The Impact of Microplastic on Human Health

2021 ◽  
Vol 11 ◽  
Author(s):  
Amanda Souza Reis Almeida ◽  
Cleide Barbieri de Souza
Keyword(s):  
Human Health ◽  
Wide Distribution ◽  
The Body ◽  
Publication Date ◽  
Present Moment ◽  
Chronic Inflammatory Response ◽  
Lung Biopsies ◽  
The Impact ◽  
Systemic Responses ◽  
Means Of Production

Background: Microplastics are considered an emerging contaminant due to their wide distribution and production in the environment, representing constant exposure to humans. However, little is known about the effects it can trigger in the body. Objective: To establish a concrete relationship between microplastics and the human body, their means of production, exposure, systemic responses, and diseases caused by their presence Methods: In this context, a review article of foreign and national literature was developed, through the PubMed and Scielo Indexers, where studies were found that address the production of plastic, the paths that lead to the production of microplastics and the exposure and damage that it represents to human health, being possible to exclude the literary sums with a publication date before 2017 Results: hey showed that translocation of the residues occurs to the circulatory and lymphatic system via the respiratory and gastrointestinal tracts. Once in the body, microplastic can stimulate a chronic inflammatory response that functions as a precursor to neoplasia and fibrosis, or carry toxic compounds such as heavy metals, endogenous disruptors, biofilms, and persistent organic pollutants. In addition, lung biopsies have shown plastic fibers in patients with respiratory diseases, highlighting a potentially dangerous accumulation. Conclusion: The present moment demonstrates that experimental research to prove the effect of microplastics is extremely necessary, since the controversy among authors and the repetition of information already described affirm that the research done so far is not sufficient.

scholarly journals Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1601 ◽  
Author(s):  
Hiroki Saito ◽  
Yu Toyoda ◽  
Tappei Takada ◽  
Hiroshi Hirata ◽  
Ami Ota-Kontani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Human Health ◽  
Serum Urate ◽  
The Body ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Uricosuric Agents ◽  
Transport Assay ◽  
The Impact

The beneficial effects of fatty acids (FAs) on human health have attracted widespread interest. However, little is known about the impact of FAs on the handling of urate, the end-product of human purine metabolism, in the body. Increased serum urate levels occur in hyperuricemia, a disease that can lead to gout. In humans, urate filtered by the glomerulus of the kidney is majorly re-absorbed from primary urine into the blood via the urate transporter 1 (URAT1)-mediated pathway. URAT1 inhibition, thus, contributes to decreasing serum urate concentration by increasing net renal urate excretion. Here, we investigated the URAT1-inhibitory effects of 25 FAs that are commonly contained in foods or produced in the body. For this purpose, we conducted an in vitro transport assay using cells transiently expressing URAT1. Our results showed that unsaturated FAs, especially long-chain unsaturated FAs, inhibited URAT1 more strongly than saturated FAs. Among the tested unsaturated FAs, eicosapentaenoic acid, α-linolenic acid, and docosahexaenoic acid exhibited substantial URAT1-inhibitory activities, with half maximal inhibitory concentration values of 6.0, 14.2, and 15.2 μM, respectively. Although further studies are required to investigate whether the ω-3 polyunsaturated FAs can be employed as uricosuric agents, our findings further confirm FAs as nutritionally important substances influencing human health.

The role of the main ingredients of chocolate in the formation of its beneficial properties for the consumer

2021 ◽  
pp. 582-587
Author(s):  
I.V. Goloviznin ◽  
A.V. Ryzhakova
Keyword(s):  
Human Health ◽  
Complete Information ◽  
The Body ◽  
Specific Product ◽  
Regular Process ◽  
The World ◽  
The Impact ◽  
Confectionery Product

