scholarly journals Physical Interaction Of Chitosan-Alginate Entrapping Extract Of Papaya Leaf And Formation Of Submicron Particles Dosage Form

2019 ◽  
Vol 4 (3) ◽  
pp. 64
Author(s):  
Budi Untari ◽  
Dina Permata Wijaya ◽  
Mardiyanto Mardiyanto ◽  
Herlina Herlina ◽  
Via Angraeni ◽  
...  
Keyword(s):  
Particle Size ◽  
Sodium Alginate ◽  
Leaf Extract ◽  
Dosage Form ◽  
Submicron Particles ◽  
Wave Number ◽  
Hydroxyl Group ◽  
Physical Interaction ◽  
Particle Size Analyzer ◽  
Optimum Formula

Research on physical interaction of chitosan-alginate entrapping extract of papaya leaf (Carica papaya L) into submicron particles formation has been performed. Preparation of papaya leaf extract into submicron particle dosage form of chitosan and sodium alginate polymer using ionic gelation method aimed to increase the solubility of extract. Submicron particles consisting of papaya leaf extract, chitosan, sodium alginate and CaCl2 were combined using variation of stirrer speed of 500, 750, and 1000 RPM. The optimum formula obtained has a speed of 1000 RPM with the percent EE value of 71.90%. The results of submicron particles characterization such as diameter and particle size distribution (PDI) using particle size analyzer (PSA) tools were 189.2 nm and 0.330. The results of XRD revealed the changes of type of crystalinity form to amorphous on submicron particles. The results of FTIR revealed the physical interaction without shifting of wave number of carbonyl, amine, and hydroxyl group which indicated that there were no chemical interactions occurred. These data indicated that papaya extract can be formulated into submicron particles of chitosan-alginate polymer.

scholarly journals FORMULATION AND CHARACTERIZATION OF TIMOLOL MALEATE-LOADED NANOPARTICLES GEL BY IONIC GELATION METHOD USING CHITOSAN AND SODIUM ALGINATE

2019 ◽  
pp. 48-54 ◽  
Author(s):  
RISA AHDYANI ◽  
LARAS NOVITASARI ◽  
RONNY MARTIEN
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Sodium Alginate ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Polydispersity Index ◽  
Ionic Gelation ◽  
Timolol Maleate ◽  
Optimum Formula

Objective: The objectives of this study were to formulate and characterize nanoparticles gel of timolol maleate (TM) by ionic gelation method using chitosan (CS) and sodium alginate (SA). Methods: Optimization was carried out by factorial design using Design Expert®10.0.1 software to obtain the concentration of CS, SA, and calcium chloride (CaCl2) to produce the optimum formula of TM nanoparticles. The optimum formula was characterized for particle size, polydispersity index, entrapment efficiency, Zeta potential, and molecular structure. Hydroxy Propyl Methyl Cellulose (HPMC) K15 was incorporated into optimum formula to form nanoparticles gel of TM and carried out in vivo release study using the Franz Diffusion Cell. Results: TM nanoparticles was successfully prepared with concentration of CS, SA, and CaCl2 of 0.01 % (w/v), 0.1 % (w/v), and 0.25 % (w/v), respectively. The particle size, polydispersity index, entrapment efficiency, and Zeta potential were found to be 200.47±4.20 nm, 0.27±0.0154, 35.23±4.55 %, and-5.68±1.80 mV, respectively. The result of FTIR spectra indicated TM-loaded in the nanoparticles system. In vitro release profile of TM-loaded nanoparticles gel showed controlled release and the Korsmeyer-Peppas model was found to be the best fit for drug release kinetics. Conclusion: TM-loaded CS/SA nanoparticles gel was successfully prepared and could be considered as a promising candidate for controlled TM delivery of infantile hemangioma treatment.

scholarly journals The submicron particles FORMULATION OF IONIC-GELATION SUBMICRON PARTICLES LOADING EXTRACT PAPAYA LEAVES (Carica papaya L.) WITH LACTIC ACID ISOLATES

2019 ◽  
Vol 4 (3) ◽  
pp. 77
Author(s):  
Mardiyanto Mardiyanto ◽  
Budi Untari ◽  
Najma Annuria Fithri ◽  
Sofia Sandi ◽  
Zahrul Mawaddah
Keyword(s):  
Particle Size ◽  
Lactic Acid ◽  
Encapsulation Efficiency ◽  
Carica Papaya ◽  
Ethanolic Extract ◽  
Submicron Particles ◽  
Ionic Gelation ◽  
Particle Characterization ◽  
Submicron Particle ◽  
Optimum Formula

