scholarly journals Hierarchical organization of the blood pressure regulation system in the human body

2021 ◽  
pp. 26-33
Author(s):  
В.М. Покровский ◽  
Л.Н. Елисеева ◽  
Н.А. Самородская
Keyword(s):  
Blood Pressure ◽  
Treatment Effectiveness ◽  
Methodological Approach ◽  
The Body ◽  
Hierarchical Organization ◽  
Regulation System ◽  
Control Group ◽  
Adaptive Capabilities ◽  
The Status ◽  
Proper Values

Цель исследования - создание на основе анализа нарушений механизмов системы регуляции артериального давления (АД) нового методологического подхода в определении эффективности антигипертензивной терапии у пациентов с гипертонической болезнью. Методика. В исследование включены данные 277 пациентов (136 мужчин, 141 женщина) с гипертонической болезнью II стадии 1-2 степени, риск II, III. Возраст пациентов 58,6±6,4 лет, давность заболевания 7,2±1,4 лет. В группу контроля вошли 57 практически здоровых лиц (25 женщин, 32 мужчины) в возрасте 52,1±4,4 года. После скрининга и получения письменного информированного согласия в виде монотерапии назначены: небиволол, лизиноприл, лозартан, индапамид, амлодипин, и нефиксированная комбинация лизиноприла и индапамида. Изучены изменения показателей АД на выделенных уровнях системы регуляции АД после 6 мес терапии. Результаты. Оценка эффективности применяемой терапии показала, что при стабилизации артериального давления у пациентов всех 6 групп на должном уровне существенные различия выявлены на интегративном уровне регуляции. При применении амлодипина, лозартана, лизиноприла, а также комбинации лизиноприла и индапамида регуляторно-адаптивные возможности организма улучшились, при лечении индапамидом - не изменились, при применении небиволола снизились. Предложена оригинальная классификация уровней регуляции (контроля) артериального давления у человека, основанная на общебиологическом принципе иерархической организации регуляции вегетативных функций. Выделены уровни: интегративный, вегетативного обеспечения (осуществляемый автономной нервной системой), органный, периферический (эндотелиально-микроциркуляторный). Заключение. Количественная оценка на интегративном уровне является универсальным показателем эффективности лечения, что открывает возможность создания методологического подхода, основанного на оценке влияния терапевтических воздействий не только на орган- или функцию-мишень, но и на состояние организма как целостной системы. Aim. To create a new methodological approach for determining the effectiveness of antihypertensive therapy in patients with arterial hypertension based on the analysis of violation of mechanisms in the blood pressure (BP) regulation system. Methods. This study included 277 patients (136 males, 141 females) with stage II, grade 1-2 hypertension, risk II, III, aged 58.6±6.4 yrs, with disease duration 7.2±1.4 yrs. The control group included 57 essentially healthy individuals (25 females, 32 males) aged 52.1±4.4 yrs. After screening and obtaining written informed consent, the following monotherapy was prescribed: nebivolol, lisinopril, losartan, indapamide, and amlodipine, plus an unfixed combination of lisinopril and indapamide. Changes in BP indexes at the predetermined levels of the BP regulation system were studied after 6 mos. of treatment. Results. Evaluation of the therapy effectiveness showed that, when BP was stabilized in all six groups at proper values, significant differences were revealed at the integrative regulatory level. When patients were treated with amlodipine, losartan, lisinopril, as well as a combination of lisinopril and indapamide, the regulatory and adaptive capabilities of the body improved. When treated with indapamide, these capabilities were unchanged, and when treated with nebivolol, these capabilities decreased. A new classification of the regulatory levels of BP control in humans is proposed. This classification is based on the general biological principle of hierarchical organization for the regulation of autonomic functions. The following levels are distinguished: integrative, autonomic support, i.e., carried out by the autonomic nervous system, organ, and peripheral, i.e., endothelial-microcirculatory. Conclusion. Quantitative assessment at the integrative level is a universal indicator of the treatment effectiveness. It makes it possible to create a methodological approach to determine possible effectiveness of treatment based on the assessed impact not only on the target organ or function, but also on the status of the body as a whole system.