Chocolate is the most staple and consumed confectionery product in Russia and the world. The determination of the beneficial properties of such a product as chocolate is an important and regular process of food institutions in every country, since new lines of already well-known manufacturers and new manufacturers with an innovative assortment are added to the retail assortment. Today, it is very relevant and important to understand the impact of new products on human health. In this regard, in order to provide complete information on a specific product, it is necessary to know its composition, ingredients and their effect on the body separately and within the framework of a specific product. Along with its beneficial properties, chocolate can also affect health negatively. It is necessary to understand the mechanism of the effect of chocolate on human health when consumed and to assess the risks that may arise subsequently after its active consumption.

scholarly journals Impact of technogenic dust pollution from the closed mining enterprise in the Amur Region on the ecosphere and human health

2021 ◽  
Vol 6 (1) ◽  
pp. 16-22
Author(s):  
N. K. Rastanina ◽  
K. A. Kolobanov
Keyword(s):  
Environmental Protection ◽  
Human Health ◽  
Natural Environment ◽  
The Body ◽  
Dust Pollution ◽  
Environmental Monitoring System ◽  
Elemental Status ◽  
The Individual ◽  
The Impact ◽  
Impact Of Mining

Environmental protection is a complex ecological and economic problem, including the need to develop and implement a number of environmental protection measures to mitigate the negative impact of mining waste on all natural environment components and human health. In this regard, the study purpose was to assess the impact of Pb, Cd, Cr, and As compounds on the environment and health of the population of the Solnechny miner’s village. Based on the purpose, the following tasks were set: 1) review and systematization of literature data on the problem of technogenic dust pollution; 2) assessment of the mining industrial system as a source of ecosystem pollution with toxic elements within the closed mining enterprises impact areas; 3) development of proposals for mitigating the impact of mining activities on ecosystems and human health. The paper presents the findings of the study of the elemental status of children and adolescents living within the closed town-forming enterprise JSC Solnechny GOK impact area. The relationship between the level of technogenic pollution of the natural environment and the changes in the elemental status of the children was shown. A feature of the elemental status of the children in the study group was high content of heavy metals, including Pb, Cr, and As. Our research confirmed the data that a growing child’s body actively adsorbs compounds of toxic chemical elements. Deficiency and imbalance of microelements in the body can cause ecologically-related diseases in the child population. Individual and population carcinogenic risks (CR) caused by the As, Pb, and Cr pollution were calculated. In accordance with the acceptance criteria for the risk caused by exposure to the pollutants, the individual carcinogenic risk CR (Cr) = 1,05 · 10–3 belongs to the fourth range and is unacceptable neither for the population, nor for occupational groups. This is De manifestis risk, and when it is reached, it is necessary to carry out emergency curative measures to mitigate it. The individual risks CR (As) = 7,05 · 10–4 also exceed the acceptable level for the population. This level of pollution is subject to permanent monitoring, requires development and implementation of planned curative measures to improve the indicators of the human environment, one of which is the organization of the environmental monitoring system in the study area.

scholarly journals RECREATIONAL LANDS AS A COMPONENT OF HEALTH CARE: SOME ASPECTS OF LEGAL REGULATION

2020 ◽  
Vol 73 (12) ◽  
pp. 2860-2864
Author(s):  
Olena M. Batyhina ◽  
Bogdan V. Derevyanko ◽  
Vitalii V. Kadala
Keyword(s):  
Human Health ◽  
New Technologies ◽  
Legal Regulation ◽  
The State ◽  
The Body ◽  
Health Improvement ◽  
It Services ◽  
Agricultural Enterprises ◽  
The Impact ◽  
Special Protection

