scholarly journals Modern and Convensional Wound Dressing to Interleukin 1 and Interleukin 6 in Diabetic wound

Jurnal NERS ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. 133
Author(s):  
Werna Nontji ◽  
Suni Hariati ◽  
Rosyidah Arafat
Keyword(s):  
Growth Factor ◽  
Interleukin 6 ◽  
Wound Dressing ◽  
Transforming Growth Factor ◽  
Wound Care ◽  
Interleukin 1 ◽  
Intervention Group ◽  
Control Group ◽  
Diabetic Wound ◽  
Control Group Design

Introduction:Holistic wound care is one of the ways to prevent gangrene and amputation, modern wound dressing is more effective than convensional with increasing transforming growth factor and cytokine, especially interleukin. This study aims to identify the effectiveness of Modern and Convensional Wound Dressing to Interleukin 1 (IL-1) and Interleukin 6 (IL-6) in Diabetic wound. Method:A Quasi eksperimental pre-post with control group design was used. The intervention given was modern wound dressing and Control group by convensional wound dressing, This study was conducted in Makassar with 32 samples (16 in intervention group and 16 in control group). Result: The result of Pooled T- test showed that p = 0.00 (p < 0.05), it means that there was signifi cant correlation between modern wound dressing to IL-6 and IL-1 than Convensional wound dressing. Discussion: Process of wound healing was produced growth factor and cytokine (IL-1 and IL-6), it will stimulated by wound dressing, modern wound dressing (Calcium alginat) can absorb wound drainage, non oklusive, non adhesif, and autolytic debridement.Keywords: Modern wound dressing, Interleukin 1 (IL-1), Interleukin 6 (IL-6)

scholarly journals Cost of treatment and reduction achieved by chronic ulcer in diabetic patients - a comparison between hydrogel and human recombinant Epidermal Growth Factor

2019 ◽  
Author(s):  
Gabriela Deutsch ◽  
Bianca Campos de Oliveira ◽  
Fernanda Soares Pessanha ◽  
Keila Mara Cassiano ◽  
Beatriz Guitton Renaud Baptista de Oliveira ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Wound Care ◽  
Intervention Group ◽  
Cost Benefit ◽  
Control Group ◽  
Diabetic Patients ◽  
Double Blind ◽  
Epidermal Growth ◽  
Reduction Cost

Abstract Background: The study provides results from a double-blind clinical trial of 25 patients with diabetic or venous chronic ulcers. The main focus was to evaluate the assessing cost of outpatient treatment with two technologies: 2% carboxymethylcellulose hydrogel or human recombinant Epidermal Growth Factor carbogel. Methods: Patients were randomly allocated to two ulcer treatment groups, human recombinant Epidermal Growth Factor carbogel treated (intervention group, n = 14), and 2% carboxymethylcellulose hydrogel (CMC) (control group, n = 11); both treated during 90 days. To calculate the costs of each patient's procedures, direct costs and human resources costs were measured in Brazilian currency and converted into US dollars. Statistical analysis of clinical data was performed based on intention to treat. For each treatment were analyzed the proportion of cases with wound reduction; cost benefit of the treatment given by the average value of each 1cm2 wound reduction; statistics on the cost of reducing each cm2 of wound for each patient presenting wound reduction. Results: In all evaluated periods, the proportion of cases with decreased lesion area was higher in the intervention group; It presented better cost-benefit ratio and lower average and median reduction cost for each reduced cm2 of the wound. Conclusion: Data suggested that growth factor therapy may be cost-effective and innovative complement to standard wound care.

The Expression of IL-1, IL-6, and TGF-β in the Synovial Fluid of Horses with Surgically-Induced Transient Synovitis

1998 ◽  
Vol 11 (03) ◽  
pp. 141-145 ◽  
Author(s):  
S. M. Barber ◽  
J. R. Gordon ◽  
Christine Theoret
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Synovial Fluid ◽  
Transforming Growth Factor Beta ◽  
Interleukin 6 ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Transient Synovitis ◽  
Growth Factor Beta ◽  
Surgically Induced

