scholarly journals Oxidative stress and antioxidant vitamins in cataract patients

2019 ◽  
Vol 7 (5) ◽  
pp. 1568
Author(s):  
Ghazala . ◽  
Syed Liaquat Ali ◽  
Jamil Ahmed Siddiqui ◽  
Aziza Khanam ◽  
Saleh Memon
Keyword(s):  
Oxidative Stress ◽  
Demographic Data ◽  
Antioxidant Vitamins ◽  
Blood Levels ◽  
Contributory Factor ◽  
Antioxidant Vitamin ◽  
Diabetic Cataract ◽  
Age Related ◽  
Significant Difference ◽  
Cataract Patients

Background: In Pakistan age related vision disturbances are mainly due to cataract. Various studies have reported relationship of ocular lesion with senile changes and diabetes mellitus resulting in reduced quality of life due to vision. Oxidative stress is an important factor in the process of cataractogenesis. The pathogenesis of the cataract may involve decreased activity of antioxidant scavenging system which includes non-enzymatic natural antioxidants as biomolecules such as carotenoids and vitamins. So, it is planned to investigate the level of serum antioxidant vitamins in diabetic cataract patients and in non-diabetic cataract patients.Methods: The study was conducted at Biochemistry department, Al-Tibri Medical College Karachi from October 2016 to October 2017. Ninety pre diagnosed cataract patients were selected from Al-Ibrahim Eye Hospital Karachi 40 normal control subjects were selected from the same population with same socioeconomic group. The demographic data was analyzed. The random blood sugar, antioxidant vitamins (C, A and E) and malondialdehyde were analyzed in the blood sample of control and cataract patients. The data was analyzed by SPSS version 20.Results: There was no significant difference in the level of vitamin C, A, E and MDA between diabetic and non-diabetic cataract patients, but the blood levels of vitamins of control are higher as compared to the cataract patients. The level of MDA is significantly high in cataract patients as compared to control. Antioxidant vitamin E was negatively correlated with serum malondialdehyde in cataract patients.Conclusions: It is concluded that in diabetic and non-diabetic cataract low level of serum antioxidant vitamins may be a contributory factor for cataractogenesis.

scholarly journals Impact of tobacco use on oxidative stress in cataract

2020 ◽  
Vol 11 (3) ◽  
pp. 2942-2947
Author(s):  
Vaishali S Pawar ◽  
Ajit Sontakke
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Tobacco Use ◽  
Smokeless Tobacco ◽  
Nuclear Cataract ◽  
User Group ◽  
Tobacco User ◽  
Age Related ◽  
Significant Difference ◽  
Cataract Patients

Even today, the leading cause of visual impairment is age related cataract.  Among the risk factors for cataract, tobacco is one of the modifiable risk factors. Association between smoking and increased oxidative stress among cataract patients has been shown by some studies. But studies related to smokeless tobacco use are not done. The aim of the study was to estimate oxidative stress by markers like enzymatic antioxidant Superoxide Dismutase (SOD) and lipid peroxiation product Malondialdehyde (MDA) in tobacco user age related cataract (ARC) subjects and compare them with tobacco nonuser age related cataract (ARC) subjects. This cross sectional study was performed in 120 subjects divided into 2 groups – 60 tobacco nonuser age related cataract subjects and 60 tobacco user age related cataract subjects. 60 tobacco user cataract subjects divided into 5 groups - tobacco smokers, tobacco chewers, tobacco mishri users, dual tobacco chewers with mishri users and dual smokers with smokeless tobacco users. Oxidative stress was assessed by estimation of erythrocytic SOD and serum MDA. The study showed that in tobacco user group age of cataract patients was significantly less than tobacco nonuser cataract patients (P<0.05).  Serum MDA levels were significantly high and erythrocytic SOD levels were significantly low in tobacco user cataract patients than tobacco nonuser cataract patients (P<0.001).  Nuclear cataract was significantly more in tobacco user group (P<0.05).  On comparison of subtypes of cataract in tobacco user subgroup, no significant difference was found. These results suggested that age related Cataract occurs at an earlier age in tobacco users due to increased oxidative stress. Also nuclear cataract was significantly associated with tobacco use.

scholarly journals Serum vitamin A, E & C in cortical & nuclear cataract patients.

