Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Ruswana Anwar ◽  
Muhammad Alif ◽  
Adhi Pribadi
Keyword(s):  
Laparoscopic Surgery ◽  
Cell Nucleus ◽  
Significant Relationship ◽  
Strong Relationship ◽  
Cyst Size ◽  
Ki 67 ◽  
Cut Method ◽  
Close Relationship ◽  
Dividing Cells ◽  
Aggressive Tumor

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst

scholarly journals Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis

2016 ◽  
pp. 124-128
Author(s):  
Muhammad Alif ◽  
Ruswana Anwar ◽  
Adhi Pribadi
Keyword(s):  
Laparoscopic Surgery ◽  
Observational Study ◽  
Strong Correlation ◽  
Obstet Gynecol ◽  
Cyst Size ◽  
Ki 67 ◽  
Cross Sectional ◽  
Keywords Endometriosis ◽  
Endometriotic Cyst ◽  
Correlation Strength

Objectives: To analyze the association between Ki-67 expression with the cyst size and stage of endometriosis, and the correlation strength between them. Methods: A cross-sectional analytic observational study involving 56 paraffin blocks from subjects diagnosed with endometriosis, who had undergone laparotomy or laparoscopic surgery. The study is conducted in Dr. Hasan Sadikin Hospital in September-November 2012. Results: Shows a significant association between Ki-67 expression and the size of endometriotic cyst (p < 0.0001), also with a strong correlation (r = 0.55) according to Guilford criteria. There is also a significant association between Ki-67 expression and the endometriosis stage (p < 0.0001), with a strong correlation (r = 0.564) according to Guilford criteria. Conclusion: Ki-67 expression is correlated with the cyst size and stage of endometriosis. [Indones J Obstet Gynecol 2013; 1-3: 124-8] Keywords: endometriosis stage, endometriotic cyst size, Ki-67

Predicting the Dose of Warfarin for Therapeutic Anticoagulation

1982 ◽  
Vol 47 (03) ◽  
pp. 230-231 ◽  
Author(s):  
N K Sharma ◽  
P A Routledge ◽  
M D Rawlins ◽  
D M Davies
Keyword(s):  
Therapeutic Range ◽  
Significant Relationship ◽  
Maintenance Dose ◽  
Warfarin Dose ◽  
Loading Dose ◽  
Intravenous Injections ◽  
Therapeutic Anticoagulation ◽  
Close Relationship ◽  
The Relationship ◽  
Anticoagulant Response

SummaryThe validity of a previously described technique for predicting warfarin requirements based on the anticoagulant response to a fixed loading dose was assessed prospectively in 57 patients. There was a close relationship between the predicted and initially observed daily warfarin dose required to maintain the patient within the therapeutic range for anticoagulation. The significant relationship between predicted and observed maintenance dose persisted at 4 and 12 weeks although it decreased with increasing time.The relationship between observed and predicted maintenance requirement of warfarin was not affected by the concomitant use of intermittent intravenous injections of heparin when 9 hr was allowed to elapse between the previous dose of heparin and the thrombotest estimation on which the prediction was based.It is concluded that the method is valuable in predicting an individual’s warfarin requirement, although it does not obviate the need for regular monitoring of anticoagulant control.

The Case of Shisong Hospital: Is Promotion the Reason for Employee Satisfaction, Commitment or Intention to Quit?

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Benard Berinyuy ◽  
Lema Catherine Forje
Keyword(s):  
Correlation Analysis ◽  
Significant Relationship ◽  
Employee Satisfaction ◽  
Employee Commitment ◽  
Strong Relationship ◽  
Health District ◽  
Intention To Quit ◽  
Significant Relationships ◽  
Northwest Region ◽  
Labour Turnover

The movement of professionals from one organisation to another in quest for satisfaction has been a matter of serious concern to health organisations especially Shisong hospital in Kumbo east health district, Bui Division of the Northwest Region of Cameroon. This hospital sought to reduce this labour turnover and increase employee satisfaction through promotion, which is one of its internal recruitment sources. The question has been whether the use of promotion will lead to employee satisfaction and commitment and reduce the urge to leave this organisation. An investigation has been done using a close ended questionnaire with 166 employees of this hospital to prove if significant relationships exist between promotion and employee satisfaction; employee satisfaction and employee commitment; and promotion and employee intention to quit the organisation. Correlation analysis concluded that there is a significantly strong relationship between promotion and employee satisfaction, a significantly very strong relationship between employee satisfaction and employee commitment and a negatively weak significant relationship between promotion and employee intention to quit this Hospital. Specially, it has been realised that even employees who have not experienced promotion in Shisong hospital are not willing to quit their job as a result of promotion. There will therefore be need to investigate the reason for this special result. Based on promotion alone, much is left to be desired from Shisong hospital.