Burnout of the Mind – Burnout of the Body?

2018 ◽  
Vol 32 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Claudia Traunmüller ◽  
Kerstin Gaisbachgrabner ◽  
Helmut Karl Lackner ◽  
Andreas R. Schwerdtfeger
Keyword(s):  
Blood Pressure ◽  
Allostatic Load ◽  
Maslach Burnout Inventory ◽  
The Body ◽  
Lower Percentage ◽  
Control Group ◽  
Urinary Catecholamines ◽  
Morning Cortisol ◽  
The Mind ◽  
Cortisol Increase

Abstract. In the present paper we investigate whether patients with a clinical diagnosis of burnout show physiological signs of burden across multiple physiological systems referred to as allostatic load (AL). Measures of the sympathetic-adrenergic-medullary (SAM) axis and the hypothalamic-pituitary-adrenal (HPA) axis were assessed. We examined patients who had been diagnosed with burnout by their physicians (n = 32) and were also identified as burnout patients based on their score in the Maslach Burnout Inventory-General Survey (MBI-GS) and compared them with a nonclinical control group (n = 19) with regard to indicators of allostatic load (i.e., ambulatory ECG, nocturnal urinary catecholamines, salivary morning cortisol secretion, blood pressure, and waist-to-hip ratio [WHR]). Contrary to expectations, a higher AL index suggesting elevated load in several of the parameters of the HPA and SAM axes was found in the control group but not in the burnout group. The control group showed higher norepinephrine values, higher blood pressure, higher WHR, higher sympathovagal balance, and lower percentage of cortisol increase within the first hour after awakening as compared to the patient group. Burnout was not associated with AL. Results seem to indicate a discrepancy between self-reported burnout symptoms and psychobiological load.

scholarly journals Pengaruh Aromaterapi Lavender secara Masase terhadap Tekanan Darah dan Tingkat Stres Mahasiswa Jurusan Keperawatan Poltekkes Palangka Raya

2020 ◽  
Vol 5 (2) ◽  
pp. 100-107
Author(s):  
Reny Sulistyowati ◽  
Syam�ani Syam�ani
Keyword(s):  
Blood Pressure ◽  
Univariate Analysis ◽  
T Test ◽  
The Body ◽  
Bivariate Analysis ◽  
Control Group ◽  
P Value ◽  
Stress Levels ◽  
Before And After ◽  
Distress Scale

Stress is an individual's adaptive response to various external pressures or demands and produces a variety of disorders including physical, emotional and behavioral disorders. Final year students often experience feelings of stress so that it can interfere with concentration to attend lectures and can even hamper completing education in a timely manner. There are several ways of managing stress, one of which is using aromatherapy. Aromatherapy is a non-pharmacological therapy, which is a type of therapy that applies direct body contact and has a therapeutic effect that combines physiological effects, caused by massage on the body, with psychological effects, which are derived from essential oils. The general purpose of the study is to analyze the effect of aromatherapy on blood pressure and stress levels by using the Kessler Psychological Distress Scale in final semester students. The research method used a quasi-experimental design with a pretest-posttest control group design approach, in 28 intervention groups, namely respondents who were given lavender aromatherapy massage and 28 respondents in the control group. The univariate analysis was conducted to show frequency distribution and bivariate analysis was conducted by independent sample T-test and dependent sample T-test. The results showed that there were significant differences in systolic blood pressure before and after the intervention in the intervention and the control group with a p-value of 0.01 < 0.05. Whereas the stress level variable found that there is no difference in stress levels in the intervention and the control group before and after the intervention with p-value 0.169> 0.05.

