scholarly journals Variations in platelet indices in hypercholesterolemia patients in a tertiary care hospital

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 302-307
Author(s):  
Janani K ◽  
Muthuvel E ◽  
Sudha Vasudevan
Keyword(s):  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Significant Variation ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Care Hospital ◽  
Platelet Indices ◽  
Medical College

Hypercholesterolemia is defined as high levels of cholesterol in the blood. Platelet indices include: Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean platelet volume (MPV). Hypercholesterolemia is associated with the increased risk of developing cardiovascular diseases like atherosclerosis which in turn results in platelet activation and thrombotic events. This study is aimed to evaluate the variations in platelet indices in adults with hypercholesterolemia which may be significant in indicating cardiovascular diseases. It is a retrospective case-control study which includes 50 patients with a total cholesterol level of more than 170mg/dl as the study group and 50 healthy controls with normal lipid profile parameters. Data were collected from the lipid profile register in the Biochemistry department of Saveetha Medical College for 3 months duration. The fasting blood samples were run in the machine ‘vitros 5600 dry chemistry’. The lipid profile values included in this study were Total cholesterol, HDL and TGL. The platelet indices were collected from the automated haematology analyzer 'Sysmex XN 1000' from the Pathology Department, Saveetha Medical College. The data collected were tabulated and analysed using SPSS software. Statistical tool used is the independent T-test. The mean value of the platelet parameters such as MPV, PCT and PDW in the study group was 10.397061, .3000, and 12.452 respectively and that of the control group was 9.907480, .2882, 11.174 respectively. On comparing the platelet parameters such as MPV, PCT and PDW between the study and the control group it was observed that there was a significant variation in MPV and PDW. In the independent sample test, the p-value of MPV, PCT and PDW were 0.21, 0.481 and 0.008, respectively. Thus MPV and PDW shows a significant variation between the study and the control group as it is higher in hypercholesterolemia patients (p-value is <0.05).

scholarly journals Lipid profile and its relevance in carcinoma breast

2017 ◽  
Vol 4 (7) ◽  
pp. 2227
Author(s):  
Hrituraj Rohariya ◽  
Pankaj Gharde ◽  
Pramita Muntode Gharde
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Carcinoma Breast ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Post Menopausal

Background: Breast cancer has emerged as a rapidly growing cancer in India and has already replaced cervical cancer. According to global cancer statistics for the year 2008, breast cancer resulted in 46 million deaths. In Asia, incidence rate of breast cancer is lower but is drastically rising. Nevertheless, while dyslipidemia [high LDL-C (low density Lipo-protein-cholesterol) and low HDL-C (high density lipo-protein-cholesterol) levels] has controversial role in this disease; the specific influence of dyslipidemia in breast cancer initiation and progression is not completely understood. So, we undertook this study.Methods: The study was conducted in the department of general surgery, at Medical College and allied Hospital, in Central rural India between year 2012 and 2014. It was a case control study with a sample size of 50 female participants attending the surgery in patient department, fitting in the inclusion criteria as cases and 50 matching controls. The Data was entered in master chart was statistically analyzed by using SYSTAT version 11 and tests were applied accordingly.Results: Age is a crucial factor in malignancy, most of the studies show malignancy presents more in elder population when compared to young ones. In most patients were between 31-50 years. The youngest patient was of 36 years and the oldest was 78 years. The mean age of the patients affected was 48.54 years which is close to the values in other studies. This study also demonstrated significantly high (p value<0.01) serum TC (total cholesterol) levels of post-menopausal study group (32%, more) as compared to post-menopausal control group. The increase in Serum TC levels was more in post-menopausal study group as compared with pre-menopausal study group. Present study had not shown a significant difference (p value >0.05) between serum levels of HDL-C levels in pre-and post-menopausal control group and study group, though post-menopausal cases had slightly lower values of HDL-C when compared with pre-menopausal controls.Conclusions: We conclude from this study that there is a definite positive correlation between carcinoma breast and fasting lipid profile. The pre-and post-menopausal cases showed significant correlation as far as Total Cholesterol and LDL. Whereas there was no significant correlation between HDL, VLDL and TG (triglycerides). Body mass index has no relation with carcinoma breast.

scholarly journals Comparative Study of Serum Lipid Profile in Pre-eclampsia in a Tertiary Care Hospital, Bangladesh

