scholarly journals Comparison of the Effect of Ethanol Extracts of Phaleria macrocarpa (scheff.Boerl) Fruit and Metformin on the Kidney Function of Hyperglycaemic Rat Models

2020 ◽  
Vol 3 (2) ◽  
pp. 20
Author(s):  
Eman Sutrisna ◽  
Eman Sutrisna ◽  
Nur Signa Aini Gumilas ◽  
Mus Topa ◽  
Evy Sulistyoningrum
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Kidney Function ◽  
P Value ◽  
Test Results ◽  
White Rats ◽  
Group I ◽  
Significant Difference ◽  
Phaleria Macrocarpa ◽  
The Mean

Diabetes mellitus is a disease that often causes diabetic nephropathy complications due to persistent hyperglycaemia. Phaleria macrocarpa (scheff. Boerl)  is one of the plants that has been widely used in the treatment of diabetes mellitus, but its effect on the risk of diabetic nephropathy is still unknown. A dose of 300mg / 200gbb / day is known as an effective dose that can significantly reduce blood sugar levels in diabetic rat. The Streptozotocin Effect (STZ) causes damage to the pancreas and causes hyperglycaemia. This study aims to compare the effect of Phaleria macrocarpa (scheff. Boerl) fruit extracts on urea and creatinine levels as a parameter of kidney function in hyperglycaemic mouse models. The study was carried out experimentally using the post-test only with control group design. Fifteen white rats were divided into 3 groups. All rats were induced with 40 mg / 200gbb of Streptozotocin (STZ) to experience hyperglycaemia. Group I as negative control was given aquades. Group II was given ethanol extract of Phaleria macrocarpa (scheff. Boerl) with a dose of 300 mg / 200gbw / day. Group III was given Metformin at a dose of 150 mg / 200gbw / day. On the 22nd day of treatment, blood specimens were taken for examination of urea and creatinine levels. The research data were statistically analyzed with α <0.05; CI95%. The mean of urea levels in Group I (79.80 ± 25.09 mg / dl), II (76.00 ± 22.59 mg / dl and III (59.60 ± 6.35 mg / dl). Kruskal-Wallis test results showed no significant difference in urea levels between treatment groups (p value = 0.273; CI95%). The mean of creatinine levels in Group I (0.68 ± 0.07 mg / dl), II (0.63 ± 0.14 md / dL) and III (0.98 ± 0.25 mg / dL). One Way Anova and Post hoc test results showed a significant difference in mean creatinine levels between Groups I and III (p = 0.014; 95% CI) and II with III ( p value = 0.006; CI95%). the results of this study can be concluded that the extract of Phaleria macrocarpa (scheff. Boerl) fruit flesh at a dose of 300 mg / 200gbb has better effectiveness than metformin dose 150 mg / 200gbb in repairing the kidney function of hyperglycaemia rats.

scholarly journals Evaluation of Salivary Procalcitonin and Macrophage Activating Factor in Generalised Chronic Periodontitis Patients with and without Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Sindhu Ramarao Ghorpade ◽  
Vijayalakshmi Rajaram ◽  
Jaideep Mahendra ◽  
Burnice Nalinakumari Chelladurai ◽  
Ambalavanan Namasivayam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
P Value ◽  
Group I ◽  
Significant Difference ◽  
The Mean ◽  
Group Ii

