scholarly journals A Review on the Latest Developments of Conducting Polymer and Composite Coatings for Enhancing Biocompatibility and Corrosion Resistance of Metallic Biomedical Implants

2021 ◽  
Vol 6 (5) ◽  
pp. 146-155
Author(s):  
Mohammed Razzaq Mohammed ◽  
Safaa Hashim Radhi ◽  
Ahmed Namah Hadi
Keyword(s):  
Human Life ◽  
Composite Coatings ◽  
Biological Properties ◽  
Metals And Alloys ◽  
Toxic Substances ◽  
Metallic Implants ◽  
Body Tissues ◽  
Biomedical Field ◽  
Materials Used

The utilisation of metals and alloys in the biomedical field was and is still of immense importance for human life. Typically, the materials used for metallic biomedical applications, particularly those are implanted in vivo, provide appropriate mechanical and biological properties that allow them to accomplish the purpose for which they are used. Nonetheless, there are some inherent limitations impede the optimal use of these materials. One of the most crucial determinants is corrosion, which results in several other problems such as the formation of toxic substances that can not only cause necrosis of the cells attached to the implant, these toxins could also be carried by blood into body tissues and organs. This in turn leads to dire consequences on patient's life. Although a wide variety of approaches may be available to address the corrosion issue, it is alleged that coating these metals and alloys with polymers, especially the conductive ones, is among the best strategies in this regard. This review will highlight the latest developments in using conductive polymers including polypyrrole, polyaniline, polythiophene and their composites in order to enhance biocompatibility, mechanical properties and most importantly corrosion protection performance of metallic implants. The findings obtained from coating 316L stainless steel, titanium and magnesium alloys, which have been widely manipulated in biomedical field as long and short-term implants, will be evaluated.

scholarly journals Thermal Sprayed Composite Coatings for Biomedical Implants: A Brief Review

2020 ◽  
Vol 2 (1) ◽  
pp. 50-55
Author(s):  
Gaurav Prashar ◽  
◽  
Hitesh Vasudev
Keyword(s):  
Mechanical Properties ◽  
Composite Coatings ◽  
Thermal Spraying ◽  
Biological Properties ◽  
Yttria Stabilized Zirconia ◽  
Biomedical Implants ◽  
Stabilized Zirconia ◽  
Metallic Biomaterials ◽  
Materials Used ◽  
Surface Modification Techniques

The implant materials used currently in field of cardiovascular and orthopedics surgery dearth in osteoconductivity. Different surface modification techniques are used, developed and investigated over the years to enhance the osteoconductivity of biomaterials like metals, polymer and ceramics. Although implants made up of metals are strong mechanically but have low bonding ability due to bio-inert nature.To overcome the limitations and to accomplish the desired purpose, composite coatings consisting of bioactive are developed on the metallic biomaterials. In general bio-inert ceramics like yttria stabilized zirconia (ysz), titania, and alumina may be incorporated into hydroxyapatite (HA) matrix to develop composite coatings with improved mechanical properties over the years. The composite coatings developed by thermal spraying have shown promising approach to have good mechanical and biological properties in comparison with single-component and/or monolayer coatings. The strategy to use composite coatings is adopted widely by the professionals/scientists in the area of biomaterials for development and production of materials in order to repair and regeneration of the human tissue. In this article, commercially used thermal spraying techniques used for deposition of composite coatings for biomedical implants are discussed.

scholarly journals A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans

2021 ◽  
Author(s):  
Muhammad Arif Asghar ◽  
Rabia Ismail Yousuf ◽  
Muhammad Harris Shoaib ◽  
Muhammad Arif Asghar ◽  
Nazish Mumtaz
Keyword(s):  
Surface Functionalization ◽  
Metallic Nanoparticles ◽  
Ex Vivo ◽  
Human Life ◽  
Biological Properties ◽  
Biological Macromolecules ◽  
Biomedical Sciences ◽  
Optimum Selection