2021 ◽  
Vol 28 (08) ◽  
pp. 1137-1141
Author(s):  
Ghazala - ◽  
◽  
Jamil Ahmed Siddiqui ◽  
Syed Naqeeb Ali ◽  
Syed Liaquat Ali ◽  
...  
Keyword(s):  
Blood Level ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Sampling Technique ◽  
Antioxidant Vitamins ◽  
Nuclear Cataract ◽  
Control Subjects ◽  
Significant Difference ◽  
The Status ◽  
Cataract Patients

Objective: To assess the status of antioxidant vitamins (A, E & C) in cortical and nuclear cataracts patients. Study Design: Prospective Comparative study. Setting: Al-Ibrahim Eye Hospital and Biochemistry Department of Al-Tibri Medical College, Karachi. Period: Sept 2016 to Aug 2017. Material & Methods: A non-probability random sampling technique was used on 80 pre-diagnosed cataracts (cortical and nuclear) patients, and 40 control subjects were selected for the study. The demographic data were collected, and the blood sample of control and cataract patients were analyzed for random blood sugar and antioxidant vitamins (A, E, and C) by Elisa Method. Results: The Blood level of vitamins E was low in cataract patients as compared to control subjects. Conclusions: The blood level of vitamin E is less in cortical and nuclear cataract patients as compared to control but had shown no significant difference between cortical and nuclear cataract patients.

scholarly journals Role of oxidative stress in cataractogenesis

2017 ◽  
Vol 5 (6) ◽  
pp. 2390 ◽  
Author(s):  
Geeta Bhatia ◽  
A. N. Sontakke ◽  
Subodhini Abhang
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Vitamin C ◽  
Protein Carbonyl ◽  
Diabetic Patients ◽  
Diabetic Cataract ◽  
Age Related ◽  
Antioxidant Defence System ◽  
Cataract Patients

Background: Cataract is a multifactorial disease and is a major cause of blindness in india. Oxidative stress is thought to be a major factor to initiate the process of cataractogenesis. It is today well established fact that oxidative stress participates in both age-related (senile) and diabetes-induced cataract (diabetic). Oxidative damage to the lens most likely arises as a consequence of an impaired antioxidant defence system, due to increased generation of ROS both by age and diabetes. The present study was designed to determine role of oxidative stress in cataractogensis and to compare levels of oxidative stress markers in senile and diabetic cataract patients.Methods: Serum malondialdehyde (MDA) and serum protein carbonyl (PC) were measured as indicator of oxidative stress whereas antioxidant status was assessed by estimating serum Total antioxidant capacity (TAC) and dietary antioxidants levels i.e vitamin C and vitamin E in senile and diabetic cataract patients compared with healthy controls.Results: The result reveal that the serum MDA and PC levels were significantly increased in patients with senile and diabetic cataract whereas serum TAC, vitamin C and Vitamin E were significantly reduced in senile and diabetic patients when compared with normal healthy controls.Conclusions: From the result, it is concluded that oxidative stress is in the foreground of cataract formation which includes senile and diabetic cataract. Oxidative stress produced in diabetic cataract patients is more as compared to senile cataract patients. 

scholarly journals Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Giuseppe Verdile ◽  
Kevin N. Keane ◽  
Vinicius F. Cruzat ◽  
Sandra Medic ◽  
Miheer Sabale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Insulin Signalling ◽  
Contributory Factor ◽  
Protein Accumulation ◽  
Age Related ◽  
Impaired Insulin ◽  
And Oxidative Stress

Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders. Alzheimer’s disease (AD) is the most common subtype of dementia. Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD. A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD. Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood. Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition. As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β(Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.