Introduction: Periodontitis is a polymicrobial and multifactorial oral disease and is the sixth complication of diabetes mellitus. Early diagnosis is important, and the use of non invasive biomarkers are highly useful for this purpose. The level of Macrophage Activating Factor (MAF) and Procalcitonin (ProCT) corresponds to the intensity of the inflammatory response and the severity of infection; thereby indicating that an increase in concentration or persistence of high values is considered as a prognostic indicator for severity of infection with an adverse outcome. Aim: To assess the periodontal parameters and quantify the levels of MAF and ProCT in saliva samples of generalised chronic periodontitis subjects with and without type 2 diabetes mellitus and to correlate these levels with the periodontal parameters. Materials and Methods: The study was a single centre cross- sectional study carried out at the Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India, from November 2018 to November 2019. A total of 80 subjects with generalised severe chronic periodontitis were selected and divided into two groups. Group I comprised of 40 subjects who were diagnosed with generalised chronic periodontitis without type 2 diabetes mellitus, whereas group II comprised of 40 subjects with generalised chronic periodontitis who had already been diagnosed with type 2 diabetes mellitus. Periodontal parameters such as Plaque Index (PI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) were recorded. The collected samples were subjected to molecular analysis for evaluating ProCT and MAF using Enzyme-Linked Immunosorbent assay (ELISA). Statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 25.1 (Chicago, USA Inc). Student’s Independent t-test was used to compare the mean values for the variables in the control and test group. The Pearson’s correlation test was used to evaluate correlation between all the variables. The p-value <0.05 was set as the level of significance. Results: On comparing the periodontal parameters between group I and group II, there was no significant difference between the groups p-value >0.05. The mean salivary ProCT level in group I and group II was 268.76±152.78 ng/mL and 785.75±244.37 ng/mL, respectively. The mean salivary MAF level in group I and group II was 7.15±2.02 ng/mL and 26.56±9.12 ng/mL, respectively. On comparing MAF and ProCT value between group I and group II, there was a statistically significant increase in group II (p-value <0.001) and a weak correlation value with the periodontal parameters was seen. Conclusion: There was a significant difference in levels of MAF and ProCT in saliva samples of generalised chronic periodontitis subjects with and without type 2 diabetes mellitus, however the periodontal variables in each group did not correlate with MAF and ProCT.

scholarly journals Efektifitas Puerperal Gymnastic dan Kegel Exercises terhadap Involusi Uterus pada Ibu Postpartum Hari 1 - 3

2021 ◽  
Vol 8 (2) ◽  
pp. 92-99
Author(s):  
Kholisotin Kholisotin ◽  
Kholifatun Naziro ◽  
Zainal Munir ◽  
Ahmad Kholid
Keyword(s):  
Sampling Technique ◽  
T Test ◽  
P Value ◽  
Test Results ◽  
Paired Sample ◽  
Uterine Involution ◽  
Kegel Exercises ◽  
Significant Difference ◽  
The Mean ◽  
Postpartum Mothers

During labor, women experience many reproductive changes, one of which is uterine involution. If the uterine involution is late to return to normal, it will cause subinvolution, puerperal gymnastic techniques and kegel exercises are the easiest techniques to use and are very effective. The purpose of this study was to determine the effectiveness of puerperal gymnastic and kegel exercises on uterine involution in postpartum mothers day 1-3 at BPM Hj. Nengah Mardani Tenggarang Bondowoso. This type of research uses a pre-experimental research methodology using a two-group interpretation-posttest design, with a sample of 30 respondents. The sampling technique in this study used total sampling. Data analysis used paired sample t test and independent t test. The independent t test results showed that there was no significant difference between puerperal gymnastic and kegel exercises in overcoming uterine involution in postpartum mothers with a p value of 0.039 (p value> α 0.05). Of the two techniques, Kegel exercises were more effective in reducing involution. uterus with a mean difference of 6.7333> than the mean puerperal gymnastic of 5.8000.

scholarly journals Effect of Giving Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract to Epithelialization In Incision Wound of White Rats (Rattus Norvegicus)

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Idola Perdana Sulistyoning Suharto
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Male Rats ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
White Rats ◽  
Significant Difference ◽  
Phaleria Macrocarpa ◽  
Incision Wound