2016 ◽  
Vol 28 (2) ◽  
pp. 61-65
Author(s):  
Kamrun Nahar ◽  
Halima Yasmin ◽  
Afsana Akhter ◽  
Latifa Shamsuddin ◽  
Sufia Khatun
Keyword(s):  
Plasma Level ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Study Group ◽  
Medical College

Objective: To estimate lipid profile in pre-eclampsia cases in Mymensingh Medical College Hospital.Materials and Methods: This cross sectional study was carried out in the dept. of Obstetrics and Gynaecology of Mymensingh Medical College and Hospital (MMCH) and outdoor Pathology Dept. of MMCH. A total 100 pregnant women were included in this study, out of which 50 were pre-eclampsia and 50 normal pregnant women. Purposive sampling technique was followed for selection of study population. Estimation of serum total cholesterol, triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) were done by colorometric method.Result: Findings of the study showed that woman with pre-eclampsia exhibits 14% higher mean plasma level of total cholesterol. It was (229.12 ± 49.31 mg/dl) in pre-eclampsia and (196.68 ± 38.60 ml/dl) in control group and the deference was statistically highly significant (p<.001). Mean plasma level of triglyceride (TG) was approximately 20% higher in the study group (251.28 ± 80.51) as compared with control (200.84 ± 80.51) which was also statistically significant (p<0.01). There was significant raised level of LDL cholesterol in pre-eclampsia (142.12 ± 44.57 mg/dl) as compared to (114.21 ± 37.81 mg/dl) in control which was statistically significant (p=0.004). HDL cholesterol level was found 13% lower in pre-eclampsia pregnant women than control group. There was statistically significant decrease of HDL cholesterol (p<0.05) in study group in which it was 36.74 ± 8.42 mg/dl and in normal pregnancy it was 42.40 ± 9.91 mg/dl.Conclusion: It can be concluded that altered serum lipid levels are seen in pre-eclampsia compared to normal pregnancy.Bangladesh J Obstet Gynaecol, 2013; Vol. 28(2) : 61-65

scholarly journals Effect of hypothyroidism on lipid profile of type 2 diabetic patients

2020 ◽  
Vol 7 (5) ◽  
pp. 754
Author(s):  
Damanpreet Singh ◽  
Gurinder Mohan ◽  
Arshdeep Bansal
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Diabetic Complication ◽  
Control Group ◽  
P Value ◽  
Diabetic Patients ◽  
Study Group ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Background: Hypothyroidism is an endocrine disorder resulting from deficiency of thyroid hormones, and Diabetes is a metabolic disorder that share the phenotype of hyperglycaemia. Both the endocrinopathies have been found to be associated with dyslipidaemia and atherosclerosis that result into various complications. Our aim was to assess the difference of dyslipidaemia in patients suffering from hypothyroidism with diabetes as compared to diabetes alone.Methods: Study was conducted in department of medicine in SGRDIMSR, Sri Amritsar. A total of 120 patients were enrolled for the present study, the one who presented to hospital from January 2018 to August 2019 diagnosed with diabetes mellitus type 2. The patients were divided into two groups. 60 patients having type 2 diabetes without hypothyroidism (control group). 60 patients having type 2 diabetes with hypothyroidism (study group). Fasting lipid profile were performed in both the groups and were analysed for the study.Results: Dyslipidaemia was seen more in study group as compared to control group with mean cholesterol of 488.3(±144.43) and mean triglyceride levels of 354.30(±128.57) in study  group as compared to control group with mean cholesterol and triglyceride levels of 179.7(±81.47) and 177.08(±118.18) with p-value of 0.001 and 0.01 respectively which were significant. Also, obesity and diabetic complication were more in patients of dual endocrinopathies as compared to diabetes alone which were also significant statistically.Conclusions: From our study it is concluded that type 2 diabetes with hypothyroidism causes more dyslipidaemia as compare to type 2 diabetes alone. So proper screening of thyroid profile of type 2 diabetic patients and its correction helps in achieving better lipidemic control which further prevent complications.

scholarly journals Role of lipid profile in early second trimester for prediction of pre-eclampsia

