scholarly journals Beneficial effects of sodium selenite on some serum biochemical parameters in alloxan-induced diabetic rats

2020 ◽  
Vol 11 (2) ◽  
pp. 2095-2100
Author(s):  
Lamia Mellahi ◽  
Zouhir Djerrou ◽  
Noureddine Bouzerna
Keyword(s):  
Body Weight ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Total Lipid ◽  
Pancreatic Lipase ◽  
Sodium Selenite ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Protective Effects

The present study aimed to determine the possible protective effects of intraperitoneally administered sodium selenite for preventing diabetes in rats. Twenty-eight male albino rats were randomly divided into four equal groups of seven each: untreated control (G1), sodium selenite treated control (G2), untreated diabetic (G3), and sodium selenite-treated diabetic group (G4). Diabetes was induced by alloxan (150 mg/kg body weight) in groups G3 and G4 and rats were then treated with sodium selenite (5 μmol/kg body weight/day) for 4 weeks (G4). On day 28 after an overnight fasting, rats were killed and concentrations of serum glucose, total cholesterol, triglycerides, total lipid, urea, creatinine, uric acid, albumin and some enzymes activities: pancreatic lipase, glutamic oxalic transaminase (GOT), glutamic pyruvic transaminase (GPT), Alkaline phosphatase(ALP) were also estimated. The administration of alloxan significantly increased serum glucose, total cholesterol, triglycerides, total lipid, urea, uric acid levels, pancreatic lipase, GOT, GPT and ALP activities, body weight gain and albumin level were significantly decreased. This alteration was restored back to near normal in diabetic rats intraperitoneal treated with sodium selenite in comparison to non treated diabetic animals. Serum creatinine concentration was normal in all groups. The study concludes that alloxan diabetes mellitus induced severe biochemical alliterations in the glucose, lipid profile concentrations, liver and kidney function markers and sodium selenite has shown protective effects preventing at least partially diabetic complications.

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

2016 ◽  
Vol 5 (06) ◽  
pp. 4641 ◽  
Author(s):  
Adel Abdel Moneim* ◽  
Sanaa M. Abd El-Twab ◽  
Mohamed B. Ashour ◽  
Ahmed I. Yousef
Keyword(s):  
Body Weight ◽  
Gallic Acid ◽  
Protein Profile ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Hypoglycemic Agents ◽  
Protective Effects ◽  
Coumaric Acid ◽  
Experimental Type

The goal of diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long-term diabetic complications resulting from hyperglycemia. Thus, our present investigation was designed to evaluate the hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin (NA/STZ)-induced diabetic rats. Experimental type 2 diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (65 mg/kg b.wt.), after 15 min of i.p. injection of NA (120 mg/kg b.wt.). Gallic acid and p-coumaric acid were orally administered to diabetic rats at a dose of 20, 40 mg/kg b.wt./day, respectively, for 6 weeks. Body weight, serum glucose, protein profile, liver function enzymes and kidney function indicators was assayed. Treatment with either gallic acid or p-coumaric acid significantly ameliorated the elevated levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and uric acid. Both compounds were also found to restore total protein, albumin, and globulin as well as body weight of diabetic rats to near normal values. It can conclude that both gallic acid and p-coumaric acid have potent hypoglycemic and hepato-renal protective effects in diabetic rats. Therefore, our results suggest promising hypoglycemic agents that can attenuate the progression of diabetic hepatopathy and nephropathy.

scholarly journals Antihyperglycemic and Antihyperlipidemic of Karala (Momordica charantia) Fruits in Streptozotocin Induced Diabetic Rats

2012 ◽  
Vol 5 (1) ◽  
pp. 29-37 ◽  
Author(s):  
MA Hossain ◽  
M Mostofa ◽  
D Debnath ◽  
AKMR Alam ◽  
Z Yasmin ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Total Cholesterol ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Higher Doses

