scholarly journals Beekeeping and Bee Products; Boon for Human Health and Wealth

2016 ◽  
Vol 4 (03) ◽  
pp. 20-27
Author(s):  
Bhalchandra Waykar ◽  
Yahya Ali Alqadhi
Keyword(s):  
Blood Pressure ◽  
Royal Jelly ◽  
Endocrine System ◽  
Gastrointestinal Disorder ◽  
Decay Resistance ◽  
Bee Venom ◽  
Antitumor Property ◽  
Antibiotic Property ◽  
Agricultural Yield ◽  
Pharmacologically Active

The cross-fertilization by bee increases average agricultural yield by 20 to 25 percent. Its products like honey, pollen, royal jelly, propolis, bee venom have immense medical importance. Honey is useful for healing the wounds, helps to build up hemoglobin, used as laxative blood purifier, preventive against cold, cough, sore throat, eye ailments, burns and gastrointestinal disorder etc. Honey has antibiotic property and is effective in reducing the risk of heart disease, cancer and diabetes. Pollen lowers blood pressure, increases hemoglobin and erythrocyte content, useful in pernicious anemia, sterility, hypertension, in complaints of the nervous and endocrine system. Royal jelly has antimicrobial, anti-inflammatory, antiaging, vasodilative and hypotensive, antioxidant, antihypercholesterolemic and antitumor property. Royal jelly has a diuretic effect, prevents obesity, builds up resistance to infection, regulates the functioning of the endocrine glands and is good for arteriosclerosis and coronary deficiency. Bee venom acts as antibiotic and useful for lowering of blood pressure, in neural disorders and rheumatoid arthritis and acute rheumatic carditis, treating certain eye diseases, hypertension and gynecological and children’s diseases. Propolis, a resinous substance has pharmacologically active constituents as flavonoids, phenolics and other various aromatic compounds. Propolis has antibacterial, antifungal, antiviral, antioxidant and antiinflammatory proprieties. It is used to treat mouth and gum disorders, gum decay, resistance to general illness, cure burns and fungal skin complaints. Beeswax is used to prepare polishes, waterproofing, electrical insulation, cosmetics, cold creams etc. It is also useful in engineering, pharmaceutical and confectionary industries.

scholarly journals Beehive Products as Antibacterial Agents: A Review

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 717
Author(s):  
Rita Abou Nader ◽  
Rawan Mackieh ◽  
Rim Wehbe ◽  
Dany El El Obeid ◽  
Jean Marc Sabatier ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Honey Bee ◽  
Antibacterial Agents ◽  
Royal Jelly ◽  
Biological Activities ◽  
Vital Role ◽  
Bee Venom ◽  
Bacterial Strains ◽  
Wide Range ◽  
Life Threatening

Honeybees are one of the most marvelous and economically beneficial insects. As pollinators, they play a vital role in every aspect of the ecosystem. Beehive products have been used for thousands of years in many cultures for the treatment of various diseases. Their healing properties have been documented in many religious texts like the Noble Quran and the Holy Bible. Honey, bee venom, propolis, pollen and royal jelly all demonstrated a richness in their bioactive compounds which make them effective against a variety of bacterial strains. Furthermore, many studies showed that honey and bee venom work as powerful antibacterial agents against a wide range of bacteria including life-threatening bacteria. Several reports documented the biological activities of honeybee products but none of them emphasized on the antibacterial activity of all beehive products. Therefore, this review aims to highlight the antibacterial activity of honey, bee venom, propolis, pollen and royal jelly, that are produced by honeybees.