Antioxidant vitamins induce angiogenesis in the normal pig kidney

2007 ◽  
Vol 293 (1) ◽  
pp. F371-F381 ◽  
Author(s):  
Elena Daghini ◽  
Xiang-Yang Zhu ◽  
Daniele Versari ◽  
Michael D. Bentley ◽  
Claudio Napoli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vascular Function ◽  
Ex Vivo ◽  
Antioxidant Vitamins ◽  
Vitamin Supplementation ◽  
Spatial Density ◽  
Antioxidant Vitamin ◽  
High Dose ◽  
Vascular Endothelial ◽  
Microvascular Proliferation

The effects of chronic supplementation with antioxidant vitamins on angiogenesis are controversial. The aim of the present study was to evaluate in kidneys of normal pigs the effect of chronic supplementation with vitamins E and C, at doses that are effective in reducing oxidative stress and attenuating angiogenesis under pathological conditions. Domestic pigs were randomized to receive a 12-wk normal diet without ( n = 6) or with antioxidant vitamins supplementation (1g/day vitamin C, 100 IU·kg−1·day−1 vitamin E; n = 6). Electron beam computed tomography (CT) was used to evaluate renal cortical vascular function in vivo, and micro-CT was to assess the spatial density and average diameter of cortical microvessels (diameter <500 μm) ex vivo. Oxidative stress and expressions of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α were evaluated in renal tissue. The effects of increasing concentrations of the same vitamins on redox status and angiogenesis were also evaluated in human umbilical vascular endothelial cells (HUVEC). Compared with normal pigs, the density of cortical transmural microvessels was significantly greater in vitamin-supplemented pigs (149.0 ± 11.7 vs. 333.8 ± 48.1 vessel/cm2, P < 0.05), whereas the cortical perfusion response to ACh was impaired. This was accompanied by a significant increase in tissue oxidative stress and levels of VEGF and HIF-1α. A low dose of antioxidant decreased, whereas a high dose increased, HUVEC oxidative stress and angiogenesis, which was partly mediated by hydrogen peroxide. Antioxidant vitamin supplementation can increase tissue oxidative redox and microvascular proliferation in the normal kidney, probably due to a biphasic effect that depends on basal redox balance.

scholarly journals Dietary Patterns and Oxidative Stress in a Population of Women with Breast Cancer in the North-Western Regions of Algeria (Saida and El-Bayadh)

2020 ◽  
Vol 10 (6) ◽  
pp. 24-30
Author(s):  
Noureddine Halla ◽  
Kebir Boucherit ◽  
Kadda Hachem ◽  
Amouria Asmouni ◽  
Hanane Derrab ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Risk Factors ◽  
Dietary Patterns ◽  
Demographic Data ◽  
The Body ◽  
Cancer Risk Factors ◽  
The North ◽  
Significant Difference ◽  
North Western

Objective: The aim of this work is the study of risk factors for breast cancer in a population of women in the north-western regions of Algeria (Saida and El-Bayadh) Methodology: A case-control study was carried out on 40 women including 20 cancerous women and 20 control women, in order to determine the dietary patterns and general characteristics of the population studied and to compare the hematological and biochemical parameters, and markers of oxidative/antioxidant status between control women and breast cancer women. Results: The results obtained show that there is no significant difference in the average age however the body mass index was significantly increased in cancer women, revealing overweight (p <0.05), compared to control women. The marital status of the target population is predominantly a married woman status and the level of education shows a relatively low level in breast cancer cases compared to women controls. The illiteracy rate is exceptionally high in cancer women compared to controls (35% versus 20%). In addition, the levels of glucose, creatinine, HDL and ALAT are similar between the two groups of women. The contents of urea, cholesterol, triglyceride, LDL, ASAT, malondialdehyde and uric acid are significantly increased in women with breast cancer compared to women controls. But the vitamin C content is significantly reduced in cancer women compared to control women. Conclusion: We conclude from this study that there is an association between breast cancer and lipid alteration, oxidative stress, age, increase in BMI, socio-demographic data, professional situation, age, means of menstruation and menopause, and ultimately the lifestyle. All these factors are risk factors for breast cancer in the region of Saida and El-Bayadh. Keywords: Breast Cancer, Risk Factors, Dietary Patterns, Oxidative Stress.

