scholarly journals A STUDY ON DRUG-DRUG INTERACTION BETWEEN GLIPIZIDE AND CIMETIDINE IN RABBITS

2021 ◽  
pp. 17-18
Author(s):  
RANJEETA GHOLVE ◽  
DHANESHWAR SHEP ◽  
PRAKASHCHANDRA GADE ◽  
MANISH RAMAVAT
Keyword(s):  
Drug Interaction ◽  
Drug Therapy ◽  
Receptor Antagonist ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
H2 Receptor Antagonist ◽  
Single Drug ◽  
Single Drug Therapy ◽  
The Mean ◽  
Sugar Levels

Objective: To study the effect of Cimetidine (H2 receptor antagonist) in combination with Glipizide (Sulfonylurea) on the blood sugar level in rabbits. Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1 and it was co-administrated with Cimetidine to each rabbit as a combinational drug therapy on day 7. Cimetidine was administrated to each rabbit from day 2 to day 6 as single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h. Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.4, 69.4, 62.9 and 65.7 mg% and on day 7 were 89.4, 74.8, 65.5, 56.4 and 61.2 mg % respectively. When mean blood sugar level on day 1 and day 7 was considered, there was a significant reduction in blood sugar level at 1, 2, 4 and 6 h and there was no significant fall in blood sugar level at 0 hour after co-administration of Glipizide and Cimetidine. Conclusion: Cimetidine, when co-administered with Glipizide, significantly increases the hypoglycaemic action of Glipizide.

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

scholarly journals Ivabradine versus carvedilol in the management of palpitation with sinus tachycardia among recovered COVID-19 patients

2020 ◽  
Vol 5 (3) ◽  
pp. 176-180
Author(s):  
Jadhav Kartik Pandurang ◽  
Jariwala Pankaj V
Keyword(s):  
Heart Rate ◽  
Patient Satisfaction ◽  
Drug Therapy ◽  
Cardiac Arrhythmias ◽  
Sinus Tachycardia ◽  
Dual Therapy ◽  
Single Drug ◽  
Single Drug Therapy ◽  
The Mean ◽  
Mean Heart Rate

Introduction: One of the major complications among COVID-19 patients include cardiac arrhythmias. Commonest arrhythmia is sinus tachycardia which is usually associated with palpitation causing discomfort to patients. In this study, we present a comparative study of use of Ivabradine vs. Carvedilol for sinus tachycardia in post-COVID-19 infected patients. Method: 50 consecutive recovered COVID-19 patients with sinus tachycardia were included in this open labelled RCT. 25 patients received Ivabradine and remaining 25 received Carvedilol. Single therapy non-responders were treated with Ivabradine with Atorvastatin. Results: The mean age of all patients is 48.8±7.66 years (Males 49.5 ± 7.21 years; Females 47.68 ± 8.23 years). The mean heart rate (MHR) of all patients is 125.52 ± 9.07/min (Males 125.67 ± 8.78/min; Females 125.26 ± 9.5/min). After five days of single drug therapy the mean drop in the heart rate was 35.04 ± 10.55/min (Males 34.41 ± 9.71/min; Females 36.05 ± 11.72/min), resulting in 27.88 ± 8.11% (Males 27.38 ± 7.56%; Females 28.69 ± 8.89%) reduction in MHR. Among the two groups, the Carvedilol group showed improvement of MHR in 14(56%) patients; whereas in Ivabradine group 18(72%) patients improved out of 25 patients each (p: 0.2385). In the Carvedilol group the MHR reduced from 128.6 ± 8.44 to 95.68 ± 10.63 (p < 0.001), which is statistically significant; similarly, the Ivabradine group showed a MHR from 122.44 ± 8.62 to 85.28 ± 10.52 (p < 0.001). The monotherapy therapy non-responders were treated with dual-therapy of (Ivabradine + Atorvastatin). Discussion: Ivabradine is more effective in controlling heart rate compared to Carvedilol. Also, Ivabradine group scores very well in ‘patient-satisfaction’ with regards to symptom (palpitation) relief. Conclusion: The COVID-19 sequelae of sinus tachycardia can be better controlled with Ivabradine when compared to Carvedilol.

scholarly journals Overview of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients at Royal Prima Hospital Medan Indonesia

