Changes in the serum level of the trace elements in chronic renal

2021 ◽  
Vol 2 (3) ◽  
pp. 402-409
Author(s):  
Baghdad Science Journal
Keyword(s):  
Trace Elements ◽  
Serum Level ◽  
Blood Serum ◽  
Healthy People ◽  
Control Group ◽  
Before And After ◽  
Iron And Zinc

Were studied changes in the concentration of copper, iron and zinc in blood serum of one hundred patients with chronic kidney and treated dialysis blood were also measured the level of calcium kidney and phosphate Calciotropic in serum of these patients took samples of blood from these patients before and after treatment dialysis vessels as well as the statement of changes in those standards Alkimaahiatih Results were compared with twenty-five healthy people (control group)

scholarly journals Changes in the serum level of the trace elements in chronic renal

2005 ◽  
Vol 2 (3) ◽  
pp. 402-409
Author(s):  
Baghdad Science Journal
Keyword(s):  
Trace Elements ◽  
Serum Level ◽  
Blood Serum ◽  
Healthy People ◽  
Control Group ◽  
Before And After ◽  
Iron And Zinc

Were studied changes in the concentration of copper, iron and zinc in blood serum of one hundred patients with chronic kidney and treated dialysis blood were also measured the level of calcium kidney and phosphate Calciotropic in serum of these patients took samples of blood from these patients before and after treatment dialysis vessels as well as the statement of changes in those standards Alkimaahiatih Results were compared with twenty-five healthy people (control group)

scholarly journals A correlative study of copper, iron, zinc and haematological parameters in oral cancer patients

2021 ◽  
Vol 19 (2) ◽  
pp. 22-25
Author(s):  
Joel Sabu ◽  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Serum Level ◽  
Cancer Patients ◽  
Serum Levels ◽  
Haematological Parameters ◽  
Oral Carcinogenesis ◽  
Group I ◽  
Iron And Zinc ◽  
Oral Cancer Patients

Background: Alteration in levels of copper, iron and zinc variate the enzymatic actions in our body and thereby play a major role in etiopathogenesis of oral carcinogenesis. Aim of the study: The present study was mainly aimed to estimate, compare and correlate the serum levels of copper, iron and zinc with haematological parameters in oral cancer patients in comparison to normal controls. Methods: The collected serum of cases and controls were analyzed by using standard spectrophotometric methods in spectrophotometer analyzer and the data obtained was analysed and represented as Mean ± SD, mean difference was analyzed by Student’s T-test and Chi- square test for significance and strength of association by Karl Pearson’s correlation using SPSSv23 software. Results: Mean serum level of iron was significantly lower and the levels of zinc and copper in patients with oral cancerous lesions were significantly higher than that of healthy individuals. Pearson’s r data analysis, revealed a significant negative correlation between iron with platelets, and MCHC (Mean Corpuscular Haemoglobin Concentration). A significant positive correlation was seen between iron with haemoglobin and lymphocytes; between copper with leucocytes. Conclusions: The serum levels of zinc and copper in group I were significantly higher when compared to controls. There was a significant lower serum level of iron in Group-I when compared to controls. A significant correlation was seen in between serum trace elements and haematological parameters in oral cancer. This suggests the involvement of trace elements in variations of haematological parameters in the pathogenesis of oral carcinogenesis.

scholarly journals Influence of Cinepazide Maleate on Vascular Endothelial Function of Patients with Acute Myocardial Infarction

2015 ◽  
Vol 4 (3) ◽  
pp. 1
Author(s):  
Jiaming Niu ◽  
Zhaoling Ma
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Function ◽  
Blood Serum ◽  
Control Group ◽  
Vascular Endothelial ◽  
Observation Group ◽  
Vascular Endothelial Function ◽  
Before And After ◽  
Better Than