A study regarding ionic-gelation submicron particle of papaya leaves (Carica papaya L.) extract with lactic acid of weeds potentially for antidiarrhea has been conducted. Preparation of papaya leaves ethanolic extract and lactic acid isolate into particles was done by ionic gelation method. This study aimed to determine: the major compound of extract, the total quercertine of extract, the percent value of encapsulation efficiency of the optimum formula which was varied by (CaOH)2 of the three formulas, and physical properties of particles. Formula 1 was using (CaOH)2 of 12.5 gram; formula 2 (CaOH)2 of 17,5 gram; formula 3 (CaOH)2 of 22.5 gram. The results showed formula 1 as the optimum formula that has the highest %EE. The average %EE values ​​of F1; F2; F3 respectively were 80,82%; 80,41%; 80,31%. The results of particle characterization using the PSA in the optimum formula produced particle size values ​​with an average of 253.6 nm, PDI of 0.218, and zeta potential +8 mV respectively.

scholarly journals Green Synthesis, Characterization, Antioxidant, Antibacterial and Dye Degradation of Silver Nanoparticles using Combretum indicum Leaf Extract

2021 ◽  
Vol 34 (1) ◽  
pp. 216-222
Author(s):  
Arnannit Kuyyogsuy ◽  
Paweena Porrawatkul ◽  
Rungnapa Pimsen ◽  
Prawit Nuengmatcha ◽  
Benjawan Ninwong ◽  
...  
Keyword(s):  
Particle Size ◽  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Dye Degradation ◽  
Sunlight Irradiation ◽  
Particle Size Analyzer ◽  
Vis Spectroscopy ◽  
Edx Analyses ◽  
Aqueous Leaf Extract ◽  
And Staphylococcus Aureus

Silver nanoparticles were synthesized by bioreduction of silver nitrate using the aqueous leaf extract of Combretum indicum (CI-AgNPs). The synthesized CI-AgNPs exhibited a distinct absorption peak at 414 nm in UV-vis spectroscopy. Various parameters such as pH, temperature and time were optimized using spectrophotometry. The particle size of the CI-AgNPs was 48 nm as evaluated from the laser particle size analyzer. The XRD and EDX analyses confirmed the presence of silver in silver nanoparticles. Synthesized CI-AgNPs revealed significant antioxidant, antimicrobial (against Escherichia coli and Staphylococcus aureus) and photocatalytic (against methylene blue under sunlight irradiation) activities. Thus, an eco-friendly method was developed to synthesize silver nanoparticles using the C. indicum leaf extract.

scholarly journals THE UTILIZATION OF BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) LEAF AS AN ANTI‑AGING

2018 ◽  
Vol 11 (13) ◽  
pp. 87 ◽  
Author(s):  
Nazliniwaty Nazliniwaty ◽  
Suryanto Suryanto ◽  
Desy Damayanti Damanik
Keyword(s):  
Surface Tension ◽  
Particle Size ◽  
Water Content ◽  
Leaf Extract ◽  
Dosage Form ◽  
Aging Effect ◽  
Ash Content ◽  
Water Soluble ◽  
Low Viscosity

Objective: To formulate binahong leaf extract in the microemulsion dosage form and to evaluate the anti-aging effect on the human skin.Methods: Binahong leaf extract was prepared by maceration then formulated into microemulsion dosage form with various concentrations of 0.1%, 0.3%, and 0.5%. The microemulsion preparation was prepared by adding the oil phase to the water phasehen mixed until a clear and transparent microemulsion was formed. Characterization of the dried powder included the determination of water content, water-soluble content, ethanol-soluble content, total ash content, and unsaturated acid ash content. Evaluation of microemulsion preparation included a stability test, determination of homogeneity, density, viscosity, pH, centrifugation, microemulsion type, surface tension, particle size, irritation test, and anti-aging effect test using skin analyzer. Anti-aging parameters measured included moisture, number of spots and wrinkles number.Results: Characterization results showed the water content of 7.48%, water-soluble content of 19.2%, ethanol soluble content of 9.46%, total ash content of 4.65%, and acid content of 0.58%. Microemulsion preparation of the binahong leaf extract was homogen, had low viscosity, pH 6.0–7.0, density of 1.049–1.0753 g/ml, surface tension of 35.24–38.00 dyne/cm, particle size of 364.68–632.72 nm, stable for 12 weeks storage and did not irritate the skin. The results of anti-aging effect measurements showed that the 0.5% binahong leaf extract microemulsion gave the best results.Conclusion: The dried powder of binahong leaf is qualified to be formulated. Microemulsion preparation of 0.5% binahong leaf extract showed the best anti-aging effect.

