scholarly journals Adherence to dietary recommendations by children and adolescents during steroid therapy in acute lymphoblastic leukemia

2020 ◽  
Vol 19 (3) ◽  
pp. 146-154
Author(s):  
Marta Hadaś ◽  
Anna Stefanowicz-Bielska
Keyword(s):  
Body Weight ◽  
Acute Lymphoblastic Leukemia ◽  
Children And Adolescents ◽  
Steroid Therapy ◽  
Lymphoblastic Leukemia ◽  
Dietary Recommendations ◽  
Normal Body ◽  
Normal Body Weight ◽  
The University ◽  
Low Glycemic Index

AbstractAim. Assessment of adherence to dietary recommendations by children and adolescents during steroid therapy in the treatment of acute lymphoblastic leukemia (ALL).Material and methods. The study was conducted among parents of children with ALL, aged from 1 to 17 years, treated at the Department of Paediatrics, Hematology and Oncology of the University Clinical Centre in Gdańsk. The paper uses the method of a diagnostic survey, the questionnaire technique. The research tool was an anonymous self-constructed questionnaire.Results. The study included 16 parents (44.4%) of female children and 20 parents (55.6%) of male children. Normal body weight was found in most of the children (22/36 children). Grade 1 hypertension was found in 15/36 children and grade 2 hypertension in 6/36. In 31/36 children, the blood glucose level was 70-180 mg%. The number of 22/36 examined children used a diet with a low glycemic index. As many as 29/36 parents of children and adolescents with ALL followed the diet recommended by a doctor.Conclusions. 1) Most children with ALL have normal body weight during steroid therapy. 2) Children with ALL are subject to arterial hypertension during steroid therapy. 3) Most parents or legal guardians of children and adolescents with ALL adhered to dietary recommendations during steroid therapy.

scholarly journals Cardiopulmonary Capacity in Overweight and Obese Children and Adolescents: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Agata Grzyb ◽  
Małgorzata Domagalska-Szopa ◽  
Andrzej Siwiec ◽  
Ilona Kwiecień-Czerwieniec ◽  
Andrzej Szopa
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Cardiopulmonary Exercise Testing ◽  
High Body Mass Index ◽  
Normal Weight ◽  
Control Group ◽  
Overweight Children ◽  
Obese Children ◽  
Normal Body ◽  
Normal Body Weight

Background: One of the objective methods of assessing the level of cardiopulmonary capacity in overweight and obese children and adolescents is cardiopulmonary exercise testing (CPET).Aims: The purpose of present study is an evaluation of aerobic capacity in high body mass index (BMI) children and adolescents by comparing them with a normal weight control group by CPET.Methods and Procedures: The subjects were recruited from participants of the Program of Treatment for Overweight and Obese Children organized by a local pediatric rehabilitation center in Poland. Based on BMI for age and gender, two validation groups were selected: (1) a group of overweight children (n = 49) and (2) a group of obese children (n = 48). The study included also 53 normal weight participants as a reference group (REF). The study consisted of two parts: anthropometric measurements and CPET. The Godfrey protocol for CPET was applied.Outcomes and Results: In this study, obese children and adolescents showed similar absolute VO2peak values in liters per minute (1.64 L/min) compared to overweight children (1.48 L/min), but significantly higher than children with normal body weight (1.39 L/min). The obese children and adolescents presented lower VO2peak in relation to body weight (25.44 ml/kg/min) compared to their peers with normal body weight (36.5 ml/kg/min), and overweight children (29.18 ml/kg/min).Conclusion and Implications: The main finding of our study was recognition of significant differences between cardiopulmonary capacity parameters in obese children in comparison not only to normal weight peers, but to overweight, too.

scholarly journals PECULIARITY PERSONALITY OF ADOLESTENTS WITH ESSENTIAL ARTERIAL HYPERTENSION AND OVERWEIGHT/OBESITY

2019 ◽  
Vol 15 (1-2) ◽  
pp. 69-73
Author(s):  
O.M. Misiura ◽  
M.V. Khaitovych
Keyword(s):  
Body Weight ◽  
Essential Hypertension ◽  
Children And Adolescents ◽  
Overweight And Obesity ◽  
Personality Characteristics ◽  
Emotional Instability ◽  
Psychological Study ◽  
Normal Body ◽  
Normal Body Weight ◽  
Comparative Group

