scholarly journals A randomised study to evaluate the efficacy of isotretinoin, electrodessication and comedone extraction in the treatment of comedonal acne

2019 ◽  
Vol 5 (3) ◽  
pp. 457
Author(s):  
Kuraganty Ramya ◽  
Bakuru Gayatri Devi ◽  
K. V. T. Gopal ◽  
T. Narayana Rao
Keyword(s):  
Statistical Analysis ◽  
Adverse Effects ◽  
Young Patients ◽  
Topical Antibiotic ◽  
Chi Square ◽  
Randomised Study ◽  
Chi Square Test ◽  
Group A ◽  
Oral Isotretinoin

<p class="abstract"><strong>Background:</strong> Comedonal acne commonly seen in adolescents and young patients which is refractory to standard treatments. This study is being undertaken to determine the efficacy and adverse effects of oral isotretinoin, electrodessication and comedone extraction in patients of comedonalacne.</p><p class="abstract"><strong>Methods:</strong> A total of 120 patients of comedonal acne were enrolled and randomly divided into 4 groups of 30 patients each. Group A, B, C and D patients were treated with isotretinoin (20 mg daily), electrodessication, comedone extraction (4 weeks interval) and topical antibiotic daily for 12 weeks. The response in each group was assessed based on decrease in total comedonal count after 12 weeks of treatment. Statistical analysis was done using chi square test.<strong></strong></p><p class="abstract"><strong>Results:</strong> Eighty seven (72%) cases had predominantly closed comedones and 33 (27%) cases showed open comedones. After 12 weeks of treatment, more than 75% decrease in comedonal count was seen in 60% of patients in electrodessication group followed by 30% (isotretinoin), 13.3% (comedone extraction). The decrease in total number of comedone was significantly higher with electrodessication (84.4%) followed by isotretinoin (73%), comedone extraction (43.2%) and topical antibiotic (5.7%). After follow up of 3 months, recurrence of comedones was least with isotretinoin followed by comedone extraction and electrodessication.</p><p class="abstract"><strong>Conclusions:</strong> For comedonal acne, initial electrodessication followed by isotretinoin over 12 weeks gives the best outcome of quick remission and least recurrence. Electrodessication and comedone extraction are the preferred modalities in patients with predominantly closed and open comedones respectively.</p><p class="abstract"> </p>

Sexual function and satisfaction in Mexican young women undergoing breast cancer treatment.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21714-e21714
Author(s):  
Cynthia Mayte Villarreal-Garza ◽  
Alejandra Platas ◽  
Andrea Castro-Sanchez ◽  
Melina Miaja ◽  
Alan Fonseca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sexual Function ◽  
Young Women ◽  
Young Patients ◽  
Study Data ◽  
Mexican Women ◽  
Chi Square ◽  
Younger Women ◽  
Chi Square Test

e21714 Background: Compared to other regions, the burden of breast cancer (BC) in Mexico is disproportionately borne by younger women. Yet, their particular needs and concerns have remained understudied, including treatment-related sexual adverse effects. We aim to assess the sexual function and satisfaction in Mexican young women with BC undergoing treatment. Methods: This is a prospective sexual assessment study in BC patients of the pilot phase of the Joven y Fuerte Mexican cohort (N=96). Sexual health was assessed using the Female Sexual Function Index (FSFI) and the Sexual Satisfaction Inventory (SSI) at two points in time: baseline (BL) and 6-months follow-up (6-FU). FSFI and SSI scores lower than 26.55 and 111, respectively, were defined as sexual morbidity. Differences between proportions of BL and 6-FU were examined with Pearson chi-square test. Matched t-tests were used to test for differences in the domains of the FSFI and in the SSI total score. Results: 70 women completed the FSFI at both time points and 69 the SSI. Our results showed a high percentage of sexual dysfunction among Mexican women at BL and 6-FU (61.4% and 74.3%, respectively, p<0.001), as well as an elevated proportion of sexual low satisfaction at both time lines (40.6% and 43.5%, p=0.004). Most 6-FU FSFI domain scores were significantly worse than those at BL (Table 1). There were no significant differences in the SSI total score (102.31 [BL] vs 96.11 [6-FU], p=0.16). Conclusions: Mexican young patients with BC report significant sexual morbidity at BL, which even worsens after the first short follow-up. Reasons for the low sexual performance among Mexican women remain understudied and should be actively sought. In this prospective study, data will be annually collected for five years. This information will provide valuable information in an often-neglected matter of BC patients’ care. [Table: see text]