2021 ◽  
Vol 3 (1) ◽  
pp. 224-228
Author(s):  
Riski N. Situmeang ◽  
Erwin Sopacua
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Mean Value ◽  
Total Data ◽  
The Mean ◽  
Sugar Levels

Diabetes Mellitus (DM) is a chronic disease characterized by blood glucose (blood sugar) levels exceeding normal. Diabetic nephropathy is a chronic microvascular complication that often occurs in diabetics. This study presents a picture of diabetic nephropathy in type 2 DM patients at the Royal Prima Hospital in Medan. This research is a type of descriptive research. The sample from this study was the total data of patients suffering from diabetic nephropathy who met the inclusion and exclusion criteria at Royal Prima Hospital from January 1, 2020 – to December 31, 2020. The inclusion criteria for the subjects of this study were complete patient medical records, type 2 diabetes patients, urinalysis tests. (proteinuria ≥ +2), renal function examination exceeds normal values, blood urea, and creatinine. The mean age of diabetic nephropathy patients was 57.52 years and the majority were 62 men (50.8%). The average picture of urea levels in diabetic nephropathy patients is 51.8 and the average creatinine level is 1.48. The majority of patients with diabetic nephropathy do not have proteinuria. And the average blood sugar level is 267 mg/dL. In conclusion, the incidence of diabetic nephropathy is highest in patients aged 57 years. The mean value of urea level is 51.80 mg/dl, creatinine value is 1.48 mg/dl, and the average blood sugar level is 267 mg/dl. Most proteinuria was in the negative category of as many as 107 people (87%).

Management of Hypertension-Journey from Single Drug Therapy to Multitargeted Ligand Therapy: A Clinical Overview

2015 ◽  
Vol 10 (4) ◽  
pp. 321-346 ◽  
Author(s):  
Prashant Naik ◽  
Hardik Gandhi ◽  
Vijay Pawar ◽  
Rajani Giridhar ◽  
Mange Yadav
Keyword(s):  
Drug Therapy ◽  
Single Drug ◽  
Single Drug Therapy ◽  
Clinical Overview

scholarly journals Pengaruh Edukasi Senam Kaki Diabetes Mellitus Berbahasa Tetum Terhadap Sirkulasi Ekstremitas Bawah Dan Kadar Gula Darah Sewaktu Di Centru Saude Comoro, Dili, Timor Leste.

2020 ◽  
Vol 5 (1) ◽  
pp. 16-24
Author(s):  
Carmelita Barros ◽  
Fitri Arofiati
Keyword(s):  
Diabetes Mellitus ◽  
Lower Extremity ◽  
Blood Sugar ◽  
Blood Circulation ◽  
Blood Sugar Level ◽  
Statistical Tests ◽  
Wilcoxon Test ◽  
Timor Leste ◽  
Post Test ◽  
Sugar Levels

ABSTRACT Diabetes mellitus (DM) in Indonesia is better known as diabetes and in Timor Leste DM known as Ra'an Midar has become a very serious health problem, and is the most common endocrine disease. Diabetes mellitus is a degenerative disease that is characterized by metabolic disorders or pancreatic damage so that the pancreas is unable to produce enough insulin to the maximum so that it can cause insulin deficiency in the body both absolute and relative can increase blood sugar levels or hyperglycemia. Data from the Dili District Health Office in 2018 showed that there were 2690 patients with diabetes mellitus, so that diabetic foot exercises were needed. The purpose of this study was to determine the effect of Tetum Language Diabetes Foot Gymnastic Education on Lower Circulation and Lower Blood Sugar Levels at the Saude Comoro Center, Dili, Timor Leste. Method : using the Pre-Experiment method. Independent variable: Education of Tetum Language Diabetes Foot Gymnastics Education, dependent variable: Circulation of Lower Extremity and Blood Sugar Level at a Time. Population 100 people, sample 28 people, sample technique: simple random, data collection: Examination of blood sugar levels, blood circulation, statistical tests: Wilcoxon Test. Results : Most respondents who had good blood circulation were 15 pre- test (53.6%) and 18 post-test (64.3%). And the majority of respondents whose blood sugar levels were good were 14 people pre-test (50.0%) and 20 people post test (71.4%). Based on the results of statistical tests using the Wilcoxon Signed Rank Test, the value of blood circulation is a significant level of 0.005 and the blood sugar level is at a significant level of 0,000. Conclusion : Conclusion there is the influence of Education on Tetun Language Diabetes Foot Gymnastics on Lower Extracurricular Circulation and Blood Sugar Levels At the Saude Comoro Center, Dili, Timor Leste.  Keyword: Leg exercise, lower extremity bloodd circulation, Blood sugar levels, Diabetes mellitus.