Pharmacologically Active Peptides and Proteins from Bee Venom

Animal Toxins ◽  
2000 ◽  
pp. 127-151
Author(s):  
Peter N. Strong ◽  
Jonathan D. F. Wadsworth
Keyword(s):  
Bee Venom ◽  
Active Peptides ◽  
Pharmacologically Active

scholarly journals Frequent Abdominal Pain in Childhood and Youth: A Systematic Review of Psychophysiological Characteristics

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Marco Daniel Gulewitsch ◽  
Judith Müller ◽  
Paul Enck ◽  
Katja Weimer ◽  
Juliane Schwille-Kiuntke ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Abdominal Pain ◽  
Endocrine System ◽  
Gastrointestinal Disorder ◽  
Autonomous Nervous System ◽  
Journal Articles ◽  
Childhood And Youth ◽  
Endocrine Parameters ◽  
The Central Nervous System

Background. Frequent abdominal pain (AP) in children and adolescents is often designated as functional gastrointestinal disorder. In contrast to research on psychological and social influences on the experience of AP in this population, psychophysiological features such as function of the autonomic nervous system, the central nervous system, or the endocrine system have rarely been studied.Methods. We conducted a systematic literature search for peer-reviewed journal articles referring to children with AP between 4 and 18 years. Studies on experimental baseline characteristics or reactivity of psychophysiological outcome parameters (autonomous nervous system, central nervous system, and endocrine parameters) were included.Key Results. Twelve of 18 included studies found psychophysiological differences between children with AP and healthy ones. These studies indicate a possible autonomic dysregulation and hypersensitivity of the central nervous system in children with AP following stimulation with stress or other intense stimuli. Mainly conflicting results were found regarding baseline comparisons of autonomic and endocrine parameters.Conclusions and Inferences. Frequent AP in children may be associated with an altered psychophysiological reaction on intense stimuli. It has to be considered that the current literature on psychophysiological characteristics of childhood AP is small and heterogeneous. In particular, multiparameter studies using validated experimental paradigms are lacking.

scholarly journals Dioscorealide B from the Traditional Thai Medicine Hua-Khao-Yen Induces Apoptosis in MCF-7 Human Breast Cancer Cells via Modulation of Bax, Bak and Bcl-2 Protein Expression

2010 ◽  
Vol 5 (12) ◽  
pp. 1934578X1000501
Author(s):  
Jiraporn Saekoo ◽  
Potchanapond Graidist ◽  
Wilairat Leeanansaksiri ◽  
Chavaboon Dechsukum ◽  
Arunporn Itharat
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Antitumor Property ◽  
Pharmacologically Active ◽  
Mcf 7

Dioscorealide B is a pharmacologically active compound from the rhizome of the Thai medicinal plant Dioscorea membranacea. Here, we demonstrated that in vitro treatment of dioscorealide B resulted in a cytotoxic effect on MCF-7 human breast cancer cells (IC50 = 2.82 μM). To determine whether this compound induces apoptosis in MCF-7, the Annexin V assay was performed. The data showed that the number of apoptotic cells were increased 7–12 folds over that of the control cells after treatment with various concentrations of dioscorealide B (3, 6 and 12 μM) for 24 hours. Dioscorealide B-induced apoptosis was associated with modulation of the multidomain Bcl-2 family members Bax, Bak and Bcl-2. After treatment with 3 μM dioscorealide B, acceleration of the level of proapoptotic proteins Bax and Bak were observed at 6 hours and 12 hours, respectively, while the decrease in the expression of antiapoptotic protein Bcl-2 was observed 3 hours after the treatment. These effects of dioscorealide B might result in the activation of caspase-8, -9 and -7, which lead to apoptosis in MCF-7 cells. Taken together, the results of this study provide evidence that dioscorealide B possesses an antitumor property against human breast cancer cells and thus provide the molecular basis for the further development of dioscorealide B as a novel chemotherapeutic agent for breast cancer treatment.

scholarly journals Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA2 Compositions in a Mouse Model of Parkinson’s Disease

Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 358 ◽  
Author(s):  
Kyung Hwa Kim ◽  
Minhwan Kim ◽  
Jaehwan Lee ◽  
Hat Nim Jeon ◽  
Se Hyun Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Therapeutic Potential ◽  
Bee Venom ◽  
Neuroprotective Activity ◽  
Protective Effects ◽  
Active Components ◽  
Therapeutic Benefits ◽  
Pharmacologically Active

