scholarly journals Effect of Methotrexate on the Liver Enzymes and Lipid Profile in Adult Female Albino Mice

2013 ◽  
Vol 10 (1) ◽  
pp. 176-181 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Profile ◽  
Adult Female ◽  
Normal Saline ◽  
Liver Enzymes ◽  
Control Group ◽  
Female Mice ◽  
The Third ◽  
Albino Mice

Methotrexate (MTX) was used for treatment of malignancies and now is widely used in treatment of rheumatoid arthritis. In this research the evaluation of the effects of MTX on some liver enzymes and lipid profile was studied. Twenty four adult female mice divided into three groups (8 mice each). The first two groups were treated with MTX while the third group was used as a control. MTX was intraperitoneally given at 50 µg/ml and 75 µg/ml to the first and second groups respectively for 35 days ,whereas the control group was intraperitoneally injected with normal saline. The results showed a significant (p

scholarly journals Effect of pesticide Glyphosate Aqua in liver enzymes activity of Barbus sharpeyi

2016 ◽  
Vol 13 (2) ◽  
pp. 240-246
Author(s):  
Baghdad Science Journal
Keyword(s):  
Liver Enzymes ◽  
Fish Nutrition ◽  
Control Group ◽  
Average Weight ◽  
Biochemical Tests ◽  
The Third ◽  
Nutrition Research ◽  
Barbus Sharpeyi ◽  
Activity Of Enzymes ◽  
And Control

The present study was designed in the aquaculture and fish nutrition research aquarium in the College of Veterinary Medicine/Baghdad University from a period 1/3 to 1/6/2013 to investigate the toxicity of the herbicide glyphosate aqua on Barbus sharpeyi fish. Fish fingerlings were used with average weight between 10 – 15 gm to measure the (LC50), and 200 fingerlings were used to know the acute and chronic toxic effect for the herbicide. The fingerlings were randomly distributed as 10 fish for each aquarium. Fish were divided into four treatments and control group (without addition of herbicide). The first processing with a concentration of 0.415 mg/L for a duration of exposure 90 days, the second processing group with a concentration 0.415 mg/L for 15 days, while the third group was treated with 0.207 mg/L of the herbicide for a duration of exposure, the forth group was exposed to 0.207 mg/L for 15 days only. The study aimed to determine the extent of the effect of the pesticide in the activity of liver enzymes, which included Alkaline phosphatase (ALP), Aspartate amino transfers (AST) and Alanine amino transfers (ALT). The results of biochemical tests for liver enzymes to fish experience has shown a rise in activity of enzymes which increased with duration of exposure. The first and the third treatments has a significant differences (P ?0.05) compared with control group. Results of the experiment to improvement in the health status of fish in second and forth treatments compared to control group.

Detraction of Diclofenac-Associated Hepatotoxicity by Fresh Beet Root Juice in Male Albino Mice

2021 ◽  
Vol 72 (2) ◽  
pp. 19-26
Author(s):  
Tahani Mohamad Alhazani ◽  
Badr Abdullah Aldahmash ◽  
Doaa Mohamed El-Nagar ◽  
Khalid Elfaki Ibrahim ◽  
Saheed Olaide Anifowose ◽  
...  
Keyword(s):  
Liver Enzymes ◽  
Immunohistochemical Analysis ◽  
Control Group ◽  
Beet Root ◽  
Hepatotoxic Effect ◽  
Anti Oxidant ◽  
Albino Mice ◽  
Anti Inflammatory ◽  
Pre Treatment ◽  
Main Component

The beet root as dietary supplement hepatoprotective ability has gained interest in recent days. The present study was designed to determine the potential hepatoprotective effect of beet root juice as anti-inflammatory and anti-oxidant agent to eliminate the hepatotoxic effect of diclofenac as wide spread analgesic agent. Male albino mice were divided randomly into 4 groups, the 1st group served as control group, the 2nd group received 8 mL/kg of freshly prepared beet root juice, the 3rd group received oral administration 20 mg/kg of diclofenac and the 4th group pre-treated with beet root before one-hour diclofenac administration for 30 days. Biochemical results revealed sharp significant raised levels of liver enzymes level (AST, ALT, ALP and GGT) in the 3rd group that received diclofenac, besides to marked pathological changes manifested by high pathological scoring system such as hepatocytes degeneration, ballooning, infiltration and fibrosis. Immunohistochemical analysis elucidated massive incidence of MDA as an indicator of oxidative stress, moreover great number of neutrophils were seen as main component of inflammation. Whereas, pre-treatment of beet root juice one hour before diclofenac resulted in significant decrease of liver enzymes, clear attenuation of pathological features, decrease of pathological score. A great reduction of MDA in liver tissue and number of neutrophils stained histochemically. It was concluded that beet root juice possessed beneficial hepatoprotective role against diclofenac, as significant anti-oxidant and anti-inflammatory effect.

