scholarly journals Extra Virgin Olive Oil meningkatkan ekpresi reseptor estrogen α dan ketebalan Endometrium Rattus Norvegicus yang dipapar Rhodamin B

2018 ◽  
Vol 5 (3) ◽  
pp. 201-206
Author(s):  
Ita Noviasari ◽  
I Wayan Arsana Wiyasa ◽  
Hidayat Sujuti ◽  
Eviana Norahmawati
Keyword(s):  
Oxidative Stress ◽  
Estrogen Receptors ◽  
Olive Oil ◽  
Rattus Norvegicus ◽  
Endometrial Thickness ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
The Body ◽  
Control Group ◽  
Rhodamin B

Abstract: Rhodamin B is harmful to the body because it is proven can increase the oxidative stress on various reproductive chain. Rhodamin B contains compounds of chlorine (Cl), is dangerous and halogen compounds are reactive. Damage to the hypothalamus will interfere with the secretion of FSH and LH cause the follicle ripening so distracted that result in a decrease in the hormone estrogen. The hormone estrogen plays an important role in the menstrual cycle and proliferation of the endometrium. This research aimed to prove the effect of Extra Virgin Olive Oil (EVOO) with the expression of estrogen receptors α and endometrial thickness of Rattus norvegicus exposed by rhodamin B. The design used true experimental with an approach of post test only control group design. The research used white rat (Rattus norvegicus wistar strain) as the sample. The results showed that EVOO could become an alternative to prevent oxidative stress due to exposure of rhodamin B.Keywords: Rhodamin B, Extra Virgin Olive Oil (EVOO), Estrogen receptors α, the thickness of the Endometrium

scholarly journals Pengaruh pemberian Extra Virgin Olive Oil terhadap jumlah Sel Granulosa dan kadar 17 β Estradiol tikus yang di papar Rhodamin B

2018 ◽  
Vol 5 (3) ◽  
pp. 241-248
Author(s):  
Fera Yuli Setiyaningsih ◽  
Pande Made Dwi Jayasa ◽  
Hidayat Sujuti ◽  
Diah Prabawati Retnani
Keyword(s):  
Treatment Group ◽  
Olive Oil ◽  
Granulosa Cells ◽  
Rhodamine B ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Positive Control ◽  
Control Group ◽  
17Β Estradiol ◽  
Rhodamin B

Abstract: The use of dyes in food today is very apprehensive. Many foods contain dyes that are prohibited to be used in food. The addition of the dye will have an impact on health. The aim of this research was to know the effectiveness of the administration of extra virgin olive oil to the number of granulosa cell and 17β estradiol level of Rats exposed by rhodamin B. The design of this study was true experimental with post test approach of group design control. The subject of the study was 30 white mice Rattus novergicus in the age of 12 weeks weight average 220 grams and in healthy condition. Rats were divided into 5 groups. Control group without treatment, positive control treatment with rhodamine B 18 mg / 200gr. Treatment 1 administration of rhodamine B 18 mg / 200gr and EVOO (Extra Virgin Olive Oil) 1.5 ml / KgBB, treatment 2 rhodamine B 18 mg / 200gr and EVOO 3 ml / KgBB, treatment 3 rhodamine B 18 mg / 200gr and EVOO 4,5 ml / KgBB. The number of granulosa cells was determined by HE staining, the level of 17β estradiol with ELISA. The data was analyzed by Kruskal Wallis test, Spearman Rank and Simple Linear Regression with degree of significance α <0.05. The average number of granulosa cells and the lowest levels of 17β estradiol were found in the positive control group and the highest average was in the treatment group 3. There was one dose that could significantly increase granulosa cells and the beta estradiol levels compared with the treatment group the other with niali α <0.05. The administration of EVOO affected the number of granulosa cells and the levels of 17β estradiol in rats exposed by rhodamine B.Keyword: granulosa cells, estradiol, rhodamin B, oxidative stress

scholarly journals The Effect of Extra Virgin Olive Oil on Low-Density Lipoprotein Levels in Productive Age Obesity Women in Kendari

2021 ◽  
pp. 59-65
Author(s):  
Arimaswati ◽  
Alfath Akbar J. Dundu ◽  
Pranita Aritrina
Keyword(s):  
Fatty Acids ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
The Body ◽  
Control Group ◽  
Antioxidant Compounds ◽  
P Value ◽  
Obese Women ◽  
Childbearing Age

Obesity is one of the burdens of nutritional problems in women of childbearing age due to fat accumulation (adiposity) in the body, thereby increasing the risk of health problems. Obese subjects tend to have high LDL levels, so consuming olive oil every day for one week will experience a decrease in LDL cholesterol and increase antioxidant compounds. Olive oil used in the medical world is a type of extra virgin olive oil (EVOO) that contains monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), omega 3, omega 6, oleic acid (omega 9), vitamin E, vitamin K, palmitic acid, pigments, phenolic, squalene. This study was a quasi-experimental study with a pretest-posttest approach without a control group. The independent variable was 30 ml extra virgin olive oil (EVOO) for 21 days in obese women of productive age in Kendari. The results of this study obtained a p-value of 0.112. Extra virgin olive oil has no effect on LDL levels in obese women of productive age in Kendari.

