scholarly journals Pengaruh Propilen Glikol dalam Patch Dispersi Padat Ketoprofen terhadap Karakteristik Fisika Kimia dan Laju Penetrasinya

2018 ◽  
Vol 6 (2) ◽  
pp. 230
Author(s):  
Lidya Ameliana ◽  
Haris Raudhatuzakinah Dwiputri ◽  
Dwi Nurahmanto
Keyword(s):  
Moisture Content ◽  
Propylene Glycol ◽  
Solid Dispersion ◽  
Confidence Level ◽  
Penetration Rate ◽  
Surface Ph ◽  
Moisture Contents ◽  
Folding Endurance ◽  
One Way Anova ◽  
Anti Inflammation

  Ketoprofen is a non steroid anti-inflammatory drug (NSAID) used as analgesic and anti-inflammation. This research had been done by ketoprofen patch preparation and evaluations aiming to enhance its penetration through the skin using propylene glycol as penetration enhancer. Evaluations included homogenity testing and FTIR for ketoprofen solid dispersion and organoleptic, weight uniformity, thickness, folding endurance, surface pH, moisture content, and penetration rate assay of ketoprofen patch. Penetration rate was determined by paddle type dissolution and the sample was analyzed by spectrophotometry UV-Vis. The value of moisture content and penetration rate were analyzed by One Way ANOVA with confidence level of 95 %. The value of moisture contents were F0 1.17 ± 0.0551 %; F1 1.27 ± 0.0208 %; F2 1.33 ± 0.08 %; and F3 1.43 ± 0.0208 %. The penetration rates of ketoprofen were F0 0.5258 ± 0.0191 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; F1 0.6935 ± 0.0613 µg/cm2.minute; and F3 1.1260 ± 0.0850 µg/cm2.minute. It can be concluded that the formula with propylene glycol 150 mg/patch can deliver the best penetration rate and moisture content that were fullfill the requirements.   Keywords: ketoprofen, patch, propilen glikol, penetratio enhancer, solid dispersion  

scholarly journals Formulation Development and Characterization of Levosalbutamol Sulphate Oral Thin Film using Propylene glycol as a Plasticizer

2017 ◽  
Vol 20 (1) ◽  
pp. 64-70
Author(s):  
Md Masud Morshed ◽  
Jewel Mallick ◽  
Fahamida Islam ◽  
Md Kamrul Islam ◽  
Md Didaruzzaman Sohel ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Propylene Glycol ◽  
Moisture Absorption ◽  
Water Soluble ◽  
Content Uniformity ◽  
Formulation Development ◽  
Disintegration Time ◽  
Surface Ph ◽  
Percent Moisture ◽  
Folding Endurance

The present study was concerned with the preparation and evaluation of oral thin films of levosalbutamol sulphate (LS) is to avoid presystemic elimination by gastrointestinal degradation and first pass hepatic metabolism. The films were prepared using four different water soluble polymers in various proportions and combinations using propylene glycol as plasticizers. Total five formulations were developed and evaluated for the various physicochemical characteristics namely mass uniformity, thickness, folding endurance, density, surface pH, swelling index, disintegration time, content uniformity, in vitro release profile, percent moisture absorption and loss and ex vivo mucoadhesion time. Data of every parameter were taken in triplicate. Results of film thickness, mass, density and swelling index of medicated films of LS were found with relatively low standard deviation along with high folding endurance (>300). The surface pH of all films approached to the salivary fluid pH range (6.1~7.0). Disintegration time and content uniformity complied with standard for all formulations. Among the total five formulations, F-2 and F-5 followed first order release and F-1 and F-4 followed Higuchi release and F-5 followed zero order and hixon-crowell release. The residence time for mucoadhesion of the tested films ranged between 1 to 5 minutes. Percent moisture absorption and loss study revealed the excellent stability of the films in dried conditions and relatively low standard deviation indicated the stability also in humid conditions.Bangladesh Pharmaceutical Journal 20(1): 64-70, 2017

scholarly journals PREPARATION AND EVALUATION OF SIMVASTATIN TRANSDERMAL FILM

2018 ◽  
Vol 10 (5) ◽  
pp. 235
Author(s):  
Haritha V. Anod ◽  
N. Vishal Gupta ◽  
D. V. Gowda ◽  
Manohar M.
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Moisture Content ◽  
Release Kinetics ◽  
Solvent Evaporation ◽  
Surface Ph ◽  
Drug Content ◽  
Folding Endurance ◽  
Transdermal Film