The research purpose was to analysis effect of giving mahkota dewa fruits (Phaleria macrocarpa) extract to epithelialization in incision wound of white rats (Rattus norvegicus). The method was randomized posted-only control group design. There were 30 male rats (Rattus norvegicus) grouped on control and treatment group. Control group divided into three groups (KK1, KK2, KK3) and also treatment group divided into three groups (KP1, KP2, KP3). Control group just given CMC 1% peroral without mahkota dewa fruits extract, the treatment group given mahkota dewa fruits extract 22.5 mg/kg body weight. The data was analyzed by Kruskall Wallis. Based on Kruskall Wallis test, obtained result that there was a significant difference (p<0.05) epithelialization variable with p value p = 0.000 between control and treatment group. And based on One-way Anova test, obtained result that there was a significant difference (p<0.05) with p value p =0.000 between control and treatment group. The conclusion of this research was giving mahkota dewa fruits (Phaleria macrocarpa) extract can increase epithelialization in incision wound of white rats (Rattus norvegicus). Keywords : Mahkota Dewa Fruits (Phaleria Macrocarpa) Extract, Epithelialization, Incision Wound 

scholarly journals Ekstrak air daun ceplikan (Ruellia tuberosa L.) serta pengaruhnya terhadap kadar glukosa darah dan gambaran histologis pankreas tikus putih (Rattus norvegicus) diabetes mellitus

2009 ◽  
Vol 6 (2) ◽  
pp. 64
Author(s):  
Taufan Hendra Tandri ◽  
Wiryatun Lestariana ◽  
Fatma Zuhrotun Nisa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Rattus Norvegicus ◽  
Diabetic Rats ◽  
Effective Control ◽  
White Rats ◽  
Group I ◽  
Significant Difference

Background: Effective control of blood glucose and activities of antioxidant are key factors that prevent diabetes mellitus (DM) and its complications. There are lots of herbal plants that have those both effects. Ceplikan leaves (Ruellia tuberosa L.) is a traditional medicine which is empirically used to lower blood glucose level. Instead of antioxidant compound, there is assumed other compound in ceplikan leaves that has side effect to pancreatic beta cells.Objective: To identify the effect of ceplikan leaves extract to blood glucose level and pancreas histology description in white diabetic rats (Rattus norvegicus).Method: Thirty subjects of Wistar strain male white rats of 2-3 months old and of 150-200 grams weight were made diabetic with aloxan and randomly divided into 5 groups. Group I consisted of diabetic rats with aquadest, group II with glibenclamide, and Group III-V were given extract of ceplikan leaves in different concentrations that were 1.6 mg, 3.2 mg, and 6.4mg, respectively. Treatment was given orally per day within 30 days. Level of blood glucose was measured in the day of 0, 3, 4, and 30. Statistical analysis used repeated measures and t-test.Result: The supply of ceplikan leaves extract could reduce level of blood glucose of diabetic rats, although the decrease was insignificant. Average diameter of wider Langerhans island occurred to the group of diabetic rats that were given extract of ceplikan leaves dosage 6.4 mg. There was no significant difference (p > 0.05) in changes of blood glucose level before and after experiment in diabetic rats. Pancreas histological description of rats showed that there was improvement as indicated by greater quantity of Langerhans Island and wider diameter of Langerhans Island.Conclusion: Ceplikan leaves was safe and efficacious, so that self-medication of DM using ceplikan leaves could be sustained through formal approach.

scholarly journals Short and Long-Term Follow up Results of Daily 5 Mg Tadalafil as a Treatment for Erectile Dysfunction and Premature Ejaculation

2021 ◽  
Author(s):  
Tarek Gharib ◽  
Ibrahim Abdelal ◽  
Adel Elatreisy ◽  
Elsayed Salih ◽  
Ahmed Sebaey
Keyword(s):  
Erectile Dysfunction ◽  
Premature Ejaculation ◽  
P Value ◽  
Group I ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
The Mean ◽  
Group Ii