Bee venom contains a number of pharmacologically active components, including enzymes and polypeptides such as phospholipase A2 (PLA2) and melittin, which have been shown to exhibit therapeutic benefits, mainly via attenuation of inflammation, neurotoxicity, and nociception. The individual components of bee venom may manifest distinct biological actions and therapeutic potential. In this study, the potential mechanisms of action of PLA2 and melittin, among different compounds purified from honey bee venom, were evaluated against Parkinson’s disease (PD). Notably, bee venom PLA2 (bvPLA2), but not melittin, exhibited neuroprotective activity against PD in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. MPTP-induced behavioral deficits were also abolished after bvPLA2 treatment, depending on the PLA2 content. Further, bvPLA2 administration activated regulatory T cells (Tregs) while inhibiting inflammatory T helper (Th) 1 and Th17 cells in the MPTP mouse model of PD. These results indicate that bvPLA2, but not melittin, protected against MPTP and alleviated inflammation in PD. Thus, bvPLA2 is a promising and effective therapeutic agent in Parkinson’s disease.

scholarly journals The endocrine system in chronic nitric oxide deficiency

2007 ◽  
Vol 156 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Félix Vargas ◽  
Juan Manuel Moreno ◽  
Rosemary Wangensteen ◽  
Isabel Rodríguez-Gómez ◽  
Joaquín García-Estañ
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Blood Pressure Response ◽  
Endocrine System ◽  
Special Focus ◽  
No Production ◽  
Regulatory Systems ◽  
Reported Study ◽  
Nitric Oxide Deficiency ◽  
Glucose And Lipid Homeostasis

The experimental model of chronic inhibition of nitric oxide (NO) production has proven to be a useful tool to study cardiovascular and renal lesions produced by this type of hypertension, which are similar to those found in human hypertension. It also offers a unique opportunity to study the interaction of NO with the humoral systems, known to have a role in the normal physiology of vascular tone and renal function. This review provides a thorough and updated analysis of the interactions of NO with the endocrine system. There is special focus on the main vasoactive factors, including the renin-angiotensin-aldosterone system, catecholamines, vasopressin, and endothelin among others. Recent discoveries of crosstalk between the endocrine system and NO are also reported. Study of these humoral interactions indicates that NO is a molecule with ubiquitous function and that its inhibition alters virtually to all other known regulatory systems. Thus, hypothyroidism attenuates the pressor effect of NO inhibitor N-nitro-L-arginine methyl ester, whereas hyperthyroidism aggravates the effects of NO synthesis inhibition; the sex hormone environment determines the blood pressure response to NO blockade; NO may play a homeostatic role against the prohypertensive effects of mineralocorticoids, thyroid hormones and insulin; and finally, NO deficiency affects not only blood pressure but also glucose and lipid homeostasis, mimicking the human metabolic syndrome X, suggesting that NO deficiency may be a link between metabolic and cardiovascular disease.

scholarly journals Apitherapy as a New Approach in Treatment of Palmoplantar Psoriasis

2018 ◽  
Vol 6 (6) ◽  
pp. 1059-1061 ◽  
Author(s):  
Egharid El–Gammal ◽  
Veronica Di Nardo ◽  
Farah Daaboul ◽  
Georgi Tchernev ◽  
Uwe Wollina ◽  
...  
Keyword(s):  
Honey Bee ◽  
Treatment Duration ◽  
Royal Jelly ◽  
Overall Response Rate ◽  
Response Rate ◽  
Aloe Vera ◽  
Bee Venom ◽  
New Approach ◽  
Effective Remedy ◽  
Age Range

