scholarly journals RUSSIAN EXPERTS’ CONSENSUS ON METABOLIC SYNDROME PROBLEM IN THE RUSSIAN FEDERATION: DEFENITION, DIAGNOSIS CRITERIA, PRIMARY PREVENTION AND TREATMENT

2010 ◽  
Vol 6 (4) ◽  
pp. 599-606 ◽  
Author(s):  
N. M. Achmegdanov ◽  
S. A. Butrusova ◽  
I. I. Dedov ◽  
L. A. Zvenigorodskaya ◽  
O. A. Kislyak ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Primary Prevention ◽  
Russian Federation ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
Diagnosis Criteria

scholarly journals Helicobacter pylori as a risk factor for gastric cancer: the evidence and primary prevention strategy

2019 ◽  
Vol 47 (6) ◽  
pp. 535-547 ◽  
Author(s):  
I. N. Voynovan ◽  
Yu. V. Embutnieks ◽  
D. V. Mareeva ◽  
S. V. Kolbasnikov ◽  
D. S. Bordin
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Risk Factor ◽  
Primary Prevention ◽  
Russian Federation ◽  
Diagnostic Methods ◽  
Rapid Urease Test ◽  
First Line ◽  
Urease Test ◽  
The Russian Federation

Russia is a country with a high prevalence of Helicobacter pylori (HP) infection, a high incidence of gastric cancer, and its late diagnosis. HР infection has been recognized as the leading manageable risk factor for gastric cancer. Accurate diagnostic tests must be used to identify and control the effectiveness of HP eradication, and effective schemes must be implemented for HP eradication. The aim of this article was to analyze the latest consensus documents, systematic reviews and meta-analyzes that reflected the role of HP as a risk factor for the development of gastric cancer, as well as measures for the risk reduction. We describe in detail the diagnostic methods for HP infection, provide data on their use in the Russian Federation, and analyze the efficacy of eradication regimens. In all HPinfected individuals, HP leads to chronic inflammation in the gastric mucosa and launches a precancerous cascade (Correa's cascade). The risk of gastric cancer increases with severe atrophy, intestinal metaplasia and dysplasia. Primary prevention of gastric cancer is most effective if the eradication is performed before atrophic gastritis develops. The available consensus documents underline the importance of HP infection identification by accurate diagnostics at this stage of chronic gastritis. In Russia, the primary HP diagnosis is based on histology (37.7%), rapid urease test (29.2%), and serology (29.7%). HP stool antigen test (31.3%), 13C-urea breath test (23.4%) and the histological method (23.3%) are most often used to control eradication. Currently, the first line of eradication therapy is recommended as triple therapy with clarithromycin prescribed for 14 days. It is recommended to use double dose of proton pump inhibitors and bismuth to increase the effectiveness of this scheme. A 14-days triple regimen enhanced by bismuth has been recommended as the first-line therapy in the Russian Federation.

The current state of the pharmaceutical market for anthelmintic drugs for veterinary use

2021 ◽  
Vol 1 (9) ◽  
pp. 37-44
Author(s):  
A. K. Klyueva ◽  
◽  
A. A. Deltsov ◽  
K. O. Belova ◽  
◽  
...  
Keyword(s):  
Russian Federation ◽  
Wide Spectrum ◽  
Pharmaceutical Market ◽  
The Past ◽  
Veterinary Medicines ◽  
Current State ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
State Registration ◽  
Anthelmintic Drugs

This paper presents an analysis of the range of veterinary medicines registered in the territory of the Russian Federation and used for the prevention and treatment of helminthiasis. The Russian Federation is a leader in the development and production of anthelmintic medicines registered on its territory. Antiparasitic medicines used for the prevention and treatment of helminthiasis are divided according to the spectrum of action depending on the class of helminths. It was revealed that the majority of medicines (89 medicines – 58,17%) have a wide spectrum of action. Of these, 62 medicines (40,52% of the total amount of anthelmintic medicines) are intended for the treatment of nematodes and cestodoses. When distributing anthelmintic medicines among target animals, it was found that 75 medicines (49.02%) are intended for the treatment of productive animals, and 78 medicines (50,98%) are intended for the treatment of unproductive animals. When assessing the dynamics of state registration of anthelmintic medicines for veterinary use, it can be noted that over the past 4 years there has been a tendency towards an increase in the average annual registration.

scholarly journals Prospects for the Primary Prevention of Myocardial Infarction and Stroke

2018 ◽  
Vol 24 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Madison Caldwell ◽  
Lisa Martinez ◽  
Jennifer G. Foster ◽  
Dawn Sherling ◽  
Charles H. Hennekens
Keyword(s):  
United States ◽  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Primary Prevention ◽  
Clinical Manifestations ◽  
The United States ◽  
Overweight And Obesity ◽  
Lifestyle Changes ◽  
Prevention And Treatment