scholarly journals Squalene: a multi-task link in the crossroads of cancer and aging

2013 ◽  
Vol 3 (12) ◽  
pp. 462 ◽  
Author(s):  
Alvaro L. Ronco ◽  
Eduardo De Stéfani
Keyword(s):  
Olive Oil ◽  
Animal Species ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
The Body ◽  
Intermediate Step ◽  
Key Words Aging ◽  
Body Structure ◽  
Anticancer Properties ◽  
In The Beginning

Since its discovery in the beginning of the XXth century, squalene has been recognized as an important link in metabolic pathways. More recently, it has been further recognized as an intermediate step in the biosynthesis of cholesterol. Its well known antioxidant capability, together with its ability to protect skin, improve the immune system, and modulate the lipid profile, confer a high potential to this natural substance, which is spread all across the body structure, though mainly in the epithelial tissues, and in particular the skin sebum. This review will focus mainly on its major properties, which are related to anticancer properties, the maintenance of the oxidation/antioxidation balance, and its antiaging capabilities. Although the substance was originally obtained from shark liver oil, it is currently possible to obtain useful amounts from vegetable sources like extra virgin olive oil, therefore avoiding the dependence on capturing the aforementioned animal species. Recognized as one of the key components of the Mediterranean dietary style, squalene is necessary to adequately manage oxygen and its derivatives in every cell of the body. Key words: aging, antioxidants, cancer, cholesterol, diet, olive oil, squalene

scholarly journals The Enhanced Beneficial Effect of Extra Virgin Olive Oil Over Evening Primrose Oil on Oxidative Stress, and Liver Function in Male Arthritic Rats

2021 ◽  
pp. 14-26
Author(s):  
Mohamed A. Kandeil ◽  
Sana’a O. Ebrahim ◽  
Basant M. Mahmoud
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Olive Oil ◽  
Liver Enzymes ◽  
Virgin Olive Oil ◽  
Antioxidant Properties ◽  
Extra Virgin Olive Oil ◽  
Male Rats ◽  
Evening Primrose Oil ◽  
Evening Primrose

Aims: Rheumatoid arthritis (RA) is characterized by the onset of oxidative stress. This study aimed to evaluate the enhancing of extra virgin olive (EVOO) and Evening primrose oil (EPO) on oxidative stress and liver enzymes in male Wistar rats and compare between them. Place and Duration: Faculty of Science biochemistry department, Between July 2018 and August 2018. Methodology: A Subcutaneous injection of 200 µl of Freund's complete adjuvant into a footpad of the right hind leg of Wistar male rats at two consecutive days induced RA. Rats received EVOO and EPO daily by oral gavage needle with gauge 18 at doses of 5 mg/kg b.wt./day. for 10 and 21 days. No loss was recorded in the experimental rats. Results: A significant depletion in serum Reduced glutathione content (GSH), glutathione peroxidase (GPX), and glutathione s transferase activities (GST) in arthritic rats compared to normal rats after 10 and 21 days of induction which improved significantly after 10 and 21 days of EPO and EVOO treatments. EPO and EVOO treatments for 21 days increased the GSH and GPX compared to 10 days treatments while no difference in GST activity. EVOO treatment improved GSH and GPX after 10 and 21 days than EPO treatment. The elevated uric acid levels in arthritic rats were markedly ameliorated as a result of EVOO and EPO treatment administration. Increased lipid peroxidation products (MDA), rheumatoid factor, and liver enzyme (Alanine transaminase ALT and Aspartate transaminase AST) were recorded in arthritic rats and they significantly progressed after EPO and EVOO treatments for 10 and 21 days but EVOO had the best effect at 21 days. Conclusion: EVOO and EPO showed significant antioxidant efficacies and improved affected liver enzymes due to rheumatoid arthritis onset. When comparing olive oil has more antioxidant properties than evening primrose oil, so we recommend more studies on olive oil combination with anti-arthritic medications to improve their efficacies with less toxicity.

scholarly journals Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 885
Author(s):  
Álvaro Santana-Garrido ◽  
Claudia Reyes-Goya ◽  
M. Carmen Pérez-Camino ◽  
Helder André ◽  
Alfonso Mate ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Olive Oil ◽  
Blood Pressure Monitoring ◽  
Virgin Olive Oil ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Extra Virgin Olive Oil ◽  
Therapeutic Effects ◽  
Beneficial Effects ◽  
Wild Olive ◽  
Minor Compounds

Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree’s counterpart, wild olive (also known in Spain as acebuche—ACE). Here, we aimed to analyze the antioxidant and retinoprotective effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of major and minor compounds present in both oils was accompanied by blood pressure monitoring, morphometric analyses, as well as different determinations of oxidative stress-related parameters in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage.

