scholarly journals Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)

2021 ◽  
Vol 10 (2) ◽  
pp. 84-103
Author(s):  
Muhaimin Muhaimin ◽  
◽  
Muhammad Irhash Shalihin ◽  
Madyawati Latief ◽  
◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Bioactive Compounds ◽  
Indole Alkaloid ◽  
Ethanol Extract ◽  
Yellow Crystal ◽  
Strong Activity ◽  
Physical Form ◽  
Ft Ir ◽  
Anti Inflammatory

Premna serratifolia known as bebuas has long been used by Malay comunity for both food and traditional medicine. The most notable advantage of this plant is to heal woman after childbirth and to raise the notion that contains anti-inflammatory bioactive compounds. In this study, the hexane extract of bebuas was only contained steroids. Meanwhile the ethanol extract contained various secondary metabolites such as phenolics, alkaloids, flavonoids, steroids and saponins. The ethanol extract was further separated since the targeted compound isolate was an alkaloid. The isolate obtained was a yellow crystal which transformed to yellow oil after being exposed to air. The anti-inflammatory evaluation of the compound gave a result with a strong activity with ED50 = 4.06 mg/KgBW. Characterization by UV-Vis and FT-IR showed that the isolate’s spectra pattern had similarities with bufotenine. It revealed that the isolate shared the same basic skeleton with the bufotenine, especially the indole skeleton. Furthermore, it also shared the same physical form with bufotenine. These evidences strengthened the assumption that the isolate was an indole alkaloid.

scholarly journals Phytoconstituents of Genus Micromelum and Their Bioactivity—a Review

2020 ◽  
Vol 15 (5) ◽  
pp. 1934578X2092712
Author(s):  
Tin Myo Thant ◽  
Nanik Siti Aminah ◽  
Alfinda Novi Kristanti ◽  
Rico Ramadhan ◽  
Hnin Thanda Aung ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Bioactive Compounds ◽  
Bioactive Constituents ◽  
Ancient Time ◽  
Leaves And Roots ◽  
New Compounds ◽  
Drug Leads ◽  
Carbazole Alkaloids

The genus Micromelum belongs to the Rutaceae family. As its rich bioactive constituents its stems, flowers, leaves, and roots have been used in traditional medicine, for the treatment of various diseases from ancient time. Phytochemically, many bioactive compounds, including coumarins, polyoxygenated flavonoids, phenylpropanoic acid derivatives, quinolone alkaloids, and also carbazole alkaloids, have been reported as secondary metabolites of the Micromelum spp. including many new compounds. Therefore, Micromelum spp. are considered potential for drug leads. In this article, we present an overview of secondary metabolites isolated from genus Micromelum and their bioactivities that have been reported between 1982 and 2019.

scholarly journals Therapeutic Potential of Kalanchoe Species: Flavonoids and other Secondary Metabolites

2008 ◽  
Vol 3 (12) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Sônia S. Costa ◽  
Michelle F. Muzitano ◽  
Luiza M. M. Camargo ◽  
Marcela A. S. Coutinho
Keyword(s):  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Point Of View ◽  
Present Review ◽  
Biological Profile ◽  
Research Programs ◽  
Potential Source ◽  
The World

The Kalanchoe genus (syn. Bryophyllum), family Crassulaceae, comprises 125 species, most of them native to Madagascar. The great importance of several of these species for the traditional medicine in several regions of the World, esspecially India, Africa, China and Brazil, stimulated research programs into these plants from both a pharmacological and chemical point of view. The present review focuses on the main results obtained during the last decade on the secondary metabolites isolated from these species – endowed or not with a specific biological profile – with emphasis on flavonoids. The distribution of these molecules in the genus will be summarized and special attention will be given to K. brasiliensis and K. pinnata, two species well-known for healing inflammatory and infectious processes. Ornamental Kalanchoe species are also discussed as a potential source of bioactive compounds. This review covers the period 1970–2008.

