scholarly journals Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA

2020 ◽  
Vol 3 (2) ◽  
pp. 51
Author(s):  
Prawesty Diah Utami ◽  
R. Varidianto Yudo Tjahjono ◽  
Indi Jazilah ◽  
Ismy Azizah Sisnawati
Keyword(s):  
Cerebral Malaria ◽  
Clinical Manifestations ◽  
Control Group ◽  
High Morbidity ◽  
Swiss Mice ◽  
Study Results ◽  
Post Test ◽  
Parasitemia Level ◽  
Malaria Model ◽  
Global Health Problem

<p>The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.</p><p><strong> </strong></p><p><strong>Keywords:</strong> <em>P.berghei ANKA, </em>C57BL/6 mice, Swiss mice, Clinical manifestation, Parasitemia level.</p>

scholarly journals The Influence of Practicum-Based Outdoor Inquiry Model on Science Process Skills in Learning Physics

2019 ◽  
Vol 8 (1) ◽  
pp. 23-33
Author(s):  
Yeni Ristya Wardani ◽  
Mundilarto Mundilarto ◽  
Jumadi Jumadi ◽  
Insih Wilujeng ◽  
Heru Kuswanto ◽  
...  
Keyword(s):  
Sampling Technique ◽  
Control Group ◽  
P Value ◽  
Cluster Sampling ◽  
Process Skills ◽  
Science Process Skills ◽  
Study Results ◽  
Post Test ◽  
Essay Test ◽  
Test Control

The main purpose of this study is to find out the influence of practicum-based outdoor inquiry model on science process skills. Quasi-experiment design was employed as the research method by Matching Only Post-test Control Group. The research sample was taken using a cluster sampling technique. The samples consisted of experimental class (XI MIA 1) in a total of 25 students treated with practicum-based outdoor inquiry model. The control class (XI MIA 3) consisted of 29 students treated with direct instruction model. In collecting the data, essay test was used in the form of worksheets containing the aspect of science process skills of formulating hypotheses, designing experiment, interpreting data into tables, and drawing a conclusion (inferring). The study results demonstrate that practicum-based outdoor inquiry model was effective in improving the science process skills. It was shown in p-value (significant) of 0.00. The implication of this study is the need to design a practicum-based outdoor inquiry model by noticing what skills are going to improve by means of more varied outdoor activities

scholarly journals Pengaruh pemberian obat anti tuberkulosis dengan vitamin D terhadap perubahan BTA pada penderita tuberkulosis paru di Kabupaten Pidie

2021 ◽  
Vol 2 (1) ◽  
pp. 25
Author(s):  
Rina Maulidar ◽  
Nurjannah Nurjannah ◽  
Aulina Adamy ◽  
Iskandar Iskandar
Keyword(s):  
Vitamin D ◽  
Drug Therapy ◽  
Intervention Group ◽  
Control Group ◽  
Significance Level ◽  
The World ◽  
Post Test ◽  
And Control ◽  
Global Health Problem ◽  
Test Control

Background: Tuberculosis (TB) is a global health problem, Indonesia had the second rank of the case in the world after India which is the fourth cause of death. Giving vitamin D together with anti-tuberculosis drugs can increase healing proses because vitamin D (anti-microbial immunomodulators) kills Mycobacterium tuberculosis.Objectives: This study aims to measure the effect of giving anti-tuberculosis drugs with vitamin D on changes in AFB in patients with pulmonary tuberculosis.Methods: This study was used a quasi-experiment design, pre-test and post-test control group was doing at 25th March – 25th July 2019. This research has been conducted in Pidie Regency. The intervention group (17 samples with tuberculosis drugs) was given Softgels vitamin D 5000 IU for 4 months, while the control group was only anti-tuberculosis drug therapy. The data were analyzed statistically using the Wilcoxon and Mann Whitney tests at a significance level of 95%.Results: Before the intervention, the BTA status of both the intervention and control group was similar (p= 0.061). After the intervention, there was a decrease in AFB interactions (p= 0.000). There was a decrease in the contribution of AFB in the control group before with after intervention (p= 0.000). There are those who support (p= 0.033) giving vitamin D the acceleration of pulmonary tuberculosis treatment. Conclusion: It is better to administer vitamin D to the successful treatment of pulmonary TB in patients undergoing anti-tuberculosis drug therapy.

