scholarly journals Effects of indiscriminate consumption of paracetamol (acetaminophen) on selected biochemical parameters in Rattus norvegicus rats

2020 ◽  
Vol 13 (3) ◽  
pp. 054-063
Author(s):  
Emmanuel Tonbra Egoro
Keyword(s):  
Rattus Norvegicus ◽  
Therapeutic Dose ◽  
Biochemical Parameters ◽  
Daily Basis ◽  
Toxicity Study ◽  
Control Group ◽  
Mean Values ◽  
Reactive Protein ◽  
Blood Specimens ◽  
Experimental Group

Paracetamol (acetaminophen) is a well-known medication for the treatment of pain and fever. The aim of this study was to assess the effects of its indiscriminate consumption on selected biochemical parameters in Rattus norvegicus rats with a view to relate the findings to humans. The data obtained from the human volunteers within the age range of 20-67years revealed that paracetamol (acetaminophen) is indiscriminately consumed mainly by traders as compared with other painkillers in the study communities. Five milliliters of blood specimens were withdrawn from Rattus norvegicus rats administered with 500 mg/2ml paracetamol (acetaminophen) for one day, acute toxicity study (experimental group one), 50 mg/2ml paracetamol (acetaminophen) on daily basis for thirty days, sub-chronic toxicity study (experimental group two), 50mg/2ml paracetamol (acetaminophen) on daily basis for three days, recommended therapeutic dose (experimental group three) and control group respectively. Thereafter, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea, creatinine, C-reactive protein and testosterone were measured using a spectrophotometer. The mean values of all the measured biochemical parameters in both experimental group one and two rats revealed statistically significant differences (p<0.05) with experimental group three rats being exception (p>0.05) as compared with that of the control group which may be suggestive of hepatic, renal, inflammatory and spermatogenesis disorders. Though the consumption of this tablet at recommended therapeutic dose was well tolerated by the rats as against its indiscriminate consumption which posed danger on the rats thus it is recommended that this tablet should be taken strictly on the prescription of a physician or health professional.

scholarly journals Abuse of Alabukun consumption: A biochemical and histomorphological study in Rattus norvegicus rats

2021 ◽  
Vol 8 (1) ◽  
pp. 037-042
Author(s):  
Emmanuel TonbraEgoro ◽  
Ikhide Godwin Ilegbedion ◽  
Prudence NkemdinimOkara
Keyword(s):  
Rattus Norvegicus ◽  
Daily Basis ◽  
Control Group ◽  
C Reactive Protein ◽  
Biochemical Finding ◽  
Mean Values ◽  
Reactive Protein ◽  
The Mean ◽  
Kidney Liver ◽  
Experimental Group

This study was aimed on the biochemical and histomorphological study of abuse in the consumption of alabukun powder in Rattus norvegicus rats. Five milliliter of blood specimen was collected into lithium heparin bottles from seven rats weighing 240±2g respectively with each of them administered with 0.2mg/kg alabukun powder daily for a period of two weeks (experimental group) while another seven rats weighing 240±2g each were not administered with alabukun powder (control group). Thereafter alanine aminotransferase, aspartate aminotransferase, urea, creatinine and C-reactive protein were measured quantitatively in both groups of rats. The mean values of all the measured biochemical parameters in Rattus norvegicus rats in the experimental group were statistically significant (p<0.05) as compared to that in the control group. This established biochemical finding was in conformity with the histomorphological examination of the kidney and liver organs. In conclusion, this study has established that administration of 0.2mg/kg of alabukun powder on daily basis for a period of two weeks on Rattus norvegicus rats may induce hepato-renal and inflammatory disorders. It is thus recommended that consumption of alabukun powder by humans should strictly be in compliance with its prescription. However, kidney, liver and inflammatory biomarkers should be quantitatively measured in humans that have abused its consumption with a view to ascertain their health status and prevent any deleterious risks.

scholarly journals Assessment of selected biochemical parameters among food hawkers along the streets of Yenagoa Bayelsa State, Nigeria