scholarly journals Efficacy of intermittent prophylaxis vis a vis no prophylactic interventions in febrile seizure recurrence: randomised controlled trail

2019 ◽  
Vol 7 (11) ◽  
pp. 4064
Author(s):  
Nitin Bhoyar ◽  
Baraturam Bhaisara ◽  
Dinesh Kumar Singh
Keyword(s):  
Recurrence Rate ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Care Hospital ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Group A ◽  
Febrile Episodes

Background: To compare efficacy of intermittent prophylaxis during subsequent febrile episodes with antipyretics alone or antipyretics with anticonvulsant (clobazam) vis a vis no prophylactic interventions except need-based antipyretic measures in preventing recurrence of febrile seizures.Methods: This prospective randomized controlled interventional study was carried out in neurologically normal children. Study conducted over 14 months (March 2014 - May 2015), tertiary care hospital Mumbai. Inclusion criteria was, children aged from 6 month to 5 years with history of simple febrile seizure, lasting for less than 15 minutes, with Frequency less than one episode in 24 hours. Children with history of afebrile or complex febrile seizure, CNS comorbidity, family history of epilepsy, abnormal electroencephalogram, Unwillingness or non-feasibility of follow up were excluded from study. The patients were randomly grouped in A (No Prophylaxis n= 60), B (Antipyretic prophylaxis n=57) and C (Antipyretics + clobazam prophylaxis n=55). All cases were followed up telephonically every 15 days from date of first seizure as well as personal follow up at 1,3,6 months either in the hospital or at home. End point of study was taken as six months of follow-up from enrolment or lost-to-follow up. Efficacy of intervention was compared using chi-square test, Pearson chi-square test with/without Yates continuity correction and/or Fisher exact test, with p value of <0.05 as test of significance.Results: Sixty cases in group A developed febrile episodes and 6 of them developed recurrence of febrile seizures, with a recurrence rate of 10% among total cases and 9.67% among all febrile episodes. Recurrence rate was significantly higher (10%) in cases who did not receive any prophylactic intervention (Group A) as compared to pooled recurrence rate in group B and C together 1.78% (p=0.022).Conclusion: Regular antipyretic prophylaxis, alone or along with clobazam does not reduce the risk of recurrence in simple febrile seizures as compared to those who receive antipyretic intervention.

A Comparative Study on the effect of Padabhyanga with Tila Taila and Nimba Taila in management of Vipadika w.s.r. to Padasputana

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Asha Karki ◽  
Dr.Mallikarjun S. Yalagond ◽  
Dr.Venkatesh Illal
Keyword(s):  
Food Habits ◽  
Complete Relief ◽  
Chi Square ◽  
Medical College ◽  
Comparative Clinical Study ◽  
Chi Square Test ◽  
Group A ◽  
Group B ◽  
Better Than

