scholarly journals Mechanism of Pancreatic Islet Number Improvement on Hyperglycemic Wistar Rats (Rattus norvegicus) After Golden Sea Cucumber (Stichopus hermanii) Extract Administration

2020 ◽  
Vol 9 (3S) ◽  
pp. 320-324
Keyword(s):  
Blood Sugar ◽  
Pancreatic Islet ◽  
Blood Sugar Level ◽  
Sea Cucumber ◽  
Histopathological Examination ◽  
Ethanol Extract ◽  
Male Rats ◽  
Laboratory Research ◽  
Control Group ◽  
Sugar Levels

Diabetes mellitus constitutes a metabolic disorder indicated by a decrease in insulin secretion, insulin insensitivity, or a combination of both. Golden sea cucumber (Stichopus hermanii) is a natural resource of Indonesian waters with benefit for reducing blood sugar levels. This research aimed to determine the anti-hyperglycemic mechanism of golden sea cucumber.This study used a experimental laboratory research with Post-test Only Control Group. The sample of this study consisted of 25 male rats aged 60-70 days, divided into 5 groups: K(-), K(+), P1, P2, and P3 randomly. Rats from K(+), P1, P2, and P3 groups were injected with streptozotocin (STZ) with a dose of 50 mg/kg BW. Treatment was administered for 21 days. K(-) and K(+) groups were fed normally while P1, P2 and P3 groups were given golden sea cucumber 80% ethanol extract with a dose of 4,25 mg/kgBW/day, 8,50 mg/kgBW/day and 12,75 mg/kgBW/day respectively. On the 22nd day, fasting blood sugar level was measured and the number of pancreatic islet was counted with histopathological examination. The administration of golden sea cucumber (Stichopus hermanii) extract on rats with hyperglycemia does not reduce blood sugar level, but the extract administration increases the number of pancreatic islet. Golden sea cucumber (Stichopus hermanni) extract may improve the number of pancreatic islet and prevent the progressive damage of pancreatic islet.C

scholarly journals Garlic: an alternative in reducing blood glucose on diabetic patients

2020 ◽  
Vol 7 (6) ◽  
pp. 2078
Author(s):  
Putri Dafriani ◽  
Roza Marlinda ◽  
Eliza Arman ◽  
Meldafia Idaman
Keyword(s):  
Blood Sugar ◽  
Group Intervention ◽  
Blood Sugar Level ◽  
Intervention Group ◽  
Antidiabetic Drugs ◽  
Control Group ◽  
Diabetic Patients ◽  
Post Test ◽  
Quasi Experimental ◽  
Sugar Levels

Background: Diabetes mellitus (DM), a metabolic disorder characterized by an increasing of blood sugar (hyperglycemia). Medication is one of the seven pillars of diabetes managementt. Garlic (Allium sativum), an alternative herb, also has an antidiabetic effect. The purpose of this study was to investigate the effect of garlic on the blood sugar level in type 2 diabetes mellitus.Methods: This study was a quasi-experimental design with two group post-test design. The participants were DM patients who only take medication without any supplemental herbs. The respondents were divided into two group; intervention group, given antidiabetic drugs and consume garlic 3 pieces of garlic/day for 2 weeks and control group only got antidiabetic drugs. Data were collected by performing blood sugar measurement using glucose-check on all respondents using capillary blood in the fingertips. Second measurement were taken after monitoring the consumption of garlic together with drugs for two weeks. Hypothesis testing used independent T-Test test.Results: The study result found that the average of blood sugar level after administering the treatment is 240 mg/dl in the intervention group, and 284 mg/dl in control group. It can be concluded that the administration of 3 pieces of garlic combining with antidiabetic drugs for 2 weeks has not been able to reduce blood sugar levels into normal limits.Conclusions: This combination found to lowering the blood sugar levels in a significant amount compare to only drugs. The length of the therapy could consider as a significant predictor.

scholarly journals Difference of Effectiveness Acarbose with Ethanol Extract Purple Eggplant’s Peel (Solanum melongena L) to Reduce Blood Sugar Levels in White Rat (Rattus norvegicus) Induced by Sucrose

2017 ◽  
Vol 6 (2) ◽  
pp. 14
Author(s):  
Nugroho Eko Wirawan Budianto ◽  
Hairullah Hairullah
Keyword(s):  
Blood Sugar ◽  
Solanum Melongena ◽  
Ethanol Extract ◽  
Male Rats ◽  
Flavonoid Compound ◽  
White Rats ◽  
Significant Difference ◽  
Oral Sucrose ◽  
Group 2 ◽  
Sugar Levels

