercury sphygmomanometer. 2 ml venous blood was taken, centrifuged and sera were used for detection of SUA. Data was saved in a pre- structured Performa. Computed based statistical software (SPSS v 22.0, IBM, Incorporation, USA) was used for data analysis. Data variables were analyzed at 95% CI (P ≤ 0.05). Results: Serum uric acid in controls was 2.91±0.75 mg/dl compared to 5.70±1.76 mg/dl (P=0.0001). 57% of cases revealed hyperuricemia compared to 11% in control (X2=17.5, P=0.0001). Serum Uric acid showed significantly positive correlation with Systolic BP (r= 0.518*, p=0.0001) and Diastolic BP (r= 0.397**, p=0.0001). Conclusion: The present study reports hyperuricemia in 57% cases of systemic hypertension and uric acid shows positive correlation with systolic and diastolic blood pressure.

scholarly journals Interaction of Alcohol Consumption and ABCG2 rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population

2021 ◽  
Vol 11 (11) ◽  
pp. 1158
Author(s):  
I-Chieh Chen ◽  
Yen-Ju Chen ◽  
Yi-Ming Chen ◽  
Hsueh-Ju Lin ◽  
Ying-Cheng Lin ◽  
...  
Keyword(s):  
Uric Acid ◽  
Alcohol Consumption ◽  
Serum Uric Acid ◽  
Genetic Locus ◽  
Epidemiologic Studies ◽  
Taiwanese Population ◽  
Logistic Regression Models ◽  
Lifestyle Risk Factors ◽  
Study Population ◽  
Lifestyle Risk

Background: ABCG2 rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., ABCG2 gene) together, contribute to enhanced serum uric acid levels. However, the interaction between ABCG2 rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with ABCG2 rs2231142 variants and how this is affected by alcohol consumption. Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between ABCG2 rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of ABCG2 rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of ABCG2 rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the ABCG2 rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the ABCG2 rs2231142 risk allele contributes to increased HUA risk.

scholarly journals Correlation between serum uric acid levels and outcomes of pre-eclampsia in Abakaliki, South-east, Nigeria

2021 ◽  
Vol 9 (10) ◽  
pp. 2914
Author(s):  
Nnabugwu A. Adiele ◽  
Odidika U. J. Umeora ◽  
Robinson C. Onoh ◽  
Ikechukwu B. O. Dimejesi ◽  
Arinze C. Ikeotuonye ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Threshold Value ◽  
Controlled Study ◽  
Perinatal Morbidity ◽  
Significant Difference ◽  
The Mean

Background: Pre-eclampsia is a leading cause of fetomaternal and perinatal morbidity and mortality. The role of serum uric acid (SUA) in determining the complications of preeclampsia has been controversial. This study compared mean SUA levels between severe pre-eclamptics and normotensive women at term and ascertained its correlation with outcomes of preeclampsia; as well as determined if there is a threshold value of SUA level beyond which fetomaternal complications occur.Methods: A case-controlled study where 80 severe pre-eclamptics at term and 80 normotensive women matched for gestational age were recruited. Blood samples were collected from them for assay of SUA levels and they were followed till delivery. The fetomaternal outcomes and the corresponding SUA levels at diagnosis were documented and variables statistically analyzed. A receiver operating characteristic curve was used to determine the cut-off value of SUA beyond which adverse fetomateral complications are likely to occur in pre-eclampsia.Results: The mean SUA level in severe pre-eclamptics (0.283±0.09 mmol/l) was not significantly higher than that of normotensive women (0.263±0.09 mmol/l, p=0.13). There was a weak positive correlation between the SUA levels and fetomaternal outcomes [maternal (r=0.102, p=0.236) and fetal (r=0.096, p=0.226)]. The study was unable to identify the threshold SUA level at which adverse fetomaternal outcomes occur as the values of SUA were closely related.Conclusions: SUA levels of pre-eclamptics and normotensive women did not show significant difference and correlated weakly with fetomaternal outcomes and are therefore poor predictor of fetomaternal outcomes in pre-eclampsia.

scholarly journals Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women

2020 ◽  
Vol 4 (1) ◽  
pp. 20-22
Author(s):  
Hudda Abbas ◽  
Samina Badar ◽  
Zunera Javed ◽  
Mohammad Ahmed Abdelmoneam Ramdan
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Outpatient Department ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Third Trimester

Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p’ value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.

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