scholarly journals The Effect of Oxymel Syrup on Some Cardiovascular Risk Factors in Overweight and Obese People: A Randomized Controlled Trial Study

2021 ◽  
Author(s):  
Marjan Mahdavi Roshan ◽  
Arsalan Salari ◽  
Sogol Emaminejad ◽  
Shirin Parvinroo ◽  
Asieh Ashouri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Controlled Trial ◽  
Test Group ◽  
The Body ◽  
Risk Indicators ◽  
Blood Cholesterol ◽  
Control Group ◽  
Obese People

High blood pressure, diabetes, hyperlipidemia and obesity are risk factors for cardiovascular diseases. With regard to the significant role of a healthy diet in the prevention and even treatment of diseases together with the high cost and side effects of drugs, finding foods effective in the treatment of metabolic disorders has been widely considered. This study aimed to evaluate the effect of oxymel – an Iranian traditional syrup with vinegar base – on cardiovascular risk indicators in obese and overweight people. Candidates were selected based on a set of inclusion criteria and were divided into two groups of control and test. The control group received 250 cc of water, while the test group received 250 cc water containing 30 cc of the oxymel for 30 days. Anthropometric and biochemical indicators were measured at the beginning and end of the study. The results showed that there were no significant changes in the body mass index, waist circumference, hip circumference, waist to hip ratio, HDL, LDL, Triglycerides, systolic and diastolic blood pressure, and blood glucose level. However, weight (P = 0.053) and cholesterol (P = 0.083) decreased relatively significantly in the test group compared to the control group. This study shows that consumption of oxymel has positive cardiovascular effects such as lowering the blood cholesterol level and can contribute to weight loss; however, studies with a larger sample size are recommended.

scholarly journals The Effects of Moderate and High-Intensity Interval Training in Cardiac Rehabilitation of Bodybuilders with Arterial Hypertension: a Randomized Controlled Trial

2020 ◽  
Vol 100 (6) ◽  
pp. 108-113
Author(s):  
A.B. Miroshnikov ◽  
A.D. Formenov ◽  
A.B. Smolensky
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
High Intensity ◽  
Controlled Trial ◽  
Sport Activity ◽  
Interval Training ◽  
Training Group ◽  
The Body ◽  
Control Group ◽  
High Intensity Interval

Athletes of power sports, often appear to us as a model of a beautiful and healthy body, but the health of the cardiovascular system ofthese athletes has long falls under the gaze of cardiologists and sport physicians. Purpose of the study. A comparative analysis of the influence of a uniform and high-intensity aerobic exercise on blood pressure lowering power sports athletes with hypertension. Research Methods. The study involved 83 representatives of power sports (bodybuilding) with arterial hypertension. The average age of male athletes was 31.2 ± 4.5 years, and the body mass index was 32.4 ± 2.8 kg/m 2. To achieve this goal, the following methods were used: examination, interrogation, triple measurement of blood pressure, ergospirometry and methods of mathematical statistics. Athletes were randomized into three groups: interval training group (n = 33), uniform training (n = 30) and control group (n = 20). For 120 days (3 times a week), the athletes of the main groups performed various aerobic work programs, and the control group athletes trained according to their traditional strength protocol. Results. After 120 days of physical rehabilitation, a similar, significant decrease in systolic and diastolic blood pressure occurred in themain intervention groups. A decrease in blood pressure in the control group was not statistically significant. Conclusions. Despite the similar benefits in cardio-rehabilitation interval work required 38% less time, which can significantly affect adherence to a non-specific for this sport activity and screening of participant’s lengthy rehabilitation.

scholarly journals Penurunanan Tekanan Darah pada Lansia Hipertensi dengan Senam Ergonomik

2020 ◽  
Vol 5 (1) ◽  
pp. 71
Author(s):  
Sri Muharni ◽  
Utari Christya Wardhani
Keyword(s):  
Blood Pressure ◽  
Time Series ◽  
Pharmacological Therapy ◽  
T Test ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Purposive Sampling ◽  
Group Time ◽  
Paired T Test