scholarly journals Screening of Bioactive Compounds from Moutan Cortex and Their Anti-Inflammatory Activities in Rat Synoviocytes

2009 ◽  
Vol 6 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Mengjie Wu ◽  
Zhiyuan Gu
Keyword(s):  
Bioactive Compounds ◽  
High Performance ◽  
Ethanol Extract ◽  
Root Bark ◽  
Tnf Α ◽  
Dependent Inhibition ◽  
Moutan Cortex ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Inflammatory Effect

Moutan Cortex, a widely used traditional Chinese medicine for the treatment of various diseases, is the root bark ofPaeonia suffruticosa Andrews(Paeoniaceae). Most of the pharmacological investigations of Moutan Cortex have been addressed to its central nervous system activities, anti-oxidative and sedative actions. Otherwise, there are few reports about the active compounds with anti-inflammatory activity of Moutan Cortex. The aim of the present study was to screen and identify bioactive compounds with anti-inflammatory effect from Moutan Cortex. With the aid of preparative high performance liquid chromatography (HPLC) technique, ethyl acetate and ethanol extract of Moutan Cortex were isolated into twenty-two fractions. Bioactivities of these fractions were evaluated by measuring expression of tumor necrosis factor-α (TNF-α) in rat synoviocytes subjected to interleukin-1β (IL-1β). Eight compounds were isolated from six active fractions and identified by HPLC/MSn. Purified compounds, paeoniflorin, paeonol and pentagalloylglucose resulted in dose-dependent inhibition of TNF-α synthesis and IL-6 production in synoviocytes treated with proinflammatory mediator. These results suggested that paeonol, paeoniflorin, glycosides and pentagalloylglucose contribute to the anti-inflammatory effect of Moutan Cortex.

Isolation and Identification of Andrographolide Compounds from the Leaves of Sambiloto Plant (Andrographis paniculata Ness)

2021 ◽  
Vol 4 (1) ◽  
pp. 108
Author(s):  
Devi Ayu Septiani ◽  
Aliefman Hakim ◽  
Lalu Raftha Patech ◽  
Zulhalifah Zulhalifah ◽  
Siswadi Siswadi
Keyword(s):  
Infrared Spectroscopy ◽  
Respiratory Tract ◽  
Bioactive Compounds ◽  
Bioactive Compound ◽  
Andrographis Paniculata ◽  
Pharmacological Effects ◽  
Isolation And Identification ◽  
Qualitative Test ◽  
Ft Ir ◽  
Anti Inflammatory

Sambiloto plant (Andrographis paniculata Ness) is a plant that has been used as medicine from generation to generation. Bioactive compounds in Sambiloto have pharmacological effects such as immunostimulants (increase immunity), antibiotic diuretics (facilitate urine), antipyretics, anti-inflammatory (anti-inflammatory), hepatoprotective, hypotensive, hypoglycemic, antibacterial, anti-inflammatory, respiratory tract, and heart and lung meridians - lungs. The bioactive compound in Sambiloto which is mostly found in the leaves is Andrographolide. In this study, the isolation of Andrographolide from the leaves of the sambiloto plant (Andrographis paniculata Ness) was carried out using purification and crystallization methods aimed at obtaining pure Andrographolide isolates more efficiently and identifying the results of Andrographolide isolates. The results showed that the isolates obtained using the purification and crystallization methods obtained a yield of 0.47%. In the qualitative test of Andrographolide isolates using eluent and acetate: n-hexane (3: 2), the Rf value was 0.38. The results obtained from Andrographolide isolates using infrared spectroscopy (FT-IR) were identical to the literature on Andrographolide. The absorption peaks at the wavenumbers obtained includes 3400,41 cm-1, 1979,68 cm-1, 1959,46 cm-1, 2928,22 cm-1, 1727,56 cm-1, 1646,98 cm-1, and 907,53 cm-1.

