Alternative medicine as a treatment options for COVID-19

2021 ◽  
Vol 07 ◽  
Author(s):  
Mahfuza Marzan ◽  
Md. Shahedur Rahman ◽  
Md. Abu Hena Mostofa Jamal ◽  
Mohammad Hossain Shariare ◽  
Md. Anowar Khasru Parvez
Keyword(s):  
Health Care ◽  
Vitamin D ◽  
Distress Syndrome ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Viral Disease ◽  
Global Pandemic ◽  
Medicinal Properties ◽  
Mode Of Transmission ◽  
High Infectivity

: COVID-19, a viral disease caused by SARS-CoV-2 is the reason of a global pandemic since the starting of the year 2020. The characteristic of the disease varies from mild common cold like symptoms to acute respiratory distress syndrome and multi-organ failure leading to death. World has already observed 213,453 deaths from this disease while 3,095,839 have been infected in 210 countries in total till 28 April, 2020. This disease has a devastating impact over the health care system because of its high infectivity, easy mode of transmission, lack of proper medicine and vaccine and deficiency of enough supportive healthcare arrangement. On verge of this situation scientists are searching the treatment options. However, nature has provided us with enormous herbs which have disease preventive as well as have medicinal properties. In this article we have reviewed several of these plants (ginger, clove, tea, black seed, tulsi, neem) and some vitamins (vitamin C and vitamin D) and zinc which have antiviral, anti-inflammatory, antioxidant, anti-asthmatic properties with scientific evidence. The intake of these products regularly to keep the immune system active, to experience its positive aspects might be supportive to prevent infection with the new coronavirus or to treat COVID-19.

A mini review on the pathogenesis, diagnosis and treatment options for COVID-19

2021 ◽  
Vol 21 ◽  
Author(s):  
Farzad Rahmani ◽  
Aghigh Ziaeemehr ◽  
Sajede Alijannejad ◽  
Gordon A Ferns ◽  
Majid Khazaei ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Distress Syndrome ◽  
Treatment Options ◽  
Antiviral Agents ◽  
Viral Disease ◽  
High Morbidity ◽  
Therapeutic Approaches ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Patient Survival Rate

: Coronavirus disease 2019 (COVID-19) is a serious viral disease caused by SARS-CoV-2, associated with a high morbidity and mortality, and represents the greatest public health crisis worldwide. Despite recent efforts for developing novel antiviral agents, no specific drugs are approved for management and treatment of COVID-19. The immune responses to viral infection followed by cytokine storm and acute respiratory distress syndrome are serious issues that may cause death in patients with severe COVID-19. Therefore, developing a novel therapeutic strategy for management of COVID-19 is urgently needed to control the virus spread and improving patient survival rate and clinical outcomes. In this mini review, we summarize the symptoms, pathogenesis and therapeutic approaches that are currently being used to managing the spread of SARS-CoV-2.

scholarly journals Nurses’ performance in COVID-19 pandemic: Integrative review

2021 ◽  
Vol 20 (1) ◽  
pp. 46-54
Author(s):  
Simone Cristina Cardoso ◽  
Arantxa S. Sforcini ◽  
Dulce Aparecida Barbosa ◽  
Cassiane D. Da Fonseca ◽  
Naila A. Oliveira
Keyword(s):  
Health Care ◽  
Professional Ethics ◽  
Scientific Evidence ◽  
Daily Basis ◽  
Integrative Review ◽  
Nursing Experience ◽  
Global Pandemic ◽  
Nurses Role ◽  
New Research ◽  
The Impact

Introducion: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan (China) in late December 2019. It has rapidly spread worldwide since then and it has become a global pandemic affecting more than 200 countries and territories. Objective: To evaluate the scientific evidence on nurses’ role in health care for COVID-19 patients Methods: Integrative review carried out in BEDENF, LILACS and MEDLINE databases of articles available between December 2019 and June 2020 by adopting PICO strategy. Results: The sample consisted of ten articles addressing nursing experience during COVID-19 pandemic, bringing an analysis of the impact of nursing activities worldwide during the pandemic. Conclusion: The studies addressed nurses’ importance in this pandemic moment; however, it shows various difficulties that these professionals face on a daily basis to keep professional ethics while ensuring the best care. This review realizes the need for new research to call attention to nurses’ role in tackling COVID-19 pandemic.

scholarly journals A Telemedicine Approach to Covid-19 Assessment and Triage

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 461
Author(s):  
Allison B. Reiss ◽  
Joshua De Leon ◽  
Isaac P. Dapkins ◽  
George Shahin ◽  
Morgan R. Peltier ◽  
...  
Keyword(s):  
Health Care Workers ◽  
Distress Syndrome ◽  
Clinical Presentation ◽  
Viral Disease ◽  
Severe Form ◽  
Global Pandemic ◽  
Acute Distress ◽  
Care Workers ◽  
Life Threatening ◽  
Upper Respiratory