scholarly journals HUBUNGAN GAYA KEPEMIMPINAN DAN BUDAYA ORGANISASI DENGAN KINERJA APARATUR PENDIDIKAN NONFORMAL DI DINAS PENDIDIKAN KOTA GORONTALO

2015 ◽  
Vol 2 (2) ◽  
pp. 173
Author(s):  
Abdul Rahmat
Keyword(s):  
Organizational Culture ◽  
Local Government ◽  
Leadership Style ◽  
Significant Relationship ◽  
Strong Relationship ◽  
Survey Method ◽  
Significance Level ◽  
Significant Performance ◽  
Relationship Performance ◽  
The Relationship

<p>This study aimed to examine the alleged causality between the dependent and independent variables. This study is a descriptive research using survey method. Datan collected by using questionnaire and analyzed using path analysis to test the hypothesis. Engineering analysis will be determined by SPSS data analysis program. The result of the study were; 1) Leadership style has a significant relationship with the performance of officials local government in Gorontalo city. It is seen in the calculation of the product r correlation counted is 0.811 at the significance level (0.05), r table at 0,239 then count r &gt; r of the table so that we can conclude the existence of a significant relationship, while the relationship is based on arithmetic interval coefficient criteria r is 0.811, which means relatively strong relationship with the leadership style of performance in local government apparatus city Gorontalo relatively strong. While t is 0.957 and compared t table with a significance level of 0.044 (0.05) turns out t count&gt; t table with the sense of the hypothesis is accepted which stated the existence of a significant relationship. 2) Organizational Culture has a significant relationship performance in local government apparatus city Gorontalo, it can be seen that the calculation of the product correlation r counted is 0.922 at the significance level (0.05)r price table is 0.098 then the count r &gt; r table. It conclude the existence of a significant relationship, while the relationship is based on interval arithmetic coefficient criteria r is 0.922, which means has relatively strong relationship with the organizational culture apparatus as very strong performance. While t is 0.957 and compared t table with a significance level of 0.044 (0.05) turns out t &gt; t table. It means the hypothesis is accepted which states the existence of a very significant. 3) Relationship between Leadership Style and organizational culture have significant performance relationship in local government of Gorontalo apparatus city. It is seen in the strength of mastery skills and cultural organization along with the performance of the apparatus, comparing the r counting with r table it is known that 0.811 &gt; 0.239, the correlation both have strong significant relationship.</p>

scholarly journals ANALISIS HASIL INVESTASI, PENDAPATAN PREMI, DAN BEBAN KLAIM TERHADAP LABA PERUSAHAAN PERASURANSIAN DI INDONESIA

2017 ◽  
Vol 5 (2) ◽  
pp. 213
Author(s):  
Sofyan Marwansyah ◽  
Ambar Novi Utami
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Significant Relationship ◽  
Secondary Data ◽  
Strong Relationship ◽  
Fund Raising ◽  
Analytical Technique ◽  
The Public ◽  
Investment Returns ◽  
Premium Income

Insurance is a fund raising agency sourced from the receipt of insurance premiums from the public and distributed by claims. In addition to premium receipts, the company also puts its funds in the form of investments. This aims of this paper is to analyze the investment returns, premium income, and claims expense to profit using partial correlation, determination and multiple linear regression. The methods that use to collects the data for this final task are using observation and study documentation using quantitative analysis. Analytical technique is multiple linear regression using IBM SPSS 21 software. The used data in this paper is secondary data that obtained from the website of Otoritas Jasa Keuangan. From the results of the correlation coefficient test partially obtained investment returns and premium income has a significant relationship to profit, a positive value of 0.657 and 0.737 means the relationship is strong and unidirectional whereas, claims load has a significant relationship to profit, negative value of -0.786 means strong relationship And counterclockwise, simultaneously (together) shows that investment returns, premium income, claims expenses have significant relationship to profit, and a positive value of 0.881. The result of determination coefficient test shows that there is a significant influence of 77.6% and the remaining 22.4% influenced by other factors. The regression equation formed is Y = -2,682 +  +  – 2,369 + e.

