scholarly journals Profil lipid wanita menopause di Panti Werdha Damai Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Prisilia D. D. Sumoked ◽  
Hermie M. M. Tendean ◽  
Eddy Suparman
Keyword(s):  
Lipid Profile ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Reference Value ◽  
Hdl Cholesterol ◽  
Mean Value ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Menopausal Women

Abstract: In Indonesia, women over the age of 50 years that will become menopause in 2020 are estimated as many as 30.3 million people. A decline in estrogen level at menopause will affect the functions of the female reproductive system as well as of the other body systems, including lipid metabolism. This study was aimed to determine the lipid profile of menopausal women at Panti Werdha Damai (senior housing) Manado. This was a descriptive, prospective, and observational study with a cross sectional design. There were 30 menopausal women obtained by using purposive sampling method. Lipid profile was examined at Prodia Laboratorium Manado. Data were analyzed by using SPSS 20. The results showed that most respondents (86.7%) were ≥65 years old. There were 21 women (70%) with total cholesterol level >200 mg/dl (mean value of 211.2 mg/dl); 27 women (90%) with LDL-cholesterol level >100 mg/dl (mean value of 137.8 mg/dl); 25 women (83.3%) with HDL cholesterol >40 mg/dl (mean value of 50.9 mg/dl); and 26 women (87.7%) with triglyceride level <150 mg/dl (mean value of 111.4 mg/dl). Conclusion: Most of the menopausal women at Panti Werdha Damai Manado were at the age of ≥65 years. The average values of total and LDL cholesterol were above the reference value, meanwhile the average values of HDL cholesterol and triglycerides were within normal limit. Keywords: menopausal women, lipid profile. Abstrak: Di Indonesia perempuan yang berusia lebih dari 50 tahun telah memasuki menopause pada tahun 2020 diperkirakan sebanyak 30,3 juta orang. Saat menopause terjadi penurunan estrogen yang tidak hanya memengaruhi fungsi sistem reproduksi wanita, tetapi juga terhadap sistem tubuh lainnya antara lain metabolisme lipid. Penelitian ini bertujuan untuk mengetahui profil lipid wanita menopause di Panti Werdha Damai Manado. Jenis penelitian ialah observasional serta deskriptif prospektif dengan desain potong lintang. Didapatkan 30 wanita menopause dengan menggunakan metode purposive sampling dan dilakukan pemeriksaan profil lipid di Laboratorium Prodia Manado. Data dianalisis menggunakan SPSS 20. Hasil penelitian memperlihatkan bahwa sebagian besar responden (86,7%) berusia ≥65 tahun. Kadar kolesterol total terbanyak ialah >200 mg/dl berjumlah 21 orang (70%) dengan nilai rerata 211,2 mg/dl. Kadar kolesterol LDL terbanyak ialah >100 mg/dl pada 27 orang (90%), nilai rerata 137,8 mg/dl. Kadar kolesterol HDL terbanyak ialah >40 mg/dl pada 25 orang (83,3%), nilai rerata 50,9 mg/dl. Kadar trigliserida terbanyak ialah <150 mg/dl pada 26 orang (86,7%), nilai rerata 111,4 mg/dl. Simpulan: Sebagian besar wanita menopause di Panti Werdha Damai Manado berusia ≥65 tahun dengan nilai rerata kolesterol total dan kolesterol LDL berada di atas nilai rujukan sedangkan nilai rerata kolesterol HDL dan trigliserida sesuai nilai rujukan.Kata kunci: wanita menopause, profil lipid

scholarly journals PERBANDINGAN PROFIL LIPID PADA SERUM DARAH PENDERITA HIPERTENSI DAN NORMOTENSI

Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (2) ◽  
pp. 131
Author(s):  
Pratiwi Widyamurti ◽  
Rusdi Rusdi ◽  
Sri Rahayu
Keyword(s):  
Blood Serum ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Clinical Chemistry ◽  
Hdl Cholesterol ◽  
Mean Value ◽  
Cross Sectional ◽  
Ex Post ◽  
The Mean

