scholarly journals A brief history of studying the role of intestinal factor in aging and/or induction of systemic inflammation: Achievements, challenges, and prospects

2019 ◽  
pp. 4-17
Author(s):  
И.А. Аниховская ◽  
В.А. Белоглазов ◽  
А.И. Гордиенко ◽  
Ю.Д. Иванов ◽  
А.В. Кубышкин ◽  
...  
Keyword(s):  
Life Support ◽  
Age Groups ◽  
World Ocean ◽  
Biological Properties ◽  
Surgical Removal ◽  
Russian Scientist ◽  
Blue Green Algae ◽  
General Pathology ◽  
Systemic Endotoxemia

Изучение кишечного фактора в скорости старения, индукции воспаления и прогрессировании заболеваний неразрывно (прямо или косвенно) связано с великим русским учёным И.И. Мечниковым. Его интуиция инициировала изучение особенностей состава микробиоты долгожителей и операций по удалению толстой кишки (как рудимента и источника токсичных продуктов гниения), результаты которых не имели научного и практического успеха и завершились чуть менее 100 лет тому назад, ознаменовав собой завершение первого этапа исследований. Параллельно с первым стартовал второй этап. Он заключался в изучении биологических свойств и структуры эндотоксина - липополисахарида (ЛПС), число молекул которого на планете очень велико, поскольку ЛПС термостабилен, а главным его источником являются сине-зелёные водоросли, заселившие Мировой океан около 2 миллиардов лет тому назад. Третий этап изучения кишечного фактора в общей патологии стартовал в России треть века назад на стыке первых двух параллельно развивающихся направлений с постулирования системной эндотоксинемии, как облигатного биологического явления и открытия клеточного рецептора TLR4, лигандом которого является ЛПС. В дальнейшем TLR4-подобные рецепторы были обнаружены даже у растений, что позволяет квалифицировать ЛПС не только как экзогормон адаптации, но и как облигатный фактор эволюции. Последняя подразумевает самообновление популяции, для реализации которой облигатные факторы жизнеобеспечения должны обладать и противоположным действием, среди которых стресс и ЛПС. Способность средств снижения содержания ЛПС в крови повышать качество лечебно-профилактического процесса позволяет оптимистично оценивать возможность замедления процессов старения. Первоочередными задачами для достижения поставленной цели являются: определение диапазона физиологических показателей системной эндотоксинемии во всех возрастных группах и создание нового поколения доступных для широкого использования средств селективной элиминации избытка ЛПС из крови (гемодиализ) и кишечника (энтеросорбция), которые могут быть созданы на основе аптамеров. Studying the role of intestinal factor in the rate of aging, induction of inflammation, and progression of diseases is inextricably (directly or indirectly) associated with the great Russian scientist I.I. Mechnikov. His intuition initiated studying the long-livers’ microbiota and the surgical removal of the colon (as a rudiment and source of toxic rotting products), which did not bring any scientific or practical success. These studies were over a little less than 100 years ago marking the end of the first stage of research. The second stage started in parallel with the first one and consisted in studying biological properties and structure of endotoxin (lipopolysaccharide, LPS). LPS molecules are as numerous on the earth as in the air since LPS is thermally stable and generated by blue-green algae that have inhabited the World Ocean two billion years ago. The third stage of studying the intestinal factor in general pathology started in Russia one third of a century ago at the junction of the two above-mentioned, paralleling endeavors - postulating systemic endotoxemia as an obligate biological phenomenon and discovery of the LPS receptor (TLR4) of innate immunity. TLR4 is carried by humans, animals, fish, sponges, and even plants, which suggests that LPS is not only an adaptive exohormone but also an obligate factor of evolution. This implies population self-renewal, which requires that the obligate life-support factors must also possess an opposite effect, including stress and intestinal LPS. The ability of LPS suppressors to enhance the therapeutic and prophylactic process makes promising a possibility of slowing aging. The primary tasks for achieving this goal are determining the range of systemic endotoxemia physiological indexes in all age groups and creating a readily accessible new generation of methods for selective elimination of LPS from blood (hemodialysis) and intestine (enterosorption) that could be developed on the basis of aptamers.

