Potential Application of Modified α-Mangostin Xanthones from Garcinia mangostana as Antibacterial Agents in Food Packaging

The microbial contamination in food packaging have been a major concern that paved the way for the search for natural based new anti-microbial agents, such as modified α-mangostin. In the present work, twelve synthetic analogs were obtained via semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher therapeutic value than the parent molecule. The anti-microbial studies proved that I E showed higher antibacterial activity whereas I I showed most significant antifungal activity. Due to their microbial properties, modified α-mangostin can be utilized as active anti-microbial agents in food packaging.

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Microbiological air analysis of industrial premises and photocatalysis efficiency for its disinfection

BIO Web of Conferences ◽

10.1051/bioconf/20201700126 ◽

2020 ◽

Vol 17 ◽

pp. 00126

Author(s):

V.S. Shkrabak ◽

E.V. Zhgulev ◽

E.I. Gavrikova ◽

R.V. Shkrabak

Keyword(s):

Antibacterial Agents ◽

Microbial Contamination ◽

Original Method ◽

Morbidity Rate ◽

Industrial Complex ◽

Air Analysis ◽

Photodynamic Treatment ◽

Basic Difference ◽

Air Contamination ◽

Survival Potential

This article analyzes the reasons of temporary disability of laborers in Agro Industrial Complex, dealing with microbial content in industrial premises. Development and implementation of equipment for correction of microbial content level results in reduction of general morbidity rate and duration of temporary disability among laborers in Agro Industrial Complex. It will help to increase labor efficiency and decrease labor intensity of production. Biofilm resistance against antibacterial agents is a vital problem during disinfection treatments. Increase in bacteria survival potential and reduction in sensitivity to the substances eliminating them, results in need for increased dosing of the latter decreased efficiency of sanitation. This is a stimulus to develop alternative antibacterial compositions and methods of disinfection treatment. The basic difference of the suggested photodynamic treatment from the disinfection methods with application of antimicrobial preparations is the lack of resistibility to destabilizing oxidant – singlet oxygen. Before disinfection treatment, we determined total microbial air contamination according to the original method, providing a possibility to use air medium sampling of the total volume of indoor area. Experimental results have shown a decrease in total microbial contamination by a factor of 5.5 on average.

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Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles

International Journal of Molecular Sciences ◽

10.3390/ijms21176211 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6211 ◽

Cited By ~ 2

Author(s):

Ha Thi Thu Do ◽

Jungsook Cho

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Garcinia Mangostana ◽

Brain Penetration ◽

Xanthone Derivatives ◽

Cholinergic Dysfunction ◽

Therapeutic Value ◽

Carrier Systems

Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression are growing burdens for society globally, partly due to a lack of effective treatments. Mangosteen (Garcinia mangostana L.,) pericarp (MP) and its xanthones may provide therapeutic advantages for these disorders. In this review, we discuss potential therapeutic value of MP-derived agents in AD, PD, and depression with their pharmacokinetic and safety profiles. MP-derived agents have shown multifunctional effects including neuroprotective, antioxidant, and anti-neuroinflammatory actions. In addition, they target specific disease pathologies, such as amyloid beta production and deposition as well as cholinergic dysfunction in AD; α-synuclein aggregation in PD; and modulation of monoamine disturbance in depression. Particularly, the xanthone derivatives, including α-mangostin and γ-mangostin, exhibit potent pharmacological actions. However, low oral bioavailability and poor brain penetration may limit their therapeutic applications. These challenges can be overcome in part by administering as a form of MP extract (MPE) or using specific carrier systems. MPE and α-mangostin are generally safe and well-tolerated in animals. Furthermore, mangosteen-based products are safe for humans. Therefore, MPE and its bioactive xanthones are promising candidates for the treatment of AD, PD, and depression. Further studies including clinical trials are essential to decipher their efficacy, and pharmacokinetic and safety profiles in these disorders.