2021 ◽  
Vol 10 (8) ◽  
pp. 3101
Author(s):  
Surbhi . ◽  
Bangali Majhi
Keyword(s):  
Diagnostic Accuracy ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Profile Analysis ◽  
Tertiary Care ◽  
Control Group ◽  
New Delhi ◽  
Care Hospital ◽  
Second Trimester ◽  
The Difference

Background: The aim of the study was to determine association of abnormal lipid profile in early second trimester (14 to 20 weeks) with development of pre-eclampsia.Methods: A prospective observational study included 260 women between 14-20 weeks of pregnancy attending a tertiary care Hospital in New Delhi. Serum lipid profile analysis was performed at the time of enrolment and cohort was followed up for occurrence of pre-eclampsia till 48 hours after delivery. Outcomes measured were difference in mean lipid levels in study (abnormal lipid profile) and control group (normal lipid profile) and accuracy of abnormal lipid profile to predict pre-eclampsia.Results: The incidence of pre-eclampsia in our study was 11.13%. The mean serum total cholesterol was significantly higher in pre-eclampsia group (199.74 mg/dl vs 171.7 mg/dl; p<0.05). The difference in mean triglyceride, HDL, VLDL and LDL levels between two groups was not significant. Total cholesterol has 44.83% sensitivity, 84.85% specificity, 27.08% PPV, 92.45% NPV with diagnostic accuracy of 80.38% in predicting pre-eclampsia (with 0.65% AUC with 95% confidence interval). While VLDL has maximum sensitivity of 68.97% while HDL has maximum specificity of 86.15% in predicting pre-eclampsia.Conclusions: Abnormal total cholesterol levels have diagnostic accuracy of 80.38% to predict pre-eclampsia and abnormal lipid profile in early second trimester is a simple, non-invasive and economical test for prediction of pre-eclampsia. 

scholarly journals Comparative study of lipid profile and C-reactive protein in hypertensive and normotensive patients of Andhra Pradesh population

2019 ◽  
Vol 6 (4) ◽  
pp. 1130
Author(s):  
Yasar Arafath Shaikh
Keyword(s):  
Cardiovascular Diseases ◽  
Comparative Study ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Andhra Pradesh ◽  
Morbidity And Mortality ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cardio Vascular

Background: Parameters of lipid profile, C-reactive protein was studied in hypertensive and Normotensive adults aged between 25 to 60 years and compared to predict the cardio-vascular disease.Methods: BP was recorded in both groups and compared. CRP lipid profile was studied in both groups and compared.Results: Systolic BP, diastolic BP in HTN and Normotensive were compared statically and p value was highly significant (p <0.01). C-reactive protein of both HTN and Normotensive was compared and statically highly significant (p <0.01). The lipid profile parameters total cholesterol, triglyceride VLDL, HDL, LDL were also compared in both HTN and Normotensive and all values were statistically highly significant (p <0.01).Conclusion: This study highlighted the diagnostic and prognostic values of HTN and cardiovascular diseases, which have high rates of morbidity and mortality.

scholarly journals EFFECT OF ERGONOMIC GYMNASTIC ON BLOOD PRESSURE AND LIPID PROFILE HYPERTENSION PATIENT AT SUMBER AGUNG VILLAGE, JATIREJO DISTRICT, MOJOKERTO CITY, INDONESIA

2017 ◽  
Vol 1 (1) ◽  
pp. 14-25
Author(s):  
Eka Nur Soemah ◽  
Agus Hariyanto ◽  
Amar Akbar
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
T Test ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Common Disease ◽  
Sample Number ◽  
Hypertension Patient

Background : Hypertension is the most common disease found in the community. It does not only degrade the quality of life, but it can be life-threatening. Hypertension is known as heterogeneous group of disease because it can affect anyone from different age groups and various economic classes. There are two therapies for hypertension ie pharmacology and nonpharmacology. One of non-pharmacology therapy is doing ergonomic gymnastics. The purpose of this study is to see the effect of ergonomic gymnastics on blood pressure in people with hypertension in Sumber Agung Village, Jatirejo Sub-district, Mojokerto Regency. Method : This research method used one group pre test - post test design with control group. Sampling technique used was simple random sampling, from 80-person population of hypertension patient in Sumber Agung Village Jatirejo Sub-district Mojokerto Regency and become sample number 20 respondents in treatment group, and 20 respondents in control group according to criteria. Data collection using interval scale blood presure and total cholesterol. Analysis using statistical test Paired T test and Independent T-test SPSS 17. Result : From the analysis we got result p value 0,00 <0,05 it indacted that means of blood presure and lipid profile before ergonomic gymnastic and after ergonomic gymnastic shown significat value, it means that ergonomic gymnastic was very effective for blood pressure and lipid profile (total cholesterol). Discussion : Ergonomic gymnastics is one of effective therapy, easy to do and useful. Because ergonomic gymnastics can make the body become relaxed and blood vessels become vasodilated so that the blood flow and oxygen supply becomes smooth and it get impact in lipid profile . keywords : Aergonomic Gymnastic, Blood Pressure, Lipid Profile, Hipertension.