Pharmacological Studies on Aerial Parts of Calotropis Procera

1991 ◽  
Vol 19 (03n04) ◽  
pp. 223-231 ◽  
Author(s):  
J. S. Mossa ◽  
M. Tariq ◽  
A. Mohsin ◽  
A. M. Ageel ◽  
M. A. Al-Yahya ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Chemical Constituents ◽  
Evaluation Studies ◽  
Ethanol Extract ◽  
Neuromuscular Blocking ◽  
Laboratory Animals ◽  
Calotropis Procera ◽  
Control Group ◽  
Aerial Parts ◽  
Anti Inflammatory

The decoction of the aerial part of Calotropis procera is commonly used in Saudi Arabian traditional medicine for the treatment of variety of diseases including fever, joint pain, muscular spasm and constipation. The present investigation was undertaken to confirm its claimed activity in traditional medicine. The ethanol extract of the plant was tested on laboratory animals for its antipyretic, analgesic, anti-inflammatory, antibacterial, purgative and muscle relaxant activities. The results of this study showed a significant antipyretic, analgesic and neuromuscular blocking activity. On smooth muscle of guinea pig ileum, the extract produced contractions which was blocked by atropine supporting its use in constipation. The extract failed to produce significant anti-inflammatory and antibacterial activities. Our phytochemical studies on the aerial parts of C. procera showed the presence of alkaloids, cardiac glycosides, tannins, flavonoids, sterols and/or triterpenes. However, the chemical constituents responsible for the pharmacological activities remains to be investigated. The safety evaluation studies revealed that the use of extract in single high doses (up to 3g/kg) does not produce any visible toxic symptoms or mortality. However, prolong treatment (90 days) causes significantly higher mortality as compared to control group.

scholarly journals Chemical Structure and Biological Activities of Secondary Metabolites from Salicornia europaea L.

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2252
Author(s):  
Sojeong Kim ◽  
Eun-Young Lee ◽  
Prima F. Hillman ◽  
Jaeyoung Ko ◽  
Inho Yang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Salt Marshes ◽  
Chemical Structure ◽  
Biological Activities ◽  
Salt Tolerant ◽  
Salicornia Europaea ◽  
Tolerant Plant ◽  
Therapeutic Properties ◽  
Anti Inflammatory

Salicornia europaea L. is a halophyte that grows in salt marshes and muddy seashores, which is widely used both as traditional medicine and as an edible vegetable. This salt-tolerant plant is a source of diverse secondary metabolites with several therapeutic properties, including antioxidant, antidiabetic, cytotoxic, anti-inflammatory, and anti-obesity effects. Therefore, this review summarizes the chemical structure and biological activities of secondary metabolites isolated from Salicornia europaea L.

scholarly journals Identifikasi Senyawa Bioaktif Alga Merah Halymenia durvillei (Identification Bioactive Compounds of Algae Halymenia durvillei)

2019 ◽  
Vol 9 (1) ◽  
pp. 21
Author(s):  
Marina Singkoh ◽  
Desy Mantiri ◽  
Cyska Lumenta ◽  
Hengky Manoppo
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Red Algae ◽  
Screening Method ◽  
Ethanol Extract ◽  
Phytochemical Screening ◽  
North Sulawesi ◽  
Screening Study