SummaryThis study investigates the presence of various cytokines in the synovial fluid of three horses with surgicallyinduced synovitis in one antebrachiocarpal joint. Synovial fluids were sampled from experimental and control joints, preoperatively and at two and 30 days post-operatively. Samples were analyzed for interleukin-1 and interleukin- 6 bioactivities with a bioassay, and for transforming growth factor-beta protein by ELISA. Peak cytokine levels were detected on day two post-synovectomy, and returned to pre-operative levels by 30 days post-synovectomy (Interleukin-6 in treated joints: day #0; 0.53 ±0.2, day #2; 9.8 ± 0.7, day #30; 0.4 ± 0.2. Transforming growth factorbeta in treated joints: day #0; 314 ± 69, day #2; 1101 ± 325, day #30; 321 ± 101). Arthrocentesis alone (i.e. control joints) caused no increase in interleukin- 1, interleukin-6 and transforming growth factor-beta levels. Interleukin-1 and interleukin-6 are thought to both prevent anabolic and enhance catabolic effects within articular cartilage matrices, whereas it has been proposed that transforming growth factor-beta may have a protective effect on the articular cartilage. This study is the first to document elevated transforming growth factor-beta levels in equine joints.This study documents elevated levels of transforming growth factor-beta, interleukin-1 and interleukin-6 in the joints of horses with surgically-induced transient synovitis.

scholarly journals Deteksi Kadar Transforming Growth Factor (Tgf-Β) Pada Luka Akut

2021 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Pratidina Wulandari ◽  
Magda Hutagalung ◽  
David Perdanakusuma
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test

Latar Belakang. TGF-β merupakan growth factor yang paling dominan dalam peningkatan sintesis kolagen, memiliki peran utama pada penyembuhan luka dengan menstimulasi fibroblas sehingga menimbulkan penyembuhan dan berperan serta dalam pembentukan parut, baik itu parut normal maupun abnormal seperti parut hipertrofik dan keloid. Penelitian ini bertujuan untuk mengukur kadar TGF-β pada fase penyembuhan luka.Metode. Penelitian eksperimental ini menggunakan randomized post test only control group design. Dua belas luka akut kulit tikus dirandomisasi menjadi dua kelompok, dimana kelompok 1 diambil spesimen pada hari ke-5 dan kelompok 2 pada hari ke-21 dan dilakukan pemeriksaan ELISA untuk mengukur kadar TGF-.Hasil. Pengukuran kadar TGF-β pada luka akut kulit tikus didapatkan jumlah yang meningkat secara signifikan dari hari ke-5 (fase inflamasi) ke hari ke-21 (fase proliferasi) dengan nilai p = 0,003. Kesimpulan. Terjadi peningkatan kadar TGF- pada akhir fase proliferasi atau awal fase remodelling. Hal ini menyebabkan peningkatan proliferasi fibroblas untuk mensintesis kolagen yang nantinya dapat menjadi parut hipertrofik dan keloid.

Effect of Regiosacralis Counterpressure Treatment on the Pain and Interleukin-6 (IL-6) Levels Among Primigravid Mothers During the First Stage Labor

2021 ◽  
pp. IJCBIRTH-D-20-00005
Author(s):  
Sri Rejeki ◽  
Tri Hartiti ◽  
Machmudah Machmudah ◽  
Ahmad Solichan ◽  
Amin Samiasih ◽  
...  
Keyword(s):  
Pain Management ◽  
Interleukin 6 ◽  
Intervention Group ◽  
Labor Process ◽  
Control Group ◽  
Control Group Design ◽  
Counter Pressure ◽  
Fear And Anxiety ◽  
Study Participants ◽  
First Stage Of Labor

BACKGROUNDSevere pain experienced by mother during the labor can cause fear and anxiety which can interfere with the overall labor process. Controlling pain during the labor process is important. Regiosacralis counterpressure pain management without altering the interleukin-6 (IL-6) level is expected to reduce the pain.OBJECTIVEThis study was aimed to investigate the effects of regiosacralis counterpressure on the pain and IL-6 levels during the first stage of labor among primigravid mothers.METHODA quasiexperiment method with pretest–posttest control group design was applied. Regiosacralis counter-pressure pain management was applied to all study participants who non-randomly recruited by consecutive sampling methods. A total of 52 primigravid mothers were selected and divided into both the intervention group (n = 26) and the control group (n = 26).RESULTThe statistical analysis of the intervention on the pain and IL-6 level showed significant different result between pretest and posttest in the intervention group (p < .001; M pretest pain = 8.96±.528; M posttest pain = 6.96±.774; M pretest IL-6 = 175.539±92.281; M posttest IL-6 = 170,764±70,026).CONCLUSIONRegiosacralis counterpressure treatment is effective to control and reduce pain level during the first stage labor.