BACKGROUND: Apitherapy is the medical use of honey bee products, "honey, propolis, royal jelly, bee wax, and bee venom to relieve human ailments. Propolis is one of the most well-documented products derived from the honeybee and has always played an important role in traditional folk medicine.AIM: The aim was to justify the consideration of Aloe Vera as an effective remedy for the treatment of psoriasis.METHODS: The study follows (857) patients (354 females, 503 males) with a mean age range from (9 - 62) years, affected with moderate to severe psoriasis in palms and foot soles treated by a combination mixture of propolis and Aloe in the form of an ointment (Aloreed) and Beauty reed cream. The treatment duration was for 12 weeks. Results were evaluated by using clinical, histological and statistical parameters.RESULTS: After the 12 - week treatment, we observed an 86% overall response rate from which 62% showed excellent results and 24% showed good results, therefore proving the efficiency in the use of the mixture of propolis 50% and aloe vera 3% as topically applied ointment in the treatment of mild to moderate psoriasisCONCLUSION: Patients who have palmoplantar psoriasis, who were treated with a topically applied mixture of propolis (50%) and aloe vera (3%), have shown noteworthy improvement thus proving the efficiency of propolis and aloe vera in the treatment of mild to moderate psoriasis.

scholarly journals Development of Apis cerana District Extractor with innovation of Machinery and Pest control in Kumelembuai Village

2019 ◽  
Vol 12 (6) ◽  
pp. 147-156
Author(s):  
Joice J.I. Rompas ◽  
Betsy Agustina Naomi Pinaria ◽  
Ventje V. Memah
Keyword(s):  
Honey Bee ◽  
Honey Bees ◽  
Royal Jelly ◽  
Apis Cerana ◽  
Cane Sugar ◽  
Bee Venom ◽  
Good Effect ◽  
North Sulawesi ◽  
The Village

This study aims to: 1). Knowing the development of Apis Cerana Honey BeesF.with extractor engine innovation 2). Control of pests that attack honey bees 3). Obtain products from honeybeesApis Cerana F.produced 4). Predict to what extent the quantity and quality of royal jelly products Apis cerana F.produced in the development of beekeeping in North Sulawesi, especially Kumelembuai Village, South Minahasa Regency. This research is expected to develop beekeeping in North Sulawesi, specifically the local bee Apis cerana in Kumelembuai Village. The benefits obtained from beekeeping development activities include increasing the income and nutritional quality of the community from beekeeping products such as honey, pollen, royal jelly, beeswax, propolis, bee venom. Conservation of natural resources, honey bees play an important role in helping the process of pollinating plants, in addition to beekeeping activities can also increase public awareness to participate in conservation efforts. North Sulawesi, especially in the village of Kumelembuai, can be developed using the methodqueen rearing best because it has bright prospects for cultivation in North Sulawesi. Honey bee cultivation is very profitable, in addition to increasing agricultural production (crop yields) and producing products from beesApis cerana namely honey, royal jelly, tepung sari, propolis, wax, bee venom which can all be utilized for human welfare. A number of studies have been carried out by various parties who feel an interest in the development of beekeeping, but the research conducted is still partial and limited to one or two environmental components, not integrated yet. It is hoped that this research can produce the best methods for developing beekeeping in the North Sulawesi kumelembu village. The research location will be conducted in the village of Kumelembuai, South Minahasa regency, North Sulawesi. Laboratory analysis is focused on the content of royal jelly products produced by honey bees Apis cerana F. Based on the results of data analysis and discussion in this study are as follows. 1. Research of the four methods namely Supersedure, Emergency cell, Miller and Doolittle produce superior methods, namely the method Emergency cell. 2. In the methodemergency cell artificial feeds provide queen cell formation and productionroyal jelly with a composition of 100 grams of sugar and 200 grams of water both cane sugar and palm sugar are higher than other treatments, although not significantly different. 3. Artificial feed with a composition of 200 grams of cane sugar and 200 grams of water gives a good effect on the fat content of royal jelly Apis cerana in the method emergency cell. 4. Product of royal jelly as a result of panelist evaluationin this study showed that the preferred odor was not pungent, slightly acidic and sticky taste on the tongue and the white color of the product of royal jelly honey bee Apis cerana

Atrial natriuretic peptide inhibits the aldosterone response to angiotensin II in man

