Cardiovascular Complications of Chronic Opium Consumption: A Narrative Review Article

2020 ◽  
Author(s):  
Mojtaba ZIAEE ◽  
Reza HAJIZADEH ◽  
Arash KHORRAMI ◽  
Nariman SEPEHRVAND ◽  
Saeideh MOMTAZ ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Complications ◽  
Review Article ◽  
High Availability ◽  
Coronary Artery Diseases ◽  
High Prevalence ◽  
The World ◽  
Drugs And Crime ◽  
Opium Use ◽  
Related Mortality

Opiates are the second most prevalent abused illicit substance after cannabis in the world. The latest United Nations Office on Drugs and Crime (UNODC) report estimated 30% increment in opium cultivation worldwide. High prevalence of opium consumption in eastern countries may be due to the high availability and traditional misconceptions. Opium consumption has been linked to hypertension, diabetes mellitus, dyslipidemia, and coronary artery diseases (CAD). In this review, we will review the association between opium use, cardiovascular diseases, and clinical outcomes. The present evidence suggests that chronic opiate consumption may increase the risk of cardiovascular diseases and related mortality.

scholarly journals Nonalcoholic steatohepatitis in posttransplantation liver: Review article

2018 ◽  
Vol 64 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Antônio Ricardo Cardia Ferraz de Andrade ◽  
Helma P. Cotrim ◽  
Paulo L. Bittencourt ◽  
Carolina G. Almeida ◽  
Ney Christian Amaral Boa Sorte
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Clinical Characteristics ◽  
Metabolic Disorders ◽  
Patient Survival ◽  
De Novo ◽  
Review Article ◽  
Liver Transplants ◽  
The Third ◽  
High Prevalence ◽  
The World

Summary Introduction: Nonalcoholic steatohepatitis (NASH) associated or not with cirrhosis is the third leading indication for liver transplantation (LT) around the world. After transplants, NASH has a high prevalence and occurs as both recurrent and de novo manifestations. De novo NASH can also occur in allografts of patients transplanted for non-NASH liver disease. Objective: To evaluate recurrent or de novo NASH in post-LT patients. Method: A literature review was performed using search engines of indexed scientific material, including Medline (by PubMed), Scielo and Lilacs, to identify articles published in Portuguese and English until August 2016. Eligible studies included: place and year of publication, prevalence, clinical characteristics, risk factors and survival. Results: A total of 110 articles were identified and 63 were selected. Most of the studies evaluated recurrence and survival after LT. Survival reached 90-100% in 1 year and 52-100% in 5 years. Recurrence of NAFLD (steatosis) was described in 15-100% and NASH, in 4-71%. NAFLD and de novo NASH were observed in 18-67% and 3-17%, respectively. Metabolic syndrome, diabetes mellitus, dyslipidemia and hypertension were seen in 45-58%, 18-59%, 25-66% and 52-82%, respectively. Conclusion: After liver transplants, patients present a high prevalence of recurrent and de novo NASH. They also show a high frequence of metabolic disorders. Nevertheless, these alterations seem not to influence patient survival.

scholarly journals Risk and possibilities of preventing cardiovascular diseases in women in peri- and postmenopause

2019 ◽  
Vol 2 (14) ◽  
pp. 6-14
Author(s):  
I. V. Kuznetsova
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Complications ◽  
The Other ◽  
Population Differences ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Female Population ◽  
Men And Women ◽  
The World ◽  
The One

Cardiovascular morbidity remains the leading cause of death in the world, in both men and women. But the programs for the prevention of cardiovascular diseases (CVD), which significantly reduced the incidence of cardiovascular complications among men, proved to be ineffective among the female population. Differences in CVD risk factors in different sexes, different responses of the female and male organism to the same treatment effects induce, on the one hand, the development of gender-oriented cardiological practices and, on the other hand, determine the need to include gynecologists in the development and implementation of cardiovascular reduction measures vascular morbidity and mortality.

scholarly journals Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan-Xi Zhou ◽  
Hong Zhang ◽  
Cheng Peng
Keyword(s):  
Cardiovascular Diseases ◽  
Molecular Targets ◽  
Cardiovascular Complications ◽  
Therapeutic Effects ◽  
Pueraria Lobata ◽  
Global Public Health ◽  
Isoflavone Glycoside ◽  
The World ◽  
Pharmacologically Active ◽  
Clinical Trails