The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences. Metallic NPs have gained immense interest over the last few decades due to their promising optical, electrical, and biological properties. However, the aggregation and the toxic nature of these NPs have restricted their utilization in more optimized applications. The optimum selection of biopolymers and biological macromolecules for surface functionalization of metallic NPs will significantly improve their biological applicability and biocompatibility. The present mini-review attempts to stress the overview of recent strategies involved in surface functionalization of metallic NPs, their specific biomedical applications, and comparison of their in vitro, ex vivo, and in vivo toxicities with non-functionalized metallic NPs. In addition, this review also discusses the various challenges for metallic NPs to undergo human clinical trials.

Mechanobiological assessment of Ti-6Al-4V fabricated via selective laser melting technique: a review

2019 ◽  
Vol 25 (7) ◽  
pp. 1266-1284 ◽  
Author(s):  
Sahil Dhiman ◽  
Sarabjeet Singh Sidhu ◽  
Preetkanwal Singh Bains ◽  
Marjan Bahraminasab
Keyword(s):  
Selective Laser Melting ◽  
Human Life ◽  
Recent Decade ◽  
Biological Properties ◽  
Biological Behavior ◽  
Laser Melting ◽  
Content Type ◽  
Porous Ti

Purpose With technology advances, metallic implants claim to improve the quality and durability of human life. In the recent decade, Ti-6Al-4V biomaterial has been additively manufactured via selective laser melting (SLM) for orthopedic applications. This paper aims to provide state-of-the-art on mechanobiology of these fabricated components. Design/methodology/approach A literature review has been done to explore the potential of SLM fabricated Ti-6Al-4V porous lattice structures (LS) as bone substitutes. The emphasize was on the effect of process parameters and porosity on mechanical and biological properties. The papers published since 2007 were considered here. The keywords used to search were porous Ti-6Al-4V, additive manufacturing, metal three-dimensional printing, osseointegration, porous LS, SLM, in vitro and in vivo. Findings The properties of SLM porous biomaterials were compared with different human bones, and bulk SLM fabricated Ti-6Al-4V structures. The comparison was also made between LS with different unit cells to find out whether there is any particular design that can mimic the human bone functionality and enhance osseointegration. Originality/value The implant porosity plays a crucial role in mechanical and biological characteristics that relies on the optimum controlled process variables and design attributes. It was also indicated that although the mechanical strength (compressive and fatigue) of porous LS is not mostly close to natural cortical bone, elastic modulus can be adjusted to match that of cortical or cancellous bone. Porous Ti-6Al-4V provide favorable bone formation. However, the effect of design variables on biological behavior cannot be fully conclusive as few studies have been dedicated to this.

scholarly journals Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Coatings ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 971 ◽  
Author(s):  
Paulina Kazimierczak ◽  
Agata Przekora
Keyword(s):  
Bone Regeneration ◽  
Bone Growth ◽  
Biological Effects ◽  
Composite Coatings ◽  
Current Trend ◽  
Surface Modifications ◽  
Biological Properties ◽  
Bone Implants

The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

Nanodrugs as a new approach in therapy of cardiovascular diseases and cancer with tumor-associated angiogenesis

2020 ◽  
Vol 28 ◽  
Author(s):  
Justyna Hajtuch ◽  
Karolina Niska ◽  
Iwona Inkielewicz-Stepniak
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Controlled Drug Release ◽  
Biological Properties ◽  
Comprehensive Information ◽  
Conventional Drug ◽  
Key Factor ◽  
Functionalized Materials