scholarly journals Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102

2020 ◽  
Vol 17 (1) ◽  
pp. 24-30
Author(s):  
Agung Setiawan ◽  
Naelaz Zukhruf Wakhidatul Kiromah ◽  
Tri Cahyani Widiastuti
Keyword(s):  
Particle Size ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Chitosan Solution ◽  
Reduce Blood Pressure ◽  
Disintegration Time ◽  
Pressing Method ◽  
Traditional Medicines ◽  
Particle Size Analyzer ◽  
Herbal Plants

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using  ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into  technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.

scholarly journals EFFECT OF CONCENTRATION OF IMPERATA CYLINDRICA L LEAF EXTRACT ON SYNTHESIS PROCESS OF GOLD NANOPARTICLES

2018 ◽  
Vol 19 (2) ◽  
pp. 72
Author(s):  
Iwan Syahjoko Saputra ◽  
Yoki Yulizar ◽  
Sudirman Sudirman
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Leaf Extract ◽  
Synthesis Method ◽  
Ion Source ◽  
Imperata Cylindrica ◽  
Hydroxyl Group ◽  
Synthesis Process ◽  
Tem Analysis ◽  
Ft Ir

Gold Nanoparticles (GoldNPs) successful was performed using HAuCl4 precursor as Au3+ ion source with 7x10-4 M concentration. The research aims to knows effect of concentration variation of Imperata cylindrica L leaf extract on synthesis process of gold nanoparticles. The research used of green synthesis method. Colloid of nanoparticles which is formed in analyzed using UV-Vis Spectrophotometer, FT-IR Spectroscopy, PSA, PZC, XRD and TEM. The results of synthesis showed the best concentration of Imperata cilindrica L leaf extract at 3,46%, happen a shift of wavelength at UV-Vis from 216 nm to 530 nm with 1.779 absorbance value. The PSA analysis showed a particle size of 51.87 nm and a PZC value of -19.2 mV. The result of FT-IR indicated a shift of wavenumber in the hidroxyl group from 3354 cm-1 to 3390 cm-1 and showed a interaction of hydroxyl group at imperata cylindrica L leaf extract with Au3+ ion. TEM analysis shows the morphology of GoldNPs that spherical shape with a particle size of 20 nm. XRD calculation results show crystallite size of gold nanoparticles is 15.47 nm.

scholarly journals The Chitosan-Sodium Alginate Submicro Particles Loading Herbal of Ethanolic Exract of Leaves Senna Alata. L for Curing of Bacterial Infection on Skin

2020 ◽  
Vol 5 (3) ◽  
pp. 85
Author(s):  
Mardiyanto Mardiyanto ◽  
Indah Sholihah ◽  
Thio Gunawan Jaya
Keyword(s):  
Sodium Alginate ◽  
Leaf Extract ◽  
Test Group ◽  
Ethanol Extract ◽  
X Ray Diffraction ◽  
X Ray ◽  
Acne Lesion ◽  
Optimum Formula ◽  
Senna Alata

Abstract Mardiyanto 1*, Indah Solihah 1, and Thio Gunawan Jaya 1 1Department of Pharmacy Faculty of Science Sriwijaya University *Corresponding Author : [email protected] This research was performed to detect the activity of the optimum formula of chitosan and sodium alginate submicro particles loading of the ethanol extract of leaves ketepeng cina (Senna alata L.) to P. acne growth. Submicro manufactured particles was used three variations of the formula from three of volume used of calcium chloride (CaCl2): 20, 40, and 100 mL based on ionic gelation method. The results obtained of %EE in formulas 1, 2 and 3 were 78.56%, 81.71%, and 77.48%. Formula 2 with a value of % EE of 81.71% was used as an optimum formula which indicates that the particles are well protected by chitosan and sodium alginate polymers so as to prevent particle damage during the homogenization process. The results of the diameter measurements showed that the optimal formula enters in the submicro particle range with the value obtained is 525,9455 nm. The submicro formula of chitosan alginate particles loading the ketepeng cina leaf ethanol extract was barely homogeneous which based on the results obtained by the PSA was 0.433 of PDI. The zeta potential value was +3.5 mV. The results of X-ray diffraction analysis or X ̶ Ray Diffraction produce a pattern shaped amorph with the resulting peak does not have a wide distance and pattern. In vivo testing using ketepeng cina leaf extract as submicro was decreased the P. acne lesion faster than using only ketepeng cina leaf extract because the submicro particle preparation has a small particle that is below to 600 nm making it easier to penetrate the skin pores to reach the target. The results of the analysis of the curing of many lesions on the skin of mice have a significance value of homogeneity. The one-way ANOVA test of < 0.05 was a significant effect of the test group on the decreasing in the number of lesions on the skin of the mouse.  

scholarly journals Sintesis Nanopartikel Perak Menggunakan Ekstrak Daun Salam (Syzygium polyanthum) Sebagai Bioreduktor Dan Uji Aktivitasnya Sebagai Antioksidan