scholarly journals Vitamin E levels in patients with controlled and uncontrolled type 2 diabetes mellitus

2018 ◽  
Vol 5 (3) ◽  
pp. 864 ◽  
Author(s):  
Manouchehr Iranparvar Alamdari ◽  
Shahram Habibzadeh ◽  
Bita Shahbazzadegan ◽  
Mohammad Mazani ◽  
Amir Bigdeli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Antioxidant Vitamin ◽  
Diabetic Patients ◽  
Check List ◽  
Cross Sectional ◽  
Significant Difference

Background: Diabetes type 2 associates with increased oxidative stress and reduced antioxidant. Vitamin E supplementation reduces oxidative stress in diabetic patients. We intended to measure the level of this vitamin in these patients to assess its relationship in control of patients' diabetes by designing present study.Methods: This is a descriptive and cross-sectional study and carried out on 186 patients with diabetes type 2 diagnosis. The levels of HbA1C (measured by HPLC method), TG, cholesterol, HDL, LDL and Cr were measured, and given to that the level of HbA1C lower than 7 (controlled group) and or more than 7 (uncontrolled group), patients were divided in two groups. Were designed a check list involved questions such as age and information of each patient associated with measured vitamin E level were entered into the check list and after that were analyzed data.Results: In the existing study 186 diabetic patients were examined. From within examined patients, 129 (69.3%) were women and the rest were men and average patients age were 53.33±11.2. In this study was observed there was no direct correlation between the level of cholesterol (p=0.284), LDL (p=0.538( and HDL (p=0.362) with controlled DM II in patients while in uncontrolled diabetic the triglyceride levels was more than those with controlled blood sugar significantly (p=0.046(. The average vitamin E level in patients was 1488.6±692.2 nmol/l its lowest level 114.4 nmol/l and the highest level was 6235 nmol/l.Conclusions: The results of this study show that the vitamin E levels no significant difference between control and non-control diabetic patients.

scholarly journals Oxidative Stress, Trace and Toxic Metal Levels In Alzheimer’S Disease In Sub-Sahara Africa

2020 ◽  
Author(s):  
ISHIAQ Olayinka OMOTOSHO ◽  
Michael Roland Ngwube ◽  
Jibril Omuya ABDUMALIK
Keyword(s):  
Oxidative Stress ◽  
Toxic Metal ◽  
Clinical History ◽  
Genetic Alterations ◽  
Stress Index ◽  
Blood Levels ◽  
College Hospital ◽  
Lead And Cadmium ◽  
Age Related ◽  
Metal Levels

