BIOLOGICAL MONITORING OF WORKERS EXPOSED TO MERCURY AND ITS COMPOUNDS

2021 ◽  
Author(s):  
N.P. Golovkova ◽  
◽  
N.I. Kotova ◽  
L.M. Leskina
Keyword(s):  
Biological Monitoring ◽  
Mercury Vapor ◽  
Risk Groups ◽  
Average Concentration ◽  
Individual Characteristics ◽  
The Body ◽  
Increased Risk ◽  
Professional Exposure ◽  
Mercury Intoxication ◽  
The Individual

Abstract: Biological monitoring is used to assess the toxic effect of mercury on the human body and to identify risk groups for the development of mercury intoxication at various stages of clinical and laboratory examination of workers who have contact with mercury vapor. A comprehensive analysis of changes in the biomarkers of exposure and effect in the conditions of professional exposure to mercury on the body of workers allows us to identify groups at increased risk of developing health disorders and optimize therapeutic and preventive measures taking into account the individual characteristics of the body. Biological monitoring should be implemented at the stage of preliminary, periodic medical examinations and in-depth examination of workers in contact with mercury vapor. Correlation and regression analysis of the data obtained showed a significant positive relationship between the average concentration of mercury in the air of the working area and the average concentration of mercury in the urine of the main occupational groups of mercury production workers.

scholarly journals Relationship between Symptoms in Women with Endometriosis and Lifestyles: a Qualitative Interview Study

2020 ◽  
Vol 4 (4) ◽  
pp. 178-183
Author(s):  
M. Scavone ◽  
C. Gizzi ◽  
E. Albi
Keyword(s):  
Physical Activity ◽  
Uterine Cavity ◽  
Individual Characteristics ◽  
The Body ◽  
Quality Of Sleep ◽  
Qualitative Interview Study ◽  
Italian Women ◽  
The Individual ◽  
Reproductive Aged Women

AbstractEndometriosis is a common condition that affects reproductive-aged women and is characterized by the presence of endo-metrial tissue outside the uterine cavity with nodules and lesions. The study aimed to analyze lifestyles of women affected by endometriosis in relation with their symptoms. In this observational study, 735 Italian women have been interviewed online through a questionnaire structured in two parts. The first part was mainly anamnestic, focused on gathering information about the age, the stage of disease, comorbidities, involved organs, symptomatology, chirurgical treatment, induced menopause. The second part focused on the individual characteristics and lifestyle of the patients such as the body mass index, physical activity, quality of sleep, and the diet. The results showed how a healthy diet and a regular physical activity reduce drastically the symptoms of the patients.

scholarly journals Resilience and disaster research

2019 ◽  
Vol 28 (3) ◽  
pp. 529-547
Author(s):  
Helena Bakić
Keyword(s):  
Disaster Preparedness ◽  
Historical Context ◽  
Well Being ◽  
Risk Groups ◽  
Mental Health Disorder ◽  
Individual Characteristics ◽  
Future Research ◽  
Psychological Well Being ◽  
The Individual

Disasters pose a significant threat to the long-term well-being of individuals, communities and societies. Therefore, studying resilience, defined as the process of maintaining and recovering psychological well-being after adversity, is crucial for disaster preparedness and mitigation. The aims of this paper are to summarize the historical context of resilience research, present the key concepts, discuss current measurement approaches and propose future research directions. Key determinants of resilience - risk, positive adaptation and resources - are discussed with the focus on studies of adults affected by disasters. This narrative review demonstrates that research up to date has focused mostly on finding the individual characteristics that predict the absence of psychopathology or mental health disorder symptoms, while other types of resources or dynamic relations between key aspects of resilience have been neglected. Future studies should aim to include multiple measurement points, high- and low-risk groups, long-term follow-up and broader perspectives on both psychological well-being and potential resources.

scholarly journals A comparative analysis of the relationship between stature and ultrasound dimensions of internal organs in adolescents

2021 ◽  
Vol 12 (2) ◽  
pp. 19-27
Author(s):  
Valerii O. Yerkudov ◽  
Andrey P. Pugovkin ◽  
Aleksej J. Volkov ◽  
Oksana I. Musaeva ◽  
Dmitriy J. Volkov ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Body Length ◽  
Individual Characteristics ◽  
The Body ◽  
Comparative Characteristic ◽  
Z Score ◽  
Internal Organs ◽  
Average Group ◽  
The Individual ◽  
The Relationship

