scholarly journals Analysis of Achyranthes aspera L. extracts for their α-Amylase and urease inhibitory activities

2021 ◽  
Vol 11 (2) ◽  
pp. 108-112
Author(s):  
Ved Prakash ◽  
Anand Sagar
Keyword(s):  
Plant Extracts ◽  
Inhibitory Activity ◽  
Therapeutic Potential ◽  
Scientific Evidence ◽  
Herbal Medicines ◽  
Achyranthes Aspera ◽  
Whole Plant ◽  
Intestinal Infections ◽  
Treatment Of Obesity ◽  
Urease Inhibitory

Plant products have served as a major source of useful drugs for centuries and about half of the pharmaceuticals in use today are derived from these natural products. The efficacy and safety of herbal medicines have attracted the attention of scientists towards medicinal plants research. The present study was designed to investigate the whole plant extracts of Achyranthes aspera L. for their anti-enzyme (α-amylae and urease) activity. All the extracts of A. aspera were reported to show good alpha-amylase and urease inhibitory activity of greater than 50% in all the solvents used at a concentration of 1 mg/mL. α- amylase inhibition ranged from 17.66±0.10-69.90±0.50% whereas urease inhibitory activity ranged from 18.60±0.50 to 79.90±0.50% suggesting a strong α- amylase and urease inhibitory effects of this plant. Thus the study provided scientific evidence to the traditional uses of this plant in the treatment of obesity, diabetes, ulcers, kidney stones intestinal infections etc. Therefore, the whole plant extracts of A. aspera can be selected for further investigation to find their therapeutic potential. Keywords: Achyranthes aspera, plant extracts, α-Amylase, Urease

scholarly journals PHYTO-MEDICINAL EFFECTS OF SYZYGIUM CUMINI ON DIABETES: A REVIEW

2020 ◽  
pp. 392-402
Author(s):  
Md. Mahmudul Amin
Keyword(s):  
Plant Extracts ◽  
Therapeutic Potential ◽  
Biological Effects ◽  
Scientific Evidence ◽  
Research Result ◽  
Treatment Strategies ◽  
Pharmaceutical Preparations ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Current State

Diabetes is a major public health problem which has been increasing day by day throughout the world with an alarming rate. In recent years, several plant extracts have been examined for their anti-diabetic properties to identify alternative treatment strategies that pose less risk for diabetes. It has been shown that different parts of these plants are collected from diverse regions and administered in different pharmaceutical preparations. The aim of the present review is to provide an overview of the phytochemicals present in S. cumini plants and their potent anti-diabetic activity, toxicological and biological effects of these plant extracts, their current state, limitation and future prospects in developing countries that are not included in the European Pharmacopoeia. In addition, a prospective research result of synergistic use of this plant with other plant (Ficus racemosa) done presently in our laboratory has been included. Based on the available evidence, we highlight the ways in which their therapeutic potential can be properly harnessed and provide scientific evidence for the discovery of novel leads for herbal drug development.

scholarly journals Studies on Analysis of Antioxidant and Enzyme Inhibitory Activity of Vitex negundo Linn.

2017 ◽  
Vol 9 (6) ◽  
Author(s):  
Ved Prakash ◽  
Shelly Rana ◽  
Anand Sagar
Keyword(s):  
Urease Activity ◽  
Therapeutic Potential ◽  
Radical Scavenging Activity ◽  
Scientific Evidence ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Vitex Negundo ◽  
Leaf Extracts ◽  
Treatment Of Obesity ◽  
Dpph Radical Scavenging