The aim: The purpose of the study is to assess the impact of recreational lands on human health and determine the priority forms of their use and protection. Materials and methods: International acts, data of international organizations and findings of scientists have been examined and used in the study. The article also summarizes information from scientific journals and monographs from a medical and legal point of view on the basis of scientific methods. This article is based on dialectical, comparative, analytic, synthetic, and comprehensive research methods. Conclusions: Recreational lands positively influence human health through a powerful effect of natural healing resources in combination with health-improving and therapeutic procedures on the body, which is becoming increasingly popular, and in some cases, it is the most effective treatment of all. Recreational lands are an independent category of land with a special legal regime of use, characterized by a developed or undeveloped natural area containing natural resources for treatment, recovery, rehabilitation, and prevention of diseases, which are under the special protection of the state and territorial communities. Special protection of the state in today's conditions is extremely important because there has been a negative trend in Ukraine regarding raider attacks. The objects of such attacks are exclusively those companies that are competitive in the market, have achieved significant profits, and continue to develop their activities by creating new branches and introducing new technologies. In particular, attacks on the property of agricultural enterprises and business entities that carry out activities in the field of IT services have become frequent in recent years [1, p. 172]. The main target of attacks by raiders on agricultural enterprises is their land. Similarly, without state support and protection, recreational land can be the object of raider attacks. The priority form of using recreational land is the placement of resorts and sanatoriums that provide recreational services. Recreational lands can also be used for health improvement in the “wellness” form or within the framework of health tourism.

scholarly journals Methodological approaches to the assessment of health risks associated with the use of repellent and insecticide agents

2021 ◽  
Vol 100 (5) ◽  
pp. 535-540
Author(s):  
Pavel Z. Shur ◽  
Nina V. Zaitseva ◽  
Svetlana V. Redko ◽  
Arina I. Vinogradova ◽  
Vladimir A. Fokin ◽  
...  
Keyword(s):  
Human Health ◽  
Health Risks ◽  
The Body ◽  
Risk Level ◽  
Quantitative Chemical Analysis ◽  
Acceptable Risk ◽  
Consumer Market ◽  
Methodological Approaches ◽  
The Impact ◽  
Risk Assessment Methodology

Introduction. The study’s relevance is due to the demand for repellent and insecticidal agents in the consumer market and their widespread use as protection against mosquitoes. At the same time, the problem of the impact on the human health of these funds has not been sufficiently studied. In this regard, analyzing the safety of repellents and insecticides for human health is of scientific interest. The aim of the study is to substantiate methodological approaches to assessing the risk to human health associated with the use of insecticides and repellents. Materials and methods. Authors used methods of analysis of scientific literature, toxicological methods for the study of health safety, methods of quantitative chemical analysis, biochemical methods for the study of blood serum, methods of mathematical modeling, health risk assessment methodology. Results. The assessment of the risk of negative responses from organs and systems of the body when exposed to repellents and insecticides has been carried out. Methodological approaches to assessing health risks under various scenarios for repellents and insecticides have been developed and tested. Conclusion. A feature of the proposed methodological approaches is the ability to take into account dose loads for various routes of entry of active substances into the body, the duration of exposure to a repellent or insecticide during regular use, and possible use in regimes exceeding normal use. As a result of the experiment, it was found that with the inhalation of an insecticide with 1% transfluthrin, the level of acceptable risk is observed at a level of exposure of transfluthrin in the air up to 0.0272 mg/m3. Under a percutaneous intake of the 50% DEET repellent, the acceptable risk level was noted at exposure less than 1200 mg/kg/day. In case of percutaneous arrival of the DETA repellent 7.5%, the level of acceptable risk is established under exposure up to 250 mg/kg/day.

scholarly journals Pelatihan pencegahan intoksikasi kadmium pada pekerja bengkel las di Kota Mataram

2021 ◽  
Vol 2 (2) ◽  
pp. 45-47
Author(s):  
Bayu Tirta Dirja ◽  
Devi Rahmadhona ◽  
Decky Aditya Zulkarnaen
Keyword(s):  
Heavy Metal ◽  
Free Radical ◽  
Human Health ◽  
Air Pollutants ◽  
Posttest Score ◽  
The Body ◽  
Cadmium Exposure ◽  
Pretest Score ◽  
The Impact ◽  
Lipid Free Radical