SUPPORTIVE EDUCATIVE SYSTEM DALAM MENINGKATKAN KEMANDIRIAN MERAWAT KAKI PADA PASIEN DIABETES MELLITUS TIPE II

2019 ◽  
Vol 9 (2) ◽  
pp. 63-72
Author(s):  
Nova Nurwinda Sari ◽  
Herlina Herlina
Keyword(s):  
Diabetes Mellitus ◽  
Health Center ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Type Ii ◽  
Foot Care ◽  
Control Group Design ◽  
Patients With Diabetes

Diabetes mellitus dapat menyebabkan cukup banyak komplikasi seperti kelainan mata, kelainan ginjal, kelainan pembuluh darah dan kelainan pada kaki. Penderita diabetes mellitus yang mengalami komplikasi kronis perlu diberikan upaya preventif untuk mencegah komplikasi, salah satunya adalah kemampuan perawatan kaki. Penelitian ini dilakukan untuk menguji efektivitas supportive educative system dalam meningkatkan kemandirian perawatan kaki pada pasien dengan diabetes mellitus Tipe II di Puskesmas Permata Sukarame, Bandar Lampung. Penelitian ini menggunakan metode quasy eksperimen dengan desain pretest-posttest with control group dengan total masing-masing kelompok sebanyak 18 responden. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada responden yang memenuhi kriteria inklusi penelitian. Penelitian ini diuji menggunakan analisis univariat, bivariat dan uji T-test. Hasil penelitian menunjukkan bahwa terdapat perbedaan rata-rata dalam kemandirian perawatan kaki pada kelompok intervensi dan kelompok kontrol dengan p-value 0,000. Pendidikan dan praktik perawatan kaki harus diberikan sejak dini sebagai upaya pencegahan untuk komplikasi.   Kata kunci : Supportive educative system, kemandirian perawatan kaki   SUPPORTIVE EDUCATIVE SYSTEM IN IMPROVING INDEPENDENCE OF FOOT CARE IN PATIENTS WITH DIABETES MELLITUS TYPE II   ABSTRACT Diabetes mellitus can cause quite a lot of complications such as eye disorders, kidney disorders, vascular disorders and abnormalities in the legs. Patients with diabetes mellitus who have chronic complications need to be given a preventive effort to prevent complications, one of which is foot care ability. This research was conducted to examine the effectiveness of supportive educative systems in increasing the independence of foot care in patients with Type II diabetes mellitus in the Permata Sukarame Health Center Bandar Lampung Working Area. This study used a quasi-experimental method with pretest-posttest with control group design with a total of 18 respondents each. Data collection is done by distributing questionnaires to respondents who meet the research inclusion criteria. This study was tested using univariate, bivariate, T-Test analysis. The results showed that the mean differences in the independence of foot care in the intervention group and the control group in the Permata Sukarame Community Health Center work area with a p-value of 0,000. Education and practice of foot care should be given early as a preventative effort for complications.   Keywords: Supportive educative system, independence of foot care

PENGARUH PELATIHAN PENGENDALIAN VEKTOR DEMAM BERDARAH TERHADAP MAYA INDEX PADA SISWA SEKOLAH DASAR DI MAJALENGKA

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wawan Kurniawan
Keyword(s):  
Vector Control ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Intervention Group ◽  
Hemorrhagic Fever ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Quasi Experimental ◽  
Dengue Vector Control