<strong>Objective</strong>: To study influence of cinepazide maleate on vascular endothelial function of patients with acute myocardial infarction. <strong>Methods</strong>: 150 cases of patients with acute myocardial infarction were divided into the observation group and the control group, two groups were treated by conventional therapy about acute myocardial infarction, the observation group added 5%GS250 mL + cinepazide maleate 160 mg IV drip q.d, the control group added 5%GS250 mL IV drip q.d, the treatment course were 3 weeks, changes of vascular endothelial function and the blood serum no level before and after treatment were detected. <strong>Result</strong>: vascular endothelial function after treatment in observation group were obviously improved than that before treatment (<em>p</em> = 0.03) , blood serum no level was obviously increased (<em>p</em> ﹤ 0.05); about 3 weeks after treatment, vascular endothelial function in the observation group was obviously better than that of the control group (<em>p</em> = 0.04), the blood serum no level of the observation group was obviously higher than that of the control group (<em>p</em> ﹤ 0.05).<strong> Conclusion</strong>: Cinepazide maleate remarkably improves vascular endothelial function of patients with acute myocardial infarction.

scholarly journals Ascorbic acid irrigation during debridement decreased the colony count of Staphylococcus aureus and interleukin-6 blood count in grade ii open fracture of long bones

2020 ◽  
Vol 8 (9) ◽  
pp. 3194
Author(s):  
I. Ketut Suyasa ◽  
Putu Astawa ◽  
Mulyadi Ridia ◽  
Trimanto Wibowo
Keyword(s):  
Staphylococcus Aureus ◽  
Ascorbic Acid ◽  
Serum Level ◽  
Open Fracture ◽  
Colony Count ◽  
Control Group ◽  
Long Bones ◽  
Acid Irrigation ◽  
Before And After ◽  
Grade Ii

Background: Infection in open fractures is still a problem that cannot be fully managed. Various types of studies have been conducted to find an effective and efficient solution to wash open fracture wounds. This study compared the effectiveness of ascorbic acid irrigation in reduction of Staphylococcus aureus colony and interleukin-6 (IL-6) serum level as systemic inflammation marker in debridement procedure of grade II Gustilo-Anderson open fracture of long bones.Methods: This study was an experimental study with pre-post-test control group design. This study included 24 subjects aged 15-75 years old with Gustillo-Anderson type II open fractures which were divided into two groups. The treatment group had additional irrigation by using 10 mg/ml ascorbic acid solution during debridement, whereas the control group had debridement only without irrigation with ascorbic acid. The culture and colony count of Staphylococcus aureus and IL-6 serum level was obtained and measured before and after the treatment in both groups. Statistical analysis (Wilcoxon test) was performed to compare the difference of the two parameters (Δ colony count and Δ IL-6) before and after the treatment.Results: There were no significant difference in Δ colony count of Staphylococcus aureus (p=0.308) and ΔIL-6 serum level (p=0.239) between the control group and treatment group.Conclusions: Ascorbic acid irrigation was not proved to decrease the colony count of Staphylococcus aureus and IL-6 serum level in grade II open fracture of long bones.

scholarly journals INFLUENCE OF UNFAVOURABLE ENVIRONMENTAL FACTORS UPON HEALTH OF WORKERS AND CORRECTION OF RESULTANT ALTERATIONS

2005 ◽  
Vol 13 (3) ◽  
pp. 141-145
Author(s):  
Dalia Stasytyte-Bunevičiene ◽  
Algirdas Juozulynas ◽  
Antanas Jurgelenas
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Environmental Factors ◽  
Blood Serum ◽  
Malonic Dialdehyde ◽  
Human Organism ◽  
Control Group ◽  
Diene Conjugates ◽  
Before And After ◽  
Metal Processing

Intensified formation of free radicals is one of the most important unfavourable consequences of factors of industry acting upon human organism. Under physiological conditions, antioxidative system preserves from harmful influence of free radicals. To avoid a disturbing influence of oxidative stress upon the processes of human homeosthasis, additional quantities of antioxidants are indispensable. Dynamics of alterations of markers of oxidative stress caused by unfavourable industrial factors of metal processing (chemical agents, vibration, noise) under impact of native biomodulators were studied using native pollen. The programme was performed on 50 workers of metal processing, 9 males and 41 female, who used pollen during a period of 1 month. Control group consisted of 57 persons, 10 males and 47 females living and working under the same conditions. Blood tests (diene conjugates, malonic dialdehyde and katalase) using spectrophotometric methodology were studied before and after the course of treatment. After the treatment, contents of metabolites of lipid peroxidation, diene conjugates and malonic dialdehyde in blood serum essentially reduced. Activity of catalase decreased significantly in blood serum of males and regularly smoking females. In conclusion, presented data demonstrate antioxidative efficiency of native pollen and suggest more often applying of native biomodulators in cases with alterated processes of homeosthasis under impact of unfavourable environmental factors.