The Adult as Foe or Friend?: Childism in Guus Kuijer's Criticism and Fiction

2013 ◽  
Vol 6 (2) ◽  
pp. 205-217 ◽  
Author(s):  
Vanessa Joosen
Keyword(s):  
Children's Literature ◽  
Children’S Literature ◽  
Age Groups ◽  
Children's Books ◽  
Children’S Books ◽  
Memorial Award ◽  
Adult Reader ◽  
Shed Light ◽  
Selection Of

Compared to the attention that children's literature scholars have paid to the construction of childhood in children's literature and the role of adults as authors, mediators and readers of children's books, few researchers have made a systematic study of adults as characters in children's books. This article analyses the construction of adulthood in a selection of texts by the Dutch author and Astrid Lindgren Memorial Award winner Guus Kuijer and connects them with Elisabeth Young-Bruehl's recent concept of ‘childism’ – a form of prejudice targeted against children. Whereas Kuijer published a severe critique of adulthood in Het geminachte kind [The despised child] (1980), in his literary works he explores a variety of positions that adults can take towards children, with varying degrees of childist features. Such a systematic and comparative analysis of the way grown-ups are characterised in children's texts helps to shed light on a didactic potential that materialises in different adult subject positions. After all, not only literary and artistic aspects of children's literature may be aimed at the adult reader (as well as the child), but also the didactic aspect of children's books can cross over between different age groups.

ON EVALUATION OF THE ROLE OF THERMAL AND WIND FACTORS FOR A PHYSICAL MODEL OF THE WORLD OCEAN GENERAL CIRCULATION SYSTEM

2019 ◽  
Vol 47 (3) ◽  
pp. 80-91
Author(s):  
V. G. Neiman
Keyword(s):  
Physical Model ◽  
Ocean Circulation ◽  
General Circulation ◽  
World Ocean ◽  
Circulation System ◽  
The Public ◽  
The World ◽  
Almost All ◽  
Conceptual Foundations

The main content of the work consists of certain systematization and addition of longexisting, but eventually deformed and partly lost qualitative ideas about the role of thermal and wind factors that determine the physical mechanism of the World Ocean’s General Circulation System (OGCS). It is noted that the conceptual foundations of the theory of the OGCS in one form or another are contained in the works of many well-known hydrophysicists of the last century, but the aggregate, logically coherent description of the key factors determining the physical model of the OGCS in the public literature is not so easy to find. An attempt is made to clarify and concretize some general ideas about the two key blocks that form the basis of an adequate physical model of the system of oceanic water masses motion in a climatic scale. Attention is drawn to the fact that when analyzing the OGCS it is necessary to take into account not only immediate but also indirect effects of thermal and wind factors on the ocean surface. In conclusion, it is noted that, in the end, by the uneven flow of heat to the surface of the ocean can be explained the nature of both external and almost all internal factors, in one way or another contributing to the excitation of the general, or climatic, ocean circulation.

Effectiveness of psychological interventions to improve emotion regulation in youth - a meta-analysis

2019 ◽  
Author(s):  
Bettina Moltrecht ◽  
Jessica Deighton ◽  
Praveetha Patalay ◽  
Julian Childs
Keyword(s):  
Emotion Regulation ◽  
Emotion Dysregulation ◽  
Psychological Intervention ◽  
Meta Analysis ◽  
Age Groups ◽  
Effect Sizes ◽  
What Works ◽  
Large Heterogeneity ◽  
Larger Sample

Background: Research investigating the role of emotion regulation (ER) in the development and treatment of psychopathology has increased in recent years. Evidence suggests that an increased focus on ER in treatment can improve existing interventions. Most ER research has neglected young people, therefore the present meta-analysis summarizes the evidence for existing psychosocial intervention and their effectiveness to improve ER in youth. Methods: A systematic review and meta-analysis was conducted according to the PRISMA guidelines. Twenty-one randomized-control-trials (RCTs) assessed changes in ER following a psychological intervention in youth exhibiting various psychopathological symptoms.Results: We found moderate effect sizes for current interventions to decrease emotion dysregulation in youth (g=-.46) and small effect sizes to improve emotion regulation (g=0.36). Significant differences between studies including intervention components, ER measures and populations studied resulted in large heterogeneity. Conclusion: This is the first meta-analysis that summarizes the effectiveness for existing interventions to improve ER in youth. The results suggest that interventions can enhance ER in youth, and that these improvements correlate with improvements in psychopathology. More RCTs including larger sample sizes, different age groups and psychopathologies are needed to increase our understanding of what works for who and when.