ABSTRAK  Latar belakang: Demam Berdarah Dengue (DBD) disebabkan oleh virus Dengue dapat menyebabkan kematian. Pencegahan DBD yang dianggap paling tepat adalah Pemberantasan Sarang Nyamuk (PSN). Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan pengendalian vektor Demam Berdarah pada siswa sekolah dasar terhadap Maya Index di Majalengka. Metode: Penelitian ini menggunakan desain quasi experiment (pretest-posttest control group design). Sebanyak 4 sekolah terpilih sebagai kelompok intervensi dan 4 sekolah lainnya sebagai kontrol. Subyek penelitian adalah siswa kelas IV-VI yang terdiri dari 171 siswa pada kelompok intervensi dan 163 pada kelompok kontrol. Instrumen yang digunakan adalah formulir pemantauan jentik berkala. Hasil: Jumlah rumah dengan kategori Maya Index tinggi berkurang dari 27,5% menjadi 9,4%. Terjadi penurunan angka BRI kategori tinggi pada kelompok intervensi dari 20,5% menjadi 1,8%. Pada kelompok kontrol tidak terjadi penurunan angka BRI kategori tinggi (22,1%), sebaliknya terjadi penurunan kategori rendah dari 34,4% menjadi 3,7%. Tidak terjadi penurunan angka HRI pada kelompok intervensi maupun kontrol. Kesimpulan: Pelatihan pengendalian vektor Demam Berdarah dapat menurunkan nilai BRI dan Maya Index, tetapi tidak berpengaruh terhadap nilai HRI. Tidak adanya perubahan nilai HRI menunjukkan bahwa kebersihan dan sanitasi lingkungan merupakan faktor yang berpengaruh terhadap probabilitas kejadian demam berdarah. Kata Kunci : Demam Berdarah, Maya Index, pelatihan, pengendalian vektor   ABSTRACT Background: Dengue Hemorrhagic Fever (DHF) caused by Dengue virus could cause death. The most appropriate prevention of Dengue is eradication of mosquito nests (PSN). This study aims to determine the effect of Dengue vector control training on elementary students towards Maya Index in Majalengka. Method: This study used quasi-experimental design (pretest-posttest control group design). A total of 4 schools were selected as intervention groups and 4 other schools as controls. The subjects were students in grades IV-VI consisting of 171 students in the intervention group and 163 in the control group. The instrument used was periodic larva monitoring form. Results: The number of houses with a high Maya Index category in the intervention group decreased from 27.5% to 9.4%. There was a decrease in the high BRI category in the intervention group from 20.5% to 1.8%. In the control group, there was no decrease in the high BRI category (22.1%), on the contrary, there was a decrease in the low category from 34.4% to 3.7%. There was no decrease in HRI rates both of intervention or control groups. Conclusion: Dengue Fever vector control training could decrease the value of BRI and Maya Index, but does not affect the value of HRI. The absence of changes in HRI  indicate that environmental hygiene and sanitation are factors that influence the probability of dengue fever occurrence. Keywords: Dengue Hemorrhagic Fever, Maya Index, training, vector control

scholarly journals The Effects of Rice Husk Liquid Smoke in Porphyromonas gingivalis-Induced Periodontitis

2021 ◽  
Author(s):  
Theresia Indah Budhy ◽  
Ira Arundina ◽  
Meircurius Dwi Condro Surboyo ◽  
Anisa Nur Halimah
Keyword(s):  
Growth Factor ◽  
Porphyromonas Gingivalis ◽  
Rice Husk ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Control Group ◽  
Proliferation Markers ◽  
Liquid Smoke ◽  
Tnf Α ◽  
Factor Α

Abstract Objectives The purpose of this study is to analyze the effects of rice husk liquid smoke in Porphyromonas gingivalis-induced periodontitis in the inflammatory and proliferation marker such as nuclear factor kappa β (NF-kB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β), fibroblast growth factor 2 (FGF2), collagen type 1 (COL-1) expression, and the number of macrophages, lymphocytes, and fibroblasts. Materials and Methods Rice husk liquid smoke is obtained by the pyrolysis process. Porphyromonas gingivalis-induced periodontitis in 20 μL phosphate-buffered saline containing 1 × 109 CFU was injected into the lower anterior gingival sulcus of Wistar rats. The periodontitis was then treated with 20 μL/20 g body weight of rice husk liquid smoke once a day for 2 and 7 days, respectively. After treatment, the bone and lower anterior gingival sulcus were analyzed with immunohistochemistry and hematoxylin–eosin staining. Results The treatment of periodontitis with rice husk liquid smoke showed a lower NF-kB, TNF-α, and IL-6 expression and a higher TGF-β, FGF2, and COL-1 expression than the control after treatment for 2 and 7 days (p < 0.05), respectively. The number of macrophages and fibroblasts was also higher when compared with the control group (p < 0.05), but the number of lymphocytes was lower than the control (p < 0.05). Conclusion Rice husk liquid smoke showed its effects on Porphyromonas gingivalis-induced periodontitis with a decrease in inflammatory markers and an increase in proliferation markers. The development of a rice husk liquid smoke periodontitis treatment is promising.

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