CORRECTION OF METABOLIC INTOXICATION SYNDROME IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS WITH UNDRLYING PNEUMOCONIOSIS ASSOCIATED WITH VEGETO-SENSORY POLYNEUROPATHY DURING MEDICAL REHABILITATION

2019 ◽  
pp. 8-14
Author(s):  
G.V. Myakotkina ◽  
Ya.A. Sotskaya
Keyword(s):  
Blood Serum ◽  
Peripheral Blood ◽  
Main Group ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Alcoholic Steatohepatitis ◽  
Before And After ◽  
Sensory Polyneuropathy ◽  
Medium Weight

The purpose of the work is to assess the severity of metabolic intoxication syndrome in patients with non-alcoholic steatohepatitis (NASH) and underlying pneumoconiosis with vegeto-sensory polyneuropathy (VSP) during medical rehabilitation. Materials and Methods. The authors examined 112 men, 30–59 years of age, with NASH and underlying pneumoconiosis associated with VSP. The patients were divided into two groups. The main group included 57 patients who were administered a combination of hepatrin and bronchomunal as medical rehabilitation; control group consisted of 55 patients under widely accepted NASH treatment. Nikolaychik method was used to determine the concentration of medium-weight molecules in the peripheral blood, before and after medical rehabilitation. Results. It is established that in patients with NASH and underlying pneumoconiosis with VSP there is a significant increase in the concentration of medium-weight molecules in blood serum. A comprehensive scheme of medical rehabilitation of patients with this comorbid pathology reduces the level of such molecules. However, the decrease it is not enough effective and rapid. Conclusions. Introduction of the combination of hepatoprotector hepatrin and bronchomunal immunomodulator in medical rehabilitation of patients with NASH and pneumoconiosis with VSP contributes to the everlast elimination of metabolic intoxication. Keywords: non-alcoholic steatohepatitis, pneumoconiosis, vegeto-sensory polyneuropathy, medical rehabilitation. Цель работы – оценить выраженность синдрома метаболической интоксикации у больных с неалкогольным стеатогепатитом (НАСГ) на фоне пневмокониоза с вегето-сенсорной полинейропатией (ВСП) под влиянием медицинской реабилитации. Материалы и методы. Обследовано 112 мужчин с НАСГ на фоне пневмокониоза с ВСП в возрасте от 30 до 59 лет, распределенных на две группы. Основную группу составили 57 больных, принимавших в качестве медицинской реабилитации комбинацию препаратов гепатрин и бронхомунал; группу сопоставления – 55 пациентов, получавших общепринятое лечение НАСГ. Концентрацию молекул средней массы в периферической крови определяли, руководствуясь методом Николайчика, до и после проведения медицинской реабилитации. Результаты. Установлено, что у больных с НАСГ на фоне пневмокониоза с ВСП имеет место достоверное повышение концентрации молекул средней массы в сыворотке крови. Комплексная схема медицинской реабилитации больных с данной коморбидной патологией снижает уровень этих молекул, однако недостаточно эффективно и стремительно. Выводы. Включение комбинации препаратов, состоящей из гепатопротектора гепатрина и иммуномодулятора бронхомунала, в комплекс медицинской реабилитации больных с НАСГ на фоне пневмокониоза с ВСП способствует стойкому устранению метаболической интоксикации. Ключевые слова: неалкогольный стеатогепатит, пневмокониоз, вегето-сенсорная полинейропатия, медицинская реабилитация.

scholarly journals Therapeutic efficacy and pharmacological safety of parenteral supplementation of different concentrations of copper in cows