Background: Vipadika affects irrespective of age, sex and socioeconomic status. The causes may be excessive/barefoot walking, contact with dust, detergents and improper food habits. Here control over Vatadosha is important which can be achieved through Padabhyanga. Materials and Methods: It was a comparative clinical study of 30 patients, who were selected by random sampling from the OPD of S.M.V.V.S, R.K.M Ayurveda Medical College, Vijayapura, and categorized into 2 groups as 'A' and 'B', each consisting of 15 patients and were advised Tila Taila and Nimba Taila Padabhyanga for 30 days respectively. Follow up was advised on 45th day of treatment. Severities of the symptoms were assessed before, after treatment and after follow up. Results: In group-A 20% of patients showed complete relief and in group-B 0% have showed complete relief. Conclusion: Tila Taila is having Sara, Sukshma Guna and pacifies Vatakapha Dosha. Nimba Taila is Kushtagna, Krimigna. Both Tailas help in reducing Rukshata and Sputana. Vipadika can be correlated with cracked heels. The results were assessed statistically by Pooled chi square test. It was concluded that group-A patients were significantly better than group-B after follow up. Hence Tila Taila Padabhyanga is beneficial in Vipadika.

scholarly journals Comparison between Conventional 2.0 mm Miniplates versus 3-D Plates In Management of Mandibular Fractures

2020 ◽  
pp. 83-88
Author(s):  
Meena Kumari ◽  
Kashif Ali Channar ◽  
Suneel Kumar Punjabi ◽  
Mahwish Memon ◽  
Salman Shams ◽  
...  
Keyword(s):  
Operative Time ◽  
Mandibular Fracture ◽  
Mandibular Fractures ◽  
Chi Square ◽  
Chi Square Test ◽  
Group A ◽  
Group B

Objective: To compare the outcomes stability, malunion and intra operative time by using 2.0mm conventional miniplates and 3-D plates in management of the anterior mandibular fracture. Materials and Methods: Total 94 patients were included and equally divided in two groups. Fixation of fracture was done by 2.0mm conventional miniplates in Group-A and a single 3D plate in Group-B. Stability, healing and malunion were assessed on follow-up at 1st week, 6th week, and 12th week using Chi Square Test. Results: Stability was 91.5% in group-A and 93.6% in group-B. Clinically malunion was 12.8% at 1st week, 14.8% at 2nd week, 14.8% at 8th week in group-A while in group-B, malunion was 8.5% at 1st week, 2nd week and at 8th week. Radiographically, malunion was 12.8% at 1st week, 14.8% at 2nd week, 14.8% at 8th week in group-A while in group-B, malunion was 8.5% at 1stweek, 2nd week and at 8th week. Conclusion: The results of the study concluded that 3-D plating system has advantages over conventional 2 mm miniplates.

scholarly journals Role of Dermaroller and Prp In Post-Traumatic Facial Scar Treatments

2020 ◽  
Vol 11 (3) ◽  
pp. 4061-4067
Author(s):  
Alpesh ◽  
Jumale V P
Keyword(s):  
Statistical Significance ◽  
T Test ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Group A ◽  
Post Traumatic ◽  
Group B

In the present study follow up kept on immediate post-operative day and at one week to evaluate pain, bleeding and inflammation. Final follow up at two months for assessment of aesthetic score by three independent personnel. Pain and inflammation were more associated with Group B compared to Group A, but there are no statistical significance differences among this groups (P value- 0.074 and 0.136 for pain and inflammation respectively on immediate post-operative day. Chi-square test). Final follow up assessment of aesthetic scores at two months calculated by Chi- square test and comparisons of two groups for aesthetic scores done by Independent t-Test. All three personnel gave higher aesthetic score to Group B but statistically this was not significant (P-value 0.287, 0.129 and 0.400 by Observer 1, 2 and patients respectively. Chi-square test). The mean aesthetic score given by Observer 1, 2 and patient was higher associated to Group B but statistically this was not significant (P=0.526, 0.055 and 0.232 independent t-Test).

scholarly journals PROGNOSTIC FACTORS OF RENAL TUMOR RECURRENCE AFTER RADICAL NEPHRECTOMY