Puerarin, an isoflavone glycoside derived from Pueraria lobata (Willd.) Ohwi, has been identified as a pharmacologically active component with diverse benefits. A large number of experimental and clinical studies have demonstrated that puerarin is widely used in the treatment of a variety of diseases. Among them, cardiovascular diseases (CVDs) are the leading cause of death in the world, and therefore remain one of the most prominent global public health concerns. In this review, we systematically analyze the preclinical investigations of puerarin in CVDs, such as atherosclerosis, cardiac hypertrophy, heart failure, diabetic cardiovascular complications, myocardial infarction, stroke and hypertension. In addition, the potential molecular targets of puerarin are also discussed. Furthermore, we summarize the clinical trails of puerarin in the treatment of CVDs. Finally, the therapeutic effects of puerarin derivatives and its drug delivery systems are overviewed.

scholarly journals MicroRNAs: New Biomarkers for the progression of Coronary Artery Diseases

2020 ◽  
Vol 185 ◽  
pp. 03039
Author(s):  
Yaxi Chen
Keyword(s):  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Early Diagnosis ◽  
Cause Of Death ◽  
Early Treatment ◽  
Coronary Artery Diseases ◽  
The World ◽  
Basic Concepts ◽  
New Biomarkers

Cardiovascular diseases (CVDs), especially the coronary arterial diseases (CADs), have become the main cause of death all around the world, attracting attentions from the whole society. Even though considerable progresses have been made for the treatment of CADs, many clinical challenges remain to be overcome. In particular, effective biomarkers for CADs need to be developed to facilitate the early diagnosis and thus early treatment of the disease. Recently, the dysregulation of microRNAs (miRNAs) has been found to be involved in the progression of multiple CADs, manifested as altered levels of miRNAs at different disease phases, suggesting that miRNAs may be capable of serving as promising biomarkers for CADs. Here, we attempt to evaluate the possibility of miRNAs as biomarkers for CADs and compare these markers with previously reported ones. In this review, we will summarize the basic concepts and advances for CADs and miRNAs, with a special emphasis on miRNAs in the progression of CADs.

COGNITIVE DEFICIENCY AT ISCHEMIC OM STROKE

2020 ◽  
Vol 1 (1) ◽  
pp. 55-57
Author(s):  
Dildora Khaydarova ◽  
◽  
Hilola Davronova ◽  
Asliddin Akbarov ◽  
Keyword(s):  
Social Problems ◽  
Cerebrovascular Diseases ◽  
Cerebral Stroke ◽  
Number Of Patients ◽  
High Prevalence ◽  
The World ◽  
Cognitive Deficiency ◽  
Complications And Mortality

Cerebrovascular diseases remain one of the most pressing medical and social problems in many countries of the world, due to their high prevalence, severity of complications and mortality. In Uzbekistan, the number of patients with cerebral stroke is quite large -about 40-45 thousandcases of cerebral stroke are registered annually

CZY ZALEWA NAS FALA PRZEMOCY? POLITYCY I MEDIA VS. DANE STATYSTYCZNE

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Katarzyna Hamer ◽  
Hanna Hamet
Keyword(s):  
European Union ◽  
United Nations ◽  
Psychological Mechanisms ◽  
Police Data ◽  
Sense Of Security ◽  
The World ◽  
The United Nations ◽  
Drugs And Crime

By detailed analyses of Polish and world statistics, the authors search for the answer if in fact,as some politicians and citizens claim, the world and in particular European Union and Polandare overcome by the wave of violence. Data gathered, among others, by Polish Public OpinionResearch Center (CBOS), Eurostat and United Nations Office on Drugs and Crime (UNOCD), aswell as anthropologists and police, clearly prove the opposite. Scientific comparisons concerningviolence over the centuries show that its scale drastically decreased and the world gets saferwith time. Statistical reports of the United Nations especially clearly indicate European Union(including Poland) as particularly peaceful region against the rest of the world, having the lowestmurder rates. Eurostat data confirm these results, also showing decrease in other crimes overthe years. Polish police data similarly prove existence of this trend and CBOS indicates thatit is reflected in increasing sense of security among Poles. In the second part of the article theauthors explain potential reasons for using such false slogans as “increasing wave of violence” bypoliticians and raising fear in voters as well as psychological mechanisms responsible for theirpotential effectiveness.