The aim of the study was a comparative characteristic of the size of internal organs according to ultrasonography data in subjects with various deviations in stature, determined using international standardized norms. Materials and methods. The stature was measured in 93 adolescents, aged 13 to 17 years. Based on the measurements, the Z-score of body length was calculated according to the WHO Growth Reference, 2007 and three groups were formed for comparing the sizes of internal organs: average, above average, below average. Ultrasonography data of the internal organs dimensions and thyroid gland was performed using a Toshiba Aplio 500 ultrasound scanner. Results. There were statistically significantly lower values of the liver span and the longitudinal size of the gallbladder in the examined subjects from the below average group compared to the rest of the subjects. The length of the spleen and the total volume of the thyroid gland were statistically significantly different in subjects from all three groups, with the highest values in volunteers from the above average group. A weak direct correlation was shown between the Z-score of body length and liver span, the length of the cauda of the pancreas, and the width of the spleen. An average direct statistical relationship was found between the Z-score of stature and the length of the spleen, as well as the total volume of the thyroid gland. Conclusion. To a greater extent, body length is associated with the size of the parenchymal organs with a pronounced connective tissue frame - the liver and spleen, as well as the thyroid gland due to the relationship of its volume with hormones that regulate growth and development. Clinical substantiation of the relationship between the structure of the body and internal organs opens up the possibility of creating anatomical standards that allow ultrasound morphometric assessment of internal organs, taking into account the individual characteristics of the patients body size.

scholarly journals Hypoergy and its significance in the course of infections

2021 ◽  
Vol 30 (9) ◽  
pp. 895-903
Author(s):  
N. N. Sirotinin
Keyword(s):  
Biological Properties ◽  
Individual Characteristics ◽  
The Body ◽  
Ancient Medicine ◽  
Sextus Empiricus ◽  
The Individual

Ancient medicine, characterized by great observation, attached great importance to the reactivity of the body in the occurrence of various diseases. Already then, Ptolemy Dioscorides and Sextus Empiricus spoke of idiosyncrasies, and Galen introduced the doctrine of idiopathies. In subsequent periods, this question has always received attention and has never been so ignored as at the end of the last century, when in connection with the blossoming of microbiology they looked for the cause of the different course of diseases in the character of the biological properties of the microorganism, while forgetting the individual characteristics of the organism itself.

scholarly journals Incidence, individual, and macro level risk factors of severe binocular visual impairment and blindness in persons aged 50 and older

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251018
Author(s):  
Daniel Kreft ◽  
Gabriele Doblhammer ◽  
Rudolf F. Guthoff ◽  
Stefanie Frech
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Individual Characteristics ◽  
Eye Diseases ◽  
Health Claims ◽  
Macro Level ◽  
Economic Wealth ◽  
Increased Risk ◽  
Retinal Vascular Occlusion ◽  
The Individual

Objective This study aims to estimate the incidence of severe binocular vision impairment and blindness (SVI/B) and to identify eye diseases and regional risk factors of persons with SVI/B at ages 50 years and older. Methods We designed an observational cohort study based on longitudinal, multifactorial, and administrative information of a random sample of 250,000 persons at ages 50+. All individuals were included in the process-produced health claims register of the Allgemeine Ortskrankenkasse in 2004, and were followed until 2015. We analyzed ten selected eye diseases and regional characteristics as risk factors for SVI/B using Cox models, adjusting for demographic characteristics and multi-morbidity. Results The age-standardized incidence was 79 new diagnoses of SVI/B per 100,000 person-years (95%-CI: 76-82); 77 for males (72-82) and 81 for females (77-85). By adjusting for multiple factors, the model revealed and confirmed that individuals who were very old (Hazard ratio90+: 6.67; 3.59-12.71), male (1.18; 1.01-1.38), had multi-morbidities (three+ diseases: 3.36; 2.51-4.49), or had diabetes (1.26; 1.07-1.49) had an increased risk of SVI/B. Compared to persons without the particular eye disease (all p<0.001), persons diagnosed with secondary glaucoma had a multiple-adjusted 4.66 times (3.17-6.85) higher risk, those with retinal vascular occlusion had a 4.51 times (3.27-6.23) higher risk, and those with angle-closure glaucoma had a 4.22 times (2.60-6.85) higher risk. Population density was not a risk factor, while persons living in wealthier regions had 0.75 times (p=0.003) to 0.70 times (p<0.001) the risk of SVI/B than persons in the least wealthy regions of Germany. Conclusion The study revealed and confirmed some profound risk factors of SVI/B at both the individual and the macro level. The sizes of the effects of the characteristics of the living context were smaller than those of the individual characteristics, especially for some severe eye diseases. While urbanity and access to health services had no effect, regional economic wealth was a risk factor for SVI/B. Future health care measures and advice by physicians should take these dimensions of inequalities in SVI/B into account.