ABSTRACT Increased blood pressure more than 140/90 mmHg taken from three measurement in 24 hours can be diagnosed as hypertension. Abnormality of lipid values condition was found at many hypertensive. Based on this reason examination of lipid profile in hypertensive and normotensive should be done. The aim of this research was to measure and compare lipid profile on blood serum in hypertensive    and normotensive. Lipid profile was measured by Konelab 20XT clinical chemistry analyzer. Ex     Post Facto used as method and Cross-sectional used as design. A total of 50 blood samples collected from Hypertensive (N1=25) and normotensive (N2=25) from June to August 2014. SPSS 16.0 was used to analyze the data, T-test was used to compare value of LDL cholesterol, HDL cholesterol and total cholesterol while U Mann-Whitney test was used to compare value of triglyceride. The result      of this research showed that the mean value of triglyceride was 146.56 mg/dL in hypertensive and 143.92 mg/dL in normotensive (p=0.11). The mean value of LDL cholesterol was 129.80 mg/dL in hypertensive and 136.72 mg/dL in normotensive (p=0.62). The mean value of HDL cholesterol was  38.80 mg/dL in hypertensive and 45.04 mg/dL in normotensive (p=0.1). The mean value of total cholesterol was 201.04 mg/dL in hypertensive and 221.88 mg/dL in normotensive (p=0.25). In conclusion, there was no different of lipid profile on blood serum in hypertensive and normotensive.  Keywords: hypertension, lipid profile, normotensive

scholarly journals Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

2014 ◽  
Vol 3 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Indrawati Wurdianing ◽  
SA Nugraheni ◽  
Zen Rahfiludin
Keyword(s):  
Treatment Group ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Wilcoxon Test ◽  
Control Group ◽  
Annona Muricata ◽  
The Mean

Background: Lipid profile effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona muricata L) isa traditional medicine plant containing metabolic compounds that contribute to the improvement of the lipid profile.Objective: To determine the effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol, HDLcholesterol and triglyceride).Methods: An experimental study using randomized pre-posttest with control group design. Sample consisted of 28 maleWistar rats, were divided into four groups. The control group (K) was only given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3) were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and 300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level significantly decreased in the treatment group P1 (p = 0.028) from 60.7 mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3) to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and triglyceridedecreased but not significantly.Conclusion: The administration of Annona muricata L extract can decrease total cholesterol and increase HDLcholesterol significantly.

scholarly journals Senam aerobik dan konsumsi zat gizi serta pengaruhnya terhadap kadar kolesterol total darah wanita

2011 ◽  
Vol 8 (1) ◽  
pp. 23
Author(s):  
Siti Fatimah ◽  
Apoina Kartini
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Adult Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Nutrient Adequacy ◽  
Significant Difference

Background: Hypercholesterolemia is a condition in which levels of cholesterol in the blood above normal levels (≥ 240 mg/dl). Physical exercises done regularly useful in the regulation of cholesterol, is total cholesterol, LDL cholesterol and triglycerides in the blood decreased, while HDL cholesterol increased. Food has an important role in association with the incident hypercholesterolemia.Objective: The purpose of this study was to determine the effect of aerobic exercise on blood total cholesterol level of adult women in the city of Semarang.Method: This research was explanatory research with cross sectional study. Subject was women aged 20-49 years gymnastic participants, as a comparison group was a housewife who was not doing gymnastics. Twenty three samples for group2 by matching on nutritional status and age and with the sampling purposive sampling. Adequacy levels of carbohydrates, proteins, fats, and also vitamins A and C were obtained through 2x24-hour recall was not a sequence, and processed using NutriSurvey. Results of independent t-test used to determine the effect of cholesterol levels between groups, and chi square test was used to determine association with nutrient adequacy levels of total cholesterol.Results: The results showed no significant difference in mean total cholesterol level between groups of gymnastic participants (201.2 g/dl) with housewife group (208.3 g/dl). Housewife group was belonging to hypercholesterolemia by 52.2%, while in group of exercise participants at 43.5%. Sufficiency level of protein showed a role in the total cholesterol level of adult women.Conclusion: The aerobic gymnastics did not affect total cholesterol. Moderate level of protein adequacy contributes to the total cholesterol level of adult women.