<div class="Section1"><p><em><em>Hypertension is one of the most common cardiovascular problem in elderly.  Prolonged high blood pressure canlead to destructionof the blood vessels throughout the body. However it can be controlled with pharmacology and non-pharmacology technique, one of the non-pharmacological therapy is ergonomic exercise. Ergonomic exercise is the gymnastic motion which is combined with breathing techniques. This study aimed was to know about the effect of ergonomic exercise to decreasing blood pressure in elderly with hypertensions in Community Health Center Sei Pancur region. The design was One Group Time Series, intervention given to one group only, without control group. Ergonomic exercise efectivity rated by comparing blood pressure pre and post exercise, during first, second, and third week. Sampling technique was used purposive sampling with 50 respondents. The respondents were given interventions four times. The data analysis used Paired T-Test and Annova Test. The results were shown that the blood pressure significantly decreased during fourth week, with p value: 0.00 for both systolic and diastolic blood pressure. As conclusions, ergonomic exercise had effect to decreasing blood pressure in elderly with hypertensions</em></em></p><p><em><br /></em></p><p><em>Hipertensi adalah salah satu masalah kardiovaskular yang sering terjadi pada lansia. Tekanan darah yang tinggi akan mengakibatkan kerusakan pembuluh darah di seluruh tubuh, kerusakan  tersebut dapat kita  kendalikan dengan terapi farmakologi maupun non farmakologi, salah satunya adalah senam ergonomik. Senam ergonomik adalah  suatu gerakan senam yang dikombinasikan dengan teknik pernapasan. Penelitian ini bertujuan untuk mengetahui pengaruh senam ergonomik terhadap penurunan tekanan darah  pada lansia  hipertensi di wilayah kerja Puskemas Sei Pancur. Desain dalam penelitian ini adalah One Group Time Series Design dengan mengintervensi satu kelompok saja tanpa kelompok pembanding. Efektifitas perlakukan senam ergonomik dinilai dengan cara membandingkan tekanan darah sebelum diberikan senam ergonomik dengan hasil tekanan darah setelah senam ergonomik minggu pertama,kedua dan ketiga. Dimana Teknik sampling yang digunakan adalah Purposive Sampling dengan jumlah sampel 50 responden. Pemberian sebanyak 4  kali intervensi. Analisa data menggunakan uji Paired T-Test dan Annova Test. Hasil penelitian menunjukkan bahwa tekanan darah mulai turun signifikan pada minggu ke-4, dengan nilai p = 0,00 untuk tekanan darah sistole dan 0,00 untuk tekanan darah diastol. Kesimpulan dalam penelitian ini adalah senam ergonomik berpengaruh terhadap penurunan tekanan darah pada lansia dengan hipertensi</em></p></div>

scholarly journals PO-259 Effect of 30%，50% and 70% VO2 max treadmill exercises on gut microbiome in hypertensive mice

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Jin Li ◽  
Wenting Shi ◽  
Pengyi Zhang
Keyword(s):  
Blood Pressure ◽  
Aerobic Exercise ◽  
Gut Microbiome ◽  
Pathogenic Bacteria ◽  
Exercise Group ◽  
The Body ◽  
National Standard ◽  
Control Group ◽  
Beneficial Bacteria ◽  
Vo2 Max