Cardiovascular disease (CVD), principally myocardial infarction (MI) and stroke, is the leading clinical and public health problem in the United States and is rapidly becoming so worldwide. Their primary prevention is promising, in theory, but difficult to achieve in practice. The principal modalities that have demonstrated efficacy include therapeutic lifestyle changes (TLCs) and adjunctive drug therapies under the guidance of the health-care provider and tailored to the individual patient. The prevention and treatment of the pandemic of overweight and obesity and lack of regular physical activity, both of which are alarmingly common in the United States, prevention and treatment of hypertension, avoidance and cessation of cigarette smoking, adoption and maintenance of a healthy diet, and avoidance of heavy alcohol consumption all have proven benefits in decreasing the risks of a first MI and stroke as well as other clinical manifestations of CVD. Although adoption of TLCs would avoid the need for adjunctive drug therapies in many primary prevention subjects, this strategy is difficult to achieve or maintain for most and may be insufficient for many, especially those at high risk with metabolic syndrome. The criteria for metabolic syndrome, affecting over 40% of the adult population older than 40 in the United States, include overweight or obesity, dyslipidemia, hypertension, and insulin resistance, a precursor of diabetes. The adjunctive therapies of proven benefit in the primary prevention of MI and stroke include statins, blood pressure medications, aspirin, and drugs to treat insulin resistance and hyperglycemia. Fortunately, even for patients who prefer prescription of pills to proscription of harmful lifestyles, these drug therapies still have net benefits. The adoption and maintenance of TLCs and adjunctive drug therapies into clinical practice will reduce both the incidence of and mortality from a first MI and stroke as well as other major clinical manifestations of CVD.

scholarly journals Comparative Characteristics of the Incidence of Healthcare-Associated Infections in the Chelyabinsk region and in the Russian Federation in Total

2015 ◽  
Vol 14 (5) ◽  
pp. 56-61 ◽  
Author(s):  
O. A. Orlova
Keyword(s):  
Health Care ◽  
Russian Federation ◽  
Healthcare Associated Infections ◽  
Prevention And Treatment ◽  
Hospital Acquired Pneumonia ◽  
The Russian Federation ◽  
General Demand ◽  
Chelyabinsk Region ◽  
Healthcare Associated ◽  
Hospital Acquired

Currently, the problem of prevention and treatment of healthcare-associated infections (HAI), only in hospitals from 5 to 20% of patients HAI get sick. In Chelyabinsk region, in comparison with the Russian Federation, the quantity of the infections connected with delivery of health care tends to growth. The greatest number of HAI is registered in hospitals of a surgical profile 70.3 ± 5.7% (in the Russian Federation - 31.4 ± 0.2%). In area hospital-acquired pneumonia steadily holds the first - second place in structure of HAI (38.2 ± 10.3%) in the country - the fourth - fifth (10.1 ± 5.1%). Detection of distinctions in structure of HAI in Chelyabinsk region and in the country in general demand further studying for the purpose of identification and introduction of the most effective preventive and antiepidemic actions.

Analysis of the range of antiprotozoal drugs for veterinary use

2021 ◽  
Vol 1 (10) ◽  
pp. 47-54
Author(s):  
Aleksandr A. Deltsov ◽  
◽  
Olga R. Rodkina ◽  
Irina V. Kosova ◽  
◽  
...  
Keyword(s):  
Russian Federation ◽  
Active Ingredient ◽  
Dosage Forms ◽  
The State ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
State Register ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
Antiparasitic Drugs

This paper presents an analysis of the range of veterinary antiparasitic drugs registered in the territory of the Russian Federation and used for the prevention and treatment of protozoan diseases. At the time of 08/07/2021, 54 antiprotozoal drugs were entered into the State Register of Medicines for Veterinary Use. The most common active ingredient in their composition is Toltrazuril (contained in 12 TN – 22,2%). It was determined that the Russian Federation is a leader in the production and development of anti-protozoal drugs registered on its territory. It was found that most of the investigated drugs are produced in solid dosage forms (35 TN – 64,8%), effective for the treatment of coccidiosis (45 TN – 83,33%) and is used in birds (39 TN – 72,22%). The average annual registration of antiprotozoal drugs is 9% (5 drugs per year).