Acarbose is an oligosaccharide human made who is a competitive inhibitor acarbose and can inhibit the action of the enzyme α-glucosidase, causing a slowdown in the digestion of carbohydrate compounds. Purple eggplant skin is included in the flavonoid compound. Purple eggplant  skin as well as an antioxidant that can control blood glucose levels and prevent complications of diabetes. Purple eggplant skin contains flavonoid kaempferol and has the effect of inhibiting the enzyme alpha-glucosidase. Based on these researchers want to know the difference in effectiveness between the ethanol extract of purple eggplant skin  and acarbose to decrease blood sugar levels of mice. The study population using white rats with a total sample size of 30 rats. Research data analysis using One Way Anova Test. Methods: Male rats strain Wistar were divided into 5 groups. 1) Control (CMC Na 1 ml io), 2) Group 1  (The ethanol extract of 50 mg / kg in the CMC Na io),  3) Group 2  (The ethanol extract 100 mg / kg in CMC Na io), 4) Group 3  (the ethanol extract 200 mg / kg in the CMC Na io), 5) Group 4 (Acarbose 4.5 mg / kg in distillated water io). The result showed ethanol extract of purple eggplant skin in group 2 showed the best effectiveness in lowering blood sugar levels of white rats by oral sucrose injection. And there is no significant difference between the effectiveness of the ethanol extract of purple eggplant skin and acarbose in lowering blood sugar levels of white rats by oral sucrose injection.

scholarly journals THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)

2020 ◽  
Vol 6 (1) ◽  
pp. 36-44
Author(s):  
Kalvin Dersing
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Water Extract ◽  
Coriandrum Sativum ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Wistar Strain ◽  
Sugar Levels

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan

scholarly journals Ekstrak Etanol Kopi Hijau Arabika (Coffea arabica L.) sebagai Antihiperglikemi pada Mencit (Mus musculus)

2020 ◽  
pp. 140-147
Author(s):  
Irawati Hamdani ◽  
Salfauqi Nurman
Keyword(s):  
Chlorogenic Acid ◽  
Blood Sugar ◽  
Mus Musculus ◽  
Coffea Arabica ◽  
Blood Sugar Level ◽  
Control Group ◽  
Green Coffee ◽  
Sugar Levels ◽  
Levene Test ◽  
Coffea Arabica L

Diabetes mellitus is an excessive level of blood sugar concentration disease. One of the compounds that can moderate the blood sugar level is chlorogenic acid that mostly found in green coffee. This study aims to determine the extract activity of Arabica (Coffea arabica L.) green coffee in decreasing the blood sugar level of mice (Mus musculus) that induced by alloxan monohydrate. The method is True Experimental Laboratories with the analysis of chlorogenic acid levels using a UV-Vis spectrophotometer. The research design is Post Test Control Group Design, using 24 mices that divided into six treatment groups. The groups consist of negative control (distilled water), Dose I (100 mg/kg bw), Dose II (200 mg/kg bw), Dose III (300 mg/kg bw), Dose IV (400 mg/kg bw), and positive control (metformin). Blood sugar levels of the mice is measured at the intervals of 1st day, 7th day, 21st day. The data is analyzed using the SPSS program with normality tests (Kolmogorov-Smirnov), homogeneity tests (Levene Test), and parametric statistical tests (One-Way ANOVA). The data results was normally distributed and homogeneous (P> 0.05) with several pairs of data in the treatment group were significantly different (P> 0.05). The extract of Arabica (Coffea arabica L.) green coffee contained 4.235% chlorogenic acid, could reduced the hyperglycemia mice blood sugar levels by the dose of 10.72% (Dose I); 19.85% (Dose II); 27.20% (Dose III); and 31.60% (Dose IV) with dose IV as the effective dose.

scholarly journals UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK DAUN SESEWANUA (Clerodendron squamatum Vahl.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.)