Covid-19 is a new highly contagious RNA viral disease that has caused a global pandemic. Human-to-human transmission occurs primarily through oral and nasal droplets and possibly through the airborne route. The disease may be asymptomatic or the course may be mild with upper respiratory symptoms, moderate with non-life-threatening pneumonia, or severe with pneumonia and acute respiratory distress syndrome. The severe form is associated with significant morbidity and mortality. While patients who are unstable and in acute distress need immediate in-person attention, many patients can be evaluated at home by telemedicine or videoconferencing. The more benign manifestations of Covid-19 may be managed from home to maintain quarantine, thus avoiding spread to other patients and health care workers. This document provides an overview of the clinical presentation of Covid-19, emphasizing telemedicine strategies for assessment and triage of patients. Advantages of the virtual visit during this time of social distancing are highlighted.

scholarly journals Coronavirus disease 2019 in neonates

2021 ◽  
Vol 8 (4) ◽  
pp. 773
Author(s):  
Jade Irene Linardi
Keyword(s):  
Health Care ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Current Knowledge ◽  
Age Groups ◽  
Older Children ◽  
Global Pandemic ◽  
Clinical Presentations

Coronavirus disease 2019 (COVID-19) as a global pandemic has become a major burden especially in the health care system and economy. COVID-19 has clinical presentations ranging from remain asymptomatic to severe acute respiratory distress syndrome (ARDS) and death. All age groups are susceptible to this virus, but it seems that children with COVID-19 have milder symptoms than adults. Neonates, however, have been reported to have more severe cases compared to older children. There is also a possibility of vertical transmission from mothers to their neonates which could not be ignored. This review provides current knowledge of COVID-19 in neonates.   

scholarly journals Study on Relevant Features in COVID-19 PCR Tests

Proceedings ◽  
2020 ◽  
Vol 54 (1) ◽  
pp. 45
Author(s):  
Plácido L. Vidal ◽  
Joaquim de Moura ◽  
Lucía Ramos ◽  
Jorge Novo ◽  
Marcos Ortega
Keyword(s):  
Health Care ◽  
Health Care Services ◽  
Viral Disease ◽  
Chain Reactions ◽  
Polymerase Chain Reactions ◽  
Care Services ◽  
Global Pandemic ◽  
Signal Features ◽  
The World ◽  
Polymerase Chain

In the year 2020, the world suffered the effects of a global pandemic. COVID-19 is a disease that mainly affects the respiratory system of patients, even causing a disproportionate response of the immune system and further spreading the damage to other vital organs. The main means by which health care services detected this viral disease was through the use of Polymerase Chain Reactions (PCRs). These PCRs allow the detection of known chains of the genetic code of the virus in samples of sputum. In this work, we study PCR signal features that allow to automatize the analysis of hundreds of PCRs. The findings obtained from the study have shown these features to be capable of obtaining successful results in the detection of COVID-19 in PCR samples, with only a small fraction of the information extracted by the clinicians for that purpose.

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity and Pathogenesis?

2020 ◽  
Author(s):  
Angelo Spinello ◽  
Andrea Saltalamacchia ◽  
Alessandra Magistrato
Keyword(s):  
Health Economic ◽  
Global Health ◽  
Receptor Binding ◽  
Binding Motif ◽  
Spike Glycoprotein ◽  
High Affinity ◽  
Global Pandemic ◽  
Medical Countermeasures ◽  
High Infectivity ◽  
Human Receptor

<p>The latest outbreak of a new pathogenic coronavirus (SARS-CoV-2) is provoking a global health, economic and societal crisis. All-atom simulations enabled us to uncover the key molecular traits underlying the high affinity of SARS-CoV-2 spike glycoprotein towards its human receptor, providing a rationale to its high infectivity. Harnessing this knowledge can boost developing effective medical countermeasures to fight the current global pandemic.</p>

Vitamin C as an Anticancer Agent: Regulation of Signaling Pathways

2020 ◽  
Vol 20 (21) ◽  
pp. 1868-1875
Author(s):  
Ghazala Butt ◽  
Ammad A. Farooqi ◽  
Aima Adylova ◽  
Rukset Attar ◽  
Seher Yilmaz ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Published Data ◽  
New Era ◽  
Molecular Oncology ◽  
Anticancer Effects ◽  
Oncogenic Pathways

Treatment options for effective treatment of cancer with minimum off-target effects and maximum clinical outcomes have remained overarching goals in the clinical oncology. Vitamin C has remained in the shadows of controversy since the past few decades; burgeoning evidence has started to shed light on wide-ranging anticancer effects exerted by Vitamin C to induce apoptosis in drug-resistant cancer cells, inhibit uncontrolled proliferation of the cancer cells and metastatic spread. Landmark achievements in molecular oncology have ushered in a new era, and researchers have focused on the identification of oncogenic pathways regulated by Vitamin C in different cancers. However, there are visible knowledge gaps in our understanding related to the ability of Vitamin C to modulate a myriad of transduction cascades. There are scattered pieces of scientific evidence about promising potential of Vitamin C to regulate JAK-STAT, TGF/SMAD, TRAIL and microRNAs in different cancers. However, published data is insufficient and needs to be investigated comprehensively to enable basic and clinical researchers to reap full benefits and promote result-oriented transition of Vitamin C into various phases of clinical trials. In this review, we will emphasize on available evidence related to the regulation of oncogenic cell signaling pathways by Vitamin C in different cancers. We will also highlight the conceptual gaps, which need detailed and cutting-edge research.

