scholarly journals The safety evaluation of ethanol extract of torbangun leaves (Coleus amboinicus Lour.) on mouse fetal development

2018 ◽  
Vol 13 (1) ◽  
pp. 27-32
Author(s):  
Elma Alfiah ◽  
Muhammad Rizal Martua Damanik ◽  
Katrin Roosita ◽  
Mokhamad Fahrudin
Keyword(s):  
Fetal Development ◽  
Safety Evaluation ◽  
Ethanol Extract ◽  
Coleus Amboinicus

scholarly journals EFEKTIVITAS SALEP KOMBINASI EKSTRAK DAUN BANGUN – BANGUN (Coleus amboinicus Lour.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) SEBAGAI OBAT LUKA SAYAT

2020 ◽  
Vol 3 (1) ◽  
pp. 48-56
Author(s):  
Rika Puspita Sari
Keyword(s):  
Wound Healing ◽  
Single Dose ◽  
Elaeis Guineensis ◽  
Ethanol Extract ◽  
Rabbit Skin ◽  
Treatment Groups ◽  
Healing Wound ◽  
Elaeis Guineensis Jacq ◽  
Coleus Amboinicus ◽  
All Treatment

Bangun-bangun leaves and palm leaves contain various secondary metabolites such as tannins, alkaloids and flavonoids which can healing wound. The aim of this study was to determine the effect of ointment combination of ethanol extract of leaves of bangun- bangun (Coleus amboinicus Lour.) And ethanol extract of palm leaves (Elaeis guineensis Jacq.) In healing wound. The bangun- bangun leaves and the palm leaves are separated from the petiole and then dried in a drying cupboard so that it becomes a simplisia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. Thick extracts from the leaves of bangun- bangun and palm leaves are then formulated into ointment preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Next mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using surgical scissors that have been sterilized first with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 23 experienced changes in wound diameter. The combination ointment of ethanol extract of leaves wake-up (EEDB) 10% and ethanol extract of palm oil leaves (EEDKS) 10% have a more effective effect in wound healing than single dose.

scholarly journals THE EFFECTIVENESS OF COLEUS AMBOINICUS LEAF EXTRACTS AS AN ANALGETIC ACTIVITY ON MICE EXPOSURED TO ACETIC ACID

2018 ◽  
Vol 11 (9) ◽  
pp. 301 ◽  
Author(s):  
Yunita Sari Pane ◽  
Sufitni Sufitni ◽  
Fitriani Lumongga ◽  
Nurfida Alrasyid ◽  
Dini Permata Sari ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Water Extract ◽  
Ethanol Extract ◽  
Mean Value ◽  
Leukocyte Migration ◽  
Leaf Extracts ◽  
Mean Values ◽  
Treatment Groups ◽  
Coleus Amboinicus ◽  
All Treatment

Objective: This study aims to observe the analgesic activity of Bangun-bangun (Coleus amboinicus) leaves by induction of pain arising from chemical excitement after exposure to acetic acid.Methods: The effectiveness test of water extract and ethanol extract of Bangun-bangun leaves as an analgesic was measured by comparing the mean of quantitative and the writhing between control and treatment group. In addition, observations on the decrease in inflammatory processes occurred by calculating the reduction in the number of leukocyte migration to the inflammatory area.Result: The decrease of excitatory pain in all treatment Groups (I-IV) were significantly different. The comparison of mean values ± SEM decreased excitatory pain Groups I-II (255.00±22.22; 88.33±14.58), p=0.000. Groups I-III (255.00±22.22; 60.00±10.04), p=0.000 and Groups I-IV (255.00±22.22; 50.83±3.09), p=0.000. On histopathology examination, all treatment groups were significantly different (p=0.006). The comparison of mean value ± SEM decrease number of leukocyte Groups I-II (31.73±5.22; 14.70±3.71), p=0.025. Groups I-III (31.73±5.22; 15.67±3.22), p=0.036 and Groups I-IV (31.73±5.22; 11.77±2.77), p=0.008. However, the comparison of decrease of excitatory of pain and number of leukocyte migration between each group did not show significantly different (p>0.05).Conclusions: This study concluded that the Bangun-bangun leaves both in the form of water extract and ethanol extract proved efficacious as a pain reliever in the mice after induction of acetic acid.