scholarly journals Abnormalities in Glucose Blood Level during Antipsychotic Treatment in Schizophrenia Patients

2021 ◽  
Vol 9 (T3) ◽  
pp. 340-344
Author(s):  
Faisal Idrus ◽  
Theodorus Singara ◽  
Dwiwahyu Sunarto ◽  
Saidah Syamsuddin ◽  
Sonny T. Lisal
Keyword(s):  
Side Effects ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Fasting Blood Glucose ◽  
Antipsychotic Treatment ◽  
Antipsychotic Therapy ◽  
Potential Health ◽  
Sugar Levels ◽  
Risperidone Group ◽  
Haloperidol Group

Background: Schizophrenia is one of the mental disorder with many problematic issues, in both psychologically and socially. This disease requires provision of long-term antipsychotic therapy, hence could rise other potential health problems. Antipsychotic treatment can cause serious glucometabolic side-effects, including type 2 diabetes and hyperglycemic emergency. Recent attention has also been focused on antipsychotic-induced hyperglycemic emergencies experienced by new users of typical and atypical antipsychotic. Patients treated with atypical APDs have ~10 times higher risk in developing hyperglycaemic emergencies. In our pre-eliminary study, hyperglycemia condition in new patients occurs in four  in seven patients who received typical and atypical antipsychotics. This condition is often overlooked and is not routinely evaluated. Moreover, it can develop into diabetes and increase the risk of morbidity and mortality in schizophrenia patients. In this study, we would like to determine the acute effects of metabolic (hyperglycemia) in patients treated with antipsychotic (Risperidone and Haloperidol) Measurement of blood sugar levels was performed in groups treated with haloperidol (N = 15) and treated with risperidone (N = 15). Plasma samples were taken at the beginning of treatment, in week IV, and in week VIII. The measurement of glucose levels was performed after meal and in early morning before breakfast (fasting blood glucose level 8 hours). Results: The blood sugar level after meals was significantly higher in the Risperidone group compared to the Haloperidol group  (p <0.001) after IV and VIII weeks. Meanwhile, the fasting blood sugar level was significantly higher in the Risperidone group compared to the Haloperidol group after VIII weeks of treatment ( p <0.001). Conclusions: Both antipsychotics can cause an increase in blood sugar levels. Treatment with Risperidone significantly increased the blood sugar levels compared to treatment with haloperidol. Measurement of blood sugar level is needed to monitor the metabolic effect of antipsychotic, especially in patients treated with Risperidone. It is necessary to have dietary regulation and physical activities to prevent undesired metabolic side effects.

scholarly journals Korelasi asupan makronutrien dengan indeks massa tubuh, kadar gula darah, dan protein total darah pada pengguna narkoba

2021 ◽  
Vol 17 (3) ◽  
pp. 147
Author(s):  
Ginta Siahaan ◽  
Tiarlince Bakara ◽  
Yusnita Yusnita ◽  
Kasmiyeti Kasmiyeti
Keyword(s):  
Body Mass Index ◽  
Blood Sugar ◽  
Body Mass ◽  
Drug Users ◽  
Blood Sugar Level ◽  
Blood Protein ◽  
Macronutrient Intake ◽  
Total Blood ◽  
Random Blood Sugar ◽  
Sugar Levels