Green synthesis of silver nanoparticles using sustainable resources and their use as antibacterial agents: A review

2020 ◽  
Vol 13 ◽  
Author(s):  
Kumari Jyoti ◽  
Punyasloka Pattnaik ◽  
Tej Singh
Keyword(s):  
Silver Nanoparticles ◽  
Plant Extracts ◽  
Metallic Nanoparticles ◽  
Cost Effective ◽  
Biological Properties ◽  
Metal Species ◽  
Sustainable Resources ◽  
Research Areas ◽  
Low Toxicity

Background:: Synthesis of metallic nanoparticles has attracted extensive vitality in numerous research areas such as drug delivery, biomedicine, catalysis etc. where continuous efforts are being made by scientists and engineers to investigate new dimensions for both technological and industrial advancements. Amongst numerous metallic nanoparticles, silver nanoparticle (AgNPs) is a novel metal species with low toxicity, higher stability and significant chemical, physical and biological properties. Methods:: In this, various methods for the fabrication of AgNPs are summarized. Importantly, we concentrated on the role of reducing agents of different plants parts, various working conditions such as AgNO3 concentration; ratio of AgNO3/extract; incubation time; centrifugal conditions, size and shapes. Results:: This study suggested that eco-friendly and non toxic biomolecules present in the extracts (e.g. leaf, stem and root) of plants are used as reducing and capping agents for silver nanoparticles fabrication. This method of fabrication of silver nanoparticles using plants extracts is comparatively cost-effective and simple. A silver salt is simply reduced by biomolecules present in the extracts of these plants. In this review, we have emphasized the synthesis and antibacterial potential of silver nanoparticles using various plant extracts. Conclusion:: Fabrication of silver nanoparticles using plant extracts have advantage over the other physical methods, as it is safe, eco-friendly and simple to use. Plants have huge potential for the fabrication of silver nanoparticles of wide potential of applications with desired shape and size.

Physical and Biological Properties and Principles

2018 ◽  
Keyword(s):  
Biological Properties ◽  
Animal Locomotion ◽  
The Media ◽  
Key Dimensions ◽  
Scaling Analyses ◽  
Physical Principles

Studies of animal locomotion are grounded in an understanding of the physical principles that govern how animals move and properties of the media through which they move. These studies, in turn, explain why certain biological devices, such as a wing or a fin, share features that have evolved for movement within their particular fluid environments. In this chapter, we examine the role of the environment and the fundamentals of loading and forces in animal mechanics. We offer a quick review of scaling analyses as well as the key dimensions and units used in this book to assist with your appreciation of the information.

The Health of Refugees

2019 ◽  
Keyword(s):  
Age Groups ◽  
Refugee Health ◽  
Mass Movements ◽  
Ethical Challenges ◽  
Displaced Populations ◽  
Political Landscape ◽  
The Media ◽  
Multidisciplinary Perspective ◽  
The Impact

There have been significant changes in the numbers, patterns, and circumstances of refugees and in the political landscape to support humanitarianism since the publication of the first edition of this collection. Like the first edition, this volume provides a multidisciplinary perspective on refugee health, tracing the health repercussions on individuals and populations from the drivers of forced mass movements of populations from situations of conflict and other disasters through to the process of resettlement in countries other than their countries of origin. Drawing on the expertise of academics, practitioners, and UN frontline experts, the collection covers three main aspects of refugee health: the concepts, definitions, and context from a human rights, humanitarianism, and social determinants of health perspective; the intersection of vulnerabilities across age groups and settings; and the ethical challenges for practitioners and researchers working with forcibly displaced populations seeking to resettle. The collection concludes with an analysis of the role of the media in shaping our perceptions of refugees and the impact on policy and access to care.

Children’s Lives and Deaths in Merovingian Gaul

2020 ◽  
pp. 185-213
Author(s):  
Émilie Perez
Keyword(s):  
Social Identity ◽  
Age Groups ◽  
New Method ◽  
Recent Analysis ◽  
Age And Gender ◽  
The Past ◽  
And Gender ◽  
Grave Goods

The role of children in Merovingian society has long been downplayed, and the study of their graves and bones has long been neglected. However, during the past fifteen years, archaeologists have shown growing interest in the place of children in Merovingian society. Nonetheless, this research has not been without challenges linked to the nature of the biological and material remains. Recent analysis of 315 children’s graves from four Merovingian cemeteries in northern Gaul (sixth to seventh centuries) allows us to understand the modalities of burial ritual for children. A new method for classifying children into social age groups shows that the type, quality, quantity, and diversity of grave goods were directly correlated with the age of the deceased. They increased from the age of eight and particularly around the time of puberty. This study discusses the role of age and gender in the construction and expression of social identity during childhood in the Merovingian period.