Abstract Objective: To evaluate effectiveness and safety of a 5mg tadalafil daily treatment for men with erectile dysfunction (ED) and premature ejaculation (PE) and assessment of long-term follow up by persistence of improvement 2 years after stoppage of tadalafil.Materials and Methods: The study included 160 patients diagnosed with erectile dysfunction from April 2018 to June 2020. All were evaluated using the international index of erectile function questionnaire-5 (IIEF-5) to evaluate ED and intravaginal ejaculatory latency time (IELT) for PE. Patients subdivided into two equal groups. I included 80 patients treated with tadalafil 5 mg daily for 3 months, and group II included 80 patients treated with a placebo for same period. After 3 months treatment and 2 years later after stoppage of tadalafil, all patients were assessed for ED and PE using the same questionnaires. Results: The mean IELT and IIEF pretreatment were 37±11.24 s and 13.2±4.2 respectively for group I, while in group II was 35.98±10.8 s and 13.12±4.11, respectively. After 3 months of treatment, the mean value of IELT in group I showed a highly significant improvement from 37±11.24 sec to 120.5±47.37 sec (p-value < 0.001), but for group II, the mean values of IELT showed no significant improvement from baseline 35.98±10.8 to endpoint 39.43±13.6 ( p-value > 0.05). As regarding the IIEF, there was a highly significant improvement from baseline 13.2±4.2 to endpoint 20.45±4.5 in group I (p-value < 0.001) while there was no significant difference in group II from baseline 13.12±4.11 to endpoint 15±4.84 (p-value > 0.05) . 2 years later after stoppage of tadalafil , 75 patients from group I complete follow up and there was significant improvement in IELT and IIEF form base line (37±11.24) (13.2±4.2) to endpoint (98±18.3) (19.1±2.3) respectively but less than the results after 3 months treatment.ConclusionDaily Tadalafil 5 mg was effective, tolerable, and safe treatment for patients suffering from ED and PE. Long-term follow up after 2 years declared persistence of significant improvement.

scholarly journals Zinc alpha 2 glycoprotein as an early biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus

2019 ◽  
Vol 41 (4) ◽  
pp. 509-517 ◽  
Author(s):  
Mohamed Elsheikh ◽  
Khaled A Elhefnawy ◽  
George Emad ◽  
Mabrouk Ismail ◽  
Maher Borai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Urine Analysis ◽  
Liver Function Tests ◽  
Control Group ◽  
Group I ◽  
Significant Difference

Abstract Introduction: Although microalbuminuria remains the gold standard for early detection of diabetic nephropathy (DN), it is not a sufficiently accurate predictor of DN risk. Thus, new biomarkers that would help to predict DN risk earlier and possibly prevent the occurrence of end-stage kidney disease are being investigated. Objective: To investigate the role of zinc-alpha-2-glycoprotein (ZAG) as an early marker of DN in type 2 diabetic (T2DM) patients. Methods: 88 persons were included and classified into 4 groups: Control group (group I), composed of normal healthy volunteers, and three patient groups with type 2 diabetes mellitus divided into: normo-albuminuria group (group II), subdivided into normal eGFR subgroup and increased eGFR subgroup > 120 mL/min/1.73m2), microalbuminuria group (group III), and macroalbuminuria group (group IV). All subjects were submitted to urine analysis, blood glucose levels, HbA1c, liver function tests, serum creatinine, uric acid, lipid profile and calculation of eGFR, urinary albumin creatinine ratio (UACR), and measurement of urinary and serum ZAG. Results: The levels of serum and urine ZAG were higher in patients with T2DM compared to control subjects and a statistically significant difference among studied groups regarding serum and urinary ZAG was found. Urine ZAG levels were positively correlated with UACR. Both ZAG levels were negatively correlated with eGFR. Urine ZAG levels in the eGFR ˃ 120 mL/min/1.73m2 subgroup were higher than that in the normal eGFR subgroup. Conclusion: These findings suggest that urine and serum ZAG might be useful as early biomarkers for detection of DN in T2DM patients, detectable earlier than microalbuminuria.

scholarly journals The Comparative Effectiveness of Phaleria macrocarpa (Scheff.) Boerl. Pericarp Ethanol Extract and Metformin in Reducing Blood Sugar Levels and Ameliorating the Langerhans Islets Degeneration in Diabetic Rat Models

2020 ◽  
Vol 17 (1) ◽  
pp. 241
Author(s):  
Eman Sutrisna ◽  
Qurrotu Aini ◽  
Ika Murti Harini ◽  
Nur Signa Aini Gumilas ◽  
Mustofa Mustofa ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Ethanol Extract ◽  
Diabetic Rat ◽  
P Value ◽  
Test Results ◽  
Langerhans Islets ◽  
Group I ◽  
Significant Difference ◽  
Sugar Levels ◽  
Post Hoc