scholarly journals Ranking the effect of services marketing mix elements on the loyalty of customers by using Topsis method (case study: city bank branches in Tehran)

2017 ◽  
Vol 13 (2) ◽  
pp. 41-46 ◽  
Author(s):  
Hossein Azimi
Keyword(s):  
Significant Relationship ◽  
Strong Relationship ◽  
Simple Random Sampling ◽  
Services Marketing ◽  
Marketing Mix ◽  
Physical Factors ◽  
Product Price ◽  
Related Factors ◽  
Statistical Sample ◽  
Loyal Customers

Successful companies do not only pursue sale, but they are looking for satisfactions of customers and their loyalty. This study aims to rank effect of services marketing mix elements on the customers’ loyalty in the City Bank. Method of this research is survey and causal-comparative and domesticated questionnaire was used for gathering data which its validity was confirmed by experts and its reliability with Cronbach alpha 0.908. Statistical sample size was 384 loyal customers of City Bank in Tehran based on Cochrane formula and simple random sampling was used as sampling method. Findings showed that there is significant relationship in average level between physical factors and environmental factors including distribution of physical facilities and customer loyalty and the relationship between competence related factors including promotion of employees or customers’ loyalty is strongly significant. Besides, there is significant relationship between services related factors including product, price, operation management and quality of services or customers’ loyalty in moderate level. It is suggested that for attracting loyal customers, more attention should be paid to promotion which has very strong relationship with customers’ loyalty. It is suggested that City Bank increases the motivation of employers in providing careful and rapid services for improving productivity and services quality by suitable incentives.

scholarly journals HUBUNG ANTARA KECERDASAN EMOSIONAL DAN KECERDASAN SPRITUAL DENGAN KEPUASAN KERJA GURU SEKOLAH DASAR NEGERI SE KECAMATAN DUMAI BARAT KOTA DUMAI

2021 ◽  
Vol 4 (2) ◽  
pp. 234
Author(s):  
Weni Weni ◽  
Zulfan Saam ◽  
Azhar Azhar
Keyword(s):  
Job Satisfaction ◽  
Elementary School ◽  
Emotional Intelligence ◽  
Elementary School Teachers ◽  
Significant Relationship ◽  
Strong Relationship ◽  
Teacher Job Satisfaction ◽  
Spiritual Intelligence ◽  
Survey Method ◽  
School Teachers

This study aims to determine the relationship between emotional intelligence and spiritual intelligence with teacher job satisfaction. This study uses a survey method with correlational techniques. The population of the study was the teachers of SDN in Dumai Barat District, Dumai City with a sample of 150 people. The instrument used for data collection is a number of written questions with 4 variations of answer choices. The instrument item validation was tested using product moment correlation, while the instrument reliability test was calculated using the Alpha Conhbach formula. The results showed that (1) there was a significant relationship between spiritual intelligence and job satisfaction of State Elementary School teachers in Dumai Barat District, Dumai City. (2). There is a very strong relationship between spiritual intelligence and job satisfaction of State Elementary School teachers in Dumai Barat District, Dumai City. (3). There is a positive and significant relationship between emotional intelligence and spiritual intelligence together with job satisfaction of State Elementary School teachers in Dumai Barat District, Dumai City. The results of this study are expected to be useful for improving work stress, emotional intelligence and personality of State Elementary School teachers in West Dumai District, Dumai City. The conclusion of this study shows that job satisfaction can be reduced through increasing emotional intelligence and spiritual intelligence either alone or together.

scholarly journals FAKTOR- FAKTOR YANG BERHUBUNGAN DENGAN KEPUTUSAN PEMBELIAN KOPI DI BANARAN 9 JAMBU GEMAWANG

2020 ◽  
Vol 14 (1) ◽  
pp. 55
Author(s):  
Ida Riana Wati ◽  
Bayu Nuswantara ◽  
Hendrik Johanes Nandapdap
Keyword(s):  
Significant Relationship ◽  
Quantitative Research ◽  
Sampling Technique ◽  
Strong Relationship ◽  
Business Owners ◽  
Purchasing Decisions ◽  
Location Factor ◽  
Coffee Powder ◽  
Product Factor ◽  
The Relationship