Correlation of macronutrient intake with body mass index, blood sugar levels, and total blood protein in drug usersBackground: Random blood sugar level and total blood protein need to be measured among drug users because their macronutrient intakes (carbohydrates, fat, protein, and energy) are not appropriate to the pattern of daily habits before uses drugs. Drug users had decreased appetite during the influence and withdrawal symptoms of drugs with the impacts on their body mass index (BMI). Objective: To analyze the correlation of macronutrient intakes between the random blood sugar level, total blood protein, and BMI drug users.Methods: This research was conducted with a cross-sectional design and observational study. 73 drug users were included in the study with the screening by inclusion criteria. 24-hour food recall was used to collect the macronutrient intakes, random blood sugar levels and total blood protein were monitored by the GOD-PAP method, and BMI was measured by weight and height. Data analysis used Pearson’s correlation test in bivariate and multivariate was carried out by multiple linear regressions. Results: Pearson’s correlation analysis showed that there was a significant correlation between macronutrient intakes (energy, carbohydrate, fat) with random blood sugar level, total blood protein, and BMI. BMI was the most affected by energy (β=0.531), random blood sugar level was the most affected by carbohydrates (β=0.073), and total blood protein was the most affected by protein (β=0.837).Conclusions: Macronutrient intake is significantly related to BMI, random blood sugar levels, and total blood protein in drug users. Community collaboration with related parties such as the public health service and National Narcotics Agency will very quickly detect drug side effects early on eating disorders that will affect the nutritional status of its users.

scholarly journals Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

2020 ◽  
Vol 9 (3S) ◽  
pp. 320-324
Keyword(s):  
Blood Sugar ◽  
Pancreatic Islet ◽  
Blood Sugar Level ◽  
Sea Cucumber ◽  
Histopathological Examination ◽  
Ethanol Extract ◽  
Male Rats ◽  
Laboratory Research ◽  
Control Group ◽  
Sugar Levels

Diabetes mellitus constitutes a metabolic disorder indicated by a decrease in insulin secretion, insulin insensitivity, or a combination of both. Golden sea cucumber (Stichopus hermanii) is a natural resource of Indonesian waters with benefit for reducing blood sugar levels. This research aimed to determine the anti-hyperglycemic mechanism of golden sea cucumber.This study used a experimental laboratory research with Post-test Only Control Group. The sample of this study consisted of 25 male rats aged 60-70 days, divided into 5 groups: K(-), K(+), P1, P2, and P3 randomly. Rats from K(+), P1, P2, and P3 groups were injected with streptozotocin (STZ) with a dose of 50 mg/kg BW. Treatment was administered for 21 days. K(-) and K(+) groups were fed normally while P1, P2 and P3 groups were given golden sea cucumber 80% ethanol extract with a dose of 4,25 mg/kgBW/day, 8,50 mg/kgBW/day and 12,75 mg/kgBW/day respectively. On the 22nd day, fasting blood sugar level was measured and the number of pancreatic islet was counted with histopathological examination. The administration of golden sea cucumber (Stichopus hermanii) extract on rats with hyperglycemia does not reduce blood sugar level, but the extract administration increases the number of pancreatic islet. Golden sea cucumber (Stichopus hermanni) extract may improve the number of pancreatic islet and prevent the progressive damage of pancreatic islet.C

scholarly journals Senam Prolanis Dm Dan Jalan Kaki Terhadap Penurunan Kadar Gula Darah Pada Penderita Diabetes Millitus Tipe II Di Klinik UMP Purwokerto

2021 ◽  
Vol 6 (2) ◽  
pp. 94
Author(s):  
Agus Sutiono ◽  
Dedy Purwito
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
The Body ◽  
Rank Test ◽  
Type Ii ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Sugar Levels ◽  
Blood Glucose Monitor

Diabetes mellitus is one of cronical degenerative disease. The prevalence of sufferers continues to increase every year, one of the non-pharmacological therapies is exercise such as gymnastics prolanis DM and walking exercises to decrease the glucose level by the body muscles during the physical body. Objective this research is to find out the effectiveness of Prolanis and walking exercises in reducing blood sugar levels in DM patients type II. Method this study uses the Quasi experiment with pre and post with two group design. The study population was 92 DM patients type II with a sample of 82 people. Glucometer (Auto check blood glucose monitor) is used to collect the data. Wiloxon Test is used to analyze the statistical data. Results the research shows that the value of Prolanis Exercises (DM) is p=0.002 which means a significant influence on decrease of the sugar level of DM patients type II. Meanwhile the value of walking exercises is p=0.001. From the statistic test of WIlconxon Signed Rank Test, It obtained Z correlation = 7.886. It means that there is a significant correlation between Prolanis and walking exercises towards the decrease of blood sugar level of Diabetes Mellitus patients type II. Physical activities done regularly, measurably, and correctly are suggested to be considered as non-pharmacological therapies for Diabetes Mellitus patients type II to decrease blood sugar level. Keywords: Prolanis Exercises (DM), Walking, sugar blood level.

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