scholarly journals Patient profiles as an aim to optimize selection in the second line setting: the role of aflibercept

2021 ◽  
Author(s):  
B. González Astorga ◽  
F. Salvà Ballabrera ◽  
E. Aranda Aguilar ◽  
E. Élez Fernández ◽  
P. García-Alfonso ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Therapeutic Option ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Line Treatment ◽  
Second Line ◽  
First Line ◽  
Effective Therapeutic Option ◽  
Line Setting ◽  
First Line Treatment

AbstractColorectal cancer is the second leading cause of cancer-related death worldwide. For metastatic colorectal cancer (mCRC) patients, it is recommended, as first-line treatment, chemotherapy (CT) based on doublet cytotoxic combinations of fluorouracil, leucovorin, and irinotecan (FOLFIRI) and fluorouracil, leucovorin, and oxaliplatin (FOLFOX). In addition to CT, biological (targeted agents) are indicated in the first-line treatment, unless contraindicated. In this context, most of mCRC patients are likely to progress and to change from first line to second line treatment when they develop resistance to first-line treatment options. It is in this second line setting where Aflibercept offers an alternative and effective therapeutic option, thought its specific mechanism of action for different patient’s profile: RAS mutant, RAS wild-type (wt), BRAF mutant, potentially resectable and elderly patients. In this paper, a panel of experienced oncologists specialized in the management of mCRC experts have reviewed and selected scientific evidence focused on Aflibercept as an alternative treatment.

scholarly journals Analysis of Facilitators and Barriers to the Delivery of Routine Care during the COVID-19 Global Pandemic: A Systematic Review

Healthcare ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 528
Author(s):  
Cristian Lieneck ◽  
Brooke Herzog ◽  
Raven Krips
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Health Care Services ◽  
Care Delivery ◽  
Routine Care ◽  
Future Research ◽  
Healthcare Organizations ◽  
Care Services ◽  
Global Pandemic ◽  
Facilitators And Barriers

The delivery of routine health care during the COVID-19 global pandemic continues to be challenged as public health guidelines and other local/regional/state and other policies are enforced to help prevent the spread of the virus. The objective of this systematic review is to identify the facilitators and barriers affecting the delivery of routine health care services during the pandemic to provide a framework for future research. In total, 32 articles were identified for common themes surrounding facilitators of routine care during COVID-19. Identified constructed in the literature include enhanced education initiatives for parents/patients regarding routine vaccinations, an importance of routine vaccinations as compared to the risk of COVID-19 infection, an enhanced use of telehealth resources (including diagnostic imagery) and identified patient throughput/PPE initiatives. Reviewers identified the following barriers to the delivery of routine care: conservation of medical providers and PPE for non-routine (acute) care delivery needs, specific routine care services incongruent the telehealth care delivery methods, and job-loss/food insecurity. Review results can assist healthcare organizations with process-related challenges related to current and/or future delivery of routine care and support future research initiatives as the global pandemic continues.

scholarly journals Symposium report: breast cancer in India—trends, environmental exposures and clinical implications

2021 ◽  
Vol 32 (6) ◽  
pp. 567-575
Author(s):  
Jasmine A. McDonald ◽  
Roshni Rao ◽  
Marley Gibbons ◽  
Rajiv Janardhanan ◽  
Surinder Jaswal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Environmental Exposures ◽  
Population Based ◽  
Clinical Implications ◽  
Think Tank ◽  
Case Control Studies ◽  
Short Term

Abstract Purpose Incidence of breast cancer (BC), particularly in young women, are rising in India. Without population-based mammography screening, rising rates cannot be attributed to screening. Investigations are needed to understand the potential drivers of this trend. Methods An international team of experts convened to discuss the trends, environmental exposures, and clinical implications associated with BC in India and outlined recommendations for its management. Results Panels were structured across three major BC themes (n = 10 presentations). The symposium concluded with a semi-structured Think Tank designed to elicit short-term and long-term goals that could address the challenges of BC in India. Conclusion There was consensus that the prevalence of late-stage BC and the high BC mortality rates are associated with the practice of detection, which is primarily through clinical and self-breast exams, as opposed to mammography. Triple-Negative BC (TNBC) was extensively discussed, including TNBC etiology and potential risk factors, the limited treatment options, and if reported TNBC rates are supported by rigorous scientific evidence. The Think Tank session yielded long-term and short-term goals to further BC reduction in India and included more regional etiological studies on environmental exposures using existing India-based cohorts and case–control studies, standardization for molecular subtyping of BC cases, and improving the public’s awareness of breast health.

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