Objective: The objective of the study was to prepare simvastatin transdermal films for the treatment of atherosclerosis and to evaluate the effect of concentration of polymer on penetration enhancement.Methods: Solvent evaporation technique was employed for the preparation of films and the prepared films were evaluated for various physicochemical properties of films such as tensile strength, thickness, surface pH, swellability, drug content, moisture content and folding endurance. In vitro drug, release study and release kinetics were also studied.Results: Tensile strength ranged from 3.56±0.343 to 4.56±0.12 (N/mm²). The films were of uniform weight. Thickness varied from 0.2±0.3 mm to 0.2±0.8 mm. Surface pH ranged from 6.6±0.14 to 6.9±0.16. Percentage swellability ranged from12.1±0.36 to 16.3±0.22. Percentage drug content ranged from 88.4±0.7% to 90.5±0.6% in all the formulation. Percentage moisture content ranged from 0.864 to 1.03%. Moisture uptake was from 2.6±0.24 to 2.9±0.072. The folding endurance test gave satisfactory results and F3 formulation showed maximum drug release.Conclusion: From the study, it was concluded that out of various formulations, the F3 formulation was found to be the optimum formulation with 88% drug release at the fourteenth hour.Keywords: Simvastatin, Transdermal film, Solvent evaporation, Penetration enhancer, Swellability

The Smoulder Stream of Cigarettes / Zur Kenntnis des Glimmstromes von Cigaretten

1965 ◽  
Vol 3 (2) ◽  
Author(s):  
F. Seehofer ◽  
W. Schulz
Keyword(s):  
Moisture Content ◽  
Spatial Position ◽  
High Yield ◽  
Physical Conditions ◽  
Moisture Contents ◽  
Cigarette Paper ◽  
First Time

AbstractThe phenomenon of the smoulder stream flowing through the cigarette during smouldering and during the puff intervals is demonstrated for the first time and its dependence upon physical conditions is examined. The volume of the smoulder stream can amount up to 180 ml per cigarette. Increasing draw resistance of the cigarette and augmenting moisture content of the tobacco as well as perforation of the cigarette paper have a decreasing effect on volume and velocity of the smoulder stream. The porosity of the cigarette paper has no perceptible influence. The spatial position of the cigarette affects volume and velocity of the smoulder stream. The influence exercised by the smoulder stream on the yields of total condensate, nicotine, phenols, aldehydes, and acroleine when the cigarette tip is open during the puff intervals is determined. When the moisture contents of the tobacco were extremely high, yield decreases reaching 50 % could be observed.

Accelerated Aging of Deacidified and Untreated Book Paper in 1967 Compared with 52 Years of Natural Aging

2020 ◽  
Vol 41 (3) ◽  
pp. 131-152
Author(s):  
Tali H. Horst ◽  
Richard D. Smith ◽  
Antje Potthast ◽  
Martin A. Hubbe
Keyword(s):  
Room Temperature ◽  
Accelerated Aging ◽  
Natural Aging ◽  
Scanning Electron Micrographs ◽  
Surface Ph ◽  
Room Temperature Storage ◽  
Folding Endurance ◽  
Endurance Tests ◽  
Breaking Length ◽  
Temperature Storage

AbstractThree copies of a book that had been optionally deacidified using two different procedures in 1967, and then subjected to accelerated aging, were tested again after 52 years of natural aging. Matched copies of the book Cooking the Greek Way, which had been printed in Czechoslovakia on acidic paper, were evaluated. Nonaqueous treatment of two of the copies with magnesium methoxide dissolved in chlorofluorocarbon solvent had been found in 1967 to have decreased the susceptibility to embrittlement, as evidenced by the results of the accelerated aging, followed by folding endurance tests. Retesting of the same books in 2019, after 52 years of room temperature storage, showed that the deacidification treatments had achieved the following benefits in comparison to the untreated book: (a) higher brightness; (b) higher folding endurance; (c) tensile breaking length higher in the cross-direction of the paper; (d) substantial alkaline reserve content, (e) an alkaline surface pH in the range 7.1–7.4, and (f) higher molecular mass of the cellulose. Remarkably, some of the folding endurance results matched those of unaged samples evaluated in 1967. Scanning electron micrographs showed no differences between the treated and untreated books.