2021 ◽  
Vol 108 (Supplement_3) ◽  
Author(s):  
G Martínez Izquierdo ◽  
A R Arnaiz Pérez ◽  
E Escolano Fernández ◽  
M Merayo Álvarez ◽  
B Carrasco Aguilera ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Radical Nephrectomy ◽  
Univariate Analysis ◽  
Malignant Neoplasms ◽  
Histopathological Analysis ◽  
Chi Square ◽  
Renal Sinus ◽  
Chi Square Test

Abstract INTRODUCTION Renal cell carcinoma (RCC) represents 3% of overall malignant neoplasms in adults. However, its aetiology has not been clearly established. Although surgery represents the cornerstone in treatment, recurrence postoperative rates are around 20-30%, what implies prognostic factors search must be mandatory in order to help to plan de follow-up and the different adjuvant therapy possibilities available in case they were necessary. MATERIAL AND METHODS A retrospective observational study was carried out in 110 patients who underwent radical nephrectomy between 2004 and 2018, with the aim of identifying possible prognostic factors of recurrence of RCC after these surgeries. Preoperative data (epidemiological, comorbidities and laboratory tests), surgical, pathological and variables related to follow-up were taken into account. A univariate and multivariate analysis were performed, using chi-square test and logistic regression, respectively. RESULTS The median follow-up time was 53.5 months (SD = 35.8), time in which 19 patients had a recurrence of RCC after radical nephrectomy (17.2%). Histopathological items such as the surgical piece size, the nodal and microvascular invasion, the renal sinus invasion and the presence of necrosis in the surgical piece were associated with RCC recurrence in the univariate analysis, while only the presence of necrosis in the surgical piece showed a significant result in the multivariate analysis (p = 0.004). CONCLUSIONS Histopathological analysis, highlighting the presence of necrosis in the histological sample, was proved to be the main risk factor of RCC recurrence.

scholarly journals Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mei-Zhen Dai ◽  
Yi Qiu ◽  
Xing-Hong Di ◽  
Wei-Wu Shi ◽  
Hui-Hui Xu
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinogenesis ◽  
Chi Square ◽  
Major Health Problem ◽  
Hpv16 E6 ◽  
Exact Test ◽  
Chi Square Test ◽  
E6 And E7

Abstract Background Human papillomavirus (HPV) type 16 accounts for a larger share of cervical cancer and has been a major health problem worldwide for decades. The progression of initial infection to cervical cancer has been linked to viral sequence properties; however, the role of HPV16 variants in the risk of cervical carcinogenesis, especially with longitudinal follow-up, is not fully understood in China. Methods We aimed to investigate the genetic variability of HPV16 E6 and E7 oncogenes in isolates from cervical exfoliated cells. Between December 2012 and December 2014, a total of 310 single HPV16-positive samples were selected from women living in the Taizhou area, China. Sequences of all E6 and E7 oncogenes were analysed by PCR-sequencing assay. Detailed sequence comparison, genetic heterogeneity analyses and maximum-likelihood phylogenetic tree construction were performed with BioEdit Sequence Alignment Editor and MEGA X software. Data for cytology tests and histological diagnoses were obtained from our Taizhou Area Study with longitudinal follow-up for at least 5 years. The relationship between HPV16 variants and cervical carcinogenesis risk was analysed by the chi-square test or Fisher’s exact test. Results In this study, we obtained 64 distinct variation patterns with the accession GenBank numbers MT681266-MT681329. Phylogenetic analysis revealed that 98.3% of HPV16 variants belong to lineage A, in which the A4 (Asian) sublineage was dominant (64.8%), followed by A2 (12.1%), A1 (11.4%), and A3 (10.0%). The A4 (Asian) sublineage had a higher risk of CIN2+ than the A1–3 (European) sublineages (OR = 2.69, 95% CI = 1.04–6.97, P < 0.05). Furthermore, nucleotide variation in HPV16 E6 T178G is associated with the development of cervical cancer. Conclusion These data could provide novel insights into the role of HPV16 variants in cervical carcinogenesis risk in China.