The current study was designed to investigate the leaf extracts of Vitex negundo Linn. for their antioxidant and enzyme inhibitory (α-amylae and urease) activity. The antioxidant capacity of the different extracts (methanol, acetone and aqueous) of this plant was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl) and reducing power tests. The plant exhibited good DPPH radical scavenging activity and moderate reducing power potential Further, all the extracts of V. negundo were reported to possess good anti-alpha amylase and anti-urease activity of greater than 50% in all the solvents used at a concentration of 1 mg/mL. Thus the study provided scientific evidence to the traditional uses of this plant in the treatment of obesity, diabetes, ulcers, kidney stones etc. Therefore, the leaf extracts of this plant can be selected for further investigation to determine their therapeutic potential.

scholarly journals Therapeutic Potential of Ayush 64 in Covid-19: An Ayurvedic Perspective

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
BALAJI POTBHARE
Keyword(s):  
Therapeutic Potential ◽  
Herbal Medicines ◽  
Specific Treatment ◽  
Point Of View ◽  
Medical Emergency ◽  
Traditional System ◽  
Whole Plant ◽  
Symptomatic Management ◽  
Drug Actions ◽  
Indian Medicine

In the human history, a medical emergency has emerged in the form of Covid-19 disease. Coronavirus disease 2019 (COVID-19), is caused by severe acute respiratory syndrome which has become pandemic. The medical treatment of Covid-19 consists of symptomatic management and oxygen supply, with ventilation for patients with acute respiratory failure. There is no specific treatment for Covid-19. Globally, efforts are being made to verify the efficacy of traditional system of medicines to fight against the Covid-19. Ayurveda, the traditional system of Indian medicine, has also number of herbal medicines which can be used to treat the systems of Covid-19. The Ayush-64 drug is used to treat Malaria (Visama Jvara) and it has been developed by CCRAS, Ministry of AYUSH, Govt. of India. Contents of Ayush 64 drug are: Saptaparna (Alstonia scholaris R. Br.) Bark Aqueous Extract 100 mg; Katuki (Picrorhiza kurroa Royle ex. Benth) Root do 100 mg; Kirata tikta (Swertia Chirata (Pexb ex. Karst) Whole plant do 100 mg; and Kaberuka (Caesalpinia crista Linn.) Seed powder 200 mg. This paper intends to understand the drug actions of contents of Ayush 64 according to Ayurvedic point of view.

scholarly journals PLANT-BASED REMEDIES FOR THE MANAGEMENT OF DIABETES

2017 ◽  
Vol 8 ◽  
pp. 34 ◽  
Author(s):  
Sumiksha Gupta ◽  
M.C. Sidhu ◽  
A.S. Ahluwalia
Keyword(s):  
Bioactive Compounds ◽  
Cultural Practices ◽  
Therapeutic Potential ◽  
Herbal Medicines ◽  
Chemical Characterization ◽  
Himachal Pradesh ◽  
Traditional Medicines ◽  
Plant Parts ◽  
Whole Plant ◽  
Structured Questionnaire

<p>The knowledge related to medicinal plants have been described in Indian Ayurveda System and survived till today through the prevalent socio-cultural practices. Present study is an attempt to document anti-diabetic plants from Una district of Himachal Pradesh. A thorough survey was conducted from 500 respondents using a semi-structured questionnaire and informal discussions. A total of 84 anti-diabetic plant species have been recorded. These plants include wild (32) or cultivated (41) species. Fabaceae was the dominant family with 10 species. The phytoremedies were prepared using different plant parts or sometimes even the whole plant or in combination with other species. There are only few reports on anti-diabetic use of some wild species from the study area. Further studies of bioactive compounds in these species can depict their hypoglycemic potential. Present study has suggested a strong link between traditional herbal medicines, their documentation and proper chemical characterization to harness their therapeutic potential to the maximum.  </p><p><strong>KEY WORDS: </strong>Diabetes, bioactive compounds, traditional medicines, phytoremedies, angiosperms, Una, Himachal Pradesh</p>