Cadmium (Cd) is a nephrotoxic heavy metal which endangers human health, especially welding workers. Cadmium can enter the body through inhalation of formed air pollutants. Cadmium would then bind with metallotionins, binds Cd+Mt, which would be deposited in the kidneys and induces the formation of lipid-free radical peroxidation that damages the kidneys, characterized by an increase of creatinine and β2 microglobulins. This service aims to educate welding workers about the impact of cadmium intoxication on the body and the prevention against cadmium exposure. The methods used are demonstration and playback of a video about prevention against cadmium exposure. This activity was carried out on May 6th, 2021 at the CV. Rigansa Mataram welding workshop. The activity was attended by ten participants. The results are an increase of knowledge from a mean pretest score of 50 to a mean posttest score of 90

scholarly journals Quantitative Assessment of the Size-dependent Whole-body to Cellular Biodistribution of Fine Particulate Matters Following Inhalation by Fluorescence Imaging

2022 ◽  
Author(s):  
Taewoong Son ◽  
Youn-Joo Cho ◽  
Hyunseung Lee ◽  
Mi Young Cho ◽  
Byeongwoo Goh ◽  
...  
Keyword(s):  
Human Health ◽  
Ex Vivo ◽  
Single Cells ◽  
Flow Cytometric Analysis ◽  
The Body ◽  
Whole Body ◽  
Particulate Matters ◽  
Fine Dust ◽  
The Impact

Abstract Background: There has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to estimate the toxicity of fine dust on the human body because of its diverse effects depending on the composition and environmental factors.Results: In this study, we focused on the difference in the biodistribution of fine dust according to the size distribution of particulate matter after inhalation into the body to predict its impact on human health. We synthesized Cy7-doped silica particulate matters (CSPMs) having different particle sizes and employed them as model fine dust, and studied their whole-body in vivo biodistribution in BALB/c nude mice. Image-tracking and quantitative analysis were performed on the ex vivo organs and tissues. Additionally, flow cytometric analysis of single cells isolated from the lungs was performed. Smaller particles with a diameter of less than 100 nm (CSPM0.1) were observed to be removed relatively rapidly from the lungs upon initial inhalation. However, they were confirmed to accumulate continuously over 4 weeks of observation. In particular, smaller particles were found to spread rapidly to other organs during the early stages of inhalation.Conclusions: It is expected that the effect of fine dust on human health can be predicted through the differences in in vivo behavior that arise depending on the particle size. This study might provide with insights on association between CSPM0.1 accumulation in several organs including the lungs and adverse effect to underlying diseases in the organs.

scholarly journals Mobile telephony and its effects on human health

2019 ◽  
pp. 225-234
Author(s):  
Andrzej Magiera ◽  
Jolanta Solecka
Keyword(s):  
Electromagnetic Radiation ◽  
Human Health ◽  
Mobile Phones ◽  
Brain Activity ◽  
The Body ◽  
Base Stations ◽  
Mobile Telephony ◽  
International Agency ◽  
Negative Effects ◽  
The Impact

In recent years, there has been a rapid increase in the number of electromagnetic radiation sources such as mobile phones and base stations of mobile telephony. This radiation has been classified by the International Agency for Research on Cancer as a possible human carcinogen (group 2B). For this reason, many studies have been carried out on the impact of mobile telephony on human health. The largest of the experiments were carried out on animals. Due to the divergent results of many studies, there was no clear answer on the possible carcinogenic effects of this type of radiation on health. Detection of cancer shortly after an exposure is the most difficult task in analyzing the results. Some of the studies require repetition and verification of the results. In the case of negative effects of electromagnetic fields on brain activity, sleep, heart rate, cognitive function and blood pressure, no consistent evidence has been obtained either. In view of the increasing popularity of mobile phones, their location at short distances from the body (mainly the head) and the development of mobile phone technologies (which entails an increase in the number of base stations), further research, especially among young people, is needed. The duration of human exposure to electromagnetic radiation is subject to an increase and only further research can provide an answer on the possible negative effects of mobile phones and base stations.