Developing a Linearization Method to Determine Optimum Blending for Surimi with Varied Moisture Contents Using Linear Programming

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Hyeon W. Park ◽  
Jae W. Park ◽  
Won B. Yoon
Keyword(s):  
Linear Programming ◽  
Moisture Content ◽  
Standard Procedure ◽  
Unit Cost ◽  
Linearization Method ◽  
Model Parameters ◽  
Additional Information ◽  
Moisture Contents ◽  
Design Variables ◽  
Critical Moisture

AbstractNovel algorithm to determine the least cost formulation of a surimi blend was developed using linear programming (LP). Texture properties and the unit cost of surimi blend at the target moisture content were used as constraint functions and the objective function, respectively. The mathematical models to describe the moisture content dependence of the ring tensile properties were developed using critical moisture content, and the model parameters were used for the least cost LP (LCLP) model. The LCLP model successfully predicted the quality of surimi blend. Sensitivity analysis was used to obtain an additional information when the perturbations of design variables are provided. A standard procedure to determine the least cost formulation for blending surimi with varied moisture contents was systematically developed.

scholarly journals Experimental Study on the Softening Characteristics of Sandstone and Mudstone in Relation to Moisture Content

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Gui-chen Li ◽  
Chong-chong Qi ◽  
Yuan-tian Sun ◽  
Xiao-lin Tang ◽  
Bao-quan Hou
Keyword(s):  
Moisture Content ◽  
Vertical Displacement ◽  
Surface Porosity ◽  
Shear Tests ◽  
Moisture Contents ◽  
Dynamic Finite Element ◽  
Rock Types ◽  
Underground Roadway ◽  
The Stability ◽  
Kinetics Of

The kinetics of fluid-solid coupling during immersion is an important topic of investigation in rock engineering. Two rock types, sandstone and mudstone, are selected in this work to study the correlation between the softening characteristics of the rocks and moisture content. This is achieved through detailed studies using scanning electron microscopy, shear tests, and evaluation of rock index properties during exposure to different moisture contents. An underground roadway excavation is simulated by dynamic finite element modeling to analyze the effect of moisture content on the stability of the roadway. The results show that moisture content has a significant effect on shear properties reduction of both sandstone and mudstone, which must thus be considered in mining or excavation processes. Specifically, it is found that the number, area, and diameter of micropores, as well as surface porosity, increase with increasing moisture content. Additionally, stress concentration is negatively correlated with moisture content, while the influenced area and vertical displacement are positively correlated with moisture content. These findings may provide useful input for the design of underground roadways.

Effect of Bromus inermis Leyss Planting on Dynamic Changes of Soil Moisture Contents on the Bare Slope

2013 ◽  
Vol 807-809 ◽  
pp. 1648-1652
Author(s):  
Tie Jun Sun ◽  
Baderihu Tajilake
Keyword(s):  
Soil Moisture ◽  
Moisture Content ◽  
Soil Moisture Content ◽  
Regulatory Mechanism ◽  
Dynamic Balance ◽  
Bromus Inermis ◽  
Dynamic Changes ◽  
Moisture Contents ◽  
Biological Characters ◽  
Underground Biomass

Experiment was executed to plant eco-grass of Bromus inermis Leyss on 15°bare slopes, and study effect of biological characters on dynamics of soil moisture contents. The results indicated that vegetation restored quickly on the bare slope after the eco-grass planted. There were 2473.4 kg/hm2 of overground biomass and 1744.1kg/hm2 of underground biomass, and 70% of underground biomass was in 0-10cm layer of soil. Meanwhile, there was a regulatory mechanism of soil moisture content for Bromus inermis Leyss. When rainfall was enough, soil moisture content in 0-80 cm layer could reach to the most of 26.83% quickly this year. Next it could decline near to the first value of 19.81% after rainfall stopped, and keep a dynamic balance between 19.48% and 19.96%. Moreover, the regulatory mechanism realized though underground biomass, and was clearer with underground biomass increasing, especially in the 0-40cm layer of soil.