To investigate the antihyperglycemic and antihyperlipidemic effect of Momordica charantia (Karala), the aqueous extract of the Karala fruit was tested on streptozotocin (STZ)-induced diabetic rats. Thirty six albino rats were used in the experiment, 30 diabetic and the remaining six as negative control (T1). Diabetes was induced by administering (injecting) STZ at dose of 55mg/kg body weight. Thirty diabetic animals were randomly divided into five groups such as diabetic control group (T2) without any application of treatment, and groups T3,T4,T5 and T6 were treated with aqueous extract of Karala fruits daily at the doses of 250,    500 and 750mg/kg and glibenclamide (at a dose of 5mg/kg body weight) respectively. The body weight was taken and blood samples were collected from individual animal to determine glucose levels at 15 day interval up to 90 days. In addition, Asparate  Transaminenase(AST), Alanine Transaminenase(ALT), Alkaline Phosphatase(ALP), Total cholesterol (TCh) and Triglyceride (TGA) were determined at day 15 and at the end of the experiment. All three doses of Karala extracts reduced diabetic induced blood sugar and the reduction is comparable with standard glibenclamide (GLM) dose particularly with higher doses Karala extracts (500 and 750mg). Karala also prevented body weight loss due to induced diabetes as did by GLM treatment.. The treatment also resulted in a significant reduction of Asparate Transaminenase(AST), Alanine Transaminenase(ALT), Alkaline Phosphatase(ALP), Total cholesterol (TCh) and Triglyceride (TGA) activities of treated rats when compared to the STZ induced  diabetic rats. Higher doses of Karala (500 and 750mg/kg) are as effective as standard GLM dose on measured variables. This study demonstrated that Karala has hyperglycemia and antihyperlipidemic effect against STZ induced diabetic rats. These findings open the possibility of using Karala extract to treat diabetic animal and human patients although further research is warranted. DOI: http://dx.doi.org/10.3329/jesnr.v5i1.11550 J. Environ. Sci. & Natural Resources, 5(1): 29 - 37, 2012  

scholarly journals Hypoglycaemic and Hypolipidemic Effects of Treculia africana Aqueous Leaves Extract in Alloxan Induced Diabetic Rats

2018 ◽  
pp. 1-9
Author(s):  
Idris A. Kankara ◽  
Gayus A. Paulina ◽  
M. Aliyu
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Treculia Africana

This study investigated the hypoglycaemic and hypolipidaemic effects of Treculia africana plant used in Nigeria as medicinal plant. Diabetes mellitus was induced by a single dose intraperitoneal injection of alloxan 150 mg/kg body weight. Twenty five (25) male albino rats were divided into five groups, five (5) rats per group; normal control, diabetic control and diabetic groups treated with aqueous leaves extract of 200,400 and 800 mg/Kg body weight respectively for 21 days orally. The effects of the extract on some biochemical parameters were evaluated; fasting blood glucose level was assayed using glucose oxidase method, total cholesterol and HDL –cholesterol were assayed using enzymatic method while LDL- cholesterol was determined by Friedewald equation. The results showed that, extract significantly (p<0.05) decrease the elevated fasting blood glucose levels, total cholesterol, triglyceride and LDL- cholesterol when compared with the diabetic control rats. The extract also caused significant (p<0.05) increased in HDL –cholesterol and body weight when compared with diabetic control rats. Aqueous leave extract of Treculia africana possess hypoglycemic effect and the most effective dose was 800 mg/Kg body weight in amelioration of hyperglycaemia and most all toxicity effects of alloxan on lipid profile.

The anti-diabetic effect of some plant extracts against Streptozotocin - induced diabetes type 2 in male albino rats.

2020 ◽  
Vol 20 ◽  
Author(s):  
Heba F. Gomaa ◽  
Imen Ben Abdelmalek ◽  
Khaled G. Abdel-Wahhab
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Plant Extracts ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Male Rats ◽  
Postprandial Blood Glucose ◽  
Albino Rats

Background: One of the widely spread disorders is Diabetes mellitus, especially type 2 (T2DM). T2DM is attributed to the change in life style and stress. A possible strategy to block dietary carbohydrate absorption, is regulation of postprandial blood glucose level as well, the use of some natural plant extracts with inhibitory effect against carbohydrate digestive enzymes such as alpha-amylase and fewer side effects than synthetic drugs. This study was conducted to investigate the anti-diabetic effect of Cinnamon and Saussurea extract, individually, on blood glucose, lipid profile, insulin, interleukin1-beta and weight loss in diabetic rats treated with Streptozotocin (STZ). Methods: The experiment was performed on 60 Wistar male rats, the experimental study include 6 groups (10 rats each): (I) normal rats, (II) Streptozotocin- induced diabetic rats, (III) normal rats orally received (200 mg/kg/day) Saussurea ethanolic extract (SEE) for consecutive 4 weeks, (IV) normal rats orally received (100mg/kg/day) Cinnamon aqueous extract (CAE) for consecutive 4 weeks, (V) Streptozotocin –treated rats received SEE orally (200mg /kg/ day) for consecutive 4 weeks, and (VI) Streptozotocin –treated rats received CAE orally (100mg /kg/ day) for consecutive 4 weeks. Results: The results of the following study revealed that SEE has more anti-diabetic effect against Streptozotocin treatment than CAE due to the high α-amylase inhibition potential and higher phenolic content, Also, GC-MS analysis of SEE exhibited higher concentrations of phenolic compounds such as : dehydrocostus lactone, azuleno, eicosa-pentaenoic acid and linoelaidic acid that revealed anti-diabetic, anti-lipidemic and anti-inflammatory activities, while CAE showed presence of cinnamic and quinic acids. Injection of STZ resulted in a decline in the insulin, high density lipoprotein and body weight values matched with increase of glucose, total cholesterol, LDL-Cholesterol, triglycerides and interleukin1- β (IL-1β). The administration of extracts of SEE and CAE into STZ-treated rats separately resulted in a decline in the elevated levels of blood glucose, total cholesterol, triglycerides and improving serum HDL-Cholesterol and body weight. Conclusion: Both tested herbal extracts performed anti-diabetic effect that mainly could be mechanized via the α-amylaseinhibitory potentials due to the high phenolic and flavonoids content.