2012 ◽  
Vol 55 (1) ◽  
pp. 25-35
Author(s):  
J. R. García-Díaz ◽  
H. Munyori-Nderitu ◽  
M. Cuesta-Mazorra ◽  
R. Quiñones-Ramos ◽  
J. M. Figueredo-Ross ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Serum ◽  
Control Group ◽  
Second Phase ◽  
Hepatic Enzymes ◽  
Physiological Level ◽  
Before And After ◽  
Two Phases ◽  
The One ◽  
The Impact

Abstract. The objective of the present study was to determine the parenteral dosage of the trace mineral copper (Cu) which re-establishes serum and hepatic levels in hypocupperhemic animals without causing intoxication in the liver or residuals in milk. The experiment was carried out in two phases; in the first phase, 20 hypocupperhemic animals were used. Those were divided into 4 groups of 5 cows each: 3 groups which received 25, 50 and 100 mg of Cu respectively and 1 control group without supplementation, but with induced copraemia 5 days before and after the treatment. The milk of the cows treated with 100 mg Cu was examined for residuals of this element for one month. In the second phase, 25 animals were selected and divided into 5 groups of 5 cows each: 1 control group and 4 groups which received 25, 50, 100 and 200 mg of Cu respectively. The impact of this Cu dosages on liver reserves of this element, on hepatic enzymes (alanine-amine-transaminase, aspartate-amine-transferase, alkaline phosphatase and glutamate dehydrogenase) and on bilirubin was analyzed. The groups treated with 50 and 100 mg Cu showed increased levels in blood serum and hepatic tissues (P<0.05) in comparison to the control group and the one treated with 25 mg, obtaining the physiological level considered normal in cows during 60 days without an effect to the level of Cu in milk or to the liver’s enzymatic activity. We conclude that treatment with this dosage results in a restoration of the Cu concentration in blood serum and hepatic tissues without toxic effects or residuals.

Clinical value of kinase Aurora-A serum level determination in patients with breast cancer qualified for neoadjuvant chemotherapy: Pilot study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12627-e12627
Author(s):  
Beata Kotowicz ◽  
Pawel Winter ◽  
Małgorzata Fuksiewicz ◽  
Agnieszka I. Jagiello-Gruszfeld ◽  
Katarzyna Pogoda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Serum Level ◽  
Neoadjuvant Chemotherapy ◽  
Blood Serum ◽  
Tumor Size ◽  
The State ◽  
Control Group ◽  
Pathological Features ◽  
Aurora A ◽  
Clinical Value

e12627 Background: Aurora A (AURKA) is serine/threonine kinase that plays a regulatory role in mitosis and multiple signaling pathways. Overexpression of AURKA has been found in many solid tumors including breast cancer. It also has been found to be a prognostic marker indicating resistance to taxane treatment and poor prognosis in ER positive breast cancer. The aim of this study is to assess clinical value of Aurora-A serum level determination in patients with breast cancer qualified for neoadjuvant chemotherapy. Methods: 60 patients with confirmed breast cancer before treatment were qualified for the study, aged 31-77 (median 52 years), including 30 premnopausal and 30 pomenopausal. The control group consisted of 30 healthy women aged 20-80 (median 53 years). Clinical and pathological features were determined in a selected group of patients with breast cancer who subsequently underwent preoperative chemotherapy, i.e. tumor size (T), lymph node status (N), presence of distant metastases (M), estrogen receptor status (ER) and progesterone (PgR), HER2 receptors and Ki 67 proliferative index. The blood serum of the examined patients and healthy women was determined by the enzyme-linked ELISA method in doublets of the AURKA biomarker concentration. Mann-Whitney test and ROC curve analysis were used for statistical calculations. Results: No significant differences were found between the concentrations of AURKA in breast cancer patients and in the control group. In both analyzed groups there were no significant differences in biomarker levels depending on the menopausal status. When assessing the relationship between AURKA concentrations and clinical-pathological features, significant differences were found depending on the state of the lymph nodes (N0 vs N1 + N2) (p = 0.006). There was no correlation between the concentrations of the tested biomarker and the tumor size (T), the state of receptors and the Ki67 index. In patients with a lack of receptors (triple negative vs others), higher levels of Aurora A (p = 0.06) in the blood serum were observed at the level of the statistical trend. Conclusions: The preliminary results obtained indicate the potential usefulness of determining the concentration of the new biomarker Aurora A in the blood serum of patients with breast cancer. The research is continuing.