Abstract BackgroundAlzheimer’s disease (AD), an age-related neurodegenerative disease characterized by loss of memory has been attributed to oxidative stress induced by accumulation of Amyloid (Aβ) protein in the brain; environmental and genetic alterations have been implicated as the pathogenesis of the disease. This work investigated levels of selected trace (Iron, Zinc and Copper) and toxic (Cadmium and Lead) metals in AD patients.MethodIn this case-control study, a total of 38 participants (aged ≥ 60 years) consisting of 18 clinically diagnosed AD subjects and 20 apparently healthy age-matched adults were recruited from the University College Hospital Ibadan Geriatric Centre. Semi-structured questionnaire was used to obtain demographic information, clinical history, lifestyle and dietary patterns from participants. Blood levels of iron, copper, zinc, lead and cadmium were analyzed using Atomic Absorption Spectrophotometry (AAS); levels of malondialdehyde (MDA), total antioxidant capacity (TAC), hydrogen peroxide (H2O2), and total plasma peroxide (TPP) were determined spectrophotometrically, while oxidative stress index (OSI) and copper to zinc ratio (Cu:Zn) were calculated.ResultsMean plasma level of zinc was significantly lower in cases (86.04 ± 11.07 µg/dl) compared to controls (108.80 ± 12.47 µg/dl), while blood lead (13.85 ± 2.96 µg/dl, 8.32 ± 2.10 µg/dl) and cadmium (1.34 ± 0.71 µg/L, 0.71 ± 0.14 µg/L) levels were significantly higher in cases than in controls respectively. Although Fe and Cu levels were similar in cases and controls, Cu:Zn ratio was significantly elevated in cases compared to controls (p = 0.000). Though other OS markers were not significantly different in both groups, TPP was significantly higher in cases (64.96 ± 7.20 µmol/H2O2 vs. 55.41 ± 2.38 µmol/H2O2) while MDA correlated inversely with TAC in cases (r= − 0.477, p = 0.045).DiscussionThe low plasma Zn coupled with high blood Pb and Cd levels may precipitate the elevated TPP and Cu:Zn ratio in cases. The reduced metallothionine defense of the system as indicated by the elevated Cu:Zn ratio in cases may also exacerbate this problem.ConclusionThe damaging effect of increasing toxic metal levels may be accentuating development of oxidative stress facilitating the progression of AD.

scholarly journals SO044ALPHA LIPOIC ACID COMPARED TO SELENIUM IN MITOCHONDRIAL RESUSCITATION AND MI RNA-126 EXPRESSION IN HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Magdy ElSharkawy ◽  
Zainab Al Kasaby ◽  
Hosny A. Elewa ◽  
Maha Abdelrahman
Keyword(s):  
Oxidative Stress ◽  
Serum Level ◽  
Lipoic Acid ◽  
Demographic Data ◽  
Serum Levels ◽  
Cardiovascular Complications ◽  
Base Line ◽  
Coq10 Level ◽  
Mitochondrial Functions ◽  
Significant Difference

Abstract Background and Aims anti-oxidants may decrease the risk of cardiovascular complications (CVC) in HD patients. We aimed to study antioxidant effect of Alpha lipoic acid and selenium on oxidative stress, endothelial repair, and mitochondrial functions in HD patients by evaluating the serum level of reactive oxygen species (ROS), miRNA-126, and CoQ10. Method 60 individuals were enrolled and randomized into 3 groups, G1; 22 HD patients as control, G2; 20 HD patients received Selenium, and G3;18 HD patients received. Serum levels of ROS, CoQ10, and miRNA-126 were assessed at base line and after three months treatment for all patients. Results At baseline, all groups were matched regarding their demographic data and target parameters. After three months, in G1; the serum level of ROS increased significantly (P &lt; 0.05), CoQ10 didn't change significantly (P &gt; 0.05), while the fold expression of miRNA-126 decreased significantly (P &lt; 0.05). In G2,3; there were statistical significant changes in target parameters after the treatment, ROS level decreased significantly by 34%, and by 79%, CoQ10 mean levels increased significantly from 13.21 to 28.35, and from 13.46 to 36.43 ng/ml, mean fold expression of miRNA126, increased significantly by 6.94, and 10.54 folds, in Selenium and, Thiotacid groups respectively. The results showed that Thiotacid was better than Selenium in ROS level reduction, and CoQ10 level improvement, while no statistical significant difference between two drugs regarding miRNA126 level (P &gt; 0.05). Conclusion Selenium and, Thiotacid reduce oxidative stress and also they enhancing the endothelial repairing, and improve mitochondrial functions and thus may reduce risk of CVC.

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