Objective Gut microbiome has a significant impact on human health through the interaction with host and environment, which is closely related to a series of chronic diseases. The diversity of gut microbiome and its metabolic disorder are the risk factor of hypertension. The changes of gut microbiome structure and abundance are closely related to the pathogenesis of hypertension, in which Bifidobacterium and lactic acid bacteria can bind with the hypotensive substances to show the hypotensive therapy. However, the diet and exercise have great impact on the structure and function of gut microbiome, and of which aerobic exercise could increase the ratio of gut beneficial bacteria to harmful bacteria effectively. The effect of treadmill exercise on gut microbiome of hypertensive mice was studied in this paper, which provided a theoretical basis for the prevention and treatment of hypertension by gut microbiome. Methods SPF Kunming mice were fed with 8% high salt diet for 6 weeks to make the hypertension model. Compared with the blood pressure of mice before the formal experiment, The standard was that the blood pressure of the experimental mice was increased by SBP >15% or DBP > 5%, which was indicated the model of hypertension was established successfully. The motion slope and velocity of the maximum oxygen uptake of 30%, 50%, and 70% were measured respectively. The mice were divided into 4 groups randomly according to their body weight, 10 mice/group. The 30% VO2 max, 50% VO2 max, and 70% VO2 max were exercised for 6 weeks as well as the control group. The mice were divided into cages and fed in accordance with the national standard rodent diet. The blood pressure of mice was measured weekly by tail pressure method (Tail-cuff).The abundance of Bifidobacterium, Bacteroides, Lactobacillus and Enterobacter in the gut microbiome of mice feces were tested by 16S sequencing every two weeks. The ratio of Firmicute / Bacteroides (F/B ratio) was also measured by sequencing as a parameter to reflect the disorder of gut microbiome. The ratio of Firmicutes / Bacteroides is almost equal 1, and the present study found that the F/B increased significantly in the hypertensive group. Real-time PCR was used to detect the changes of plasma inflammatory factors IL-1β, IL-6 and TNF-ɑ. The previous study had shown that the intestinal disorders can lead to an increase in pathogenic bacteria, further leading to the inflammation. Finally, the experimental data were analyzed by independent sample t-test. Results (1) After six weeks of exercise intervention, the blood pressure (132.87mm Hg±5.23mm Hg) of the exercise group was significantly lower than the control group (99.57mm Hg±7.47mm Hg), especially in the 50%VO2 max mice. (2) Compared with the rest group, the abundance of gut microbiome in the exercise group was increased, among which the number of Bifidobacteria, Lactobacillus, and Bacteroides were increased significantly, of which 50% of VO2 max group increased most significantly, and the number of Enterobacter was less than the control group (p<0.05). (3) Compared with the control group, the ratio of F/B in the exercise groups were lower than the control group, but the 50% VO2 max group was decreased most obviously (p < 0.05). (4) Compared with the control group, the plasma levels of IL-1β, IL-6 and TNF-ɑ in exercise groups were significantly lower than the control group (p < 0.05). Conclusions  (1) The aerobic exercise could change the abundance and structure of gut microbiome in hypertensive mice, increase the beneficial bacteria Bifidobacteria and lactobacillus in the intestinal tract of mice, and reduce the ratio of Firmicutes/Bacteroides, improving the gut microbiome disorder. (2) The aerobic exercise could alleviate the inflammatory reaction of the body by regulating the structure of gut microbiome of hypertensive mice, improving the blood pressure of mice; (3) 50%VO2 max was the most significant exercise intensity to improve the abundance and structure of gut microbiome in hypertensive mice.  

scholarly journals Prevention of Postradiational Disorders in the Testes of Rats with the use of Magnetic Field

2021 ◽  
Vol 20 (2) ◽  
pp. 104-108
Author(s):  
Yuri N. Korolev ◽  
Lyudmila A. Nikulina ◽  
Lyubov V. Mikhailik
Keyword(s):  
Magnetic Field ◽  
Radiation Exposure ◽  
The Body ◽  
Male Rats ◽  
Ultrastructural Changes ◽  
Control Group ◽  
Preventive Action ◽  
Intracellular Regeneration ◽  
Intact Group ◽  
Adaptive Capabilities