2021 ◽  
Vol 16 (3) ◽  
pp. 103-108
Author(s):  
Emmanuel Tonbra Egoro ◽  
Emmanuel Sunday Oni ◽  
Otaraku Jonathan Oye ◽  
Annabel Awele Idama
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Control Group ◽  
C Reactive Protein ◽  
Mean Values ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean ◽  
Experimental Group

This study was aimed on assessment of selected biochemical parameters among food hawkers along the streets of Yenagoa, Bayelsa State, Nigeria. Five milliliter of blood specimen was collected from fifteen food hawkers with ≤ 5 years working experience (experimental group one), ≥ 5 years working experience (experimental group two) and nonfood hawkers (control group) respectively into lithium heparin anti-coagulated bottles. Thereafter alanine aminotransferase, aspartate aminotransferase, urea, creatinine and C-reactive protein were measured quantitatively. The mean values of volunteers in experimental group one showed no statistically significant difference (p>0.05) in alanine aminotransferase (7.46 ± 1.02), aspartate aminotransferase (7.02 ± 0.86), urea (7.70 ± 1.29) and creatinine (70.44 ± 3.54) as compared with the control group (7.42 ± 0.98), (6.98 ± 0.82), (7.65 ± 1.28) and (70.40 ± 3.52) respectively, but there was a statistically significant difference (p<0.05) in C-reactive protein (17.40 ± 1.98) when compared with the control group (2.70 ± 0.70). However, the mean values of food hawkers in experimental group two showed statistically significant difference (p< 0.05) in all the measured biochemical parameters 27.70±2.98, 21.40±2.06, 15.50±2.02, 110.70±3.74, 29.42±3.20 as compared with that of the control group 7.42±0.98, 6.98±0.82, 7.65±1.28, 70.40±3.52, 2.74±0.70. The volunteers in experimental groups one and two showed 13% -27% and 53% -80% abnormal values of the measured biochemical parameters respectively as compared with that of the control group. In conclusion, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and C-reactive protein may be altered in food hawkers with ≥ 5 years working experience. It is therefore recommended that food hawkers in this category should go for hepato-renal and inflammatory biochemical parameters checkup occasionally in any registered and licensed Medical Laboratory Facility.

scholarly journals Studies on some Biochemical Parameters among Charcoal (Physiculus nematopus) Traders in Swali Market Yenagoa Bayelsa State

2021 ◽  
Vol 6 (3) ◽  
pp. 74-80
Author(s):  
E.T. Egoro ◽  
E.S. Oni ◽  
J.O. Otaraku ◽  
D.E. John
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Medical Laboratory ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Laboratory Facility ◽  
Blood Specimens ◽  
Experimental Group

The aim of this study was to assess some biochemical parameters among charcoal (Physiculus nematopus) traders in Swali market Yenagoa Bayelsa State, Nigeria. Five milliliter of blood specimens was collected from each of the fifteen charcoal (Physiculus nematopus) traders with < 5 years working experience (experimental group one), fifteen charcoal (Physiculus nematopus) traders with ≥5 years working experience (experimental group two) and fifteen non charcoal traders (control group) into lithium heparin anti-coagulated bottles respectively. Thereafter alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine and C-reactive protein (CRP) were measured quantitatively. The results of charcoal traders in experimental group one showed no statistically significant differences (p>0.05) in all the measured biochemical parameters ALT (7.26U/I), AST (5.61U/I), CRP (2.48mg/L), urea (8.68mmol/L), creatinine (82.14µmol/L) as compared to that of the control group (7.22U/I), (5.58U/I), (2.47mg/L), (8.65mmo/L), (82.10µmol/L) respectively while that of experimental group two showed statistically significant differences (p<0.05) in alanine aminotransferase (20.40U/I), aspartate aminotransferase (16.20U/I) and C-reactive protein (22.42mg/L) as compared to that of the control group (7.22U/I), (5.58U/I), (2.47mg/L) respectively. However, urea (8.68mmol/L) and creatinine (82.25µmol/L) showed no statistically significant differences (p>0.05) as compared to that of the control group (8.65mmol/L), (82.10µmol/L) respectively. In conclusion alanine aminotransferase, aspartate aminotransferase and C-reactive protein may be altered in charcoal (Physiculus nematopus) traders exposed to charcoal dust for ≥ 5 years. It is therefore recommended that charcoal traders in this category should embark on hepato-inflammatory biochemical parameters investigation intermittently in any registered and licensed Medical Laboratory facility so as to monitor the concentrations of these parameters.