scholarly journals A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women

2019 ◽  
Vol 8 (5) ◽  
pp. 2060
Author(s):  
Sridhara S. K.
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
The Mean ◽  
Pregnant Mothers

Background: The pregnancy results in the development of the placenta which is characterized by the hormonal changes in the women body, which results in the alteration of lipid profile, diabetic state of the pregnant mothers and many others. Objective of this study was to compare the of serum lipid profile between normotensive and hypertensive pregnant women.Methods: A hospital based cross sectional study was conducted by the department of OBG, Hassan Institute of Medical Sciences, Hassan from July 2018 to December 2018. A total of 6 months the study was conducted. A total of 50 pregnant mothers who were more than 20 weeks of gestation and suffering from Preeclampsia were include in the study group and 50 Pregnant mothers who were more than 20 weeks of gestation and normotensive were included in the controls.Results: Majority of the study subjects in both the groups were less than 25 years of age. The mean age of mothers in study group was 23.19 years and 24.19 years in the control group. The mean HDL level was more among the normotensive group than the pre eclamptic group and the p value was found to be statistically insignificant. The VLDL, LDL and triglyceride level was more in the pre eclamptic group than the normotensive group and the association was also found to be statistically significant.Conclusions: Hormonal changes in pregnancy results in physiological Hyperlipidemia, in conditions like pre-eclampsia triglyceride are elevated more than the normal rise seen in normal pregnancy. Increased lipid profile with raised TG, VLDL, LDL levels leads to the development of Preeclampsia by increasing the oxidative stress and the endothelial dysfunction.

scholarly journals Thyroid disorders in pregnancy: prevalence and its fetomaternal outcome in a tertiary hospital of Delhi, India

2020 ◽  
Vol 9 (2) ◽  
pp. 549
Author(s):  
Neha Bansal ◽  
Divya .
Keyword(s):  
Pregnant Women ◽  
Tertiary Care ◽  
Group Versus ◽  
Fetal Distress ◽  
First Trimester ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Thyroid Disorders ◽  
Care Hospital

Background: This study was conducted to determine the feto maternal outcome in pregnant women with thyroid disorders. The prevalence of thyroid disorders in present study was 15.75%.Methods: This was a prospective observational study carried out in all pregnant women irrespective of their parity, who attended ANC clinic in department of obstetrics and gynaecology in a tertiary care hospital over a period of 2 years. After registering, the patients were followed up with routine antenatal visits up to delivery and records were reviewed for development of abortion, PIH, preterm delivery, GDM, anemia, placental abruption, still birth, anomalies, fetal distress, meconium stained liquor, low birth weight and neonatal outcome by neonate Apgar score and TSH value.Results: Mean age group in our study was 27.61±3.14. Family history was present in 8% of study group versus 0% in control group which was statistically significant (p=0.028). Eighteen percent of preeclampsia was diagnosed in study group as compared to 4% in control group which was statistically significant (p-value= 0.005). Fourteen percent patients had preterm labour in study group as compared to 6.7% in control group which was statistically significant (p value= 0.047). Increased neonatal TSH was found in study group (61.3%) as compared to control group (32%), this difference was statistically significant (p-value <0.001). There was increased importance of measuring TSH in first trimester as it was statistically significant in study group (p-value <0.001).Conclusions: All pregnant women should be screened for hypothyroidism as early as possible or before conception to prevent any fetomaternal complications.

scholarly journals Effect of Estrogen on Serum Total Cholesterol and Triglyceride Levels in postmenopausal women