ANTIOESTROGENIC ACTIVITY IN FAHLI CLOVER HAY AND OAT HAY

1965 ◽  
Vol 49 (1) ◽  
pp. 90-96 ◽  
Author(s):  
J. H. Adler
Keyword(s):  
Plant Extracts ◽  
Avena Sativa ◽  
Inhibitory Activity ◽  
Weight Increase ◽  
Trifolium Alexandrinum ◽  
Uterine Weight ◽  
Extraction Procedures ◽  
Fodder Plants

ABSTRACT The presence of oestrogen inhibitory activity in oat hay (Avena sativa) and Fahli clover hay (Trifolium alexandrinum var. Fahli) has been established. The antioestrogenic effect was demonstrated by the inhibition of uterine weight increase in rats (Astwood test) in response to oestradiol injected together with the above mentioned plant extracts. The extraction procedures are described in detail and the possible biological implications of antioestrogenic and oestrogenic activity in fodder plants is discussed.

Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential

2018 ◽  
Vol 25 (14) ◽  
pp. 1663-1681 ◽  
Author(s):  
Chun-Ting Lee ◽  
Heng-Chun Kuo ◽  
Yung-Hsiang Chen ◽  
Ming-Yen Tsai
Keyword(s):  
Biological Activity ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Research Field ◽  
Protective Effects ◽  
Pharmacological Effects ◽  
The Family ◽  
Anti Tumor Activity

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives

2018 ◽  
Vol 15 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Mehdi Asadi ◽  
Mohammad Mahdavi ◽  
Shabnam Mahernia ◽  
Zahra Rezaei ◽  
Maliheh Safavi ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Thiobarbituric Acid ◽  
Urease Inhibitory

Synthesis and Investigation of Therapeutic Potential of Isoform-Specific HDAC8 Inhibitors for the Treatment of Cutaneous T Cell Lymphoma

2019 ◽  
Vol 19 (7) ◽  
pp. 916-934 ◽  
Author(s):  
Appavoo Umamaheswari ◽  
Ayarivan Puratchikody ◽  
Natarajan Hari
Keyword(s):  
Side Effects ◽  
Inhibitory Activity ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Therapeutic Potential ◽  
In Vitro Assays ◽  
Normal Cells ◽  
Standard Drug ◽  
In Silico Studies ◽  
Hdac8 Inhibitors

Background:The available treatment option for any type of cancer including CTCL is chemotherapy and radiation therapy which indiscriminately persuade on the normal cells. One way out for selective destruction of CTCL cells without damaging normal cells is the use of histone deacetylase inhibitors (HDACi). Despite promising results in the treatment of CTCL, these HDACi have shown a broadband inhibition profile, moderately selective for one HDAC class but not for a particular isotype. The prevalence of drug-induced side effects leaves open a narrow window of speculation that the decreased therapeutic efficacy and observed side effects may be most likely due to non specific HDAC isoform inhibition. The aim of this paper is to synthesis and evaluates HDAC8 isoform specific inhibitors.Methods:Based on the preliminary report on the design and in silico studies of 52 hydroxamic acid derivatives bearing multi-substituent heteroaromatic rings with chiral amine linker, five compounds were shortlisted and synthesized by microwave assisted approach and high yielding synthetic protocol. A series of in vitro assays in addition to HDAC8 inhibitory activity was used to evaluate the synthesised compounds.Results:Inhibitors 1e, 2e, 3e, 4e and 5e exerted the anti-proliferative activities against CTCL cell lines at 20- 100 µM concentrations. Both the pyrimidine- and pyridine-based probes exhibited μM inhibitory activity against HDAC8. The pyrimidine-based probe 1e displayed remarkable HDAC8 selectivity superior to that of the standard drug, SAHA with an IC50 at 0.1µM.Conclusion:Our study demonstrated that simple modifications at different portions of pharmacophore in the hydroxamic acid analogues are effective for improving both HDAC8 inhibitory activity and isoform selectivity. Potent and highly isoform-selective HDAC8 inhibitors were identified. These findings would be expedient for further development of HDAC8-selective inhibitors.

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