Background: Cancer along with cardiovascular diseases are globally defined as leading causes of death. Importantly, some risk factors are common to these diseases. The process of angiogenesis and platelets aggregation are observed in cancer development and progression. In recent years, studies have been conducted on nanodrugs in these diseases that have provided important information on the biological and physicochemical properties of nanoparticles. Their attractive features are that they are made of biocompatible, well-characterized and easily functionalized materials. Unlike conventional drug delivery, sustained and controlled drug release can be obtained by using nanomaterials. Methods: In this article, we review the latest research to provide comprehensive information on nanoparticle-based drugs for the treatment of cancer, cardiovascular disease associated with abnormal haemostasis, and the inhibition of tumorassociated angiogenesis. Results: The results of the analysis of data based on nanoparticles with drugs confirm their improved pharmaceutical and biological properties, which gives promising antiplatelet, anticoagulant and antiangiogenic effects. Moreover, the review included in vitro, in vivo research and presented nanodrugs with chemotherapeutics approved by Food and Drug Administration. Conclusion: By the optimization of nanoparticles size and surface properties, nanotechnology are able to deliver drugs with enhanced bioavailability in treatment of cardiovascular disease, cancer and inhibition of cancer-related angiogenesis. Thus, nanotechnology can improve the therapeutic efficacy of the drug, but there is a need for a better understanding of the nanodrugs interaction in the human body, because this is a key factor in the success of potential nanotherapeutics.

Tamarix articulata (T. articulata) - An Important Halophytic Medicinal Plant with Potential Pharmacological Properties

2019 ◽  
Vol 20 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Abdullah M. Alnuqaydan ◽  
Bilal Rah
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
In Vivo Model ◽  
Drug Candidate ◽  
Phytochemical Analysis ◽  
Pharmacological Properties

Background:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in combination with other plant extracts against different ailments since ancient times.Methods:Electronic database survey via Pubmed, Google Scholar, Researchgate, Scopus and Science Direct were used to review the scientific inputs until October 2018, by searching appropriate keywords. Literature related to pharmacological activities of T. articulata, Tamarix species, phytochemical analysis of T. articulata, biological activities of T. articulata extracts. All of these terms were used to search the scientific literature associated with T. articulata; the dosage of extract, route of administration, extract type, and in-vitro and in-vivo model.Results:Numerous reports revealed that T. articulata contains a wide spectrum of phytochemical(s), which enables it to have a wide window of biological properties. Owing to the presence of high content of phytochemical compounds like polyphenolics and flavonoids, T. articulata is a potential source of antioxidant, anti-inflammatory and antiproliferative properties. In view of these pharmacological properties, T. articulata could be a potential drug candidate to treat various clinical conditions including cancer in the near future.Conclusion:In this review, the spectrum of phytochemical(s) has been summarized for their pharmacological properties and the mechanisms of action, and the possible potential therapeutic applications of this plant against various diseases discussed.

Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments

2019 ◽  
Vol 15 (1) ◽  
pp. 102-118 ◽  
Author(s):  
Carolina Campos-Rodríguez ◽  
José G. Trujillo-Ferrara ◽  
Ameyali Alvarez-Guerra ◽  
Irán M. Cumbres Vargas ◽  
Roberto I. Cuevas-Hernández ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
In Silico ◽  
Biological Properties ◽  
Chiral Molecules ◽  
Chiral Compounds ◽  
Plus Maze ◽  
In Silico Studies ◽  
The Central Nervous System

Background: Thalidomide, the first synthesized phthalimide, has demonstrated sedative- hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides have an interesting chemical structure that confers important biological properties. Objective: Non-chiral (ortho and para bis-isoindoline-1,3-dione, phthaloylglycine) and chiral phthalimides (N-substituted with aspartate or glutamate) were synthesized and the sedative, anxiolytic and anticonvulsant effects were tested. Method: Homology modeling and molecular docking were employed to predict recognition of the analogues by hNMDA and mGlu receptors. The neuropharmacological activity was tested with the open field test and elevated plus maze (EPM). The compounds were tested in mouse models of acute convulsions induced either by pentylenetetrazol (PTZ; 90 mg/kg) or 4-aminopyridine (4-AP; 10 mg/kg). Results: The ortho and para non-chiral compounds at 562.3 and 316 mg/kg, respectively, decreased locomotor activity. Contrarily, the chiral compounds produced excitatory effects. Increased locomotor activity was found with S-TGLU and R-TGLU at 100, 316 and 562.3 mg/kg, and S-TASP at 316 and 562.3 mg/kg. These molecules showed no activity in the EPM test or PTZ model. In the 4-AP model, however, S-TGLU (237.1, 316 and 421.7 mg/kg) as well as S-TASP and R-TASP (316 mg/kg) lowered the convulsive and death rate. Conclusion: The chiral compounds exhibited a non-competitive NMDAR antagonist profile and the non-chiral molecules possessed selective sedative properties. The NMDAR exhibited stereoselectivity for S-TGLU while it is not a preference for the aspartic derivatives. The results appear to be supported by the in silico studies, which evidenced a high affinity of phthalimides for the hNMDAR and mGluR type 1.