Computational Overview of Mycobacterial Thymidine Monophosphate Kinase

2020 ◽  
Vol 26 (15) ◽  
pp. 1676-1681
Author(s):  
Sana Gul ◽  
Ruqaiya Khalil ◽  
Zaheer Ul-Haq ◽  
Mohammad S. Mubarak
Keyword(s):  
Molecular Docking ◽  
Structure Elucidation ◽  
Tuberculosis Patient ◽  
Review Article ◽  
Morbidity Rate ◽  
Drug Resistant ◽  
Tuberculosis Control ◽  
Bacterial Enzyme ◽  
High Prevalence ◽  
Thymidine Monophosphate

: Tuberculosis (TB) ranks among the diseases with the highest morbidity rate with significantly high prevalence in developing countries. Globally, tuberculosis poses the most substantial burden of mortality. Further, a partially treated tuberculosis patient is worse than untreated; they may lead to standing out as a critical obstacle to global tuberculosis control. The emergence of multi-drug resistant (MDR) and extremely drug-resistant (XDR) strains, and co-infection of HIV further worsen the situation. The present review article discusses validated targets of the bacterial enzyme thymidine monophosphate kinase (TMPK). TMPKMTB enzyme belongs to the nucleoside monophosphate kinases (NMPKs) family. It is involved in phosphorylation of TMP to TDP, and TDP is phosphorylated to TTP. This review highlights structure elucidation of TMP enzymes and their inhibitors study on TMP scaffold, and it also discusses different techniques; including molecular docking, virtual screening, 3DPharmacophore, QSAR for finding anti-tubercular agents.

Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics

2019 ◽  
Vol 15 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Eric Francelino Andrade ◽  
Víviam de Oliveira Silva ◽  
Débora Ribeiro Orlando ◽  
Luciano José Pereira
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Skeletal Muscle ◽  
Glycemic Control ◽  
Sedentary Lifestyle ◽  
World Population ◽  
Pharmacological Interventions ◽  
High Prevalence ◽  
The World ◽  
Main Factors

Introduction: Diabetes mellitus is a metabolic disease characterized by high glycemic levels for long periods. This disease has a high prevalence in the world population, being currently observed an increase in its incidence. This fact is mainly due to the sedentary lifestyle and hypercaloric diets. Non-pharmacological interventions for glycemic control include exercise, which promotes changes in skeletal muscle and adipocytes. Thus, increased glucose uptake by skeletal muscle and decreased insulin resistance through modulating adipocytes are the main factors that improve glycemic control against diabetes. Conclusion: It was sought to elucidate mechanisms involved in the improvement of glycemic control in diabetics in front of the exercise.

Paracrine Mechanisms Involved in Mesenchymal Stem Cell Differentiation into Cardiomyocytes

2019 ◽  
Vol 14 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Maryam Farzaneh ◽  
Fatemeh Rahimi ◽  
Masoumeh Alishahi ◽  
Seyed E. Khoshnam
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Dysfunction ◽  
Stem Cell Differentiation ◽  
Myocardial Cells ◽  
Coronary Artery Diseases ◽  
Low Cardiac Output ◽  
Mesenchymal Stem Cell Differentiation ◽  
Proliferation And Differentiation ◽  
The World ◽  
Biochemical Analyses

Cardiovascular disease (CVD) is one of the world-wide healthcare problem that involves the heart or blood vessels. CVD includes myocardial infarction and coronary artery diseases (CAD). Dysfunctional myocardial cells are leading causes of low cardiac output or ventricular dysfunction after cardiac arrest and may contribute to the progression of CVD which could not generate new cardiomyocytes in human adult heart. The mesenchymal stem cells (MSCs) which are present in adult marrow can self-renew and have the capacity of differentiation into multiple types of cells including cardiomyocytes. Recent biochemical analyses greatly revealed that several regulators of MSCs, such as HGF, PDGF, Wnt, and Notch-1 signaling pathways have been shown to be involved in the proliferation and differentiation into cardiomyocytes. Preclinical studies are paving the way for further applications of MSCs in the repair of myocardial infarction. In this study, we discuss and summarize the paracrine mechanisms involved in MSCs differentiation into cardiomyocytes.

Critical Insight into the Attributes of Emerging Novel Coronavirus (COVID-19) in India and Across the World

Coronaviruses ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Gaurav M. Doshi ◽  
Hemen S. Ved ◽  
Ami P. Thakkar
Keyword(s):  
Review Article ◽  
World Health ◽  
Effective Vaccine ◽  
Human Contact ◽  
The World ◽  
Critical Insight ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Insight Into ◽  
Old Drugs

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.

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