Cervical cancer in the Russian Federation and the risks of vaginal fistula

2021 ◽  
Vol 11 (2) ◽  
pp. 49-54
Author(s):  
M. N. Saryev ◽  
R. K. Valiev ◽  
M. I. Nechushkin ◽  
M. B. Nurberdyev ◽  
I. V. Panichenko ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Russian Federation ◽  
Vaginal Fistula ◽  
Factors Associated ◽  
Increased Risk ◽  
Relevant Task ◽  
Prevention And Treatment ◽  
Oncological Diseases ◽  
The Russian Federation

This review aims to provide up-to-date information on the factors associated with an increased risk of vaginal fistula in women with cervical cancer, as well as on methods of their prevention and treatment. It includes data on various types of vaginal fistulas in cervical cancer patients and risk factors for their development, according to foreign and Russian research articles published over the last 20 years. Cervical cancer is one of the most challenging oncological diseases in the Russian Federation, because it is detected at stage III–IV in more than 30 % of women. Such a high incidence of cervical cancer and the need for radiotherapy determine high risk of fistulas, which significantly impairs the quality of life. Thus, identification of factors associated with vaginal fistulas, as well as methods of their prevention and treatment remains a highly relevant task for the Russian healthcare system.

Economic burden of noncommunicable diseases attributable to risk factors in the Russian Federation

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Kontsevaya ◽  
A Myrzamatova ◽  
D Mukaneeva ◽  
Y u Balanova ◽  
M Khudyakov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Russian Federation ◽  
Economic Burden ◽  
Alcohol Intake ◽  
Noncommunicable Diseases ◽  
High Alcohol ◽  
Strong Argument ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
High Alcohol Intake

Abstract Aim to estimate the economic burden of major chronic noncommunicable diseases (NCDs) attributable to risk factors in the Russian Federation in 2016 Material and Methods The following risk factors were included in the analysis: smoking, high alcohol intake, high salt intake, low intake of fresh vegetables and fruits, consumption of processed red meat, low physical activity, obesity, hypertension, which reliably have a causal relationship with major NCDs: cardiovascular diseases(CVD),type 2 diabetes, chronic obstructive pulmonary disease(COPD), cancer of 10 localizations. The relative risks (RR)of morbidity and mortality from major NCDs associated with risk factors are identified through a literature search. Based on the data on the prevalence of risk factors in the Russian population and RR, the population attributable risk (PAR)was calculated for each analyzed disease. Statistical analysis calculations using descriptive statistics methods were performed in the MSExcel 10.0 program. Results The largest burden from the four main NCDs is associated with hypertension - 10.9 billion€, which is equivalent to 1.01% of GDP. The next largest contribution to the burden from NCDs was the burden from obesity 7.6 billion€ 0.7% of GDP, smoking over 5.2 billion €, 0.49% of GDP and the low physical activity 3.4 billion€, 0.32% of GDP. Of all the analyzed risk factors, the least contribution to total costs in connection with NCDs was determined by the burden from high alcohol intake 1.1 billion€, 0.1% of GDP, due to the low prevalence of high alcohol intake in the Russian population. Conclusions In this study, for the first time, the assessment of the economic burden of risk factors by the share (contribution) to the morbidity and mortality of main NCDs (CVD, T2DM, COPD and 10 cancer localizations) in the Russian Federation for 2016 was performed. Such the significant economic burden is a strong argument for increasing investments in the prevention and treatment of risk factors of NCDs. Key messages In Russia the largest burden from the four main NCDs is associated with hypertension. Such the significant economic burden is a strong argument for increasing investments in the prevention and treatment of risk factors of NCDs.

scholarly journals Regulatory and Ethical Basis of Primary Prevention of Drug Addiction in the Education System

2019 ◽  
Vol 9 (4) ◽  
pp. 103-119 ◽  
Author(s):  
A.V. Milekhin ◽  
I.B. Umnyashova ◽  
I.A. Egorov
Keyword(s):  
Primary Prevention ◽  
Drug Addiction ◽  
Russian Federation ◽  
Healthy Lifestyle ◽  
Educational Institution ◽  
Integrated Approach ◽  
Drug Prevention ◽  
Main Concern ◽  
The Russian Federation ◽  
The University

Drug addiction is a mental illness and is included in the list of socially significant diseases that cause significant damage to society. From the expert point of view, adolescence is one of the sensitive periods for the contraction of the disease development. Prevention of drug addiction in the student community is one of the activities of the university, ensuring the preservation and strengthening of the health of students. The main concern of primary prevention of drug addiction in the university is the construction and development of students' values of their own health and motivation to maintain a healthy lifestyle. The article provides an analysis of the regulatory legal documents of the Russian Federation governing the organization of primary prevention of drug addiction in the educational institution of higher education. The necessity of an integrated approach to the organization of preventive activities at the university is emphasized, based on the requirements of the legislation of the Russian Federation in the field of drug prevention in the youth environment and taking into account the ethical principles of the organization of psychological and pedagogical support in an educational organization.

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