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 774
Author(s):  
Billy N. Nangoy ◽  
Edwin De Queljoe ◽  
Adithya Yudistira
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Pancreatic Beta Cells ◽  
Blood Sugar Level ◽  
Pancreatic Beta Cell ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Leaf Extracts ◽  
White Rats ◽  
Sugar Levels

ABSTRACTSesewanua leaves contain flavonoids which can be potentially as antidiabetic. Flavonoids reduce blood sugar levels by capturing free radicals that cause damage to pancreatic beta cells and inhibit pancreatic beta cell damage. The purpose of this study was to determine the effect of antidiabetic activity on the administration of Sesewanua (Clerodendron squamatum Vahl.) Leaf extracts in wistar white rats (Rattus norvegicus) induced by Aloxan. This type of research is a laboratory experiment using a completely randomized design. Test animals are grouped into 5 groups each consisting of 3 test animals. The negative control group (K-) was not treated, the positive control group (K +) was given metformin, groups 2, 3, and 4 were treated with different extract concentration of 200, 400, and 800 mg. Before the treatment was done the rats were examined the initial blood sugar level, then induced alloxan monohydrate 120 mg / kg BW intraperitonially (ip), and checked the blood sugar level on the 3rd day and continued with the administration of the leaf extracts of the animal every two days until the 14th day. The results showed that sesewanua leaf extracts with a concentration of 200, 400, and 800mg had a decreased activity in blood sugar levels from day 4 to day 14 with a decrease of 13.66 mg / dL in the concentration group 1, 43 mg / dL in the dose concentration 2, and 103 mg / dL in the concentration group 3. Keywords: Blood Glucose, Clerodendron squamatum Vahl., Flavonoids,  Rattus norvegicus ABSTRAKDaun sesewanua mengandung flavonoid yang dapat berpotensi sebagai antidiabetes. Flavonoid menurunkan kadar gula darah dengan cara menangkap radikal bebas penyebab kerusakan sel beta pankreas dan menghambat kerusakan sel beta pankreas. Tujuan penelitian ini adalah mengetahui efek aktivitas antidiabetes terhadap pemberian ekstrak Daun Sesewanua (Clerodendron squamatum Vahl.) pada Tikus Putih Galur Wistar (Rattus norvegicus) yang telah diinduksi Aloksan. Jenis penelitian ini adalah eksperimen laboratorium menggunakan rancangan acak lengkap. Hewan uji dikelompokan dalam 5 kelompok masing-masing terdiri dari 3 ekor hewan uji. Kelompok kontrol negatif (K-) tidak diberi perlakuan, kelompok kontrol positif (K+) diberikan metformin, Kelompok 2, 3, dan 4 diberi perlakuan dengan konsentras ekstrak yang berbeda-beda yaitu 200, 400, dan 800 mg. Sebelum perlakuan dilakukan tikus diperiksa kadar gula darah awal, kemudian diinduksi aloksan monohidrat 120 mg/kgBB secara intraperitonial (ip), dan diperiksa kadar gula darah pada hari ke-3 dan dilanjutkan dengan pemberian ekstrak daun sesewanua setiap dua hari sekali sampai hari ke-14. Hasil penelitian menunjukkan bahwa ekstrak daun sesewanua dengan konsentrasi 200, 400 , dan 800mg memiliki aktivitas penurunan kadar gula darah dari hari ke-4 sampai hari ke-14 dengan penurunan sebesar 13.66 mg/dL pada kelompok konsentrasi 1, 43 mg/dL pada kelompok konsentrasi 2, dan 103 mg/dL pada kelompok konsentrasi 3. Kata Kunci: Clerodendron squamatum Vahl., Flavonoid, Glukosa Darah, Rattus norvegicus

scholarly journals UJI EFEK EKSTRAK GEDI MERAH (Abelmoschus manihot L. Medik) TERHADAP KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus novergicus) YANG DIINDUKSI ALOKSAN

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Friska Adeline ◽  
Jane Wuisan ◽  
Henoch Awaloei
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Leaf Extract ◽  
White Male ◽  
Male Rats ◽  
Male Rat ◽  
The People ◽  
Wistar Strain ◽  
Medicinal Substances ◽  
Sugar Levels