Importance of Hip-Spine Syndrome in Hip Arthroplasty: Influence on the Outcome and Therapeutic Consequences

2021 ◽  
Author(s):  
Severin Langer ◽  
Maximilian Stephan ◽  
Rüdiger von Eisenhart-Rothe
Keyword(s):  
Hip Arthroplasty ◽  
Spinal Deformity ◽  
Risk Groups ◽  
Lateral View ◽  
Individual Risk ◽  
Essential Condition ◽  
Total Hip ◽  
Therapeutic Consequences ◽  
Increased Risk ◽  
The Individual

AbstractCorrect interaction between the spine, pelvis, and hip is an essential condition for successful progress after total hip replacement. Spinal pathologies, such as degeneration, fractures, and spinopelvic imbalance with and without lumbar fusions, are closely associated with an increased risk of impingement or even dislocation of the prosthesis. To significantly reduce this risk, various parameters are required to quantify the risk groups. Knowledge on the presence of stiffness of the spine (change in pelvic tilt between standing and sitting at < 10°) and sagittal spinal deformity (pelvic incidence–lumbar lordosis mismatch > 10° or 20°) is essential in identifying patients with corresponding risk. The individual risk profile can be assessed through a specific history and examination. Before total hip arthroplasty, a routine preoperative workup is recommended for high-risk patients: using information from standardised preoperative radiographs while sitting and standing (pelvis, anteroposterior view, lying and standing; spine and pelvis, lateral view, standing and sitting). Important changes can be made during the surgery. If the spine is stiff, attention should be paid to the position of the cup, with increased anteversion, sufficient offset, and larger head that is secure to dislocation – to reduce the risk of dislocation. In the case of a sagittal spinal deformity, the functional coronary pelvic level must be carefully controlled so that it is better to use double mobility cups. Digital systems, such as navigation and robotics, can optimise component positioning although, so far, there is little evidence that the complication rate decreased. Therefore, further studies are warranted.

Biobehavioral Factors in Chemotherapy-Induced Nausea and Vomiting

2004 ◽  
Vol 2 (5) ◽  
pp. 501-508 ◽  
Author(s):  
Joseph A. Roscoe ◽  
Gary R. Morrow ◽  
Jane T. Hickok ◽  
Karen M. Mustian ◽  
Abhay R. Shelke
Keyword(s):  
Warning Signal ◽  
Brain Structures ◽  
Individual Characteristics ◽  
The Body ◽  
Nausea And Vomiting ◽  
Chemotherapy Treatment ◽  
The Individual

Although emesis can be considered a reflex to clear toxins from the body and involves mostly lower brain structures, nausea's purpose appears to be a warning signal to the individual to not engage in behaviors that he or she was doing at the time. As such, it involves the functioning of cognition and memory from higher developed neural structures. Given this, it should not be surprising that biobehavioral factors are important in predicting and controlling nausea. This article reviews the individual characteristics that are clinically useful in predicting which patients will have an increased probability of experiencing nausea or emesis during chemotherapy treatment, and also briefly review psychologic and biobehavioral treatments that can be useful in managing chemotherapy-related nausea.

scholarly journals THE INFLUENCE OF SPORTS ACTIVITY ON THE IMPORTANCE OF THE SEXUAL SOMATOTYPE OF ATHLETES IN PAIRED WOMEN’S ACROBATICS AND GYMNASTICS