2019 ◽  
Vol 7 (1) ◽  
pp. 51-60
Author(s):  
Paulina Taba ◽  
Nadya Yuli Parmitha ◽  
Syahruddin Kasim
Keyword(s):  
Particle Size ◽  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Average Particle Size ◽  
Average Diameter ◽  
Average Particle ◽  
X Ray ◽  
Synthesis Of Nanoparticles ◽  
Particle Size Analyzer ◽  
Ic50 Value

Silver nanoparticles have been synthesized by the reduction method using salam leaf extract (Syzygium polyanthum) as a reducing agent. The silver nanoparticles produced were then tested for their activity as antioxidants. The formation of silver nanoparticles was carried out by adding the leaf extract into the solution of AgNO3 and homogenized using a magnetic stirrer. A UV-Vis spectrophotometer was used to confirm the formation of silver nanoparticles. Particle Size Analyzer (PSA), Scanning Electron Microscope (SEM), X-Ray Diffractometer (XRD) and Fourir Transform Infra Red (FTIR) spectrometers were used to characterize the nanoparticles produced before being tested for antioxidant activity. The results showed that the absorbance value increased with increasing reaction contact time. The maximum uptake was obtained at wavelengths of 432-446 nm using a UV-Vis spectrophotometer. The particle size was determined using a PSA with an average particle size distribution of 45.7 nm. The average diameter of silver nanoparticles was 10.06 – 13.97 nm and the silver nanoparticles had rod-shapes. Functional groups that play a role in the synthesis of nanoparticles were –OH, –C=O, and –C-O groups. Silver nanoparticles inhibited free radicals as antioxidants with the IC50 value of 582.7 ppm.

scholarly journals Synthesis And Characterization Of Gold Nanoparticles Using Beluntas Leaf Extract Plucheaindica

2019 ◽  
Vol 12 (1) ◽  
pp. 13
Author(s):  
Dewi Lidiawati ◽  
Abdul Wahid Wahab ◽  
Abdul Karim
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Diffraction Pattern ◽  
Size Distribution ◽  
Leaf Extract ◽  
Synthesis And Characterization ◽  
Particle Size Analyzer ◽  
Average Shape ◽  
Average Distribution

Gold nanoparticles have been successfully synthesized using beluntas leaf extract as reducing agents. This is indicated by the change of the color from yellow gold to purple solution after the addition of the beluntas leaf extract. The gold nanoparticles formed were observed for 92 hours using uv-vis and obtained stability after 72 hours with a wavelength about 545.50-546.00 nm. The size distribution of gold nanoparticles was determined using Particle Size Analyzer (PSA) with an average distribution of 101.6 nm. Based on the characterization using XRD, the diffraction pattern obtained at 2θ is 38.1077; 44,2935; 64,5155; 77,4862 which show the presence of gold nanoparticles. Furthermore, it was characterized using SEM EDX showed that the average shape of gold nanoparticles was spherical with a composition ofAu 48%, C 43.33%, and several other elements around 8.67%.

SINTESIS DAN KARAKTERISASI NANOPARTIKEL KITOSAN – EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana)

2013 ◽  
Vol 14 (3) ◽  
Author(s):  
Eriawan Rismana ◽  
Susi Kusumaningrum ◽  
Olivia Bunga P ◽  
Idah Rosidah ◽  
Marhamah Marhamah
Keyword(s):  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Chitosan Solution ◽  
The Other ◽  
Ionic Gelation ◽  
Garcinia Mangostana ◽  
Particle Size Analyzer ◽  
Cadmium Lead ◽  
Solvent Residue ◽  
Mold And Yeast

The chitosan – Garcinia Mangostana extract nanoparticles has been prepared by ionic gelation reaction by mixture 0.2 % chitosan solution in acetic acid with Garcinia Mangostana extract and it’s continued by reaction process with 0.1 % sodium tripolyphosphate. The particle size of material was determined by Particle Size Analyzer (PSA) that it showed in the range of 200 – 500 nm. The color, pH, water, α- mangostin, mercury, arsenic, cadmium, lead, totally microbe aerobic, totally mold and yeast, and solvent residue contents of nanoparticles were also examined by many methods that these resulted are yellow, 4.50 – 5.50, 89 – 90 %, 1.05 %, < 0.005 ppm, < 0.01 ppm, < 0.01 ppm, < 0.05 ppm, < 10 CFU/g, < 10 CFU/g and not detected, respectively. The other characterization was also observed that it’sincluded stability andTLC chromatogram. A mixture of nanoparticles with cosmetics bases was showed that it’s increased stability, homogeneity and easy to formed.

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