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A Review on Graphene Based Materials and Their Antimicrobial Properties

Coatings ◽

10.3390/coatings11101197 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1197

Author(s):

Srinivasarao Yaragalla ◽

Karanath Balendran Bhavitha ◽

Athanassia Athanassiou

Keyword(s):

Oxidative Stress ◽

Food Packaging ◽

Hybrid Composites ◽

Antimicrobial Properties ◽

Preparation Methods ◽

Number Of Layers ◽

Current Review ◽

Microbial Agents ◽

Transfer Mechanisms ◽

Significant Attention

Graphene-based materials are found as excellent resources and employed as efficient anti-microbial agents, and they have been receiving significant attention from scientists and researchers in this regard. By giving special attention to recent applications of graphene-based materials, the current review is dedicated to unveiling the antimicrobial properties of graphene and its hybrid composites and their preparation methods. Different factors like the number of layers, concentration, size, and shape of the antibacterial activity are thoroughly discussed. Graphene-based materials could damage the bacteria physically by directly contacting the cell membrane or wrapping the bacterial cell. It can also chemically react to bacteria through oxidative stress and charge transfer mechanisms. This review explains such mechanisms thoroughly and summarizes the antibacterial applications (wound bandages, coatings, food packaging, etc.) of graphene and its hybrid materials.

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Combined Treatment with Hydrogen Peroxide and Ultra-violet Irradiation to Reduce Microbial Contamination Levels in Pre-formed Food Packaging Cartons

Journal of Food Protection ◽

10.4315/0362-028x-46.12.1060 ◽

1983 ◽

Vol 46 (12) ◽

pp. 1060-1064 ◽

Cited By ~ 14

Author(s):

CATHERINE J. STANNARD ◽

JOHN S. ABBISS ◽

JOHN M. WOOD

Keyword(s):

Hydrogen Peroxide ◽

Food Packaging ◽

Microbial Contamination ◽

Combined Treatment ◽

Ultra Violet ◽

Lethal Effect ◽

Low Concentrations ◽

Inner Surface ◽

Contamination Levels ◽

Uv C

A treatment combining hydrogen peroxide and ultra-violet (UV-C) irradiation was assessed for reduction of microbial contamination in pre-formed food packaging cartons. There was a synergistic effect between low concentrations (0 – 5% wt/vol) of hydrogen peroxide and UV-C irradiation (10 s) on spores of Bacillus subtilis, the maximum lethality occurring between 0.5 and 1% peroxide. A combined treatment using 1% hydrogen peroxide and 10 s of UV-C irradiation was also effective against a variety of other organisms (spores and vegetative cells). The efficiency of the treatment was dependent on the type of inner surface of the carton. A greater lethal effect was obtained against B. subtilis spores in polyethylene-lined cartons than in aluminium/polyethylene laminate-lined cartons (5.1 and 3.5 decimal reductions in numbers respectively, using a combined treatment with 1% peroxide and 10 s of UV-C).

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Polymeric Antimicrobial Food Packaging and Its Applications

Polymers ◽

10.3390/polym11030560 ◽

2019 ◽

Vol 11 (3) ◽

pp. 560 ◽

Cited By ~ 44

Author(s):

Tianqi Huang ◽

Yusheng Qian ◽

Jia Wei ◽

Chuncai Zhou

Keyword(s):

Food Packaging ◽

Antibacterial Agents ◽

High Efficiency ◽

Low Cost ◽

Urgent Problem ◽

Antibacterial Drugs ◽

Food Borne Pathogens ◽

Food Borne ◽

Low Toxicity ◽

Growth Of Bacteria

Food corruption and spoilage caused by food-borne pathogens and microorganisms is a serious problem. As a result, the demand for antibacterial drugs in food packaging is growing. In this review, biodegradable and non-biodegradable materials for food packaging are discussed based on their properties. Most importantly, antibacterial agents are essential to inhibit the growth of bacteria in food. To keep food fresh and prolong the shelf life, different kinds of antibacterial agents were used. The composition and application of natural antibacterial agents and synthetic antibacterial agents are discussed. Compared with natural antibacterial agents, synthetic antibacterial agents have the advantages of low cost and high activity, but their toxicity is usually higher than that of natural antibacterial agents. Finally, future development of antimicrobial food packaging is proposed. It is an urgent problem for researchers to design and synthesize antibacterial drugs with high efficiency and low toxicity.