scholarly journals Occupational effect of spray painting fumes on some biochemical parameters in automobile spray painters in Yenagoa Bayelsa State, Nigeria

2021 ◽  
Vol 9 (2) ◽  
pp. 038-044
Author(s):  
Emmanuel Tonbra Egoro ◽  
Emmanuel Sunday Oni ◽  
Jonathan Ebipade Lawrence
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Control Group ◽  
Chemical Toxicity ◽  
C Reactive Protein ◽  
Spray Painting ◽  
Plasma Urea ◽  
Reactive Protein ◽  
Experimental Group

Automobile spray painters are often prone to chemical toxicity due to their routine work. This study was aimed at the occupational effect of spray painting fumes on some biochemical parameters in automobile spray painters. Five milliliters of blood specimen were collected into lithium heparin anti-coagulated bottles from twenty five automobile spray painters with ≤ 10 years working experience (experimental group one), ≥ 11 years working experience (experimental group two) and non-automobile spray painters which were monitored as control group respectively. After this, plasma alanine aminotransferase, aspartate aminotransferase, C-reactive protein, urea and creatinine were measured quantitatively using a spectrophotometer. The mean values of all the measured biochemical parameters showed no statistically significant differences (p>0.05) in the automobile spray painters with ≤ 10 years working experience as compared with that of the control group with the exception of plasma C-reactive protein, while those with ≥ 11 years working experience showed statistically significant differences (p<0.05) in plasma alanine aminotransferase, aspartate aminotransferase and C-reactive protein however, the plasma urea and creatinine showed no statistically significant differences (p>0.05). In conclusion, the concentration of plasma alanine aminotransferase, aspartate aminotransferase and C-reactive protein may be altered in automobile spray painters with ≥ 11 years working experience, thus these biochemical parameters should be monitored regularly in spray painters within this category of working experience

Reproductive traits and blood biochemical parameters of sows when using a vitamin feed additive “LipoCar”

2020 ◽  
pp. 25-31
Author(s):  
I. A. Pushkaryev ◽  
N. M. Kostomakhin ◽  
S. V. Burtseva ◽  
N. A. Novikov
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Total Duration ◽  
Reproductive Traits ◽  
Feed Additive ◽  
Control Group ◽  
Large White ◽  
Basic Diet ◽  
Blood Biochemical ◽  
Experimental Group

The reproductive traits of sows are of paramount importance in the production of high-quality pork. The world experience of pig farming shows the need to solve first of all the feed problem. Diets unbalanced in the content of vitamins restrain the manifestation of genetically inherent high prolificacy of sows. The purpose of the research was to study the influence of feeding the vitamin feed additive “LipoCar” on the reproductive traits of sows and the biochemical parameters of blood serum. The results of research on the introduction of vitamin feed additive “LipoCar” into the diet of pregnant sows have been presented in the article. The experiment has been carried out in the production conditions in JSC “Linevsky pedigree farm” on sows of Large White breed. Pregnant sows have received a basic diet, balanced for all the normalized elements of nutrition. Sows of the experimental group in the composition of the basic diet fed the feed additive “LipoCar”. The dosage of the drug “Lipocar” was 2,1 g/head/day. “Lipocar” has been fed for 20 days. The total duration of the experiment was 3 months. When introducing the vitamin feed additive “LipoCar” into the main diet of sows in the second half of pregnancy the increase in the number of piglets in the litter by 1,6-6,8 % and the weight of the litter – by 5,6-56,2 % (P ≤ 0,001) have been revealed in comparison with the control group of animals. There was a higher content of carotene in the blood serum of sows of the experimental group by 50,0 % (P ≤ 0,01), vitamin A - by 48,7 % (P ≤ 0,05), and total protein – by 4,9 % (P ≤ 0,05).