 On the other hand, with concern from this research, it can encourage coffee business owners themselves to produce better and quality ground coffee to increase consumers to buy the Banaran coffee powder products. This study aims to analyze the relationship between marketing mix factors such as price, product, promotion, and location to the decision to purchase Kopi Bubuk Banaran in cafee restaurant Banaran Gemawang. This research was carried out in July-August 2018. The location located in the area of ??the Coffee Plantation road. Raya Semarang Yogyakarta Gemawang, Jambu District, Semarang Regency. The type of research conducted is descriptive quantitative research. The sampling technique uses accidental sampling. Respondents in this study were 50 respondents who visited and bought Banaran powder coffee. Data collection is obtained by means of interviews, questionnaires, documentation and literature. The results show that the price factor (X1) has a positive and significant relationship with the purchasing decision (Y), and a strong level of relationship. Product factor (X2) has a positive and significant relationship with purchasing decisions (Y), as well as a strong level of relationship. Location factor (X4) has a positive and significant relationship with purchasing decisions (Y), as well as a strong relationship level. Promotion factor (X3) does not have a significant relationship with purchasing decisions (Y).

scholarly journals Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Qi-Wen Man ◽  
Yan-Qi Ma ◽  
Jin-Yuan Liu ◽  
Yi Zhao ◽  
Bing Liu ◽  
...  
Keyword(s):  
Rank Correlation ◽  
Double Labelling ◽  
Keratocystic Odontogenic Tumor ◽  
Mrna Levels ◽  
Ki 67 ◽  
Normal Oral Mucosa ◽  
Real Time Quantitative Pcr ◽  
Close Relationship ◽  
Proliferative Growth ◽  
Spearman Rank Correlation Test

The aim of this study is to clarify whether YAP/TAZ is involved in the pathogenesis and proliferative growth of keratocystic odontogenic tumor (KCOT). The expression levels of YAP/TAZ and downstream proteins and genes in normal oral mucosa (OM) and KCOT were determined and compared by immunohistochemistry and real-time quantitative PCR. The results showed that the expression of YAP/TAZ and downstream proteins (Cyr61, CTGF) was significantly upregulated in KCOT with upregulation of Ki-67 compared to OM. Importantly, the mRNA levels of transcription factors (TEAD1, TEAD4, and RUNX2) and cell cycle related genes (CDK2, PCNA), which interact with the transcriptional coactivators YAP/TAZ, are also upregulated in the KCOT. In addition, the results from Spearman rank correlation test revealed the close relationship between YAP/TAZ and Ki-67, which was further evidenced by double-labelling immunofluorescence that revealed a synchronous distribution for YAP/TAZ with Ki-67 in KCOT samples. All the data suggested YAP/TAZ might be involved in the proliferative behavior of KCOT.

scholarly journals Diamond Nanoparticles Downregulate Expression of CycD and CycE in Glioma Cells

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1549 ◽  
Author(s):  
Marta Grodzik ◽  
Jaroslaw Szczepaniak ◽  
Barbara Strojny-Cieslak ◽  
Anna Hotowy ◽  
Mateusz Wierzbicki ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Glioma Cells ◽  
Migration And Invasion ◽  
Control Group ◽  
Ki 67 ◽  
Normal Cells ◽  
Diamond Nanoparticles ◽  
Dividing Cells

Our previous studies have shown that diamond nanoparticles (NDs) exhibited antiangiogenic and proapoptotic properties in vitro in glioblastoma multiforme (GBM) cells and in tumors in vivo. Moreover, NDs inhibited adhesion, leading to the suppression of migration and invasion of GBM. In the present study, we hypothesized that the NDs might also inhibit proliferation and cell cycle in glioma cells. Experiments were performed in vitro with the U87 and U118 lines of GBM cells, and for comparison, the Hs5 line of stromal cells (normal cells) after 24 h and 72 h of treatment. The analyses included cell morphology, cell death, viability, and cell cycle analysis, double timing assay, and gene expression (Rb, E2F1, CycA, CycB, CycD, CycE, PTEN, Ki-67). After 72 h of ND treatment, the expression level of Rb, CycD, and CycE in the U118 cells, and E2F1, CycD, and CycE in the U87 cells were significantly lower in comparison to those in the control group. We observed that decreased expression of cyclins inhibited the G1/S phase transition, arresting the cell cycle in the G0/G1 phase in glioma cells. The NDs did not affect the cell cycle as well as PTEN and Ki-67 expression in normal cells (Hs5), although it can be assumed that the NDs reduced proliferation and altered the cell cycle in fast dividing cells.

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