Relevance. Recent changes in lifestyle and diet have led to a significant increase of overweight and obesity among children and adolescents. According to the results of our previous studies, it was found that among adolescents with overweight/obesity, essential hypertension is 1,5-7,5 times more common than among peers. It is known that children and adolescents with obesity are inherent in emotional instability and impulsivity. Objective of this work was to study the personality characteristics of adolescents with essential hypertension and overweight/obesity. Materials and methods. In the Kiev Children's Clinical Hospital No. 6, a comprehensive clinical and psychological study of 67 adolescents (18 girls, 49 boys) aged 12-17 years (average of 14,40±1,63 years) was carried out, who were hospitalized for essential hypertension. Overweight was found in 7 girls and 21 boys, obesity - in 2 girls and 8 boys. The remaining patients (9 girls and 20 boys) had normal body weight (comparative group). We evaluated the level of anxiety, alexithymia, depression, the type of attitude to the disease, and also determined the personality characteristics of the patients. Results. Adolescents with essential hypertension and overweight/obesity on average differed significantly higher pulse daily blood pressure (61,98±8,13 mmHg versus 57,02±6,70; P<0,005), lower values of anxiety scales (5,11±4,77 points versus 9,62±7,72 points; P<0,01), hypochondria (5,70±5,20 points versus 9,00±5,20 points; P<0,05), neurasthenia (7,19±7,49 points versus 11,14±7,90 points; P<0,05) and egocentrism (5,70±4,44 points versus 8,57±5,08 points; P<0,05) related to TOBOL test. According to the personality test R.-B. Kettell in adolescents with overweight/obesity was on average higher level Q2 scale (6,72±2,14 points versus 4,91±2,63 points; P<0,05). Conclusion. Adolescents with essential hypertension and overweight, obesity, in contrast to patients with normal body weight, are less neurotic by the disease, but they are characterized by non-conformity.

scholarly journals Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

2020 ◽  
Author(s):  
Anna Socha-Banasiak ◽  
Arkadiusz Michalak ◽  
Krzysztof Pacześ ◽  
Zuzanna Gaj ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Serum Concentrations ◽  
Normal Body ◽  
Normal Body Weight

Abstract Background: Fibroblast growth factor 19 (FGF19), Fibroblast growth factor 21 (FGF21) and Klotho are regulators of energy homeostasis. However, in the paediatric population the relationship between obesity, metabolic disorders and mentioned factors has not been clearly investigated. We analysed serum concentrations of FGF19, FGF21 and Klotho in children and adolescents with normal body weight as well as in overweight and obese subjects – and their associations with components of metabolic syndrome and insulin resistance (IR).Methods: The cross-sectional study conducted in the group of hospitalised children and adolescents. Laboratory investigation included serum ELISA tests for FGF19, FGF21, Klotho as well as lipid profile and oral glucose tolerance test for calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The clinical analysis included blood pressure measurement, body fat percentage estimation and assessing the prevalence of metabolic syndrome (MS) and its components. Results: The study was conducted on 174 children/adolescents aged 6-17 years divided into the following groups: with normal body weight (N=48), with obesity (N=92) and overweight subjects (N=34). Klotho levels were significantly higher in the group of subjects with obesity [median 168.6 pg/ml]) than those with overweight [131.3 pg/ml] and normal body weight [116.6 pg/ml] (p=0.0334). Median serum FGF21 level was elevated in the group of patients with MS in comparison to other subjects [136.2 pg/ml vs 82.6 pg/ml, p=0.0285]. Increased Klotho concentrations were noted in patients affected by IR compared with subjects with normal insulin sensitivity [185.3 pg/ml vs 132.6 pg/ml, p=0.0282]. Multivariable model for HOMA-IR showed FGF19 as an independent predictor for IR after adjusting for the pubertal stage and BMI Z-score.Conclusions: Klotho levels were associated with body weight status in children and adolescents. Moreover, Klotho, FGF19 and FGF21 concentrations correlated with IR status and traits of MS.

scholarly journals No difference in outcome between children and adolescents transplanted for acute lymphoblastic leukemia in second remission

Blood ◽  
2011 ◽  
Vol 118 (25) ◽  
pp. 6683-6690 ◽  
Author(s):  
Giorgio Dini ◽  
Marco Zecca ◽  
Adriana Balduzzi ◽  
Chiara Messina ◽  
Riccardo Masetti ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Confidence Interval ◽  
Children And Adolescents ◽  
Lymphoblastic Leukemia ◽  
Disease Recurrence ◽  
Hematopoietic Stem ◽  
Free Survival ◽  
Total Body ◽  
Related Mortality