POLYMORPHISM OF GENE IL2-330Т>>G AND EXPRESSION OF INTERLEUKIN-2 IN PATIENTS WITH VENOUS THROMBOEMBOLIC COMPLICATIONS OF POLYTRAUMA

2017 ◽  
Author(s):  
А. Мироманов ◽  
В. Доржеев ◽  
Н. Мироманова ◽  
Ю. Витковский
Keyword(s):  
Molecular Genetic ◽  
Interleukin 2 ◽  
Clinical Manifestations ◽  
Molecular Genetic Analysis ◽  
Control Group ◽  
Thromboembolic Complications ◽  
Inclusion Criteria ◽  
Study Results ◽  
Venous Thromboembolic ◽  
Analysis Point

Введение. Политравма отличается особой тяжестью клинических проявлений, сопровождается значительным нарушением жизненно важных функций организма, трудностью диагностики и лечения, частым развитием разнообразных осложнений, длительным периодом пребывания в стационаре и высокой инвалидизацией. Тромбоэмболические осложнения при политравме встречаются в 40–77% случаев и характеризуются скрытым клиническим течением, трудностью лечения и высокой летальностью. Цель исследования. Изучить влияние полиморфизма гена IL2-330T{>{G на экспрессию интерлейкина-2 (IL-2) у пациентов с венозными тромбоэмболическими осложнениями (ВТЭО) политравмы в Забайкальском крае. Материалы и методы. В исследование включено 114 пациентов (71,9% мужчин и 28,1% женщин) в возрасте от 20 до 40 лет с политравмой. Критерий включения в исследование: политравма с индексом по шкале ISS более 9. Первая группа — 73 пациента с неосложнённым течением политравмы, вторая группа — 41 пациент с ВТЭО политравмы. Контрольную группу составили 100 практически здоровых мужчин и женщин в возрасте от 20 до 40 лет. Материалом для молекулярно-генетического анализа служили образцы ДНК, выделенные из периферической крови. Для исследования выбрана точковая мутация IL-2 в позиции 330 (Т{>{G). Результаты. У пациентов с ВТЭО политравмы регистрировали более частое носительство генотипа -330T/T гена IL2; наличие этого генотипа сопровождалось увеличением продукции IL-2. Заключение. Идентификация генов и раскрытие их влияния на экспрессию кодируемых молекул способствует более глубокому пониманию патогенетических механизмов развития осложнений. Introduction. Polytrauma is characterized by a specifi c severity of clinical manifestations, is accompanied by a signifi cant impairment of vital body functions, the diffi culty of diagnosis and treatment, frequent development of various complications, prolonged period of hospitalization and high disability. Thromboembolic complications of polytrauma occur in 40–77% of cases and characterized by latent clinical course, diffi culties in treatment and high mortality. The aim was to study the eff ect of gene IL2-330T{>{G polymorphism on the expression of interleukin-2 (IL-2) at patients with venous thromboembolic complications (VTE) of polytrauma in Zabaykalskiy Krai. Materials and methods. The study included 114 patients (71,9% men and 28,1% women) with polytrauma aged from 20 to 40 years. Inclusion criteria: polytrauma with index according ISS scale more than 9. First group — 73 patients with uncomplicated polytrauma, second group — 41 patients with VTE of polytrauma. Control group consisted of 100 practically healthy men and women aged from 20 to 40 years. DNA samples isolated from the peripheral blood were the material for molecular genetic analysis. Point mutation of IL-2 at position 330 (T{>{G) was selected for study. Results. Genotype -330T/T of IL2 gene was registered more frequently at patients with VTE of polytrauma; the presence of this genotype was accompanied by increased production of IL-2. Conclusion. Identifi cation of genes and their eff ects on the expression of encoded molecules assists more overall understanding of pathogenetic mechanisms of complications development.

scholarly journals The Efficacy of the “Dat-e Adolescence” Prevention Program in the Reduction of Dating Violence and Bullying

2019 ◽  
Vol 16 (3) ◽  
pp. 408 ◽  
Author(s):  
Noelia Muñoz-Fernández ◽  
Javier Ortega-Rivera ◽  
Annalaura Nocentini ◽  
Ersilia Menesini ◽  
Virginia Sánchez-Jiménez
Keyword(s):  
Dating Violence ◽  
Behavioral Problems ◽  
Prevention Program ◽  
Growth Models ◽  
Control Group ◽  
Efficacy Evaluation ◽  
Multiple Group ◽  
Study Results ◽  
Post Test ◽  
Experimental Group

Background: The aim of this study was to assess the efficacy of the school-based “Dat-e Adolescence” prevention program in the reduction of dating aggression and victimization and bullying in adolescents. Method: a RCT design with three waves (pre-test, post-test and follow-up six months apart) and two groups (an experimental group and a control group) were used. One thousand four hundred and twenty three (1423) adolescents, mean age 14.98 (557 in the experimental group) participated in the study. Results: Efficacy evaluation was analyzed using Multiple-group latent growth models and showed that the Dat-e Adolescence program was effective in reducing sexual and severe physical dating violence and bullying victimization. Conclusions: The results suggest that dating violence prevention programs could be an effective approach for tackling different behavioral problems in adolescence given the protective and risk factors shared between dating violence and bullying.