Comparative Evaluation of Prophylactic and THP of CO (Hawthorn) Fruit with Atorvastatin in Murine Model of Dyslipidemia

2021 ◽  
Vol 15 (11) ◽  
pp. 2913-2916
Author(s):  
Syeda Mah-e- Noor Zahra ◽  
Saadia Shahzad Alam ◽  
Maryam Nadeem ◽  
Huma Zia Arain ◽  
Neelofer Warraich ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Murine Model ◽  
Normal Saline ◽  
Biochemical Parameters ◽  
Ethanolic Extract ◽  
Research Centre ◽  
Control Group ◽  
Therapeutic Groups ◽  
Healthy Control ◽  
Hawthorn Fruit

Background: Dyslipidemia or hyperlipidemia is a consequential condition resulting from derangement in lipid profile. Standard treatment such as Atorvastatin though beneficial, causes many serious adverse effects thus an alternative like Crataegus oxyacantha (Hawthorn) with hypolipidemic potential was investigated. Aims: To evaluate prophylactic and therapeutic hypolipidemic potential of crataegus oxyacantha (hawthorn) fruit in comparison with atorvastatin in murine model of dyslipidemia through assessing physiological parameter i.e., weight and serum biochemical parameters i.e., lipid profile: TC, TGs, VLDL, LDL and HDL. Study design: This experimental study was carried out in research laboratory of Akhtar Saeed Medical and Dental College and National Health Research Centre (NHRC), Lahore Methods: A murine study of 60 days was conducted on 64 male albino Wistar rats (Age  6 weeks) divided into 8 groups with 8 rats each weighing 180-200 grams. Group 1 (healthy control) received normal diet and 2 ml of normal saline for 60 days. Group 2 (disease control) received HFD and 2 ml of normal saline for 30 days while 3-5 (prophylactic groups) were given HFD along with ethanolic extract of Crataegus oxyacantha fruit, atorvastatin and their combination in doses of 40 mg/kg OD, 80 mg/kg OD and 20+40 mg/kg OD orally respectively for the same period. 6-8 (therapeutic groups) received ethanolic extract of Crataegus oxyacantha fruit, atorvastatin and their combination respectively after induction of dyslipidemia from 30th till 60th day in the same doses as mentioned above. Each rat was weighed and fasting samples for biochemical parameters were drawn by cardiac puncture in all groups at baseline and repeated at 30th day in all groups while also at 60th day in therapeutic groups as well as healthy control group. The results were analyzed using one way ANOVA for Mean±SD, post hoc Tukey’s test for group comparison in the Graph-Pad Prism (V.5) software. A p-value ≤ 0.05 was considered as statistically significant. Study period: This study was conducted from September, 2020-November, 2020. Results: Our murine study concludes that Crataegus oxyacantha (40 mg/kg OD orally) when administered prophylactically and therapeutically shows a noteworthy hypolipidemic potential when compared with Atorvastatin (80mg/kg OD orally). Better results were obtained in prophylactic doses as well as in low dose combination with Atorvastatin (20 mg/kg + 40 mg/kg respectively). Conclusion: Results suggest that Crataegus oxyacantha can be used as alternative in treating hyperlipidemias. Keywords: Crataegus oxyacantha, Atorvastatin, Hyperlipidemia.

Resistance by cattle to cattle tick, Boophilus microplus. III. The development of resistance to experimental infestations by purebred Sahiwal and Australian Illawarra Shorthorn cattle

1971 ◽  
Vol 22 (2) ◽  
pp. 331 ◽  
Author(s):  
RW Hewetson
Keyword(s):  
Adult Female ◽  
Acquired Resistance ◽  
Boophilus Microplus ◽  
Cattle Tick ◽  
Control Group ◽  
The Third ◽  
Development Of Resistance ◽  
Significant Difference ◽  
Sahiwal Cattle ◽  
Males And Females

Purebred Sahiwal cattle acquired resistance to Boophilus microplus in a similar manner to crossbred Sahiwal cattle as previously reported. The purebred entire males and females were more resistant than a control group of crossbred steers because they dropped significantly fewer replete ticks than the crossbreds at the third and fourth, but not at the first and second infestations. Adult female ticks dropped by purebred animals were significantly lighter than those dropped by crossbred animals at the fourth infestation only. There was no significant difference in the numbers of eggs laid and hatched from ticks dropped by purebred and crossbred animals. Australian Illawarra Shorthorn steers developed resistance at a second and third infestation which waned at a fourth infestation, but individual steers displayed developing resistance throughout the four infestations. Day of modal drop of replete female ticks appeared to be affected by breed, and developing resistance or season.

Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial

2020 ◽  
Vol 124 (4) ◽  
pp. 450-456
Author(s):  
Abbas Ali Sangouni ◽  
Mohammad Reza Mohammad Hosseini Azar ◽  
Mohammad Alizadeh
Keyword(s):  
Liver Disease ◽  
Treatment Group ◽  
Lipid Profile ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Liver Enzymes ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Garlic Powder ◽  
Alcoholic Fatty Liver Disease

AbstractNon-alcoholic fatty liver disease (NAFLD) includes a range of disorders from simple steatosis to non-alcoholic steatohepatitis. There is no proven drug treatment for NAFLD, and diet modification is considered part of the main line of treatment for this disease. The aim of this study was to investigate the efficacy of garlic supplementation in NAFLD patients. The effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile was investigated in NAFLD patients. Ninety NAFLD patients were randomly assigned to take either a garlic powder supplement or a placebo for 12 weeks. The treatment group received four tablets of garlic daily (each tablet contained 400 mg garlic powder). The control group received four tablets of placebo (each placebo contained 400 mg starch). At the end of the study, hepatic steatosis was significantly reduced in the treatment group compared with the control group (P = 0·001). In addition, a significant decrease was seen in the serum concentration of alanine transaminase (P < 0·001), aspartate transaminase (P = 0·002), γ-glutamyltransferase (P = 0·003) as well as total cholesterol (P = 0·009), TAG (P < 0·001), HDL-cholesterol (P < 0·001) and LDL-cholesterol (P = 0·01) in the treatment group compared with the control group. No significant difference was seen between the two groups in serum concentration of alkaline phosphatase. Overall, garlic powder supplementation improved hepatic features and lipid profile among NAFLD patients.

scholarly journals Effect of Yeast (Saccharomyces cerevisiae) Supported by Selenium and Zinc on Lipid Profile of Local Sheep Males

2019 ◽  
Vol 12 (1) ◽  
pp. 89-96
Author(s):  
Mohannad Aremmt ◽  
T Mohammed ◽  
saad Alrawi
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Synergistic Effect ◽  
Lipid Profile ◽  
Animal Health ◽  
The Other ◽  
Control Group ◽  
Organic Form ◽  
Yeast Saccharomyces Cerevisiae ◽  
The Third ◽  
Group 3

This study was conducted to investigate the effect of (Saccharomyces cerevisiae) supported with zinc and selenium on the lipid profile. of Twenty-one Iraqi males sheep were used aged (1-1.5) years and the weight mean approximately (38±4) kg. experiment animals used divided randomly into three treated groups each group have 7 males. All males were fed on the same ration. The first group was considered as a control group without treatment (T1), the second group (T2) were given yeast enriched with zinc (Saccharomyces cerevisiae -zinc) with dosage (0.2 g/kg/bw), the third group (3) was given yeast enriched with selenium (Saccharomyces cerevisiae-selenium) with dosage (0.03 g/kg/bw). The results showed significant (P≤0.05) differences control group compare with the other two-treated groups (T3 and T2) in triglyceride, LDL , VLDL and HDL . The results indicate to significant differences (P≤0.05) of (T2 and T3) compare with the control group by HDL . From the results concluded that there synergistic effect of Saccharomyces cerevisiae with zinc and selenium as organic form (Saccharomyces cerevisiae-zinc/selenium) could be attributed to improved animal health.

scholarly journals Association between Exposure to Ambient Air Pollution and Rheumatoid Arthritis in Adults

2019 ◽  
Vol 16 (7) ◽  
pp. 1227 ◽  
Author(s):  
Jiyoung Shin ◽  
Jiyoung Lee ◽  
Jueun Lee ◽  
Eun-Hee Ha
Keyword(s):  
Rheumatoid Arthritis ◽  
Air Pollution ◽  
Positive Association ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Control Group ◽  
Binary Logistic Regression Analysis ◽  
The Third ◽  
Increased Risk ◽  
One Year

Environmental factors may play roles in the development of rheumatoid arthritis (RA), and some studies have shown that air pollution was associated with the development of autoimmune disease. This study was designed to investigate the effect of air pollutants on the development of adult RA. A nested case-control cohort study was performed using the National Health Insurance Service-National Sample Cohort during 2002–2014 in Korea. Air pollution data were collected from the National Ambient Air Monitoring System (NAMIS), and exposure levels were extrapolated using geographic information systems. The group with RA (n = 444) was compared with a propensity score-matched control group (n = 1776), and one-year average concentrations of air pollution were predicted at each patient’s residence. The adjusted binary logistic regression analysis showed a positive association between O3 exposure and the incidence risk of RA for the third (odds ratios (OR) = 1.45, 95% confidence intervals (CI): 1.08–1.96) and fourth (OR = 1.35, 95% CI: 1.00–1.83) quartiles in adults over 20 years of age. The third quartile CO exposure was also associated with an increased risk of RA (OR = 1.57, 95% CI: 1.16–2.12). The results of this nationwide population-based study showed that a one-year exposure to CO and O3 in adults was associated with an increased risk of RA.