scholarly journals Association between Lipid Profile and Glycemic Status in Iraqi patients with Acromegaly Receiving Depot Long-Acting Octreotide

2021 ◽  
Vol 1 ◽  
pp. 140-144
Author(s):  
Omar Mohammed Al-Juboori
Keyword(s):  
Glycemic Control ◽  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Treatment Modalities ◽  
Cross Sectional ◽  
Octreotide Lar ◽  
Profile Changes ◽  
Long Acting

Background: Treatment modalities of acromegaly and disease control impact differently on glucose homeostasis and lipid changes, and consequently on cardiometabolic risk. Aim: To investigate the possible association of lipid profile changes with the glycemic control status in acromegaly patients treated with octreotide LAR. Methods: This cross-sectional study included 52 Iraqi patients with acromegaly treated with octreotide LAR and not using statins. Demographic, anthropometric, and clinical data were collected, as well as the duration of Octreotide LAR administration. The glycemic state was assessed and classified as DM, prediabetes, or normal. Plasma levels of triglycerides, LDL cholesterol, HDL cholesterol, and non-HDL were evaluated using standard methods. Results: Most of the participants presented with low levels of triglycerides, LDL cholesterol, and HDL cholesterol. The lipid profile variables were not significantly correlated with the glycemic control status after treatment with octreotide LAR. Conclusion: Lipid profile parameters were not associated with the different glycemic control status of acromegaly patients treated with octreotide LAR.

scholarly journals Pengaruh pemberian yogurt sinbiotik tepung pisang tanduk terhadap profil lipid tikus sindrom metabolik

2017 ◽  
Vol 13 (4) ◽  
pp. 159 ◽  
Author(s):  
Zana Fitriana Octavia ◽  
Kis Djamiatun ◽  
Nyoman Suci
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Intervention Group ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Group I ◽  
Banana Flour ◽  
Group Ii

Background: The metabolic syndrome, which is characterized by hyperglycemia, obesity, dyslipidemia, hypertension, prothrombic and proinflamatory state, is a risk factor for cardiovascular disease and diabetes mellitus. The synbiotic yogurt of tanduk banana (Musa paradisiaca fa. corniculata) flour contains lactic acid bacteria, fructooligosaccarides, flavonoids, and vitamin C which all of them play role in improving the lipid profile.Objective: The aim of this study was to prove the effect of synbiotic yogurt of tanduk banana flour on lipid profile of metabolic syndrome rats.Method: This study was an true experimental with pre-post test  control group design. The subject of this study were 18 metabolic syndrome male Wistar rats divided into 3 groups,i.e control group (standart diet), intervention group I (standart diet and synbiotic yogurt of banana flour 0,009 ml/g weight/day), and intervention group II (standart diet and synbiotic yogurt of banana flour 0,018 ml/g weight/day). The intervention period was 2 weeks. Different test before and after intervention used paired t-test. The difference test between groups used One-Way ANOVA and Kruskal wallis.Results: The result showed that both of intervention group improved lipid profile significantly (p<0,05). The intervention group II showed more effective improvement of lipid profile significantly (p<0,05) than intervention group I. The intervention group II decreased triglycerides level 41,56%; total cholesterol level 41,39%; LDL-cholesterol level 57,5%; and increased HDL-cholesterol level 139,62%.Conclucion: The intervention of synbiotic yogurt of  tanduk banana flour can decrease triglyceride level, total cholesterol level, LDL-cholesterol level, and increase HDL-cholesterol level.

scholarly journals Gambaran profil lipid pada pasien stroke iskemik dan stroke hemoragik yang di rawat inap di Irina F RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2015-Juni 2016

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Astrid Laulo ◽  
Melke J. Tumboimbela ◽  
Corry N. Mahama
Keyword(s):  
Lipid Profile ◽  
Hemorrhagic Stroke ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Clinical Signs ◽  
Secondary Data ◽  
Hdl Cholesterol ◽  
Haemorrhagic Stroke ◽  
Cerebral Function ◽  
Vascular Origin