scholarly journals Evaluation of the Effectiveness of Dynamic Neuromuscular Stability Exercises on Balance and Walking Function in the Elderly

2021 ◽  
Vol 19 (3) ◽  
pp. 279-288
Author(s):  
Mohammad Hani Mansori ◽  
◽  
Yousef Moghadas Tabrizi ◽  
Kamal Mohammadkhani ◽  
◽  
...  
Keyword(s):  
Dynamic Balance ◽  
The Elderly ◽  
The Body ◽  
Control Group ◽  
Static Balance ◽  
Daily Routine ◽  
Study Results ◽  
Significant Difference ◽  
Post Test ◽  
Gait Function

Objectives: Walking and balance control are determining factors in the independence of the elderly because they are the main components of daily physical activity. This study evaluated the effectiveness of Dynamic Neuromuscular Stability (DNS) training on balance and gait function in the elderly. Methods: This study had a pre-test/post-test design. It was a quasi-experimental study performed on 30 older men aged 60-70 years in Qom Province, Iran, in 2021. The elderly was randomly divided into experimental (n=15) and control (n=15) groups. The Experimental Group (EG) participated in three 45-min sessions of dynamic neuromuscular stability training every week for 6 weeks, and the Control Group (CG) continued their normal daily routine. Berg balance scale (dynamic balance), modified stork stand (static balance), and temporal and spatial gait parameters were used to collect information before and after applying the training protocol. The obtained data were analyzed using ANCOVA statistical method and the paired t test. Results: There were significant differences between pre-test and post-test in EG regarding the variables of dynamic balance, static balance (P=0.001), and gait function, but in the CG, no significant difference was observed for these variables (P>0.05). Also, there was a significant difference between the mean scores obtained in the balance and gait tests between the two groups (P<0.05), and EG performed better in the post-test. Discussion: DNS training due to the great variety of movement in different parts of the body and the effect on improving strength, flexibility, range of motion, and physical fitness can also improve balance and gait function in the elderly. According to the present study results, one of the best ways to reduce the costs and physical, psychological, and social problems caused by aging is to use DNS training for the elderly.

scholarly journals The Effect of KWL and SQ3R Strategies on Developing Reading Comprehension Skills Among Eighth Graders in Gaza

2021 ◽  
Vol 29 (4) ◽  
Keyword(s):  
Reading Comprehension ◽  
Eighth Graders ◽  
Average Score ◽  
Control Group ◽  
Study Results ◽  
Comprehension Skills ◽  
Post Test ◽  
Reading Comprehension Skills ◽  
Experimental Group ◽  
Total Average

The current study aimed at investigating the effect of KWL and SQ3R strategies on Palestinian eighth graders' reading comprehension skills. To achieve the study goals, the researcher adopted the experimental approach on a sample of (119) female students from Al-Kuwait Secondary School at Rafah governorate for the academic year 2019-2020. The participants were divided into three equivalent groups. The researcher used a pre and post reading comprehension test to achieve the aims of the study. Results revealed there are statistically significant differences at (α ≤ 0.01) in the total average score of the post-test between the first experimental group and the control group in favor of the first experimental group that learns by KWL strategy. Additionally, the study results showed that there are statistically significant differences at (α ≤ 0.01) in the total average score of the post-test between the second experimental group and the control group in favor of the second experimental group that learns by SQ3R strategy. Also, the study results revealed that there are statistically significant differences at (α ≤ 0.01) in the total average score of the post-test between the first and second experimental groups in favor of the first experimental group. In the light of these results, the researcher introduced some recommendations such as designing some training courses for teachers to encourage them to use these strategies.

scholarly journals Development of snakes and ladders game (disaster response) as earthquake mitigation for children

2021 ◽  
Vol 3 (2) ◽  
pp. 97
Author(s):  
Besse Nirmala ◽  
Andi Agusniatih ◽  
Haerul Annuar
Keyword(s):  
Disaster Response ◽  
Field Trials ◽  
Disaster Mitigation ◽  
Control Group ◽  
Initial Field ◽  
Earthquake Disaster ◽  
Study Results ◽  
Significant Difference ◽  
Post Test ◽  
Quantitative Descriptive

This study aims to produce of snakes and ladders game with feasible to increase understanding of children related to earthquake disaster mitigation. Snakes and ladders game will be applied to children aged 5-6 years in Palu city. This research is a research and development according to Borg and Gall. Data collection techniques using observation, interviews and questionnaries. Data analysis in the form of quantitative descriptive. The results showed that the assessment of the material validators get an average of 3.63, media validators get an average of 3.8, and disaster validators get an average of 3.75 (feasible category). In the initial field trials, it averaged persentage 78% and was included in the feasible category. Operational field trials get an average persentage of 87% included in the feasible category. Comparative study results obtained sig. (2-tailed) of 0,000 <0.05, it can be concluded that Ha is accepted, which means that "there is a significant difference" between the average post-test results of the control group and the experimental group. The results obtained after applying the snake and ladder game, children can understand and carry out self-rescue activities when simulating an earthquake disaster.