scholarly journals Paradigms of Protist/Bacteria Symbioses Affecting Human Health: Acanthamoeba species and Trichomonas vaginalis

2021 ◽  
Vol 11 ◽  
Author(s):  
Fiona L. Henriquez ◽  
Ronnie Mooney ◽  
Timothy Bandel ◽  
Elisa Giammarini ◽  
Mohammed Zeroual ◽  
...  
Keyword(s):  
Human Health ◽  
Trichomonas Vaginalis ◽  
Opportunistic Pathogen ◽  
The Body ◽  
Evolutionary Significance ◽  
Morphological Identification ◽  
Human Pathogens ◽  
Symbiotic Relationships ◽  
Lynn Margulis ◽  
The Impact

Ever since the publication of the seminal paper by Lynn Margulis in 1967 proposing the theory of the endosymbiotic origin of organelles, the study of the symbiotic relationships between unicellular eukaryotes and prokaryotes has received ever-growing attention by microbiologists and evolutionists alike. While the evolutionary significance of the endosymbiotic associations within protists has emerged and is intensively studied, the impact of these relationships on human health has been seldom taken into account. Microbial endosymbioses involving human eukaryotic pathogens are not common, and the sexually transmitted obligate parasite Trichomonas vaginalis and the free-living opportunistic pathogen Acanthamoeba represent two unique cases in this regard, to date. The reasons of this peculiarity for T. vaginalis and Acanthamoeba may be due to their lifestyles, characterized by bacteria-rich environments. However, this characteristic does not fully explain the reason why no bacterial endosymbiont has yet been detected in unicellular eukaryotic human pathogens other than in T. vaginalis and Acanthamoeba, albeit sparse and poorly investigated examples of morphological identification of bacteria-like microorganisms associated with Giardia and Entamoeba were reported in the past. In this review article we will present the body of experimental evidences revealing the profound effects of these examples of protist/bacteria symbiosis on the pathogenesis of the microbial species involved, and ultimately their impact on human health.

The Impact of Shariah Governance and Corporate Governance on the Risk Management Practices: Evidence from Local and Foreign Islamic Banks in Malaysia

2018 ◽  
Vol 15 (2) ◽  
pp. 1-20
Author(s):  
Sabri Embi ◽  
Zurina Shafii
Keyword(s):  
Risk Management ◽  
Corporate Governance ◽  
Management Practices ◽  
Principal Component ◽  
T Test ◽  
The Body ◽  
Primary Data ◽  
Islamic Banks ◽  
Shariah Governance ◽  
The Impact

The purpose of this study is to examine the impact of Shariah governance and corporate governance (CG) on the risk management practices (RMPs) of local Islamic banks and foreign Islamic banks operating in Malaysia. The Shariah governance comprises the Shariah review (SR) and Shariah audit (SA) variables. The study also evaluates the level of RMPs, CG, SR, and SA between these two type of banks. With the aid of SPSS version 20, the items for RMPs, CG, SR, and SA were subjected to principal component analysis (PCA). From the PCA, one component or factor was extracted each for the CG, SR, and RMPs while another two factors were extracted for the SA. Primary data was collected using a self-administered survey questionnaire. The questionnaire covers four aspects ; CG, SR, SA, and RMPs. The data received from the 300 usable questionnaires were subjected to correlation and regression analyses as well as an independent t-test. The result of correlation analysis shows that all the four variables have large positive correlations with each other indicating a strong and significant relationship between them. From the regression analysis undertaken, CG, SR, and SA together explained 52.3 percent of the RMPs and CG emerged as the most influential variable that impacts the RMPs. The independent t-test carried out shows that there were significant differences in the CG and SA between the local and foreign Islamic banks. However, there were no significant differences between the two types of the bank in relation to SR and RMPs. The study has contributed to the body of knowledge and is beneficial to academicians, industry players, regulators, and other stakeholders.

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