scholarly journals Klotho and fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity and their associations with metabolic parameters

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Anna Socha-Banasiak ◽  
Arkadiusz Michalak ◽  
Krzysztof Pacześ ◽  
Zuzanna Gaj ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Body Weight ◽  
Growth Factors ◽  
Children And Adolescents ◽  
Fibroblast Growth Factors ◽  
Metabolic Parameters ◽  
Fibroblast Growth ◽  
Serum Concentrations ◽  
Normal Body ◽  
Normal Body Weight

scholarly journals Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

2020 ◽  
Author(s):  
Anna Socha-Banasiak ◽  
Arkadiusz Michalak ◽  
Krzysztof Pacześ ◽  
Zuzanna Gaj ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Serum Concentrations ◽  
Normal Body ◽  
Normal Body Weight

Abstract Background: Fibroblast growth factor 19 (FGF19), Fibroblast growth factor 21 (FGF21) and Klotho are regulators of energy homeostasis. However, in the paediatric population the relationship between obesity, metabolic disorders and mentioned factors has not been clearly investigated. We analysed serum concentrations of FGF19, FGF21 and Klotho in children and adolescents with normal body weight as well as in overweight and obese subjects – and their associations with components of metabolic syndrome and insulin resistance (IR).Methods: The cross-sectional study conducted in the group of hospitalised children and adolescents. Laboratory investigation included serum ELISA tests for FGF19, FGF21, Klotho as well as lipid profile and oral glucose tolerance test for calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The clinical analysis included blood pressure measurement, body fat percentage estimation and assessing the prevalence of metabolic syndrome (MS) and its components. Results: The study was conducted on 174 children/adolescents aged 6-17 years divided into the following groups: with normal body weight (N=48), with obesity (N=92) and overweight subjects (N=34). Klotho levels were significantly higher in the group of subjects with obesity [median 168.6 pg/ml]) than those with overweight [131.3 pg/ml] and normal body weight [116.6 pg/ml] (p=0.0334). Median serum FGF21 level was elevated in the group of patients with MS in comparison to other subjects [136.2 pg/ml vs 82.6 pg/ml, p=0.0285]. Increased Klotho concentrations were noted in patients affected by IR compared with subjects with normal insulin sensitivity [185.3 pg/ml vs 132.6 pg/ml, p=0.0282]. Multivariable model for HOMA-IR showed FGF19 as an independent predictor for IR after adjusting for the pubertal stage and BMI Z-score.Conclusions: Klotho levels were associated with body weight status in children and adolescents. Moreover, Klotho, FGF19 and FGF21 concentrations correlated with IR status and traits of MS.

scholarly journals Cardiopulmonary Capacity in Overweight and Obese Children and Adolescents: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Agata Grzyb ◽  
Małgorzata Domagalska-Szopa ◽  
Andrzej Siwiec ◽  
Ilona Kwiecień-Czerwieniec ◽  
Andrzej Szopa
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Cardiopulmonary Exercise Testing ◽  
High Body Mass Index ◽  
Normal Weight ◽  
Control Group ◽  
Overweight Children ◽  
Obese Children ◽  
Normal Body ◽  
Normal Body Weight

Background: One of the objective methods of assessing the level of cardiopulmonary capacity in overweight and obese children and adolescents is cardiopulmonary exercise testing (CPET).Aims: The purpose of present study is an evaluation of aerobic capacity in high body mass index (BMI) children and adolescents by comparing them with a normal weight control group by CPET.Methods and Procedures: The subjects were recruited from participants of the Program of Treatment for Overweight and Obese Children organized by a local pediatric rehabilitation center in Poland. Based on BMI for age and gender, two validation groups were selected: (1) a group of overweight children (n = 49) and (2) a group of obese children (n = 48). The study included also 53 normal weight participants as a reference group (REF). The study consisted of two parts: anthropometric measurements and CPET. The Godfrey protocol for CPET was applied.Outcomes and Results: In this study, obese children and adolescents showed similar absolute VO2peak values in liters per minute (1.64 L/min) compared to overweight children (1.48 L/min), but significantly higher than children with normal body weight (1.39 L/min). The obese children and adolescents presented lower VO2peak in relation to body weight (25.44 ml/kg/min) compared to their peers with normal body weight (36.5 ml/kg/min), and overweight children (29.18 ml/kg/min).Conclusion and Implications: The main finding of our study was recognition of significant differences between cardiopulmonary capacity parameters in obese children in comparison not only to normal weight peers, but to overweight, too.

scholarly journals PECULIARITY PERSONALITY OF ADOLESTENTS WITH ESSENTIAL ARTERIAL HYPERTENSION AND OVERWEIGHT/OBESITY

2019 ◽  
Vol 15 (1-2) ◽  
pp. 69-73
Author(s):  
O.M. Misiura ◽  
M.V. Khaitovych
Keyword(s):  
Body Weight ◽  
Essential Hypertension ◽  
Children And Adolescents ◽  
Overweight And Obesity ◽  
Personality Characteristics ◽  
Emotional Instability ◽  
Psychological Study ◽  
Normal Body ◽  
Normal Body Weight ◽  
Comparative Group