Safety Evaluation of Crude Ethanol Extract of Waltheria Indica Linn. Root In Male Wistar Rats

2021 ◽  
Vol 3 (1) ◽  
pp. 112-125
Author(s):  
A. Basiru
Keyword(s):  
Wistar Rats ◽  
Safety Evaluation ◽  
Ethanol Extract ◽  
Serum Levels ◽  
Hepatic Necrosis ◽  
Control Group ◽  
Percentage Increase ◽  
Male Wistar Rats ◽  
Group A ◽  
Renal Tubular

Safety evaluation of Waltheria indica Linn. root was carried out in Wistar rats. Twenty adult male Wistar rats were randomly divided into four groups (n=5); A–D. Group A served as control group while groups B, C and D were administered with 200, 400 and 800 mg/Kg of crude ethanol extract of Waltheria indica Linn. root. After 28 days of administration, the rats were sacrificed and blood samples were collected and serum prepared. Haematological and biochemical parameters, as well as serum electrolyte were determined according to standard procedures. The 200 mg/Kg of Waltheria indica Linn. root caused the highest percentage increase in body weight. The kidney was also significantly increased at 400 mg/kg. The total WBC and lymphocytes counts were significantly increased at 400 mg/kg. The serum levels of ALT and chloride were significantly increased at 800 mg/kg. Waltheria indica Linn. root also caused hepatic necrosis and renal tubular degeneration in Wistar rats. Therefore, Waltheria indica Linn. root should be used with caution especially at higher dose despite its therapeutic potentials.

Sub-chronic safety evaluation of the ethanol extract of Aralia elata leaves in Beagle dogs

2016 ◽  
Vol 79 ◽  
pp. 1-11 ◽  
Author(s):  
Fengjin Li ◽  
Xiaoli He ◽  
Wenying Niu ◽  
Yuenan Feng ◽  
Jingqi Bian ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Ethanol Extract ◽  
Beagle Dogs ◽  
Aralia Elata

scholarly journals EFEK PENYEMBUHAN LUKA BAKAR GEL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia Amygdalina) DAN EKSTRAKETANOLDAUNBANGUN–BANGUN(ColeusamboinicusLour)

2020 ◽  
Vol 3 (1) ◽  
pp. 57-61
Author(s):  
Nina Irmayanti Harahap
Keyword(s):  
Ethanol Extract ◽  
Effective Control ◽  
Vernonia Amygdalina ◽  
Positive Group ◽  
Healing Wound ◽  
Coleus Amboinicus

african leaves ( Vernonia Amygdalina )and wake-up leaves (Coleus amboinicus Lour)are plants traditional plants that are used as medicine. Leaves african which is contain flavonoid, saponin, tanin and leaves wake up which is contain flavonoid, tanin, saponin and steroid. This study to find aims out as effect healing of burns.Method : Sample in this study was african leaves and wake-up leaves which were taken purposively without comparing sampel from other regions, then extrated by maceration using ethanol 96 %. Result : Testing of rhe healing effects of burns can be divided in five treatment, positive group using biolacenton , negatif group using basis gel and the last group using the extract ethanol gel EEDA and EEDB concentrations of 4%+2,5%,8%+5%,16%+10%. Given burns to the back of rabbits length with of 2cm, and the gel is applied twice a day for 11 day and diameter measured of the wound. Conclusion : The combination of EEDA and EEDA the ethanol extract the concentration of 16% + 10% was the effective control for healing burns. When compared bioplacenton gel as a healing wound in rabbit.

scholarly journals Neem Leaf (Azadirachta indica A. Juss) Ethanolic Extract on the Liver and Kidney Function of Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Irma Seriana ◽  
Muslim Akmal ◽  
Darusman Darusman ◽  
Sri Wahyuni ◽  
Khairan Khairan ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Herbal Medicines ◽  
Safety Evaluation ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Male Rats ◽  
Control Group ◽  
Tropical Plants ◽  
Neem Leaves ◽  
Liver And Kidney

Neem (Azadirachta indica A. Juss) is one of the tropical plants found in Indonesia that has been used to prevent and treat various diseases. This study aimed to investigate the effect of the ethanol extract of neem leaves on the concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in male rats. Twenty-four male Wistar rats were randomly divided into four groups (T0, T1, T2, and T3) with 6 rats in each group. T0 is the control group, and T1, T2, and T3 are the treatment groups that were administered 100, 200, and 300 mg/kg body weight of neem leaf ethanolic extracts for 48 days, respectively. On day 49, blood samples were collected to measure the concentration of AST, ALT, creatinine, and urea followed by an evaluation of liver and kidney histology. The results showed that the ethanolic extract of neem leaves did not affect the concentration of AST, ALT, and creatinine, The ethanol leaves reduced extract on the urea concentration, no abnormal changes were observed in the liver and kidney organs. In the future, it is required to carry out a comprehensive safety evaluation of the neem leaf ethanol extract for herbal medicines.

scholarly journals Passionflower Extract Improves Diurnal Quality of Life in Japanese Subjects with Anxiety: A Randomized, Placebo-controlled, Double-blind Trial