The action effects of the low-intensity low-frequency magnetic field (LMF) are mainly studied in its therapeutic use and to a much lesser extent in the mode of primary prevention. Aim. To identify adaptive metabolic and ultrastructural changes in the testes of rats under the preventive action of LMF under radiation conditions. Material and methods. The experiments were carried out on 28 mature non-linear male rats weighing 180-200 g. the animals were divided into 3 groups: in the experimental group, the animals received a course of LMF procedures followed by radiation exposure; in the control group, the animals were subjected only to radiation exposure; in the intact group, the animals were not exposed to any effects. The animals were slaughtered the day after the radiation exposure. the research methods were used: biochemical (to determine the content of RNA, DNA, antioxidant activity of the testes), light – optical (to count the number of convoluted seminiferous tubule – CST, exfoliated cells, spermatogonia, to determine the index of spermatogenesis); transmission electron microscopy; morphometric analysis of mitochondria (number, average and total area). Results. The preventive effect of LMF enhanced the adaptive capabilities of the body and increased the resistance of the testes to the effects of radiation. This was manifested in an increase in the power of the antioxidant system, activation oof the cellular and intracellular regeneration processes, and a decrease in the permeability of the structures of the CST’s own shell. Conclusion. The obtained data substantiate the possibility of using LMF as a means of protecting the organs of the reproductive system in the complex prevention of the body under the influence of radiation.

Complex pharmaco-ozone therapy in the prevention of placental insufficiency in high-risk pregnancy

2020 ◽  
pp. 19-27
Author(s):  
L. V. Tsallagova ◽  
L. V. Maisuradze ◽  
S. V. Sagkaeva ◽  
T. I. Tsidaeva
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
The Body ◽  
High Risk Pregnancy ◽  
Placental Lactogen ◽  
Control Group ◽  
Ozone Therapy ◽  
Morphological Examination ◽  
Adaptive Capabilities ◽  
Risk Pregnancy

Summary. Purpose of research. Development of a method for prevention of placental insuffi ciency (PN) in high-risk pregnancy in women of the Republic of North Ossetia-Alania (RSO-A) with the complex use of antihypoxant limontar and ozone therapy (OT). Material and methods. Observations were made of 75 pregnant residents of RSO-A with diagnosed PN, whose average age was 32,6 ± 8,14 years. Using a simple randomization method, 3 groups were formed: in the main group (OG), patients received prevention of PN by using OT and antihypoxant limontar; in the comparison group (GS), only limontar; in the control group (KG), pregnant women did not receive prevention of PN. All patients observed before and after PN prevention were examined for placental lactogen and estriol, ultrasound of the fetoplacental complex (FPC), Doppler examination of the uterine blood fl ow and ultrasound examination of the placenta structure, and morphological examination of the placenta. Results. Based on identifi ed pathogenetic mechanisms of the disorders in the system “mother — placenta — fetus” are defined by a high clinical effi cacy of combined pharmaco-ozone therapy (CT) in the prevention of PN in pregnant women at risk, which was manifested by the lack of progression of PN, whereas in GS, where patients received only pharmacotherapy with limontar, progression was noted in 31,8 % of cases, in KG, where there was no prevention, is 56 %. Conclusion. In the present study, the positive effect of OT and antihypoxant limontar on the processes of microcirculation, metabolism, and adaptation of the body, which provides a signifi cant reduction in the frequency of pregnancy complications, increasing the adaptive capabilities of the fetus and improving perinatal outcomes.

Effect of seawater immersion on pathophysiological changes in rats combined burns with open abdominal injury

2020 ◽  
Author(s):  
lin ying ◽  
liu liangming ◽  
qu jifu
Keyword(s):  
Blood Pressure ◽  
Low Temperature ◽  
Kidney Function ◽  
Early Stage ◽  
Myocardial Damage ◽  
The Body ◽  
Abdominal Injury ◽  
Control Group ◽  
Coagulation Function ◽  
Liver And Kidney