Resorbable Collagen Barrier Impeding the Extrusion of Obturating Material in Primary Molars Undergoing Resorption – A Randomized Clinical Trial

2021 ◽  
Vol 45 (5) ◽  
pp. 312-316
Author(s):  
Mishra Neha Sanjeev ◽  
Harsimran Kaur ◽  
Sandeep Singh Mayall ◽  
Rishika ◽  
Ramakrishna Yeluri
Keyword(s):  
Test Group ◽  
Primary Molars ◽  
Control Group ◽  
Chi Square ◽  
Significance Level ◽  
Significant Difference ◽  
Chi Square Test ◽  
Group A ◽  
Group B ◽  
And Control

Objective: To evaluate the effectiveness of placing a resorbable collagen barrier in impeding the extrusion of obturation material in primary molars undergoing resorption. Study design: All the 94 canals in 47 mandibular molars were allocated to 2 groups- Group ‘A’- 47 canals with collagen barrier (Test group) and Group ‘B’- 47 canals without collagen barrier (Control group) based on randomization protocol. Pulpectomy was performed and obturation of both test and control canals were radiographically assessed. Pearson’s chi – square test was applied to analyze the results. The significance level was predetermined at p &lt; 0.05. Results: Among the test group, 93.6% of the canals showed no extrusion while, 6.4% showed visible extrusion of the material outside the apex. In the control group, 83% showed no extrusion whereas 17% of the canals showed visible extrusion outside the apex. But no significant difference was noted (p&gt;0.05). Conclusion: The placement of resorbable collagen barrier in the apical third of the canal prevented the extrusion of obturating material beyond the apex in resorbing primary molars.

Association Between Positive Occipital Sharp Transients of Sleep and Lambda Waves

2018 ◽  
Vol 50 (3) ◽  
pp. 219-221
Author(s):  
Ushtar Amin ◽  
Lucy Sullivan ◽  
Pat Trudeau ◽  
Selim R. Benbadis
Keyword(s):  
Statistical Analysis ◽  
Chi Square ◽  
High Association ◽  
Similar Morphology ◽  
Strong Similarity ◽  
Continuity Correction ◽  
Chi Square Test

Positive occipital sharp transients of sleep (POSTS) and lambda waves have similar morphology and location. We studied a possible association between these 2 normal EEG patterns. We reviewed a series of consecutive unselected ambulatory EEGs during a 3-month period (October 16, 2017 to January 19, 2018) and identified records with POSTS and records with lambda waves. Statistical analysis was performed using a chi-square test. A total of 140 ambulatory EEGs were reviewed. Duration of EEGs ranged from 24 to 168 hours (mean 76 hours). The population was 34% males, with ages ranging from 3 to 93 years (mean 48 years). Of the 140 records, 30 were abnormal, including 20 with epileptiform abnormalities. A chi-square test for independence (with Yates continuity correction) indicated a significant association between POSTS and lambda waves, χ2(1, n = 140) = 69.208, p < .001, φ = 0.72. In addition, 100% of records with lambda waves had POSTS, and 72% of records with POSTS had lambda waves. There is a high association between lambda waves and POSTS. This suggests a strong similarity between the 2 waveforms, and possibly a common occipital generator.

scholarly journals Evaluation of laboratory markers of progression of HIV disease to death

2011 ◽  
Vol 44 (6) ◽  
pp. 657-660 ◽  
Author(s):  
Graça Maria de Castro Viana ◽  
Maria do Desterro Soares Brandão Nascimento ◽  
Aila de Menezes Ferreira ◽  
Érica Milena Fernandes Rabelo ◽  
João Arnaud Diniz Neto ◽  
...  
Keyword(s):  
Viral Load ◽  
Hiv Disease ◽  
Significant Relation ◽  
Chi Square ◽  
Laboratory Markers ◽  
Cd4 Lymphocyte Count ◽  
Chi Square Test ◽  
Cd4 Lymphocyte ◽  
Hiv Aids

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

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