scholarly journals في ترقية مهارة القراءة لطلاّب الصفِ السابع بِالمدرسةِ المتوسطة الحكومية العاشرة سليمان (Index Card Match) فعالية استخدام الاستراتيجيّةِ مطابقة بطاقة الرقمَ القياسى

2019 ◽  
Vol 4 (1) ◽  
pp. 68-81
Author(s):  
Rihanatul Fauziah ◽  
Nurhadi Nurhadi
Keyword(s):  
Middle School ◽  
Learning Process ◽  
Reading Skills ◽  
Alternative Hypothesis ◽  
Control Group ◽  
Index Card ◽  
Mean Values ◽  
Motivation For Learning ◽  
Experimental Group ◽  
Reading Texts

This research is motivated by the low reading comprehension of Arabic which is possessed by students of Middle School 10 Sleman in understanding reading texts because of the absence of a linguistic environment and active, so it caused a lack of interest and motivation for learning in the learning process. This study aims to improve reading skills in Arabic for 7th grade students of  Middle School 10 Sleman especially in understanding reading texts by using the Index Card Match strategy in learning reading skills. With this research, it is expected to be able to help teachers in the learning process of reading Arabic skills and improve students' ability to read. In its implementation, this study used a quasi-quantitative approach with the Experimental method. To find out the extent of the effectiveness of the Index Card Match strategy in learning Arabic reading skills, the formula used is the t-test. This study resulted in differences in statistical calculations in mean values ​​in the experimental group and the control group. For the experimental group reached an average of 81.28 and the control group 76.88. The value of "t" counts 2.335 and "t" table 2.042 so that "t" counts greater than "t" table, the alternative hypothesis (Ha) is accepted and the null hypothesis (Ho) is rejected and there are significant differences. From the results above the researchers concluded that the use of the Index Card Match strategy in learning Arabic reading skills was effective so that it could improve reading skills in 7th grade students of Middle School 10 Sleman.

scholarly journals Implications of Aerobic Exercises and Walking Parallel to Diabetes Medications on Diabetic Sportspersons

2021 ◽  
pp. 197-204
Author(s):  
Fehmida Ayub ◽  
Abida Naseer ◽  
Saeed Javed ◽  
Adnan Asghar ◽  
Abd Rahim Mohd Shariff ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Blood Glucose Control ◽  
Daily Basis ◽  
Control Group ◽  
Type I ◽  
Type Ii ◽  
Glucose Levels ◽  
Spare Time ◽  
And Control ◽  
Experimental Group

Objective: Diabetes have a central contribution with type I or type II towards the healthy lifestyles of sportspersons. Aerobic exercise and daily walking stay them fit and control their glucose levels in their bloodstream. The aim of this study was to find out the effects of aerobic exercises and walk on the sportspersons of type I and II diabetes. Methodology: The existing research has experimental design itself wherein pre-tests and post-tests were employed to make sure the novelty of results. The data was collected from the diabetic sportspersons dividing them equally into control group (N-20) and experimental group (N-20). Both groups had type I (N-20) and type II (N-20) diabetic individuals. Aerobic exercise and walk protocol was applied for six weeks on experimental group, whereas, control group continued their routine activities. Afterwards, the data was collected through pre and post treatments and edited into SPSS (v-26). The collected data was analyzed through descriptive statistics using frequencies and percentages, whereas, T-test was applied to make the differences of pre and post treatments. Results: The findings has shown that aerobic exercises and walk decrease the higher levels of glucose in blood and enable to stable glycemic balance, weight loss maintenance, decrease insulin resistance, blood pressure decrease, and blood glucose control. Conclusion: The prominent differences were observed between control and experimental groups either type I or type II. It was concluded that the sportspersons may reduce the excessive glucose engaging in aerobic exercises and walk on daily basis rather than using medications. They should spend their happy lives and get rid of medications and insulin through spending their spare time using light exercises and maintain their glucose levels in blood as well.

