scholarly journals Potency of Combination of Fucoidan Microsphere and MiRNA-200b as Therapy in Chemoresistant Breast Cancer

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
Sinta Wiranata ◽  
Made VW Yani ◽  
Agung Bagus S Satyarsa ◽  
I Ketut R Ardiana ◽  
Putu AT Adiputra
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Incidence ◽  
Migration And Invasion ◽  
Intrinsic Pathway ◽  
Extrinsic Pathway ◽  
Major Health Problem ◽  
Major Health ◽  
Mortality And Morbidity ◽  
Histone 3 ◽  
Apoptotic Signal

Breast cancer still become a major health problem in Indonesia and worldwide until today. Based on WHO 2012, breast cancer incidence is reported as 1.67 million cases with 90% of mortality rate in the metastasis stage. Chemoresistant is one cause of this increased mortality and morbidity. Nowadays, there are many treatment choices for cancer, but 90% incident of chemoresistant breast cancer occur even with prior chemotherapy. This review aimed to describe the potential of microsphere combinations fucoidan and miRNA-200b as a treatment for chemoresistant in breast cancer. Literature review were derived from scientific journals using www.pubmed.com and scholar.google.com database with “chemoresistant breast cancer, Fucoidan, microRNA-200b” as keyword. Fucoidan can induce apoptosis through the extrinsic pathway involving apoptotic receptor, or intrinsic pathway involving changes in mitochondrial membrane potential (MMP) to release cytochrome C and activating the apoptotic signal. Meanwhile, miRNA-200b expression, will decrease Sp1 expression and decrease histone-3 acetylation level in a miRNA-200b promoter, resulting in decreased cancer cell migration and invasion. However, no studies have evaluated this combination clinically. So, further studies are needed to confirm the potential of microsphere combination fucoidan and miRNA-200b in chemoresistant breast cancer.   Keywords: chemoresistant breast cancer; Fucoidan; miRNA-200b.

Cell-adhesion molecules as key mechanisms of tumor invasion: the case of breast cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Carla Luís ◽  
Raquel Soares ◽  
Rúben Fernandes ◽  
Mónica Botelho
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cardiovascular Diseases ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Tumor Invasion ◽  
Malignant Neoplasms ◽  
Major Health Problem ◽  
Major Health ◽  
Mortality And Morbidity

: Cancer is a major health problem worldwide and the second leading cause of death only overcome by cardiovascular diseases. Breast cancer is the leading cause of mortality and morbidity among women and one of the most common malignant neoplasms prompt to metastatic disease. In the present review, the mechanisms of the major cell adhesion molecules involved in tumor invasion are discussed, focusing in the case of breast cancer. A non-systematic updated revision of the literature was performed in order to assemble information regarding the expression of the adhesion cell molecules associated with metastasis.

scholarly journals Lifestyle breast cancer patients among Indonesian women: A nationwide survey

2021 ◽  
Vol 10 (4) ◽  
pp. 730
Author(s):  
Solikhah Solikhah ◽  
Khairunnisaa Nuur Aliifah Setyawati ◽  
Monthida Sangruangake
Keyword(s):  
Breast Cancer ◽  
High School ◽  
Cancer Patients ◽  
Breast Cancer Incidence ◽  
Education Level ◽  
Lifestyle Changes ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Significance Level

Recently, cancer is a major health problem in the world. Lifestyle changes and growing urbanization likely led to increasing breast cancer incidence in such in Indonesia. Therefore, this study aimed to explore lifestyle breast cancer patients among Indonesian women. The investigation was a cross-sectional study distributed among 3,392 females drawn from 13 out of 27 provinces in Indonesia. Multiple binary logistic regressions were conducted to investigate breast cancer risk among Indonesian. A significance level of 0.05 was employed in all analysis. Of the 3,392 respondents included in the analysis, more than half (52.71%; n=1,788) was aged 40–49 years old. The most common marital status of the participants was married (98.20%; n=3,331), followed by no smoking (94.69%; n=3,212) and active exercise (62.12%; n=2,107). Education level was significantly associated with breast cancer (AdjOR_Junior high school=0.21; 95%CI=0.06 to 0.70; p<0.01 and AdjOR_senior high school=0.60; 95%CI=0.15 to 2.26; p<0.05). Education level was significantly related to breast cancer. Lifestyle such as smoking and physical activity was suspected to affect breast cancer indirectly.