scholarly journals Pengaruh Intervensi Kognitif Spiritual Terhadap Penerimaan Diri Pada Klien Stroke Iskemik

1970 ◽  
Vol 5 (1) ◽  
pp. 19
Author(s):  
Novita Setyowati ◽  
Uswatun Hasanah
Keyword(s):  
Muscle Strength ◽  
Group Treatment ◽  
Healing Process ◽  
Evaluation Research ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
Test Study ◽  
Study Results ◽  
Post Test

Hemiparese is a common problem that can caused disability. Exercise is still considered effective to prevent disability. This study is aimed to increased the muscle strength on hemiparese patient's muscle strength caused by ischemic stroke in RSUD Gambiran Kota Kediri. This study used Quasi Experiment pre and post test research designs. Number of samples were 9 respondents who were divided into intervention group and control group. Evaluation research was done on the first day and eigth day for the two groups. Data were analyzed Paired T test and Independent T Test. Study results showed an increased in muscle strength (p =0.000) in both the intervention groups and there are significant differences between the two groups (p = 0009), which means there is a difference between the control group treatment group. The implication of this research are to use exercise as one of the independent nursing interventions in caring stroke patients with hemiparase and to improve the quality of nursing care, makes healing process faster, prevent complications dan also enrich nursing science.;Keywords: stroke; hemiparese; Spiritual intervention on cognitive; Self acceptance.

scholarly journals Effectiveness of art therapy on pain and anxiety level among postoperative children

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 50-55
Author(s):  
Resmy V ◽  
Raj Kumar N
Keyword(s):  
Art Therapy ◽  
Demographic Data ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Well Being ◽  
Structured Interview ◽  
Control Group ◽  
Study Results ◽  
Post Test ◽  
Experimental Group

As children grow, they learn each day, of how to live tomorrow watching the grace and disgrace that surround them. The utilization of imaginative strategies to treat mental issues and upgrade emotional well-being is known as art treatment. Art treatment is a strategy established in the possibility that inventive articulation can cultivate recuperating and mental prosperity. Craftsmanship, either making it or survey others' specialty, is utilized to assist individuals with investigating feelings, create mindfulness, adapt to pressure, help confidence, and work on social abilities. Postoperative care may be an emotional and developmental set back to the child. It causes anxiety and pain due to imbalance between environmental and societal demands and child's coping abilities. The present study aims to assess the effectiveness of art therapy on anxiety and pain level among postoperative children. A quantitative true experimental research design was conducted among 30 postoperative children by using a simple random sampling technique and 15 were divided in control and experimental group. The demographic data were collected using structured interview questionnaire. The pre-test was done to assess level of anxiety by five facial anxiety scale and pain by numerical pain scale for both the experimental and control group. The experimental group was given art therapy, the control group was given a routine care and then the post test was done. The study results show that the level of pain and anxiety was considerably reduced in the experimental group than the control group in the post test at p<0.005. This indicates SART therapy is effective non-pharmacological method and cost effective method to treat pain and anxiety among postoperative children. The result of the study is it was concluded that art therapy as no side effects and it is an easy and comfortable method which can be practiced to treat pain and anxiety.

scholarly journals استخدام طريقة حل المشكلات لترقية قدرة الطلبة على قراءة النصوص العربية (البحث التجريبي بمعهد دار العلوم العصري ببندا أتشيه)

2020 ◽  
Vol 9 (1) ◽  
pp. 89
Author(s):  
Fachrur Razi
Keyword(s):  
Fifth Grade ◽  
Control Group ◽  
Third Language ◽  
Fifth Grade Students ◽  
Study Results ◽  
Students First ◽  
Post Test ◽  
Quasi Experimental ◽  
Second Year ◽  
Experimental Group

Reading is the third language skill of the four main skills, namely Listening, Speaking, Reading and Writing skills. The Qiraatul Kutub is one of lessons though for fourth and fifth grade students (first and second year of high school) at Dayah Modern Darul ‘Ulum Banda Aceh. And the researcher intends to research about the حل المشكلات method and effects of its application to the teaching of Qiraatul Kutub’s lesson to students in this school, so that the researchers can find out that this method is effective or not effective to the teaching of Qiraatul Kutub’s lessons. This study used a quasi-experimental method. Researchers took samples 50 students, namely 25 students of class 5-a as the experimental group and 25 students of class 5-b as  the control group. And the research’s instrument is Interview, Observation and Test (pre test-post test). The study results showed that The use of the حل المشكلات method is effective for students in learning of Qiraatul Kutub’s lesson. It was shown by the result of the t-test = 4,2 is greater than 2,021 results (0,05).

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