1986 ◽  
Vol 70 (5) ◽  
pp. 507-512 ◽  
Author(s):  
J. V. Anderson ◽  
A. D. Struthers ◽  
N. N. Payne ◽  
J. D. H. Slater ◽  
S. R. Bloom
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Pressor Response ◽  
Endocrine System ◽  
Significant Rise ◽  
Plasma Aldosterone Concentration ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

1. We have investigated the interaction between the recently discovered natriuretic factor alpha human atrial natriuretic peptide (alpha h-ANP) and the renin-angiotensin-aldosterone system in man. 2. Angiotensin II infused with placebo produced a significant rise of plasma aldosterone concentration (mean ± sem increment 352 ± 23 pmol/l, n = 7, P < 0.001). The infusion of alpha h-ANP together with angiotensin II largely abolished the aldosterone response (P < 0.001). 3. Diastolic blood pressure rose in response to the infusion of angiotensin II with placebo (mean increment 21.0 ± 0.9 mmHg, P < 0.001). Systolic blood pressure increased to a lesser degree (mean increment 12.5 ± 0.7 mmHg, P < 0.001). 4. The infusion of alpha h-ANP together with angiotensin II significantly blunted the diastolic pressor response (P < 0.01). This ability of alpha h-ANP to blunt the pressor effect of angiotensin II may be important in the control of systemic blood pressure. 5. The inhibition of angiotensin II-stimulated aldosterone release demonstrates that alpha h-ANP may not only be a circulating natriuretic factor in its own right but that it may also act as a modulator of a related endocrine system.

B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects

2017 ◽  
Vol 122 (5) ◽  
pp. 1249-1254 ◽  
Author(s):  
Gabriele Grimm ◽  
Michael Resl ◽  
Birgit B. Heinisch ◽  
Martin Hülsmann ◽  
Anton Luger ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Heart Rate ◽  
Thyroid Hormones ◽  
Natriuretic Peptide ◽  
Elevated Serum ◽  
Endocrine System ◽  
Serum Cortisol ◽  
Neuroendocrine Activation ◽  
The Impact

B-type natriuretic peptide (BNP) is a hormone released by the heart in response to volume load and exerts natriuretic properties. It is clinically used as a diagnostic and prognostic biomarker and investigated as a pharmacological agent in the therapy of heart failure. Here we investigate the changes in pituitary, adrenal, and thyroid hormones in response to BNP administration in a randomized single-blinded crossover study conducted in ten healthy men aged 21–29 yr. Participants received in two study sessions a continuous intravenous infusion during 4 h (once placebo and once 3 pmol·kg−1·min−1 BNP) and remained in supine position throughout the study. Circulating concentrations of pituitary, adrenal, and thyroid hormones, heart rate, and blood pressure were measured at baseline and hourly afterwards. BNP prevented the physiological decrease in cortisol during the late morning hours leading to elevated serum cortisol levels ( P = 0.022) and increased circulating epinephrine and norepinephrine concentrations ( P = 0.018 and P = 0.036, respectively). These hormone changes were accompanied by an increase in heart rate ( P = 0.019) but no differences in blood pressure. Taken together, the impact of BNP on the endocrine system extends beyond the well-known inhibition of the renin-angiotensin-aldosterone system and includes increased adrenergic activity and cortisol concentrations. This neuroendocrine activation might impact the outcome of therapeutical BNP administrations and should be further investigated in conditions associated with increased BNP secretion. NEW & NOTEWORTHY The heart hormone B-type natriuretic peptide (BNP) is increased in patients with heart failure, where it is thought to have beneficial effects by reducing the preload. Here we report that intravenous administration of BNP in men leads to increases in adrenal hormones cortisol, epinephrine, and norepinephrine. Cortisol and catecholamine levels are independent predictors of increased cardiovascular mortality risk; therefore, drugs targeting the BNP system should be evaluated regarding their effects on the neuroendocrine activation accompanying heart failure.

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