Abstract: Epidemiological study in Manado indicated that the prevalence of Diabetes Melitus (DM) was 6.1%. It is necessary to do scientific assessment of the various species of plants which are thought containing medicinal substances (phytopharmaca). Based on the information from the people living in the subdistrict Pineleng Minahasa red gedi leaves (Abelmoschus manihot L.Medik ) can be used as herbal treatment for lowering blood sugar level. This study aimed to evaluate the effect of red gedi leaves extract in lowering blood sugar level on white male rat induced by aloksan. This study used 15 white male rats of Wistar strain with diabetic induced by 200 mg/kg BW aloksan intraperitoneal. The rats were randomly divided into 5 groups; each group were given aquadest 2,5 ml/ 200 g BW, insulin Novomix 0,9 U/Kg BW, red gedi leaf extract 1.25 mg/200 g BW, 2.5 mg/200 g BW, and 3.75 mg/200 g BW, once daily for 24 hours. Blood sugar levels were measured at 6th, 12th, 18th, and 24 th hours after treatment by using glucometer. The result showed that red gedi leaf extract can lower blood level in diabetic white male rat induced by aloksan.Keywords: red gedi leaf extract, blood glucose, aloksan, diabeticAbstrak: Pada penelitian epidemiologis di kota Manado didapatkan prevalensi penderita DM 6,1 %. Untuk itu perlu dilakukan pengkajian ilmiah terhadap berbagai spesies tumbuhan yang diduga mengandung zat berkhasiat obat (fitofarmaka). Berdasarkan informasi masyarakat di daerah kecamatan Pineleng kabupaten Minahasa daun Gedi Merah (Abelmoschus manihot L.Medik) dapat dimanfaatkan sebagai penanganan herbal untuk menurunkan kadar gula darah. Penelitian ini bertujuan menguji efektivitas ekstrak daun Gedi Merah (Abelmoschus manihot L. Medik) dalam menurunkan kadar gula darah tikus putih jantan galur Wistar (Rattus norvegicus) yang diinduksi aloksan. Tikus galur Wistar sejumlah 15 dinduksi dengan aloksan intraperitoneal 200 mg/kg BB dan dibagi secara acak dalam 5 kelompok penelitian yaitu kelompok perlakuan dengan aquadest 2,5 ml/200 g BB, insulin Novomix 0,9 U / Kg BB, ekstrak daun gedi merah 1,25 mg/ 200 g BB, 2,5 mg/ 200 g BB dan 3,75 mg/ 200 g BB. Perlakuan diberikan satu kali sehari selama 6 hari. Pengukuran kadar glukosa darah dilakukan pada hari ke 2, 4 dan 6 setelah perlakuan menggunakan glukometer. Hasil penelitian menunjukkan bahwa ekstrak daun gedi merah dapat menurunkan kadar glukosa darah tikus putih jantan diabetes yang diinduksi dengan aloksan.Kata kunci: ekstrak daun gedi merah, glukosa darah, aloksan, diabetes

scholarly journals Pengaruh Spiritual Emotional Freedom Technique (Seft) Terhadap Penurunan Kadar Gula Darah Penderita Diabetes Mellitus Tipe 2 Di RSUD Kota Surakarta

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Ros Endah Happy Patriyani ◽  
Sunarsih Rahayu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Life Style ◽  
Blood Sugar Level ◽  
Intervention Group ◽  
Control Group ◽  
Type 2 Dm ◽  
Sugar Levels ◽  
The Impact

Backgound: The incidence and severity levels of Diabetes Mellitus (DM) can be reduced through life style modification. The nurses’ ability in complementary modalities can help the patients to modify their life style by managing the stress levels; doing standard medical cares to help reducing and controlling blood sugar levels. One form of complementary modalities is SEFT. SEFT is one relaxation technique that can reduce anxiety and optimally reduce blood sugar level. Relaxation can affect hypothalamus to regulate and decrease the activity of the sympathetic nervous system. The purpose of this research is to find out the impact of SEFT to the decrease blood sugar levels on type 2 DM patients. Method: The method applied in the research was quasi-experimental pre-posttest with control group. The research population was 100 type 2 DM patients (50 respondents as intervention group and 50 respondents as control group). Samples were taken using purposive sampling method. The data was analyzed using t dependent test. Result: The result of the research shows that SEFT can reduce blood sugar levels of the type 2 DM patients with the value of p =0.000, and there was 220.060 points of blood sugar level reduction Conclusion: Nurses should teach type 2 DM patients to do SEFT; to monitor the blood sugar levels before and after SEFT.

scholarly journals The combined effect of magnetic and electric fields using on/off infrared light on the blood sugar level and the diameter of Langerhans islets of diabetic mice

2020 ◽  
Vol 13 (10) ◽  
pp. 2286-2293
Author(s):  
S. Suhariningsih ◽  
Suryani Dyah Astuti ◽  
Saikhu Akhmad Husen ◽  
Dwi Winarni ◽  
Dian Astri Rahmawati ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Electric Fields ◽  
Blood Sugar Level ◽  
Combined Treatment ◽  
Combined Effect ◽  
Infrared Light ◽  
Control Group ◽  
Diabetic Mice ◽  
Langerhans Islets ◽  
Sugar Levels