Phaleria macrocarpa (Scheff.) Boerl. has been widely used in the treatment of diabetes mellitus but its effectiveness is still inconclusive so it needs to be compared with standard drugs such as metformin. This study aims to analyze the effects of P. macrocarpa fruit extracts on blood sugar levels and the repairing of the pancreatic Langerhans islets of diabetic rat models. The study was conducted experimentally by pre and post-test design with a control group. Thirty white rats were divided into 6 groups. All rats were treated with 40 mg/200 g BW of streptozotocin (STZ) to induce hyperglycemia, except group I. Group II as a negative control was given with aquadest. Group III, IV, and V were given with ethanol extract of P. macrocarpa pericarps at doses of 200, 250, and 300 mg/200 g BW/day, respectively. Group VI was given with metformin at a dose of 150 mg/200 g BW/day. On the 22nd day of treatment, blood specimens were taken for examination of fasting blood sugar levels and pancreatic organs were analyzed for histopathological examination of the islets of pancreatic Langerhans. The data were statistically analyzed with α<0.05; CI95%. Paired sample t-test results showed a significant decrease in blood sugar levels before and after treatment in group V (p-value=0.048). One way anova and post hoc Least Significant Difference (LSD) test results showed a significant difference in mean blood sugar levels after the final treatment between groups I and II (p-value=0.013), I and III (p-value=0.004), I and IV (p-value=0.002), I and VI (p-value=0.000), II and VI (p-value=0.031), and V with VI (p-value=0.005); one way anova and post hoc LSD test results showed a significant difference in the mean area of islets of pancreatic Langerhans between group I and all treatment groups (p-value=0.000), II with V and VI (p-value=0.000 and 0.009), III with V and VI (p-value=0.000 and 0.001), and IV with V (p-value=0.003). It can be concluded that the extract of P. macrocarpa pericarps showed a hypoglycemic effect and repaired the damage in Langerhans islets of STZ-induced rat in a dose-dependent manner.

scholarly journals Study of TSH level at the time of diagnosis of Hypothyroidism in patients with Diabetes Mellitus- A Retrospective Study

2020 ◽  
Vol 4 (2) ◽  
pp. 24-28
Author(s):  
Indu K.C. ◽  
S Ghimire ◽  
R Deo
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Kidney Disease ◽  
P Value ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Other Information ◽  
Patients With Diabetes ◽  
History Of ◽  
The Mean ◽  
The Difference

Background: To evaluate the difference in the level of TSH in diabetic and non diabetic patients at the time of the diagnosis of hypothyroidism. Methods: 100 diagnosed cases of hypothyroidism, 50 with diabetes and 50 without diabetes were studied. The level of TSH at the time of diagnosis and other information were obtained from the medical records. Results: The mean TSH in patients with the history of diabetes at the diagnosis of hypothyroidism was 19.9616±26.990 and in those without the history of the diabetes was 10.4797±6.503 (p value 0.018). The females with diabetes had higher level of TSH level at the time of diagnosis of hypothyroidism than females without diabetes (p value 0.045). There was no statistically significant difference in the level of TSH in males with and without diabetes at the time of diagnosis of hypothyroidism. Conclusion: Patients with diabetes mellitus had higher level of TSH at the time of diagnosis of hypothyroidism in comparison to those without diabetes. Early identification of the raised TSH levels in diabetic patients and timely intervention will help to reduce the chances of adverse cardiovascular outcomes and diabetic kidney disease in this group of patients.

scholarly journals Fracture Resistance of Primary Canines Restorations Reinforced with a Flowable or a Packable Composite Resin Posts; In- Vitro

2021 ◽  
Author(s):  
Ghasem Ansari ◽  
Fatemeh javadi ◽  
Kiana Hanjani ◽  
Ahmad Najafi Abrandabadi ◽  
Mahshid Gashtasb ◽  
...  
Keyword(s):  
Fracture Resistance ◽  
Composite Resin ◽  
Testing Machine ◽  
P Value ◽  
Anterior Teeth ◽  
Group I ◽  
Significant Difference ◽  
The Mean ◽  
Group Ii ◽  
Type Of Fracture