scholarly journals Comparison of serum level of some trace elements and vitamin D between patients with premenstrual syndrome and normal controls: A cross-sectional study

2019 ◽  
Author(s):  
Mahnoosh Fatemi ◽  
Maryam Allahdadian ◽  
Mehrnoosh Bahadorani
Keyword(s):  
Vitamin D ◽  
Trace Elements ◽  
Serum Level ◽  
Premenstrual Syndrome ◽  
Cross Sectional Study ◽  
Female Students ◽  
Control Group ◽  
Cross Sectional ◽  
Calcium Magnesium ◽  
Normal Controls

Background: Premenstrual syndrome (PMS) is a common problem among women and is identified by reversal emotional, psychological, and physical signs during the luteal phase. These signs, however, lower down in the follicular phase. The cause of PMS isn’t very well-known up to now control group and many researchers have suggested that mineral compounds and vitamins can inhibit these symptoms. Objective: The objective of this study is to compare the serum level of some trace elements and vitamin D between normal controls and patients with PMS. Materials and Methods: 300 female students (19–21 yr old) from Falavarjan County were randomly selected and asked to complete a standard questionnaire on PMS during three menstruation cycles. The students were divided into two groups: healthy persons (control) and PMS persons, and PMS was determined on the basis of the answers to the questionnaire. Thereafter, the serum concentrations of zinc, iron, calcium, magnesium, potassium, sodium, and Vitamin D3 were measured and compared between the two groups. Results: Our results showed that the PMS prevalence was about 41.5%. The level of vitamin D decreased in both the control and PMS groups, with a significantly lower range of vitamin D (p 0.05) in the PMS group. Other factors had no significant change between the two groups. Conclusion: Vitamin D deficiency was probably one of the most important causes of unpleasant symptoms of PMS between these students. Key words: Premenstrual syndrome, Trace elements, Vitamin D.

scholarly journals ВПЛИВ ІНТРАВАСКУЛЯРНОГО ЛАЗЕРНОГО ОПРОМІНЕННЯ НА ПОКАЗНИКИ КРОВІ У КОРІВ ЗА ЛІКУВАННЯ ГНІЙНО-ЗАПАЛЬНИХ ПРОЦЕСІВ ДИСТАЛЬНОГО ВІДДІЛУ КІНЦІВОК

2014 ◽  
pp. 134-137
Author(s):  
І. І. Юрченко
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Serum ◽  
Biochemical Parameters ◽  
Inflammatory Process ◽  
Control Group ◽  
Laboratory Results ◽  
Before And After ◽  
Inflammatory Processes ◽  
Hematological And Biochemical Parameters ◽  
Experimental Group

Висвітлені результати лабораторних дослідженькрові (сироватки) за низкою гематологічних і біохі-мічних показників від корів, хворих на гнійно-запальніпроцеси в дистальному відділі кінцівок, до та післявикористання інтраваскулярного лазерного опромі-нення крові. Встановлено, що використання ІЛОК ілокально порошку сульфату міді сприяє нормалізаціїзапального процесу. До того ж у сироватці крові ре-єструється вірогідне зниження активності аспара-гінової трансамінази та збільшення (в контрольнійгрупі) лужної фосфатази. Крім того у дослідній групівідмічали зниження, а в контрольній збільшення від-сотка лімфоцитів, а також збільшення гемоглобіну вдослідній та зменшення його в контролі. Laboratory results of blood (serum) for a range of hematological and biochemical parameters of cows sick on inflammatory processes in the distal extremities before and after use of intravascular laser irradiation of blood have been lit. It has been established that the use of locally ILOK and copper sulfate powder contributes to the normalization of the inflammatory process. In the blood serum is achieved a significant reduction of the activity of aspartic trans a minase and alkaline phosphatase is increased (in the control group).Also in the experimental group we saw a decreasing of the percentage of lymphocytes, and in control one - increasing the percentage of lymphocytes, as well as an increasing of hemoglobin in the experimental group and in control group – its reduction.

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