scholarly journals The long-term administration of a clinoptilolite-supplemented feed to layers and its effect on performance, haematological parameters and metabolic profile

2008 ◽  
Vol 53 (No. 5) ◽  
pp. 212-218 ◽  
Author(s):  
E. Straková ◽  
P. Suchý ◽  
I. Herzig ◽  
V. Šerman ◽  
N. Mas
Keyword(s):  
Experimental Period ◽  
Reference Intervals ◽  
Control Group ◽  
Average Weight ◽  
Adaptation Period ◽  
Mean Values ◽  
Total Plasma Protein ◽  
Term Administration ◽  
The Mean ◽  
Experimental Group

120 selected layers (Bovans Goldline hybrid) aged 19 weeks with an average weight of 1 735 g were divided into two balanced groups: control group (Group C) and experimental (Group E). Layers were reared in three-tier cages with automatic watering, manual feeding, and at controlled light and temperature regimens. One cage accommodated two layers, the floor surface area was 0.1125 m<sup>2</sup> per layer. The experiment started after a 20-day adaptation period with layers aged 22 weeks (Week 22) and ended when layers were 68 weeks old (Week 68). In a period of initiation (i.e. Weeks 19–38), layers were fed the complete feeding mixture N1. Then they received the feeding mixture N2 until the end of the experiment. Feeding mixtures in both groups (C and E) had the same composition; the only difference between mixtures was that the feeding mixture in the experimental group was enriched with 1% clinoptilolite (i.e. the commercially available additive ZeoFeed). Layers received feeding mixtures and drinking water <I>ad libitum.</I> In the course of the experimental period, control layers laid 16 289 eggs while experimental layers laid 16 474 eggs. It follows from the results that the laying intensity in experimental layers was 1.7% higher as compared to control layers, i.e. the number of laid eggs in experimental layers increased by 5.6 eggs per layer. The mean weight of all laid eggs was 66.3 ± 6.25 g in the control group and 65.6 ± 5.44 g in the experimental group (<I>P</I> ≤ 0.01). Such performance was achieved at the consumption of feeding mixture being 141.7 g per laid egg in the control group and 137.6 g per laid egg in the experimental group. The consumption of feeding mixture in the experimental group was 4.1 g lower than that in the control group. The mean values of parameters monitored in blood plasma such as uric acid, cholesterol, glucose, lactose, calcium, phosphorus, ALP, and LDH in both groups of layers ranged within reference intervals, with no significant differences being detected between both groups.However, statistically significant differences between both groups were found in total plasma protein (<I>P</I> ≤ 0.01), triacylglycerol levels (<I>P</I> ≤ 0.05), and magnesium (<I>P</I> ≤ 0.01), which were elevated in the control group, and in AST (<I>P</I> ≤ 0.05) whose level in the control group was significantly lower than that in the experimental group. The results of haematological tests performed with layers’ blood revealed statistically significant changes in parameters such as the erythrocyte count (<I>P</I> ≤ 0.01), haemoglobin level (<I>P</I> ≤ 0.01), and MCHC (<I>P</I> ≤ 0.05), which were elevated in the experimental group, and in the leukocyte count (<I>P</I> ≤ 0.05), which was lower in the experimental group, as compared with the control. However, the values found varied within physiological ranges.

scholarly journals Metabolic and Functional Profile of Premenopausal Women With Metabolic Syndrome After Training With Elastics as Compared to Free Weights