Development and Pharmacokinetics Study of Antifungal Peptide Nanoliposomes by Liquid Chromatography-tandem Mass Spectrometry

2019 ◽  
Vol 15 (4) ◽  
pp. 312-318
Author(s):  
Shuoye Yang
Keyword(s):  
Mass Spectrometry ◽  
Biological Properties ◽  
Pharmacokinetic Property ◽  
Antifungal Peptide ◽  
Simple Liquid ◽  
Physico Chemical ◽  
Liquid Chromatography Tandem Mass ◽  
Pegylated Lipids

Background: The therapeutic ability and application of antifungal peptide (APs) are limited by their physico-chemical and biological properties, the nano-liposomal encapsulation would improve the in vivo circulation and stability. </P><P> Objective: To develop a long-circulating liposomal delivery systems encapsulated APs-CGA-N12 with PEGylated lipids and cholesterol, and investigated through in vivo pharmacokinetics. Methods: The liposomes were prepared and characterized, a rapid and simple liquid chromatographytandem mass spectrometry (LC-MS/MS) assay was developed for the determination of antifungal peptide in vivo, the pharmacokinetic characteristics of APs liposomes were evaluated in rats. Results: Liposomes had a large, unilamellar structure, particle size and Zeta potential ranged from 160 to 185 nm and -0.55 to 1.1 mV, respectively. The results indicated that the plasma concentration of peptides in reference solutions rapidly declined after intravenous administration, whereas the liposomeencapsulated ones showed slower elimination. The AUC(0-∞) was increased by 3.0-fold in liposomes in comparison with standard solution (20 mg·kg-1), the half-life (T1/2) was 1.6- and 1.5-fold higher compared to the reference groups of 20 and 40 mg·kg-1, respectively. Conclusion: Therefore, it could be concluded that liposomal encapsulation effectively improved the bioavailability and pharmacokinetic property of antifungal peptides.

scholarly journals 99mTc Labelling Strategies for the Development of Potential Nitroimidazolic Hypoxia Imaging Agents

Inorganics ◽  
2019 ◽  
Vol 7 (11) ◽  
pp. 128 ◽  
Author(s):  
Giglio ◽  
Rey
Keyword(s):  
Rational Design ◽  
Biological Properties ◽  
Fine Tuning ◽  
Oxidation States ◽  
Hypoxia Imaging ◽  
Biological Target ◽  
99Mtc Radiopharmaceuticals ◽  
99Mtc Labelling

Technetium-99m has a rich coordination chemistry that offers many possibilities in terms of oxidation states and donor atom sets. Modifications in the structure of the technetium complexes could be very useful for fine tuning the physicochemical and biological properties of potential 99mTc radiopharmaceuticals. However, systematic study of the influence of the labelling strategy on the “in vitro” and “in vivo” behaviour is necessary for a rational design of radiopharmaceuticals. Herein we present a review of the influence of the Tc complexes’ molecular structure on the biodistribution and the interaction with the biological target of potential nitroimidazolic hypoxia imaging radiopharmaceuticals presented in the literature from 2010 to the present. Comparison with the gold standard [18F]Fluoromisonidazole (FMISO) is also presented.

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

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