Abstract: Stroke is rapidly developing clinical signs of focal or global disturbance of cerebral function, with symptoms lasting for 24 hours or longer or leads to death, with no apparent cause other than of vascular origin. This study was aimed to know description of lipid profile in patients with ischemic and haemorrhagic stroke hospitalized at Prof.Dr.R.D.Kandou hospital period of July 2015 – June 2016. This research was a descriptive retrospective research using secondary data, including the ischemic and haemorrhagic stroke patient’s medical record. The results showed the highest percentage ischemic and haemorrhagic stroke patients is male, 51-60 year age group, who work as housewifes (40%), had an optimal total cholesterol level, desired levels of HDL cholesterol, a near optimal of LDL cholesterol, an optimal triglyceride level. Based on this research, it can be concluded that patients with ischemic and hemorrhagic stroke had more patients with normal lipid levels.Keywords: stroke, lipid profile Abstrak: Stroke adalah manifestasi klinik dari gangguan fungsi serebral, baik fokal maupun global, yang berlangsung dengan cepat, berlangsung lebih dari 24 jam, atau berakhir dengan kematian, tanpa ditemukannya penyebab selain gangguan vaskuler. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid pada pasien stroke iskemik dan stroke hemoragik yang di rawat inap di RSUP Prof.Dr.R.D.Kandou Manado periode juli 2015-juni 2016. Metode yang digunakan bersifat deskriptif retrospektif yaitu dengan mengambil data sekunder penderita stroke iskemik dan stroke hemorgik periode juli 2015-juni 2016 di bagian rekam medik RSUP Prof.Dr.R.D.Kandou Manado. Hasil penelitian menunjukan bahwa persentase terbanyak pasien stroke iskemik dan stroke hemoragik adalah berjenis kelamin laki-laki, berusia 51-60 thn, bekerja sebagai ibu rumah tangga, memiliki kadar kolesterol total optimal, kadar kolesterol HDL diinginkan, kadar kolesterol LDL mendekati optimal, kadar trigliserida optimal. Berdasarkan hasil penilitian ini disimpulkan bahwa pasien stroke iskemik dan stroke hemoragik lebih banyak memiliki kadar profil lipid yang normal. Kata kunci: stroke, profil lipid

scholarly journals THE ASSOCIATION OF INSULIN RESISTANCE AND LIPID PROFILE RATIO IN METABOLIC SYNDROME

2019 ◽  
Vol 25 (1) ◽  
pp. 21
Author(s):  
Rini Rahmayani ◽  
Adi Koesoema Aman ◽  
Santi Safril
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Serum Glucose ◽  
Lipid Concentration ◽  
Cross Sectional ◽  
Serum Lipid Concentration

The cause of metabolic syndrome is still not known for sure, but it is suspected that the pathophysiology of metabolic syndrome is associated with insulin resistance and central obesity. Researchers have attempted to evaluate insulin resistance using various serum lipid concentration ratio. This study was to observe the association between insulin resistance and lipid profile ratio using HOMA-IR in metabolic syndrome patients. This study was a cross-sectional that was conducted in Inpatient and Outpatient Adam Malik Hospital during March 2016 - April 2016. Subjects were patients with metabolic syndrome criteria according to the International Diabetic Federation 2005. All samples were examined for their waist circumference, weight, height, blood pressure, insulin, serum glucose, total cholesterol, HDL cholesterol, LDL cholesterol, Triglycerides. Among sixty-six patients in the study 40 (60.6%) were male and 26 (39.4%) female. In this study, there was a significant correlation between HOMA-IR with CT/HDL ratio (r: 0.244 p <0.05); and there was no correlated HOMA-IR, and TG/HDL ratio (r: 0.086 p > 0.05) and there was no correlation between HOMA-IR and LDL/HDL (r: 0.336 p > 0.05). There was a significant relationship between insulin resistance and ratio CT/HDL

scholarly journals Gambaran Profil Lipid pada Pasien Infark Miokard Akut di RSUP M. Djamil Padang Periode 1 Januari 2011 - 31 Desember 2012