Assessment of Moisture Content in Sandy Beach Environments from Multispectral Satellite Imagery

2021 ◽  
Author(s):  
Julie Paprocki ◽  
Nina Stark ◽  
Hans C Graber ◽  
Heidi Wadman ◽  
Jesse E McNinch
Keyword(s):  
Moisture Content ◽  
Laboratory Data ◽  
Field Measurements ◽  
Weather Conditions ◽  
Sandy Beaches ◽  
Percent Error ◽  
Moisture Contents ◽  
Multispectral Satellite Imagery ◽  
Factor C

A framework for estimating moisture content from satellite-based multispectral imagery of sandy beaches was tested under various site conditions and sensors. It utilizes the reflectance of dry soil and an empirical factor c relating reflectance and moisture content for specific sediment. Here, c was derived two ways: first, from in-situ measurements of moisture content and average NIR image reflectance; and second, from laboratory-based measurements of moisture content and spectrometer reflectance. The proposed method was tested at four sandy beaches: Duck, North Carolina, and Cannon Beach, Ocean Cape, and Point Carrew, Yakutat, Alaska. Both measured and estimated moisture content profiles were impacted by site geomorphology. For profiles with uniform slopes, moisture contents ranged from 3.0%-8.0% (Zone 1) and from 8.0%-23.0% (Zone 2). Compared to field measurements, the moisture contents estimated using c calibrated from in-situ and laboratory data resulted in percent error of 3.6%-44.7% and 2.7%-58.6%, respectively. The highest percent error occurred at the transition from Zone 1 to Zone 2. Generally, moisture contents were overestimated in Zone 1 and underestimated in Zone 2, but followed the expected trends based on field measurements. When estimated moisture contents in Zone 1 exceeded 10%, surface roughness, debris, geomorphology, and weather conditions were considered.

Propagation velocity model of stress waves in larch wood (Larix gmelinii) three-dimensional space with different moisture contents

BioResources ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 6680-6695
Author(s):  
Xiwen Wei ◽  
Liping Sun ◽  
Hongjv Zhou ◽  
Yang Yang ◽  
Yifan Wang ◽  
...  
Keyword(s):  
Moisture Content ◽  
Wave Velocity ◽  
Stress Wave ◽  
Propagation Velocity ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Stress Waves ◽  
Moisture Contents ◽  
Direction Angle ◽  
Stress Wave Velocity

Based on the effects of stress wave propagation in larch (Larix gmelinii) wood, the propagation mechanism of stress wave was explored, and a theoretical model of the propagation velocity of stress waves in the three-dimensional space of wood was developed. The cross and longitudinal propagation velocities of stress wave were measured in larch wood under different moisture contents (46% to 87%, 56% to 96%, 20% to 62%, and 11% to 30%) in a laboratory setting. The relationships between the propagation velocity of stress waves and the direction angle or chord angle with different moisture contents were analyzed, and the three-dimensional regression models among four parameters were established. The analysis results indicated that under the same moisture content, stress wave velocity increased as the direction angle increased and decreased as chord angle increased, and the radial velocity was the largest. Under different moisture contents, stress wave velocity gradually decreased as moisture content increased, and the stress wave velocity was more noticeably affected by moisture content when moisture content was below the fiber saturation point (FSP, 30%). The nonlinear regression models of the direction angle, chord angle, moisture content, and the propagation velocity of stress wave fit the experiment data well (R2 ≥ 0.97).

EFFECT OF MOISTURE CONTENT ON VIABILITY AND INFESTATION OF HULLESS TERRA OATS IN STORAGE

1979 ◽  
Vol 59 (4) ◽  
pp. 911-916 ◽  
Author(s):  
R. N. SINHA ◽  
N. D. G. WHITE ◽  
H. A. H. WALLACE ◽  
R. I. H. McKENZIE
Keyword(s):  
Relative Humidity ◽  
Moisture Content ◽  
Mite Infestation ◽  
Tyrophagus Putrescentiae ◽  
Adsorption And Desorption ◽  
Safe Storage ◽  
Moisture Contents ◽  
Seed Moisture ◽  
Effect Of Moisture

The effects of various seed moisture contents in hulless (cv. Terra) and hulled oats (cv. Random) on susceptibility to mite infestation and on mycofloral growth and germination loss were studied at weekly intervals. Fat acidity values were determined for Terra oats only after 4 wk of storage. Moisture content-relative humidity adsorption and desorption curves were determined for Terra at 22 °C and at relative humidities of 35–100%. Terra oats, which had a higher level of Penicillium infection at 90–100% RH than Random oats, lost viability more rapidly than Random. Fat acidity values of Terra increased rapidly from 35 mg KOH/100 g of seed to 87–118 mg KOH/100 g of seed, only when seeds were stored at 90–100% RH. Terra offered a more favorable substrate for the multiplication of the mites Tyrophagus putrescentiae, Acarus farris, and Lepidoglyphus destructor than did Random. With the exception of susceptibility to mite infestation, safe storage criteria are similar for hulled and hulless oats at usual moisture contents.

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