Identifikasi Senyawa Bioaktif  Alga Merah Halymenia durvillei(Identification Bioactive Compounds of Algae Halymenia durvillei) Marina Flora Oktavine Singkohˡ)*, Desy Maria Helena  Mantiri ²) Cyska Lumenta²), Henky Manoppo²)1) Program Studi Biologi FMIPA Universitas Sam Ratulangi, Manado 951152) Fakultas Perikanan dan Ilmu Kelautan Universitas Sam Ratulangi, Manado *Email korespondensi: [email protected]  Diterima 17 Februari  2019, diterima untuk dipublikasikan 28 Februari  2019  Abstrak Alga merah memiliki kemampuan untuk memproduksi metabolit sekunder yang bersifat sebagai senyawa bioaktif. Penelitian ini bertujuan untuk mengidentifikasi senyawa bioaktif pada alga merah Halymenia durvillaei. yang diambil dari pesisir Pantai Desa Rendingan, Kecamatan Tabukan Kepulauan Sangihe, Sulawesi Utara dengan metode skrining Fitokimia. Hasil penelitian  menunjukan bahwa alga merah  Halymenia durvillaei mengandung senyawa-senyawa  bioaktif. Berdasarkan hasil penelitian skrining fitokimia dapat disimpulkan bahwa  ekstrak etanol Halymenia durvillaei  mengandung senyawa bioaktif alkaloid, fenol, saponin, tanin, dan steroid.Kata Kunci: Halymenia durvillaei,  senyawa bioaktif,  fitokimia  Abstract Red algae have the ability to produce secondary metabolites that are bioactive compounds. This study aims to identify bioactive compounds in Halymenia durvillaei red algae taken from the coast of Rendingan Village Beach, Tabukan District, Sangihe Islands, North Sulawesi with the phytochemical screening method. The results showed that Halymenia durvillaei red algae contained bioactive alkaloid compounds. Based on the results of the phytochemical screening study it can be concluded that the Halymenia durvillaei ethanol extract contains bioactive alkaloid compounds, phenols, saponins, tannins, and steroids.Keywords: Halymenia durvillaei, bioactive compounds,  phytochemicals

In vitro antioxidant and anti-inflammatory activities of isolated compounds of ethanol extract from Sanchezia speciosa Leonard’s leaves

2017 ◽  
Vol 28 (1) ◽  
Author(s):  
Tung Bui Thanh ◽  
Loi Vu Duc ◽  
Hai Nguyen Thanh ◽  
Vung Nguyen Tien
Keyword(s):  
Traditional Medicine ◽  
Ethanol Extract ◽  
Phytochemical Study ◽  
Anti Inflammatory

AbstractBackground:has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed thatMethods:The leaf ofResults:We have isolated four compounds quercetin 3-Conclusions:These compounds

scholarly journals Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1364 ◽  
Author(s):  
Bahare Salehi ◽  
Zainul Amiruddin Zakaria ◽  
Rabin Gyawali ◽  
Salam A. Ibrahim ◽  
Jovana Rajkovic ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Essential Oils ◽  
Traditional Medicine ◽  
Biological Activities ◽  
Biological Effects ◽  
Chemical Constituents ◽  
Food Preservation ◽  
Piper Nigrum ◽  
Piper Betle ◽  
Anti Inflammatory

Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

scholarly journals Anti-inflammatory Activity of Sclerotium stipitatum Berk. et. Curr. an Ethnomedicinal Fungus, in Chronic and Acute Animal Models of Inflammation

2021 ◽  
pp. 209-218
Author(s):  
Alina K. Sebastian ◽  
P. V. Anto
Keyword(s):  
Bioactive Compounds ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Significant Inhibition ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Isolation And Identification ◽  
Standard Drug ◽  
Significant Inhibitory Effect ◽  
Anti Inflammatory

Sclerotium stipitatum Berk. et. Curr., locally known as ‘nilamanga’ is a rare macro fungus, traditionally used to treat numerous diseases like arthritis, earache, jaundice etc. The present study aims to evaluate the anti-inflammatory activity of ethanol extract of S. stipitatum and identify the bioactive compounds present in them. Phytochemical screening of extracts obtained using different solvents like petroleum ether, chloroform, ethanol and water were done. The best extract was chosen for the acute carrageenan-induced and chronic formalin-induced anti-inflammatory studies. Diclofenac was used as the standard drug. Ethanol extract showed significant inhibition of inflammation induced by carrageenan and formalin-induced paw edema models compared to the control. GC-MS analysis shows certain bioactive compounds. The significant inhibitory effect on paw edema proves that S. stipitatum possesses remarkable anti-inflammatory activity, and isolation and identification of bioactive compounds can be used for new drug formulations.

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