Extra Virgin Olive Oil Improves Oxidative Stress, Functional Capacity, and Health-Related Psychological Status in Patients With Fibromyalgia

2016 ◽  
Vol 19 (1) ◽  
pp. 106-115 ◽  
Author(s):  
Alma Rus ◽  
Francisco Molina ◽  
Manuel Miguel Ramos ◽  
María Josefa Martínez-Ramírez ◽  
María Luisa del Moral
Keyword(s):  
Oxidative Stress ◽  
Olive Oil ◽  
Functional Capacity ◽  
Short Form ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Psychological Status ◽  
Protein Carbonyls ◽  
Antioxidant Enzyme Activities ◽  
Health Related

Objectives: Fibromyalgia (FM) is a chronic disease that imposes physical, psychological, and social limitations. We have reported that oxidative stress may play a role in the pathophysiology of FM. Olive oil has been shown to be effective treatment against the oxidative stress associated with several diseases. The aim of this study was to investigate the effect of olive oil on oxidative stress and health-related parameters in FM. Methods: This preliminary study was performed on blood samples of 23 women diagnosed with FM who consumed 50 ml of organic olive oil daily for 3 weeks. Subjects were randomized into two groups: one ingested extra virgin olive oil (EVOO) and the other refined olive oil (ROO), which have different antioxidant content. The patients’ oxidative (lipid, protein, and DNA oxidation) and antioxidative (antioxidant enzyme activities and compounds) profiles were examined before and after the treatment period. Functional capacity and physical and mental health status were assessed using the Fibromyalgia Impact Questionnaire (FIQ) and the Physical Component (PCS-12) and Mental Component Summaries (MCS-12) of the Short Form-12 Health Survey, respectively. Results: Significant differences were found in pre–post change between the EVOO and ROO groups for protein carbonyls, lipid peroxidation, and FIQ and MCS-12 scores. Differences between groups approached statistical significance for oxidative DNA damage and levels of the antioxidant compound zinc. Conclusions: EVOO may protect women with FM against oxidative stress in addition to improving functional capacity and health-related psychological status. Findings suggest that olive oil may be a valuable therapeutic support in FM.

scholarly journals Extra Virgin Olive Oil Modulates Vasodilator Enzyme Level by Repairing Angiogenesis Function in Rat Model of Preeclampsia

2020 ◽  
Author(s):  
Yulia Silvani ◽  
Agnestia Naning Dian Lovita ◽  
Afniari Maharani ◽  
I Wayan Arsana Wiyasa ◽  
Hidayat Sujuti ◽  
...  
Keyword(s):  
Olive Oil ◽  
Rat Model ◽  
Enzyme Level ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Pregnant Rats ◽  
Vegf Level

Objective: This study aimed to determine the effect of Extra Virgin Olive Oil (EVOO) on vasodilator enzyme by repairing angiogenic function in rat model of preeclampsia. Materials and methods: This research consisted of five groups; negative control (normal pregnant rats) group, positive control (preeclampsia rat model) group, preeclampsia rat model groups given EVOO in 3 different doses (0.5 ml/day, 1 ml/day, and 2 ml/day, respectively). Blood pressure measurements were carried out on day 12, 15, and 19 of pregnancy. After the rats were sacrificed, the placentas were collected to determine endothelial Nitric Oxide Synthase (eNOS) level of maternal plasma to determine soluble Fms-like Tyrosine Kinase 1 (sFlt-1) and Vascular Endothelial Growth Factor (VEGF) level. Results: There were significant higher sFlt-1 level (p < 0.001), lower VEGF level (p = 0.009), and lower eNOS level (p = 0.034) between negative and positive control groups. After EVOO administration, sFlt-1 level was lower in dose 1 and 2 groups but higher in dose 3 group in accordance with VEGF and eNOS levels that were increasing both in dose 1 and dose 2 groups but decreasing in dose 3. There were significant differences between positive control and dose 1 (p = 0.015) and dose 2 (p = 0.001) in sFlt-1 level. None of all dose groups were statistically different with positive control group in VEGF level (dose 1 p = 0.601; dose 2 p = 0.297; dose 3 p = 0.805). eNOS levels of all dose groups were statistically different from that of the positive control group (dose 1 p = 0.014; dose 2 p = 0.001; dose 3 p = 0.024). Conclusion: Administration of EVOO modulates eNOS as vasodilator enzyme by repairing the angiogenic function indicated by decreased sFlt-1 level and increased VEGF in rat model of preeclampsia.

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