Background and Aim: At present, diabetes is treated with oral antidiabetic medicines, such as sulfonylureas and thiazolidine, as well as insulin injection. However, these methods have several shortcomings. Therefore, alternatives for treating diabetes mellitus (DM) are needed. This study aims to determine the combined effect of magnetic and electric fields on blood sugar levels and the diameter of Langerhans islets of diabetic mice. Materials and Methods: Induction of DM in mice was carried out by administering lard for 2 weeks and continued with an intraperitoneal injection of streptozotocin, dissolved in a 4.5 pH citrate buffer, and administered in a dose of 30 mg/kg bodyweight for 5 days. Treatments were used in combination with magnetic and electric fields using on/off infrared light. Blood samples were pipetted through the tip of mice's tails to establish the blood sugar level for each individual mouse. Histology preparation of the pancreas organ was affected using the histology standard as well as hematoxylin and eosin staining methods. Langerhans islet diameter data were analyzed using analysis of variance followed by Duncan's multiple range test. Data analysis was performed at α=0.05. Results: The results showed that the combined treatment of permanent magnetic and unidirectional electric fields (PS) caused changes in blood sugar levels that were not significantly different from the normal control group. The PS treatment improved the diameter of the Langerhans islets but not to a significant degree compared to other treatments. Conclusion: The use of PS treatment is effective for reducing the blood sugar levels of diabetic mice and improving the diameter of their Langerhans islets.

PERBANDINGAN PENGARUH AIR KELAPA DAN MINUMAN ISOTONIK TERHADAP TINGKAT HIDRASI ATLET CABANG OLAHRAGA BOLA BASKET

2019 ◽  
Vol 1 (2) ◽  
pp. 15
Author(s):  
Siska Triana Budiman ◽  
Hamidie Ronald Daniel Ray
Keyword(s):  
Muscle Fatigue ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Coconut Water ◽  
Hydration Status ◽  
Control Group ◽  
Significant Difference ◽  
The Status ◽  
The Subject ◽  
Sugar Levels

The purpose of this research was to find out the comparison and the effect of coconut water and Isotonic drink on hydration status, to reduce anaerobic muscle fatigue and to anticipating blood sugar level increase of basketball athletes. This is quasy experimental research and use a pretest and posttest control group desain. The subject of this research are 18 basketball athletes from UPI's basketball student activity unit with ages 19-21 years old and divided randomly into 3 groups which is 2 treatment groups and control group. The subject given intervention coconut water, 250 ml of Isotonic drink and placebo, it given 30 minutes before the test. The hydration status on basketball athletes is seen from the color of urine and the muscle fatigue measured by using RAST (Running-based Anaerobic Sprint Test) by calculating the value of AF (Anaerobic Fatigue) and blood sugar levels is measured using Autocheck measuring instrument. The result of this research identified that mostly basketball athletes are get dehydration, There is a significant effect on the status of fatigue index according to the type of coconut Water and Isotonic Drink, and also there is a significant difference in the Blood Sugar level of basketball athletes according to the type of drink.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN BAWANG DAYAK (Eleutherine Palmifolia L. Merr) TERHADAP KADAR GULA DARAH MENCIT PUTIH (Mus muscullus) YANG DIINDUKSI GLUKOSA

2020 ◽  
Vol 5 (2) ◽  
pp. 288-297
Author(s):  
Eka Kumalasari ◽  
◽  
Syifa Maharani ◽  
Aditya Maulana Perdana Putra ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Test Group ◽  
Ethanol Extract ◽  
Negative Control ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
Sugar Levels

Diabetes Mellitus (DM) is a collection of metabolic symptoms that arise in a person caused by an increase in blood glucose due to damage to insulin secretion or resistance to insulin or both. Diabetes mellitus medication can be either parenteral or oral which can cause side effects in long-term use such as mild diarrhea, bloating, fatigue acidosis, even hypoglycemic renal impairment. To prevent it can use alternative medicine using Dayak onion (Eleutherine palmifolia (L) Merr.). One of the active substances contained in the Dayak onion is the flavonoids. Flavonoids have antidiabetic activity through their functions as antioxidants. The study aims to determine the activity of Dayak scallion Extract (Eleutherine palmifolia (L) Merr.) To decrease blood sugar levels (Mus muscullus), which is glucose-induced. The research was conducted with research draft pre and post test with control group design. The mice used amounted to 25 male white mice that were divided into 5 groups i.e. negative control (CMC Na 0.5%), control positive (Glibenklamid 3 mg/kgBB), Dayak onion-leaf ethanol extract at a dose of 50 mg/kgBB, 100 mg/kgBB and 200 mg/kgBB. Observations of the decrease in blood sugar levels of each test group were conducted on the same day, 30 minutes, 60 and 90 after hyperglycemia. Results showed that Dayak onion leaves ethanol extract had activity as a lowering of blood sugar levels in glucose-induced white mice

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