2016 ◽  
Vol 19 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Jorge Flandez ◽  
Noelia Belando ◽  
Pedro Gargallo ◽  
Julio Fernández-Garrido ◽  
Ronald A. Vargas-Foitzick ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Premenopausal Women ◽  
Control Group ◽  
Positive Trend ◽  
C Reactive Protein ◽  
Functional Profile ◽  
Reactive Protein ◽  
Almost All ◽  
Sedentary Women ◽  
Experimental Group

The aim of this study was to compare the effects of a strength training program (STP) using free weights (FW) versus elastic tubing (ET) in 62 premenopausal, sedentary women diagnosed with metabolic syndrome (MS). Participants were randomly assigned to the FW or ET experimental group (EG) or a control group whose members remained sedentary. Members of each EG followed their assigned STP for 12 weeks, and biomarkers (BMs) related to MS and motor function (MF) parameters were evaluated. Both EGs showed a significant reduction in C-reactive protein level and a positive trend in the other BMs. Almost all MF parameters increased significantly in both EGs. No positive changes were found in the CG. These results indicate that the implementation of an STP, with either FW or ET, improves both metabolic health and MF and should be considered part of the basic approach to health care in women.

scholarly journals State of metabolism of cows at dry period as the basis for reasoning of preven-tion and treatment of calves with gastrointestinal diseases

2019 ◽  
Vol 21 (93) ◽  
pp. 53-59
Author(s):  
V. Honcharenko ◽  
G. Gryshchuk ◽  
S. Sheremet
Keyword(s):  
Group Treatment ◽  
Biochemical Parameters ◽  
Metabolic Disorders ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Second Phase ◽  
Dry Period ◽  
Mineral Supplement ◽  
Treatment Regimens ◽  
Experimental Group

One of the real ways of increasing the production of livestock products is to increase the conservation of young animals, the mortality rate of which remains at this time still very high. Many calf treatment regimens have been developed, but they are not always effective, which prompts scientists and practitioners to improve already known methods of treatment, to find and justify new medical preparation. Material for research were dry-cows, healthy and sick calves. After the clinical examination of cows, the experiment was conducted in two phases: the first phase – in 3 groups of cows, the second – in clinical healthy and sick calves. Mineral supplement of Sapocorm were added to the first experimental group of cows; cows of the second experimental group – the preparation Betamint; animals of control group get basic diet. At the second phase, a group of healthy calves, as well as control and two experimental groups of patients were formed. The first group was treated with Intecol in combination with the probiotic Vetom. Calves of the second group – the preparation Intecoll, but in a complex with electrolyte solution Electrosol oral. The calves of the control group were treated with 4% solution of gentamicin sulfate and 30% solution of natrium thiosulfate. It was found out that during the dry period, cows were often subjected to metabolic disorders, and the causes of digestive disorders in calves were associated with a metabolic disorders in cows as a result of malnutrition. In the first stage of the research, the data obtained show the stimulatory effect of Betamint on the processes of hemopoiesis of the cows. In other side,  the probable magnification increase hemoglobin in the blood of cows can be explained by the influence of the components of the preparation on the metabolism of proteins. In cows of the first experimental group, which received the mineral supplement of Sapocorm, there were no probable changes in these indices. The next stage of the work was aimed at studying the effectiveness of preparation for the treatment of sick calves. In the analysis of biochemical parameters, was obtained low effectiveness of control group treatment, which was manifested by a slight increase in the biochemical parameters of the blood of diseased calves, which indicates an ineffective action of preparation. In the treatment of calves in the first group, the general condition was normal within 4–5 days of treatment. This indicates the complex effect of compounds and other elements that are components of the preparation Intecol and probiotic Vetom, on restoring the structure and functions of digestion. An analysis of the biochemical parameters of the blood of the second group when treated with the preparation Intecol and Electrosol oral plagued the normalization of the general state occurred within 2–3 days of treatment. The revealed changes indicate the complex influence of nutrients, which are components of the preparation Electrosol oral. On the basis of the conducted studies, the positive influence of the proposed treatment regimens and the effectiveness of the use of a complex of preparation with the antibiotic “Intecol” has been proved.

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