Relevance. Recent changes in lifestyle and diet have led to a significant increase of overweight and obesity among children and adolescents. According to the results of our previous studies, it was found that among adolescents with overweight/obesity, essential hypertension is 1,5-7,5 times more common than among peers. It is known that children and adolescents with obesity are inherent in emotional instability and impulsivity. Objective of this work was to study the personality characteristics of adolescents with essential hypertension and overweight/obesity. Materials and methods. In the Kiev Children's Clinical Hospital No. 6, a comprehensive clinical and psychological study of 67 adolescents (18 girls, 49 boys) aged 12-17 years (average of 14,40±1,63 years) was carried out, who were hospitalized for essential hypertension. Overweight was found in 7 girls and 21 boys, obesity - in 2 girls and 8 boys. The remaining patients (9 girls and 20 boys) had normal body weight (comparative group). We evaluated the level of anxiety, alexithymia, depression, the type of attitude to the disease, and also determined the personality characteristics of the patients. Results. Adolescents with essential hypertension and overweight/obesity on average differed significantly higher pulse daily blood pressure (61,98±8,13 mmHg versus 57,02±6,70; P<0,005), lower values of anxiety scales (5,11±4,77 points versus 9,62±7,72 points; P<0,01), hypochondria (5,70±5,20 points versus 9,00±5,20 points; P<0,05), neurasthenia (7,19±7,49 points versus 11,14±7,90 points; P<0,05) and egocentrism (5,70±4,44 points versus 8,57±5,08 points; P<0,05) related to TOBOL test. According to the personality test R.-B. Kettell in adolescents with overweight/obesity was on average higher level Q2 scale (6,72±2,14 points versus 4,91±2,63 points; P<0,05). Conclusion. Adolescents with essential hypertension and overweight, obesity, in contrast to patients with normal body weight, are less neurotic by the disease, but they are characterized by non-conformity.

scholarly journals Adherence to dietary recommendations by children and adolescents during steroid therapy in acute lymphoblastic leukemia

2020 ◽  
Vol 19 (3) ◽  
pp. 146-154
Author(s):  
Marta Hadaś ◽  
Anna Stefanowicz-Bielska
Keyword(s):  
Body Weight ◽  
Acute Lymphoblastic Leukemia ◽  
Children And Adolescents ◽  
Steroid Therapy ◽  
Lymphoblastic Leukemia ◽  
Dietary Recommendations ◽  
Normal Body ◽  
Normal Body Weight ◽  
The University ◽  
Low Glycemic Index

AbstractAim. Assessment of adherence to dietary recommendations by children and adolescents during steroid therapy in the treatment of acute lymphoblastic leukemia (ALL).Material and methods. The study was conducted among parents of children with ALL, aged from 1 to 17 years, treated at the Department of Paediatrics, Hematology and Oncology of the University Clinical Centre in Gdańsk. The paper uses the method of a diagnostic survey, the questionnaire technique. The research tool was an anonymous self-constructed questionnaire.Results. The study included 16 parents (44.4%) of female children and 20 parents (55.6%) of male children. Normal body weight was found in most of the children (22/36 children). Grade 1 hypertension was found in 15/36 children and grade 2 hypertension in 6/36. In 31/36 children, the blood glucose level was 70-180 mg%. The number of 22/36 examined children used a diet with a low glycemic index. As many as 29/36 parents of children and adolescents with ALL followed the diet recommended by a doctor.Conclusions. 1) Most children with ALL have normal body weight during steroid therapy. 2) Children with ALL are subject to arterial hypertension during steroid therapy. 3) Most parents or legal guardians of children and adolescents with ALL adhered to dietary recommendations during steroid therapy.

Cytogenetics, Immunostaining for Fibroblast Growth Factors, p53 Sequencing, and Clinical Features of Two Cases of Cystosarcoma Phyllodes

2000 ◽  
Vol 5 (3) ◽  
pp. 179-190 ◽  
Author(s):  
PAUL V. WOOLLEY ◽  
SUSANNE M. GOLLIN ◽  
WAHEEB RISKALLA ◽  
SYDNEY FINKELSTEIN ◽  
DAVID F. STEFANIK ◽  
...  
Keyword(s):  
Growth Factors ◽  
Clinical Features ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
Cystosarcoma Phyllodes

Implications of Fibroblast Growth Factors (FGFs) in Cancer: From Prognostic to Therapeutic Applications

2019 ◽  
Vol 20 (8) ◽  
pp. 852-870
Author(s):  
Hassan Dianat-Moghadam ◽  
Ladan Teimoori-Toolabi
Keyword(s):  
Growth Factors ◽  
Wound Repair ◽  
Fibroblast Growth Factors ◽  
Predictive Biomarkers ◽  
Fibroblast Growth ◽  
Loss Of Function ◽  
Cellular Processes ◽  
Fgfr Signaling ◽  
Proliferation And Metastasis ◽  
Immense Potential

Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further trigger a variety of cellular processes including angiogenesis, evasion from apoptosis, bone formation, embryogenesis, wound repair and homeostasis. Four major mechanisms including angiogenesis, inflammation, cell proliferation, and metastasis are active in FGF/FGFR-driven tumors. Furthermore, gain-of-function or loss-of-function in FGFRs1-4 which is due to amplification, fusions, mutations, and changes in tumor–stromal cells interactions, is associated with the development and progression of cancer. Although, the developed small molecule or antibodies targeting FGFR signaling offer immense potential for cancer therapy, emergence of drug resistance, activation of compensatory pathways and systemic toxicity of modulators are bottlenecks in clinical application of anti-FGFRs. In this review, we present FGF/FGFR structure and the mechanisms of its function, as well as cross-talks with other nodes and/or signaling pathways. We describe deregulation of FGF/FGFR-related mechanisms in human disease and tumor progression leading to the presentation of emerging therapeutic approaches, resistance to FGFR targeting, and clinical potentials of individual FGF family in several human cancers. Additionally, the underlying biological mechanisms of FGF/FGFR signaling, besides several attempts to develop predictive biomarkers and combination therapies for different cancers have been explored.

Sign in / Sign up

Export Citation Format

Share Document