Abstract Objective: To observe the effects of seawater immersion on the pathophysiological changes in rats combined burns with open abdominal injury.Method: Eighty-eight male Sprague-Dawley(SD) rats combined burns with open abdominal injuries were randomly divided into the seawater immersion group (SI) and the control group (Ctl).Rats in SI group were immersed in seawater at 15℃ for 1 hour. The changes of respiration, blood pressure, rectal temperature, blood gases, blood electrolyte, liver and kidney function, coagulation function, heart damage and animal survival at different time points in the early stage (within 9 hours after injury) were observed.Result: After immersed in seawater, the body temperature of rats in SI group were significantly decreased, the respiration were remarkably inhibited and the blood pressure were obviously declined as compared to those in Ctl group. The blood pH of rats in SI group were significantly lower than those in Ctl group, showing severe acidosis(P<0.05). The changes of HCO3-, PCO2 and BE also presented the similiar trends(P<0.05). PO2 and PCO2 in SI group were significantly higher than those in Ctl group (P<0.05). However, the SaO2 in SI group were lower than those in Ctl group (P<0.05). Blood sodium and chlorine in SI group were higher than those in Ctl group, showing severe hypernatremia and hyperchloremia(P<0.05). The concentration of potassium and calcium were not obviously changed. The liver and kidney function parameters(AST,ALT,Urea,Crea) in SI group were lower than those in Ctl group 4 hours after injury(P<0.05), while myocardial damage markers (TNT) in SI group were higher than those in Ctl group. There were no significant differences in coagulation function between the two groups. The survival time of the SI group rats were shorter than those in Ctl group and the mortality was higher than those in Ctl group (66.7% vs 41.7%).Conclusion: Low-temperature seawater immersion might aggravate injury, accelerate animal death, induce hypothermia, respiratory depression, acidosis, hypernatremia and hyperchloremia. Immersing in low temperature seawater for 1 hour can cause myocardial damage, but it has protective effects on the liver and kidney. Therefore, more attentions should be paid to the secondary injury caused by seawater immersion in the emergency treatment of the wounded, such as rapidly rewarming, rectifying the acidosis and maintaining the stability of homeostasis of the wounded, so as to lay the foundation for the further definitive treatments.

scholarly journals EFEKTIFITAS AIR KELAPA HIJAU MUDA TERHADAP PENURUNAN TEKANAN DARAH TINGGI PADA LANSIA DI POSYANDU USILA PUSKESMAS PERAK TIMUR SURABAYA

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Ninik Ambar Sari ◽  
Dya Sustrami
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
High Blood Pressure ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
T Test ◽  
The Body ◽  
Coconut Water ◽  
Control Group ◽  
Lower Systolic Blood Pressure

Hypertension is an increase in blood pressure where the systolic pressure is more than 140 mmHg and diastolic pressure is more than 90 mmHg. The cause of the onset of hypertension can be of age factor. Elderly who suffer from hypertension usually cause interruption of daily activities, so routine treatment is needed in order not to cause complications. Young coconut water contains potassium, magnesium and vitamin C which has benefits to help the body regulate blood pressure, so it can reduce hypertension. The purpose of this study was to determine the effect of young coconut water on the decrease of high blood pressure in the elderly. Experimental Quasy research design with Non-Equivalent Control Group Desaign approach. The population of this study is elderly who are not dependence of hypertension drugs as much as 32 people with the number of samples of 30 respondents selected by Probability Sampling with Simple Random Sampling approach. The independent variable is young coconut water therapy, the dependent variable is the decrease of high blood pressure. Data were collected using questionnaires and observations. Data were analyzed by using Paired t-test and Independent t-test. The results showed that the consumption of young coconut water as much as 250 ml morning and afternoon for 2 weeks in the treatment group can lower systolic blood pressure. The independent t test in the treatment group and the control group obtained the result p = 0.013 (p <a = 0.05). The implication of this study is that young coconut water can lower blood pressure in elderly people with hypertension, so that young coconut water treatment can be used as one of the non-pharmacological alternative to reduce blood pressure.  

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