Abstract Aim and Background: Restoration of severely damaged primary anterior teeth are deemed as serious challenges for pediatric dentists. The aim of this study was to evaluate the fracture resistance of primary canines restored with flowable or packable composite resin posts. Material and Methods This study was conducted on a group of extracted primary canines. After cutting the coronal section, standard pulpectomy was performed and root canals were filled with ZOE paste leaving 3 mm coronal root space. A liner was placed above the root canal filling as a barrier. Samples were then randomly divided into two groups of fifteen. Both groups, received etch, bond, then in group I Core Flo Composite resin placement into canal, in group II, post shaping using designated packable composite resin and inserted into the canal. Followed by Core buildup and Crown reconstruction using Z250 composite resin. Samples were mounted at 148 ° angle on the acrylic blocks and stored in de-ionized water for 72 hours. Fracture resistance was measured using Universal Testing Machine. Data analysis were performed using independent t-test. Chi- square test were also employed to assess the type of fracture within groups. Results The mean fracture resistance in the group I was 830.31(+/-328.69N) and 803.09(+/-326.45N) in group II. Moreover, statistical analyses of the results showed no significant difference between the mean values of the fracture resistance (p-value=0.822) of groups as well as the type of fracture (p-value=0.79) between groups. Conclusion The ease of use and proper adhesion of the Core Flo composite resin, seems to help its use in the reconstruction of severely destructed anterior primary teeth.

scholarly journals Lower Incisor Positions in Different Malocclusions and Facial Pattern

2021 ◽  
pp. 298-304
Author(s):  
Abdul Jabbar ◽  
. Saba ◽  
Ramesh Lal ◽  
Amber Farooq ◽  
Uzma Bashir ◽  
...  
Keyword(s):  
Treatment Plan ◽  
Interobserver Reliability ◽  
Intraclass Correlation ◽  
P Value ◽  
Test Results ◽  
Lower Incisor ◽  
Normal Occlusion ◽  
Significant Difference ◽  
Facial Pattern ◽  
The Mean

Aims: The position of lower incisor has been of significant concern when seeking orthodontic treatment plan, it has been recognized as one of diagnostic key and play an important in the development of normal occlusion and facial pattern. This study was aimed at the determination of lower incisor position and its possible association with different sagittal malocclusions and facial patterns. Study Design: Descriptive Cross-sectional Study Place and Duration of Study:  Department of Orthodontics Institute of Dentistry Liaquat University Medical and Health Sciences (LUMHS) Jamshoro between June 2019 to July 2020. Methodology: Ninety-seven pre-treatment lateral cephalometric radiographies were taken, and they were classified sagittally into skeletal class I, II and III, and vertically into normodivergent, hyperdivergent and hypodivergent facial pattern using ANB and SNMP, respectively. Lower     incisor position was assessed by means of FMIA and IMPA. One way analysis of variance (ANOVA) was applied to check any association between lower incisor position and sagittal malocclusion and facial pattern.  P value of 0.05 was considered statistically significant. Results: The study sample consisted of 97 patients. The mean age of the patients was 25.55 SD ±3.93. The mean SNMP value was 28.84 SD ±7.354 and mean ANB value 4.809 SD ±3.85. Mean Incisor position based on IMPA was 98.598 SD ± 9.413 and FMIA 54 SD ±9.995.  Intra and interobserver reliability was assessed with intraclass correlation coefficient values ranging between 0.825 and 0.990 respectively. The ANOVA test results showed significant relationship between the sagittal malocclusion and incisor position with P value .036. The Bonferroni analysis indicated that statistically significant association existed in term of lower incisor position between Class II and Class III malocclusion with P value .047. Test results further indicated that there is no significant difference in the position of lower incisor in relation to facial pattern with P value .355. Conclusions: Statistically significant association was found between lower incisor position with respect to the sagittal malocclusion. However, no significant association was found between facial pattern and lower incisor position.

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