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Polylactic acid (PLA): Improve it, use it, and dump it faster

BioResources ◽

10.15376/biores.16.2.2196-2199 ◽

2021 ◽

Vol 16 (2) ◽

pp. 2196-2199

Author(s):

Narongrit Sombatsompop ◽

Panupong Srimalanon ◽

Teerasak Markpin ◽

Benjaphorn Prapagdee

Keyword(s):

Waste Management ◽

Environmental Pollution ◽

Polylactic Acid ◽

Renewable Resources ◽

Food Packaging ◽

Antibacterial Agents ◽

It Use ◽

The World ◽

Single Use ◽

Alternative Approaches

Today, many people enjoy an easy lifestyle. However, this comfort has come with a price because of plastic that is thrown away after a single use. As such, governments around the world have pushed for biodegradable plastics to be produced, especially for food packaging, and these can be easily seen in supermarkets, for example. Using plastic for only one time has resulted in environmental pollution. To solve this problem, polylactic acid (PLA) has been introduced as an alternative bio-based plastic to replace artificial petroleum-based plastics. PLA comes from renewable resources and is biodegradable under certain conditions. Furthermore, the development of the properties of PLA could solve problems related to its weakness in packaging applications. This editorial proposes expansion of the property attributes of PLA to include hygienic character, through the addition of antibacterial agents. This can be done by introducing two alternative approaches for waste management: PLA recycling and degradation. However, some key research is still needed to improve the properties and waste management of PLA relative to the effectiveness of its reprocessing and acceleration of its (bio)degradation.

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Understanding the challenges of non-food industrial product contamination

FEMS Microbiology Letters ◽

10.1093/femsle/fnaa010 ◽

2019 ◽

Vol 366 (23) ◽

Cited By ~ 3

Author(s):

Edward Cunningham-Oakes ◽

Rebecca Weiser ◽

Tom Pointon ◽

Eshwar Mahenthiralingam

Keyword(s):

Microbial Contamination ◽

Bacterial Species ◽

Historical Analysis ◽

Food Product ◽

Food Products ◽

Gram Negative Bacteria ◽

Product Recalls ◽

Microbial Identification ◽

Microbial Contaminants ◽

Microbial Agents

ABSTRACT Preventing microbial contamination of non-food products is a major area of industrial microbiology where preservatives are used to stop microbial growth. However, microorganisms occasionally overcome product preservation, causing recalls and the implementation of multiple procedures to prevent further contamination. Correct reporting of microbial contamination in non-food industrial products is vital, especially if spoilage organisms are antimicrobial resistant and pose a health threat. Gram-negative bacteria such as Pseudomonas, Burkholderia and Enterobacteriaceae are frequently reported as non-food product contaminants, including species that overlap current antimicrobial resistance priorities. Historical analysis of recall databases highlighted that for greater than 15% of contamination incidents, the causative microbial agents are reported as unidentified. Here we review the current antimicrobial resistant bacterial species associated with non-food product contamination and evaluate recall reporting in Europe from 2005 to 2018. Our review shows that 49% of microbial contaminants are reported as unidentified despite frequent detection of antimicrobial resistant pathogens; in contrast, 98% of food-related microbial contaminants are classified. Recommendations to fill this microbial identification gap in non-food product recalls are made. Overall, reporting standards for microbial contamination in non-food products must be improved to enable surveillance and for understanding the risks associated with antimicrobial resistant microorganisms

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Progress on biodegradable films for antibacterial food packaging

E3S Web of Conferences ◽

10.1051/e3sconf/202014501036 ◽

2020 ◽

Vol 145 ◽

pp. 01036

Author(s):

Guocheng Han ◽

Rui Guo ◽

Zhaohui Yu ◽

Guangxue Chen

Keyword(s):

Biodegradable Polymer ◽

Food Packaging ◽

Antibacterial Agents ◽

Fruits And Vegetables ◽

Polymer Materials ◽

Research Progress ◽

Biodegradable Films ◽

Plant Essential Oils ◽

And Storage ◽

Food Packaging Films

The applications of common-used antibacterial agents and biodegradable polymer materials in food packaging were reviewed. The research progress on biobased antibacterial agents (such as chitosan, plant essential oils, plant extracts, bacteriocins) in food packaging films synthesized from biodegradable polymer materials (such as starch and its derivatives, chitosan, cellulose, protein) was summarized. Most of the biodegradable antibacterial films are applied in the packaging of postharvest transportation and storage of fruits and vegetables. This work provides guidance to develop new intelligent food packaging materials featured by degradability, bacteriostasis and environmental protection.

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