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Lamuna Fathila ◽  
Zulkarnain Edward ◽  
Rosfita Rasyid
Keyword(s):  
Myocardial Infarction ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Muscle Necrosis

AbstrakInfark Miokard Akut (IMA) merupakan nekrosis otot jantung akibat terganggunya kebutuhan dan suplai oksigen ke jantung secara mendadak. Faktor risikonya adalah perubahan profil lipid yaitu Kolesterol total, Kolesterol LDL. Kolesterol HDL, dan trigliserida yang dikaitkan dengan pembentukan plak aterosklerosis. Manfaat penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA. Tujuan penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA di RSUP M. Djamil Padang periode 1 Januari 2011-31 Desember 2012. Penelitian dilakukan dengan metode deskriptif dengan desain cross sectional study di bagian Rekam Medik RSUP M. Djamil Padang. Hasil penelitian menunjukkan umur terbanyak pasien IMA 45-59 tahun, Jenis kelamin terbanyak pasien IMA adalah laki-laki, perbandingannya adalah 2,7 : 1, Pasien IMA yang memiliki kadar kolesterol total tinggi 79 orang (38,92%) dan normal 124 orang (61,08%), Pasien IMA yang memiliki kadar kolesterol LDL tinggi 76 orang (37,44%) dan normal 127 orang (62,56%), Pasien IMA yang memiliki kadar kolesterol HDL rendah 145 orang (71,43%) dan normal 58 orang (28,57%), dan Pasien IMA yang memiliki kadar trigliserida tinggi 44 orang (21,67%) dan normal 159 orang (78,33%).Kata kunci: infark miokard akut, kolesterol total, kolesterol LDL, Kolesterol HDL, trigliserida AbstractAcute Myocardial Infarction (AMI) is a muscle necrosis of the heart through disruption of demand and supply of oxygen to the heart suddenly. Risk factors of AMI is a change of lipid profile (Total Cholesterol, LDL Cholesterol, HDL Cholesterol, and Triglycerides) associated with the formation of atherosclerotic plaque. The benefit of this research is to reveal the lipid profile in patients with AMI. The objective of this study was to determine the description of lipid profile in patients with AMI at RSUP M. Djamil Padang period January 1st, 2011-December 31th, 2012. The study was conducted with descriptive methods to the design of cross sectional study at the Medical Records Department of RSUP M. Djamil Padang. The results of this study indicate that the most age of the patients of AMI 45-59 years old, the most gender of AMI are male and the ratio 2.7 : 1, AMI patients with high total cholesterol levels 79 people (38.92%) and normal 124 people (61.08%), AMI patients with high LDL cholesterol levels 76 people (37,44%) normal 127 people (62.56%), AMI patients with low HDL cholesterol levels 145 people (71.43%) and normal 58 people (28.57%), and AMI Patients with high triglyceride levels 44 people (21.67%) and normal 59 people (78.33%).Keywords: acute myocardial infarction, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride

scholarly journals The influence of age and the beginning of menopause on the lipid status, LDL oxidation, and CRP in healthy women

2007 ◽  
Vol 135 (5-6) ◽  
pp. 280-285 ◽  
Author(s):  
Zorica Caparevic ◽  
Nada Kostic
Keyword(s):  
Lipid Profile ◽  
Inflammatory Markers ◽  
Ldl Cholesterol ◽  
Premenopausal Women ◽  
Hdl Cholesterol ◽  
Ldl Oxidation ◽  
Healthy Women ◽  
Increased Risk ◽  
Menopausal Women ◽  
Significant Difference