scholarly journals The effect of different intensities of magnetically treated water on lipid profile of Turkish- Awassi rams

2012 ◽  
Vol 36 (0A) ◽  
pp. 181-186
Author(s):  
Suad A. Jashamy
Keyword(s):  
Lipid Profile ◽  
Blood Sample ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Treated Water ◽  
The Third

A total of 15 Turkish- Awassi rams at ages ranged 2 - 2.5 years, and their weight rangedbetween 79.5 – 80.3 kg, Rams were randomly divided into 3 equal groups of 5 rams eachgroup. The first group were taken1000 while the second group were taken 2000 gaussmagnetic water, the third group were taken normal streaming water which is considered as a(control group). Blood sample were taken at the beginning of the experiment, and repeatedevery two weeks during the experimental period (four months). Results revealed that treatedthe rams with magnetically treated water resulted in significantly decreased (p<0.01) incholesterol (1.78-4.08), triglycerides (0.94-0.054), low density lipoprotein (LDL) (1.4-0.2),Very low density lipoprotein (VLDL) (1.87-0.14) and significant increase (p<0.01) in highdensity lipoprotein (HDL)(0.17-0.49) .It could be concluded that rams received magneticallytreated water resulted in significant improvement in level of lipid involved in this experiment.

scholarly journals Randomized Control Trial Study On The Effect Of Wet Cupping On Lipid Profile

2020 ◽  
Vol 16 (2) ◽  
Author(s):  
Suhaily MH ◽  
Ismail AA ◽  
Najib MY
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Controlled Trial ◽  
Low Density Lipoprotein ◽  
Venous Blood ◽  
Intervention Group ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
The Third

Introduction: Dyslipidaemia is one of the risk factors contributing to the pathogenesis of cardiovascular   diseases (CVDs). This study was conducted to investigate the effect of wet cupping on lipid profile. Methods: This randomized controlled trial was conducted in 2012 at the School of Medical Sciences, Universiti Sains Malaysia, Malaysia. Sixty-two healthy volunteers ranging from 30 to 60 years old were randomized into control and intervention groups. Subjects in the intervention group were assigned to two sessions of wet cupping at the beginning of the study and at the third month; individuals in the control group did not undergo any cupping procedure. Venous blood sample was collected for serum lipid profile: Total Cholesterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), and triglycerides; measured at baseline, first, third and fourth month. Results: Subjects in the cupping group had significant improvements from baseline to third and fourth month for TC (MD=-0.56, P=0.004), HDL-C (MD=-0.22, P<0.001) and LDL-C (MD=0.58, P=0.001). There was also a significant reduction from baseline to one month for triglycerides (MD=0.38, P<0.001). Subjects in the cupping group had significantly better values in HDL-C and LDL-C as compared with the control group at the third and fourth month. Significantly lower levels of TC and triglycerides in the cupping group of the fourth month. In the control group, there were no significant changes in any serum lipid profiles. Conclusion: After two sessions of wet cupping, TC, HDL-C, LDL-C and triglycerides were significantly improved by 8.2%, 13.7%, 16.4% and 20.8% respectively.

scholarly journals Effect of the Silver Nanoparticles on the Histology of Albino Mice Ovaries

2017 ◽  
Vol 14 (4) ◽  
pp. 662-668
Author(s):  
Baghdad Science Journal
Keyword(s):  
Silver Nanoparticles ◽  
Blood Vessels ◽  
Normal Saline ◽  
Fatty Degeneration ◽  
Control Group ◽  
Histopathological Changes ◽  
Follicular Cells ◽  
Histological Changes ◽  
Adult Females ◽  
Albino Mice

The aim of study is to identify the histological changes in ovaries of the albino mice exposed to silver nanoparticles. Sixty adult females were collected and exposures by 4000 p.p.m. and 50-150 nm in size, Females were divided into 3treated groups. The concentration dosage was (1, 1.5 and 2) p.p.m. of silver nanoparticles for 7, 14 and 21 days as exposure periods as well as control group which treated by normal saline. Treated groups appeared different histopathological changes, it is depending on the concentration of silver nanoparticles and the period of exposure. These changes were included congestion in the blood vessels, hemorrhage, hyaline degeneration, fatty degeneration, pyknosis, necrosis as well as fusion of cells in follicular cells, amyloid proteins in the blood vessels and Fatty necrosis.

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