scholarly journals Antidiabetic Activity of Extracts of Pithecellobium dulce Benth Leaves in Alloxan Induced Diabetic Rats

2016 ◽  
Vol 8 (05) ◽  
Author(s):  
V. S. Mul ◽  
N. Naikwade ◽  
C. Magdum ◽  
V. Jagtap
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Glycogen Level

The objective of the present study was to study effect of Pithecellobium dulce Benth (P. dulce) leaves in alloxan induced diabetic rats. The P. dulce leaves were extracted by maceration and soxhelation method by using water and ethanol as solvent. Acute toxicity study was performed according to OECD 425 guidelines for both aqueous and ethanolic extracts of P. dulce leaves. The dose of 200 mg/kg and 400 mg/kg was selected for further studies. Animals were rendered diabetic by administration of alloxan (130 mg/kg, i.p.). The albino rats were divided in to seven groups with five animals in each group. Diabetic animals were treated with aqueous and ethanolic extract for 20 days. Then blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, aspartate aminotransferase (AST), alanine transaminase (ALT) and glycogen level in liver, muscle and kidney were estimated according to standard procedures. The result shows significant decrease in blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, AST and ALT level when compared to diabetic group. The liver and muscle glycogen level was increased significantly in extract treated groups when compared to diabetic control group. Both extract of P. dulce posses antidiabetic and hypolipidemic potential.

Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats

2010 ◽  
Vol 30 (8) ◽  
pp. 870-875 ◽  
Author(s):  
Hyung-In Moon
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Serum Insulin ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Antidiabetic Drug ◽  
Antidiabetic Effect ◽  
Dendropanax Morbifera ◽  
Aspartate Amino Transferase ◽  
Antidiabetic Effects

The present study evaluated the antidiabetic effect of Dendropanoxide (DP) from Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats. DP in the streptozotocin-induced diabetic rats showed significant hypoglycemic activity for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05; at doses of 30, 60 and 100 mg/kg for 14 days). A comparison was made between the action of DP and glibenclamide (600 μg/kg), a known antidiabetic drug. The antidiabetic effect of the DP was more effective than that observed with glibenclamide.

EFFECT OF KAEMPFERIA GALANGA RHIZOME EXTRACT ON HAEMATOLOGICAL PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC WISTAR RATS

2020 ◽  
pp. 255-259
Author(s):  
Subbaian Kokila ◽  
Balliah RAGAVAN
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Weight Changes ◽  
Reduced Body ◽  
Kaempferia Galanga ◽  
Wistar Strain ◽  
Haematological Profile

Diabetes mellitus is a metabolic disorder that is characterized by elevated blood glucose level, altered lipids, carbohydrates and protein metabolism. The present investigation was undertaken to determine the hypoglycemic potential of hydroethanolic extract of Kaempferia galanga rhizome and to assess haematological profile in diabetic rats. Adult male albino rats of Wistar strain were induced with diabetes by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg body weight). Changes in haematological profile reported by STZ induced diabetic rats were found to be restored to normal condition upon administration of K. galanga extract in treated groups indicating hematoprotective effect of the extract. Diabetic rats exhibited increased level of serum glucose and reduced body weight compared to normal control rats. The K. galanga rhizome extract treated animals exhibited significant increase in body weight and reduced level of blood glucose thereby restoring to near normal levels. The present findings indicate that K. galanga rhizome can be considered for treating diabetes induced complications.

scholarly journals Effect of Aqueous Leaf Extract of Eriosema psoraleoides on Antihyperglycemic and Hypolipidemic Potentials in Alloxan-Induced Diabetic Rats

2019 ◽  
pp. 1-8
Author(s):  
Nduka, Florence O. ◽  
Ogugua, Victor N. ◽  
Nwigwe, Juliet O. ◽  
Nwaso, Chika B. ◽  
Abdulrasheed, Momoh B.
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Analysis Of Variance ◽  
Repeated Measures ◽  
Leaf Extract ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Aqueous Leaf Extract