Introduction: Atherogenic lipid profile is an important risk factor in development of atherosclerosis in menopausal women. High level of small dense LDL, that is more susceptible to oxidation, and high levels of inflammatory markers are also associated with an increased risk for development of atherosclerosis. Objective. The aim of this study was to investigate the relationship between lipid profile, oxidized LDL (Ox-LDL) and C-reactive protein (CRP) as inflammatory reaction in healthy women dependent on age and menopause. Method. The study included a group of clinically healthy women (total of 97 women). Group 1: 15 women younger than 45 years; group 2: 62 women between 46 and 55 years, group 3: 20 women between 56 and 65 years, group of menopausal women (73) and group of premenopausal women (24). None of the women had history of obesity, diabetes mellitus, cerebrovascular, ischaemic heart disease, and hypertension. Lipid profiles were measured by enzymatic methods. Ox-LDL was measured by using a specific monoclonal antibody, mAb4E6. CRP was measured using hemiluminiscent methods (Immulite-DPC). Results. Results showed significantly higher levels of total cholesterol (p<0.01) and LDL cholesterol (p<0.01) in women over 56 years compared with women younger than 45 years. We also found similar results in menopausal women. Levels of Ox-LDL (p<0.05) and CRP (p<0.01) showed significantly higher levels in women over 56 years. In menopausal women, we found significantly higher levels of CRP (p<0.05). There was no significant difference in the levels of oxLDL between the menopausal and premenopausal women. Levels of triglycerides and HDL cholesterol were not different among groups. We found that 51% women had levels of HDL cholesterol lower than 1.3 mmol/L. In all groups of women, we found positive correlation among age, Ox-LDL (p<0.01) and CRP (p<0.01). Ox-LDL also positively correlated with CRP (p<0.01). Conclusion. In healthy women older than 56 as in menopausal women, we found significantly higher levels of LDL cholesterol and inflammatory markers. These results suggest that strategies of primary prevention in women are needed to reduce the risk of developing cardiovascular disease.

scholarly journals Clinical profile and lipid abnormalities in subclinical and overt primary hypothyroidism

2019 ◽  
Vol 7 (6) ◽  
pp. 2003 ◽  
Author(s):  
Mrutyunjay B. Hiregoudar ◽  
Pradeep Kumar Mohanty ◽  
Sagnika Tripaty ◽  
Amita Kerketta ◽  
Uttam Kumar Soren ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Subclinical Hypothyroidism ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Common Symptom ◽  
Cardiovascular Morbidity And Mortality

Background: Overt and subclinical hypothyroidism, affects metabolism of lipids particularly that of cholesterol, low density lipoprotein and triglyceride. Hypercholesterolemia predisposes to atherosclerosis and thereby increases cardiovascular risks.Methods: Hundred patients of primary  hypothyroidism of age more than 15 yrs were included. Five milliliters of venous blood was drawn in fasting state and serum obtained; thyroid function test (TFT) and fasting lipid profile were performed. Based on the TFT, patients were categorized as sub clinical or overt hypothyroidism. Clinical data, thyroid and lipid profiles obtained were analyzed and compared using statistical methods.Results: Seventy patients were females and thirty were males in the ratio of 2.3:1. Most common age group was 51-60years followed by 41-50years. Most common symptom was generalised weakness followed by weight gain, cold intolerance, constipation, hair loss, paraesthesia’s. Most common signs were myxoedema, delayed ankle reflex relaxation, dry and  coarse skin, bradycardia, non-pitting peripheral edema, madarosis, pallor, goiter. Patients with Overt hypothyroidism had significantly higher serum levels of total cholesterol(249.1±31.7 mg/dl), Triglycerides (191.5±68.5 mg/dl) and LDL cholesterol(167.7±31 mg/dl) than the Subclinical hypothyroidism with total cholesterol(202±19.8),triglycerides(155.6±35) and LDL cholesterol(129±21.1) but HDL cholesterol  level remains normal in both overt  (44.0±4.7) and subclinical  (43.1±4.4)hypothyroidism respectively.Conclusions: Patients with Overt hypothyroidism had significantly higher levels of Total cholesterol, Triglycerides (TG) and LDL cholesterol than the Subclinical hypothyroidism but HDL cholesterol level remains normal in both. So, concomitant estimation of lipid profile in hypothyroidism patients is needed for early intervention and prevention of cardiovascular morbidity and mortality.

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