2019 ◽  
Vol 9 (5) ◽  
pp. 312
Author(s):  
Tsuyoshi Takara ◽  
Kazuo Yamamoto ◽  
Naoko Suzuki ◽  
Marina Hirano ◽  
Norihito Shimizu ◽  
...  
Keyword(s):  
Placebo Group ◽  
Short Form ◽  
Random Number Generator ◽  
Safety Evaluation ◽  
Ethanol Extract ◽  
Japanese Version ◽  
Controlled Study ◽  
Flavonoid Glycosides ◽  
Double Blind ◽  
Sf 36

Background and objective: Passiflora incarnata (passionflower) has traditionally been used to treat insomnia and anxiety. We recently reported that an aqueous ethanol extract of passionflower (PFE) and its flavonoid glycosides enhanced the expression of Period (Per) 2, a clock gene, in mouse liver and fibroblasts. However, the influence of PFE on daily activities or emotions has not been examined in humans. Therefore, we conducted a clinical trial of PFE supplementation in healthy Japanese subjects.Methods: This randomized, double-blind, placebo-controlled study examined the effects of PFE (200 mg daily) containing 3% flavonoid glycosides (6 mg daily). We enrolled 44 Japanese men and women who were reluctant to work or doing house chore or engaging in irregular flame works. All subjects were randomly allocated into either the PFE group (n=22) or the placebo group (n=22) using a computerized random-number generator. Capsules containing either PFE or placebo were administered for 12 weeks between August 2017 and January 2018. Emotional status and sleep quality were evaluated by using the Japanese version of Medical Outcomes Study Short-Form 36-Item Health (SF-36) questionnaire and the Oguri-Shirakawa-Azumi (OSA) sleep inventory score at 6- and 12-week of ingestion.Results: The per protocol set comprised 20 subjects in the PFE group and 18 subjects (20 subjects for OSA and safety evaluation) in the placebo group. After intake of PFE (200 mg/day) for 6 weeks, some of the SF-36 domain scores were significantly improved compared with those of the placebo group, including the scores for role/social component summary, social functioning, and role-emotional. After 12 weeks, the scores for mental component summary and vitality showed significant improvement in the subjects taking PFE (200 mg/day) compared to those taking placebo. In contrast, none of the OSA sleep score parameters were significantly improved by PFE compared with placebo. Laboratory tests did not reveal any abnormalities suggesting adverse effects of PFE.Conclusions: Intake of PFE (200 mg/day for 12 weeks) improved several emotional parameters related to daytime social and mental activities. PFE was suggested to be useful for improving anxiety.

scholarly journals Biochemical and haematological safety evaluation of the ethanol extract of the stem bark of Blighia sapida using Swiss albino mice

2017 ◽  
Vol 2 (2) ◽  
pp. 21-28 ◽  
Author(s):  
Chinweizu Ejikeme Udobi ◽  
◽  
Betseabasi Edward Umoh ◽  
Ememobong Gideon Asuquo ◽  
◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Blighia Sapida

scholarly journals ANTI-BACTERIAL ACTIVITY OF ETHANOL EXTRACT OF INDIAN BORAGE (Coleus Amboinicus) LEAVES AGAINST BACILLUS CEREUS

2021 ◽  
Vol 7 (1) ◽  
pp. 30-34
Author(s):  
Maya Sari Mutia ◽  
Elvia Annisa ◽  
Suhartomi Suhartomi
Keyword(s):  
Antibacterial Activity ◽  
Bacillus Cereus ◽  
Antibacterial Effect ◽  
Ethanol Extract ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Activity Increase ◽  
Significant Difference ◽  
Coleus Amboinicus

Bacillus cereus is aerobic, positive gram, and spore-forming bacilli bacteria. The enterotoxin of this bacteria can cause food poisonous that manifest as diarrhea and vomitus. Some previous study has been performed to explore the antibacterial effect of Indian borage leaf, but none of them were explore the antibacterial effect of Indian borage against Bacillus cereus. Hence this study was design to explore the antibacterial activity of ethanol extract of Indian borage against Bacillus cereus. This was an experimental study with post only control group design. Ethanol extract was extracted by maceration methods and antibacterial activity against Bacillus cereus was evaluated by disc diffusion methods. The obtained ethanol extract was dissolved into some concentraions (1 g/ml, 0.8 g/ml, 0.6 g/ml, 0.4 g/ml, 0.2 g/ml). Data was analysed by One Way ANOVA and followed by Post hoc Test Tukey HSD using SPSS 25. Ethanol extract of Coleus amboinicus showed significant difference at the two highest concentration group against the lowest concentration (P- Value < 0.05). The average of inhibition zone diameter from the lowest (0.2 gr/ml) and highest (1.0 gr/ml) concentration were 14.87 mm and 31.50 mm, respectively. Overall, ethanol extract of Indian borage leaves had potential antibacterial activity against Bacillus cereus. This antibacterial activity increase followed by the increase of the concentration.

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