2017 ◽  
Vol 26 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Nahid Yeasmin ◽  
Qazi Shamima Akhter ◽  
Sayeeda Mahmuda ◽  
Sharrmin Nahar ◽  
Rukhshana Rabbani ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Total Cholesterol ◽  
Postmenopausal Women ◽  
Negative Correlation ◽  
Premenopausal Women ◽  
Serum Total Cholesterol ◽  
Control Group ◽  
Cross Sectional ◽  
Medical College ◽  
Estrogen Level

Background: Hyperlipidemia is a major risk factor for cardiovascular diseases in postmenopausal women. Increased incidence of cardiovascular diseases in postmenopausal women may be due to hyperlipidemia caused by lower level of estrogen hormone.Objectives: The study was carried out to observe the association of serum estrogen with total cholesterol (TC) and triglyceride (TG) levels in postmenopausal women.Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January to December 2011. A total of 90 females were selected from different areas of Dhaka city. Among them, 60 postmenopausal women with age ranging from 50 to 60 years were taken as study group and 30 apparently healthy premenopausal women with age ranging from 20 to 30 years were included as control group for comparison. The study parameters total cholesterol and triglyceride were estimated by enzymatic method in both groups. Serum estrogen level was estimated by Radioimmunoassay ( RIA) method in order to assess the hormonal level of both groups. Data was analyzed by Unpaired Student’s t- test and Pearson’s correlation co-efficient (r) test as applicable.Results: In this study, the mean serum TC level was higher in postmenopausal women than those of premenopausal women and result was statistically significant. The level of mean serum TG was significantly (p<0.001) higher in postmenopausal women in comparison to those of premenopausal women. In postmenopausal women serum estrogen level was lower than premenopausal women and serum estrogen level showed negative correlation with TC level. .Again serum TG level also showed negative correlation with serum estrogen level. All these correlation were statistically non-significant.Conclusion: From the results of the present study it may be concluded that the serum total cholesterol and triglyceride levels are significantly higher in postmenopausal women that may be due to low level of estrogen.J Dhaka Medical College, Vol. 26, No.1, April, 2017, Page 25-31

Evaluation of Serum Lipid Profile in Hypertensive Patients at Mirpur Khas, Sindh, Pakistan

2021 ◽  
Vol 15 (12) ◽  
pp. 3172-3174
Author(s):  
Iram Jehan Balouch ◽  
Ghazal Irfan ◽  
Muhammad Tahir ◽  
Pir A. Hayee ◽  
Atta Ullah ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Systolic Blood Pressure ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
College Hospital ◽  
Hypertensive Patients ◽  
Medical College ◽  
Elevated Systolic Blood Pressure ◽  
One Year

Aim: To assess the lipid profile of hypertensive patients. Study Design: Evaluation-based study. Place and duration of study: Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas, Sindh, Pakistan for a period of one year from 1stJuly 2020 to 30thJune 2021. Methodology: Three hundred and fifty-three hypertensive patients were enrolled in the study based on Rao-soft formula. Only those hypertensive patients who had confirmed diagnosis of hypertension were enrolled. The patients were requested for fasting to take the blood sample. Results: 64.87% were males and 35.1% were females. 39.6% patients were above 60 years old and highest range values for systolic blood pressure 201-220mmHg. The majority of the patients 26.34% showed 91-100 mm Hg. The 11.05% of the patients were prescribed with the Atenolol, 7.08% of patients were prescribed with another beta blocker medication Propranolol. The majority of patients were prescribed with Rosuvastatin as antilipidemic drugs however the least majority i.e. 11.61 were prescribed with Simvastatin.The 16.9% patients showed HDL40mg/dL, higher LDL<100mg/dL, total glycerides<150mg/dL, total cholesterol<200mg/dL HDL30-39mg/dL, LDL100-150mg/dL, total glycerides150-200 mg/dL, total cholesterol200-250mg/dL among 31.73% of the patients. The 28.9% of the patients showed the pattern HDL20-29mg/dL. Conclusion: The dyslipidemia associated with the hypertension and hypertensive patients. The irregular values and alteration of in the serum cholesterol and total cholesterol levels of lipid profile proves the association of lipid profile with the elevated systolic blood pressure levels. The total cholesterol, LDL and HDL can be controlled with an appropriate controlling of high blood pressures, thus preventing the cardiovascular diseases and cardiovascular diseases. Key words: Lipid, Hypertension, Assess

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