A Computer-Assisted Diagnostic (CAD) of Screening Mammography to Detect Breast Cancer Without a Surgical Biopsy

2019 ◽  
Vol 11 (4) ◽  
pp. 31-49 ◽  
Author(s):  
Hadj Ahmed Bouarara
Keyword(s):  
Breast Cancer ◽  
Screening Mammography ◽  
Computer Assisted ◽  
Surgical Biopsy ◽  
Major Health Problem ◽  
Major Health ◽  
Cad System ◽  
Digital Database ◽  
The Social ◽  
N Gram

Breast cancer has become a major health problem in the world over the past 50 years and its incidence has increased in recent years. It accounts for 33% of all cancer cases, and 60% of new cases of breast cancer occur in women aged 50 to 74 years. In this work we have proposed a computer-assisted diagnostic (CAD) system that can predict whether a woman has cancer or not by analyzing her mammogram automatically without passing through a biopsy stage. The screening mammogram will be vectorized using the n-gram pixel representation. After the vectors obtained will be classified into one of the classes—with cancer or without cancer—using the social elephant algorithm. The experimentation using the digital database for screening mammography (DDSM) and validation measures—f-measure entropy recall, accuracy, specificity, RCT, ROC, AUC—show clearly the effectiveness and the superiority of our proposed bioinspired technique compared to others techniques existed in the literature such as naïve bayes, Knearest neighbours, and decision tree c4.5. The goal is to help radiologists with early detection to reduce the mortality rate among women with breast cancer.

scholarly journals NMR-based metabolomics associated with chronic kidney disease in humans and animals: a one health perspective

2021 ◽  
Author(s):  
Elena Hunter ◽  
Benita Percival ◽  
Zeeshan Ahmad ◽  
Ming-Wei Chang ◽  
John A. Hunt ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
One Health ◽  
Analytical Techniques ◽  
Major Health Problem ◽  
Major Health ◽  
Mortality And Morbidity ◽  
Initial Stage ◽  
New Biomarkers

AbstractChronic kidney disease (CKD) is a renal dysfunction that can lead to high rates of mortality and morbidity, particularly when coupled with late diagnosis. CKD has become a major health problem due to its challenging detection at early stages when clear symptoms are yet to be presented. Thus, CKD is likely to be identified when the substantive conditions of the disease are manifest. In order to address the development of the disease and provide necessary treatments at the initial stage, the investigation of new biomarkers and metabolites associated with early detection of CKD are needed. Identified metabolites could be used to confirm the presence of the disease, obtain information on its mechanism and facilitate the development of novel pharmaceutical treatments. Such metabolites may be detected from biofluids and tissues using a range of analytical techniques. There are a number of metabolites that have been identified by mass spectrometry at high sensitivities, whilst the detection of metabolites directly from biofluids using NMR could present a more rapid way to expand our understanding of this disease. This review is focused on NMR-based metabolomics associated with CKD in humans and animals.

scholarly journals Regulation of Exosomes in the Pathogenesis of Breast Cancer

2021 ◽  
Author(s):  
Congjian Shi ◽  
Hongqin Yang ◽  
Zhengchao Wang ◽  
Zhenghong Zhang
Keyword(s):  
Breast Cancer ◽  
Lipid Bilayers ◽  
Cell Types ◽  
Cancer Diagnostics ◽  
Major Health Problem ◽  
Major Health ◽  
Diagnostic Strategies ◽  
Therapeutic Tools ◽  
Common Malignancy

Extracellular vesicles (EVs) are a heterogeneous group of endogenous nanoscale vesicles that are secreted by various cell types. Based on their biogenesis and size distribution, EVs can be broadly classified as exosomes and microvesicles. Exosomes are enveloped by lipid bilayers with a size of 30–150 nm in diameter, which contain diverse biomolecules, including lipids, proteins and nucleic acids. Exosomes transport their bioactive cargoes from original cells to recipient cells, thus play crucial roles in mediating intercellular communication. Breast cancer is the most common malignancy among women and remains a major health problem worldwide, diagnostic strategies and therapies aimed at breast cancer are still limited. Growing evidence shows that exosomes are involved in the pathogenesis of breast cancer, including tumorigenesis, invasion and metastasis. Here, we provide a straightforward overview of exosomes and highlight the role of exosomes in the pathogenesis of breast cancer, moreover, we discuss the potential application of exosomes as biomarkers and therapeutic tools in breast cancer diagnostics and therapeutics.

scholarly journals Molecular links between obesity and breast cancer

2006 ◽  
Vol 13 (2) ◽  
pp. 279-292 ◽  
Author(s):  
A M Lorincz ◽  
S Sukumar
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Molecular Basis ◽  
Causal Link ◽  
Cancer Risks ◽  
Major Health Problem ◽  
Major Health ◽  
Obesity And Overweight ◽  
The Usa

Breast cancer continues to be a major health problem for women in the USA and worldwide. There is a need to identify and take steps to alter modifiable breast cancer risks. Conditions of obesity and overweight are risk factors that have reached epidemic proportions. This article reviews the evidence in the literature that test mechanism-based hypotheses which attempt to provide a molecular basis for a causal link between obesity and breast cancer risk, particularly the effects of metabolic syndrome and insulin resistance, peripheral estrogen aromatization in adipose tissue, and direct effect of adipokines. Future areas for study and implications for therapy are discussed.