scholarly journals Sex differences in the phylum‐level human gut microbiota composition

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alexander Koliada ◽  
Vladislav Moseiko ◽  
Mariana Romanenko ◽  
Oleh Lushchak ◽  
Nadiia Kryzhanovska ◽  
...  
Keyword(s):  
Sex Differences ◽  
Gut Microbiota ◽  
Age Groups ◽  
Microbiota Composition ◽  
Human Gut ◽  
Cross Sectional ◽  
Total N ◽  
Human Gut Microbiota ◽  
Gut Microbiota Composition

Abstract Background Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. Results Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. Conclusions In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases.

scholarly journals Seasonality in extra-pulmonary tuberculosis notifications in Germany 2004-2014- a time series analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tanja Charles ◽  
Matthias Eckardt ◽  
Basel Karo ◽  
Walter Haas ◽  
Stefan Kröger
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Disease Onset ◽  
Age Groups ◽  
Age Group ◽  
Pulmonary Tb ◽  
Series Analysis ◽  
Disease Site ◽  
Extra Pulmonary

Abstract Background Seasonality in tuberculosis (TB) has been found in different parts of the world, showing a peak in spring/summer and a trough in autumn/winter. The evidence is less clear which factors drive seasonality. It was our aim to identify and evaluate seasonality in the notifications of TB in Germany, additionally investigating the possible variance of seasonality by disease site, sex and age group. Methods We conducted an integer-valued time series analysis using national surveillance data. We analysed the reported monthly numbers of started treatments between 2004 and 2014 for all notified TB cases and stratified by disease site, sex and age group. Results We detected seasonality in the extra-pulmonary TB cases (N = 11,219), with peaks in late spring/summer and troughs in fall/winter. For all TB notifications together (N = 51,090) and for pulmonary TB only (N = 39,714) we did not find a distinct seasonality. Additional stratified analyses did not reveal any clear differences between age groups, the sexes, or between active and passive case finding. Conclusion We found seasonality in extra-pulmonary TB only, indicating that seasonality of disease onset might be specific to the disease site. This could point towards differences in disease progression between the different clinical disease manifestations. Sex appears not to be an important driver of seasonality, whereas the role of age remains unclear as this could not be sufficiently investigated.

scholarly journals Some biological properties of spiny eel (Mastacembelus mastacembelus, Banks & Solander, 1794) living in the Upper Euphrates River Basin, Turkey

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mehmet Zülfü Çoban ◽  
Mücahit Eroğlu ◽  
Mustafa Düşükcan
Keyword(s):  
River Basin ◽  
Growth Parameters ◽  
Age Groups ◽  
Mortality Rates ◽  
Biological Properties ◽  
Von Bertalanffy ◽  
Growth Type ◽  
Euphrates River ◽  
Fish Samples ◽  
Exploitation Rate

AbstractThis study was carried out to determine some bioecological characteristics of Mastacembelus mastacembelus, which is the only species of Mastacembelidae family living in Turkey. Fish samples were caught between 2014–2018 from Keban Dam Lake, one of the most important reservoirs of the upper Euphrates Basin. In totally, 348 Mastacembelus mastacembelus individuals were examined, including 178 males and 170 females. The age distributions were defined between the I–XV age groups. Total lengths ranged from 14.20 to 81.80 cm in males and from 15.60 to 77.30 cm in females. Total length–weight relationships were calculated as W = 0.0083 × TL2.6516 for males, W = 0.0043 × TL2.8310 for females and W = 0.0063 × TL2.7256 for all population, and the growth type was estimated as “negative allometric”. The von Bertalanffy growth parameters for all individuals were computed as L∞ = 90.99, k = 0.13, t0 = − 0.45. The total (Z), natural (M), fishing (F) mortality rates and exploitation rate (E) were estimated as Z = 0.313, M = 0.270, F = 0.043 and E = 0.137, respectively. The length at first capture (Lc) was found as 50.72. The optimum, maximum and economic yields were calculated as E0.5 = 0.361; Emax = 0.776; E0.1 = 0.664, respectively.

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