Abstract Acute lymphoblastic leukemia (ALL) in second complete remission is one of the most common indications for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients. We compared the outcome after HCST of adolescents, aged 14 to 18 years, with that of children (ie, patients < 14 years of age). Enrolled in the study were 395 patients given the allograft between January 1990 and December 2007; both children (334) and adolescents (61) were transplanted in the same pediatric institutions. All patients received a myeloablative regimen that included total body irradiation in the majority of them. The donor was an HLA-identical sibling for 199 patients and an unrelated volunteer in the remaining 196 patients. Children and adolescents had a comparable cumulative incidence of transplantation-related mortality, disease recurrence, and of both acute and chronic graft-versus-host disease. The 10-year probability of overall survival and event-free survival for the whole cohort of patients were 57% (95% confidence interval, 52%-62%) and 54% (95% confidence interval, 49%-59%), respectively, with no difference between children and adolescents. This study documents that adolescents with ALL in second complete remission given HSCT in pediatric centers have an outcome that does not differ from that of patients younger than 14 years of age.

scholarly journals POS0358 EVALUATION OF THE EFFECT OF mTOR EXPRESSION ON THE CLINICAL MANIFESTATIONS OF KNEE OSTEOARTHRITIS IN OBESE AND NORMAL WEIGHT PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 409.2-409
Author(s):  
E. Strebkova ◽  
E. Tchetina ◽  
L. Alekseeva
Keyword(s):  
Body Weight ◽  
Knee Pain ◽  
Mammalian Target Of Rapamycin ◽  
Clinical Manifestations ◽  
Normal Weight ◽  
Womac Pain ◽  
Obese Patients ◽  
Normal Body ◽  
Knee Oa ◽  
Normal Body Weight

Background:Currently, a large number of molecular biological and genetic markers are known to be involved in the development of osteoarthritis (OA). The mammalian target of rapamycin (mTOR) signaling pathway is responsible for chondrocyte proliferation, cartilage matrix production, and cell growth. OA is characterized by increased mTOR synthesis, which is accompanied by an increase in proliferative activity and destruction of chondrocytes. Obesity is an important factor in the progression of knee OA. The study of mTOR expression in patients with OA and obesity is an urgent task in the development of personalized OA therapy.Objectives:To determine the expression of mTOR in patients with knee OA in combination with obesity and normal body weight. To evaluate the effect of mTOR on the clinical manifestations of OA in patients with different body mass index (BMI).Methods:The study included 73 female patients aged 45-65 y.o. with Kellgren-Lawrence stage II-III knee OA. The patients were divided into 2 groups: group 1 (n=50) with obesity (BMI > 30 kg / cm2) and group 2 (n=23) with normal or increased body weight (BMI < 30 kg/cm2). The average age of patients with obesity is 56.5 ± 5.87 years, without obesity - 58.7 ± 5.43 years. Clinical manifestations were evaluated by a WOMAС. RNA was isolated from the patients ‘ blood samples, which was used to determine the expression of mTOR.Results:Patients with knee OA with and without obesity did not differ in age. OA develops at an earlier age in obese patients, than in non-obese patients (p < 0.001). Patients from 1 group had a high BMI > 30 kg/m2 at the onset of OA. Obese patients had more severe knee OA is significantly more often detected: Kellgren-Lawrence stage III was determined in 10% of obese patients and in 4.35% - without obesity (p < 0.001). Significantly higher values of the WOMAC index pain, stiffness, joint functional failure, and total WOMAC were observed in obese patients (p = 0.006, p = 0.039, p = 0.037, and p = 0.014, respectively). Obese patients had higher VAS pain scores (p < 0.05) compared to patients with a lower BMI. Obese patients had a higher mTOR expression (p < 0.05) of 8.02±8.62, compared to non-obese patients. High mTOR expression was associated with VAS knee pain (r=0.78; p < 0.05) and WOMAC pain (r=0.89; p<0.05) in obese patients (Table 1).Table 1.Correlation of m-TORParametersmTOR (1 group, n=50)mTOR (2 group, n=23)Body weightр > 0,05р > 0,05Pain (VAS)r=0,78; р<0,05p = 0,07; r = 0,45Pain (WOMAC)r=0,89; р<0,05р > 0,05Total WOMACр > 0,05р > 0,05Conclusion:Our study showed that patients with obesity and knee OA have higher rates of mTOR expression, compared to patients with normal body weight. High mTOR expression correlates with the severity of knee pain in obese patients. Thus, the evaluation of mTOR expression in obese patients and knee OA plays an important role in predicting the severity of clinical manifestations of OA, and may influence the choice of personalized therapy tactics for such patients.Disclosure of Interests:None declared

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