Frequency of Hypothyroidism in Chronic Hepatitis C patients treated with Standard Interferon Therapy

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Muhammad Farooq ◽  
Sami Ullah Mumtaz ◽  
Hina Akhtar ◽  
Kanza Ashraf ◽  
Tayyeba Komal ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Thyroid Dysfunction ◽  
Standard Treatment ◽  
Major Health Problem ◽  
Major Health ◽  
Mortality And Morbidity ◽  
Chronic Hepatitis C Patients

Chronic hepatitis C is a major health problem associated with high mortality and morbidity. It is the most common chronic hepatitis leading to chronic liver disease and hepatocellular carcinoma. One of the standard treatment used for hepatitis C is interferon therapy which can lead to thyroid dysfunction i.e. hyperthyroidism and hypothyroidism

scholarly journals Potential of Fucoidan From Brown Seaweeds (Sargassum sp.) as Innovation Therapy on Breast Cancer

2019 ◽  
Vol 2 (3) ◽  
Author(s):  
Agung B S Satyarsa
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Communicable Disease ◽  
Target Cells ◽  
Major Health Problem ◽  
Major Health ◽  
Brown Seaweeds ◽  
The World ◽  
New Treatment ◽  
Non Communicable Disease

Breast cancer is a non-communicable disease and a major health problem in the world. Based on the data from WHO in 2012, the incidence of breast cancer is reported as 1.67 million cases. One cause of the highest morbidity and mortality in breast cancer is chemoresistance. Various attempts were made to solve this problem. The purpose of this review is to describe the potential of fucoidan from brown seaweeds (Sargassum sp.) as innovation therapy on breast cancer. Fucoidan as proapoptotic agents affect many target cells (multi-targets) to induce apoptosis. Fucoidan has a potential for a new treatment of breast cancer because of its potent proapoptotic and anti-metastatic properties. However, no research has yet evaluated this in clinical trial. Hence,  further studies are needed to confirm the true potential of fucoidan from brown seaweeds as therapy for breast cancer.     Keywords: anti-proliferative agents, pro-apoptotic agents, fucoidan, breast cancer

scholarly journals THE ROLE OF MICRORNA-200C IN CHEMORESISTANT BREAST CANCER

2020 ◽  
Vol 4 (2) ◽  
pp. 74
Author(s):  
Agung Bagus Sista Satyarsa ◽  
IGP Supadmanaba ◽  
PAT Adiputra
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Cells ◽  
Target Cells ◽  
Major Health Problem ◽  
Major Health ◽  
Apoptosis Inducer ◽  
New Treatment ◽  
The One ◽  
Mesenchymal Epithelial Transition

Breast cancer is a non-communicable diseases and also major health problem in the world. Based on data from WHO in 2012, the incidence of breast cancer reported as 1.67 million cases. One cause of highest morbidity and mortality in breast cancer is chemoresistancy. Many pathways could cause chemoresistant in breast cancer. The one of pathways are from genetic such as miR-200c. Base on the other study, mir-200c act an apoptosis inducer and inhibit metastasis in chemoresistant breast cancer cells. The mir-200c act the role in specific target cells in chemoresistant breast cancer. Meanwhile, the expression of miR-200c induces Mesenchymal Epithelial Transition (MET) by inhibits ZEB 1 or 2 and TGF-β2 as anti-metastases in chemoresistant breast cancer. miR-200c has a promising potential as a new treatment for chemoresistant breast cancer, because of its potent pro-apoptotic and anti-metastatic properties.

scholarly journals HUBUNGAN ANTARA KEPRIBADIAN DENGAN KEJADIAN RELAPS PADA PASIEN KANKER PAYUDARA DI POLI ONKOLOGI RSUD DR. SOETOMO SURABAYA

2020 ◽  
Vol 5 (2) ◽  
pp. 45
Author(s):  
Danang Nur Adiwibawa
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Big Five ◽  
Case Control Study ◽  
Case Control ◽  
Personality Factors ◽  
Breast Cancer Patients ◽  
Major Health Problem ◽  
Major Health ◽  
Control Study

Background. Breast cancer is a major health problem that affects the lives of millions of women. Some patients have treatment but still found relapse.Suggest personality factors influence relapse breast cancer.But until now it is still controversy. Methods. Analytic research observational case control study to find relationship between personality with the incidence of relapse in breast cancer patients and comparing personality relapse and non relapse. Research in Poli Onkologi RSUD Dr.Soetomo with 56 patients,28 patients relapse and 28 non relapse.Use Instrument OCEAN-Big Five Inventory 44 Quessioner and Demogarfi Quessioner. Result. There is no relationship between personality with incidence of relapse (p>0,05). neuroticism personality (29%) in relapse, openness personality (32%) and extraversion personality (36%) in non relapse. Conclusion. The incidence of relapse breast cancer is not simply due to personality but maybe other factors.

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