Aim: This study was targeted at valuing a claim by traditional herbal practitioners that the leaf of Eriosema psoraleoides possesses a hypoglycemic and hypolipidemic property by assessing the effect of aqueous leaf extract of Eriosema psoraleoides on antihyperglycemic and hypolipidemic potentials in alloxan-induced diabetic rats. Methodology: Thirty male albino rats weighing 180-220 g were divided into 5 experimental groups of six rats each; control, diabetic untreated, diabetic treated with glibenclamide and diabetic treated with Eriosema psoraleoides. Diabetes was induced by 130 mg/kg body weight (b.wt) of alloxan monohydrates. The control and diabetic groups received normal saline while the diabetic treated groups were administered with 0.3 mg/kg body weight glibenclamide, and 200 mg/kg, 400 mg/kg body weight of aqueous leaf extract of Eriosema psoraleoides respectively. The experiment period was 7 days, with the determination of their glucose level and body weight every two days.  At the end of the experimental period, the animal’s blood samples were taken from the animals for the determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Statistical comparisons were performed by one-way analysis of variance with repeated measures and one-way analysis of variance followed by Duncan’s multiple range tests. Results: The results of the study show a significant reduction in blood glucose. The result also showed that in diabetic rats, body weight was decreased but the application of the extract increased (P<0.05, n=6). Similarly, the result showed a significant decrease in total cholesterol, TG and LDL level of the diabetic group when compared with the control, glibenclamide and extract treated diabetic groups (with the highest performance at 400 mg/kg). Also, Eriosema psoraleoides aqueous leaf extract treated diabetic rat’s shows a significant increase in HDL levels compared to the diabetic control. Conclusion: The study indicates that Eriosema psoraleoides possess hypolipidemic and antihyperglycemic potentials.

Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats

1985 ◽  
Vol 106 (2) ◽  
pp. 225-231 ◽  
Author(s):  
A.-M. Mendes ◽  
R. J. Madon ◽  
D. J. Flint
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Insulin Receptor ◽  
Body Weight Gain ◽  
Serum Insulin ◽  
Insulin Binding ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Receptor Concentration

ABSTRACT Cortisol implants in normal and diabetic rats reduced body weight, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in isolated adipocytes, whilst insulin sensitivity was unchanged. In normal but not diabetic rats these changes were accompanied by increased serum glucose and insulin concentrations. In contrast, progesterone implants in normal and diabetic rats increased body weight gain, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in adipose tissue, again without affecting insulin sensitivity. Progesterone did not affect serum insulin concentrations in normal or diabetic rats but accelerated the decline in serum glucose concentrations which occurred during an overnight fast in diabetic rats. The results suggest that (1) cortisol inhibits lipogenesis in adipose tissue without affecting insulin sensitivity, (2) cortisol reduces insulin binding in adipose tissue without a requirement for hyperinsulinaemia, which might itself indirectly lead to down-regulation of the insulin receptor, and (3) in diabetic rats progesterone stimulates lipogenesis in adipose tissue without any increase in food intake or serum insulin concentrations suggesting that progesterone may have a direct anabolic role in adipose tissue. J. Endocr. (1985) 106, 225–231

Attenuation of erythrocyte membrane oxidative stress bySesbania grandiflorain streptozotocin-induced diabetic rats

2015 ◽  
Vol 93 (4) ◽  
pp. 385-395 ◽  
Author(s):  
Chandrabose Sureka ◽  
Thiyagarajan Ramesh ◽  
Vavamohaideen Hazeena Begum
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Blood Glucose ◽  
Erythrocyte Membrane ◽  
Osmotic Fragility ◽  
Diabetic Rats ◽  
Glycosylated Haemoglobin ◽  
Albino Rats ◽  
Enzymatic Antioxidants ◽  
Protective Effects

The aim of the present study was to investigate the protective effects of Sesbania grandiflora flower (SGF) extract on erythrocyte membrane in Streptozotocin (STZ)-induced diabetic rats. Adult male albino rats of Wistar strain, weighing 190–220 g, were made diabetic by an intraperitonial administration of STZ (45 mg/kg). Normal and diabetic rats were treated with SGF, and diabetic rats were also treated with glibenclamide as drug control, for 45 days. In this study plasma insulin and haemoglobin levels were decreased and blood glucose, glycosylated haemoglobin, protein oxidation, lipid peroxidation markers, and osmotic fragility levels were increased in diabetic rats. Moreover, erythrocytes antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxide, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase activities and non-enzymatic antioxidants such as vitamin C, vitamin E, reduced glutathione (GSH), and oxidized glutathione (GSSG) levels were altered. Similarly, the activities of total ATPases, Na+/K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase were also decreased in the erythrocytes of diabetic rats. Administration of SGF to STZ-induced diabetic rats reduced blood glucose and glycosylated haemoglobin levels with increased levels of insulin and haemoglobin. Moreover, SGF reversed the protein and lipid peroxidation markers, osmotic fragility, membrane-bound ATPases activities, and antioxidant status in STZ-induced diabetic rats. These results suggest that SGF could provide a protective effect on diabetes by decreasing oxidative stress-associated diabetic complications.

Sign in / Sign up

Export Citation Format

Share Document