2021 ◽  
pp. 66-73
Author(s):  
Кonstantin Bugaevsky ◽  
Lina Rybalko ◽  
Tetiana Synytsya ◽  
Marek Napierała ◽  
Olga Smoleńska ◽  
...  
Keyword(s):  
Female Athletes ◽  
Individual Characteristics ◽  
The Body ◽  
Literary Analysis ◽  
Ratio Method ◽  
Sources Of Information ◽  
Sports Activity ◽  
Female Partners ◽  
Paired Female ◽  
The Individual

The article presents research materials relating to the study of the individual characteristics of the 2D:4D finger index in young athletes in pair female acrobatics and gymnastics. The aim of the study is to study and comparatively analyze the features of the 2D: 4D finger proportions in the "upper" and "lower" female partners in paired female acrobatics and among the female athletes involved in artistic gymnastics, referred to adolescence; confirmation of the influence of the 2D:4D finger ratio on the athletic capabilities of athletes and the formation of their sexual somatotype. It has been proved that the presence in these groups of female athletes with certain values of the inverse, andromorphic sexual somatotype indicates an increased level of testosterone in the body of these athletes and inverse adaptive changes with the formation of masculinization phenomena in them. Research methods and organization. To conduct research on the features of the 2D:4D finger proportions in the "upper" and "lower" female partner athletes in paired female acrobatics and in athletes engaged in artistic gymnastics, the following methods were used: anthropometric method to determine: IPD) and somatotyping according to the classification of J. Tanner and W. Marshall; 2) measurement and comparison of II and IV fingers of the hands of athletes using the finger ratio method according to J.T. Menning – 2D:4D Digit Ratio; 3) as well as the method of literary analysis, using available sources of information; 4) method of mathematical statistics. Organization of the study. This study was conducted in 2019-2020 with the involvement of 31 pairs of acrobats and 59 athletes involved in artistic gymnastics in Ukraine (Nikolaev and Poltava). "Lower" acrobats and gymnasts (n=90) - adolescent – 19.35±1.07 years; "Upper" acrobats (n=31) – pubertal age – 14.68±1.14 years (p≤0,01). Their experience in these sports ranged from 2.5 to 10 years. The level of sportsmanship – from I-III sports category to a candidate for master of sports, master of sports. Research results. After carrying out the study of the necessary anthropometric measurements for each participant (indicators of the width of the shoulders and pelvis, the length of the II and IV fingers of both hands) and processing the obtained anthropometric values, the values of the sexual dimorphism index (SDI) in each study group were determined by mathematical recalculation.

scholarly journals Prediction Model for Disease Progression and Relevant Prognostic Factors in Hodgkin Patients: An Application of Frailty Multistate Model

2021 ◽  
Keyword(s):  
Prognostic Factors ◽  
Disease Progression ◽  
Survival Data ◽  
Individual Characteristics ◽  
Multistate Models ◽  
Multistate Model ◽  
High Tendency ◽  
Risk Of Death ◽  
Increased Risk ◽  
The Individual

Background: In clinical cancer studies, there has been a high tendency of searching for more specific and new prognostic factors in cancers in the last few years. This multistate study aimed to model the progression of Hodgkin's disease by accounting for individual effect (heterogeneity) using the joint and independent frailty models. Method: After the utilization of the illness-death model, joint-modeling accounted for the dependency between relapse and death by considering the individual characteristics as a frailty term. Therefore, the effect of influential prognostic factors was evaluated on disease progression by frailty and joint-frailty multistate models. Results: The individual predictions were determined using the frameworks of the both models. The model was applied to 389 Hodgkin lymphoma patients. Gender (male), age (over 55 years), and low level of hemoglobin (less than 10.5) were associated with an increased risk of death and relapse in patients. The likelihood cross-validation criterion was proposed to choose the joint frailty model as a better fitting model. Conclusion: Multistate models were appropriate tools to study the whole event history of the subjects, which provided a deep insight into the dynamics of the disease. The problem of events-subjects dependency in the survival data was clarified using the multistate model. Therefore, the heterogeneity and dependency between the states led to more accurate estimations of the effects of the prognostic factors, thereby improving the predictions.

scholarly journals Opioid-Induced In-Hospital Deaths: A 10-Year Review of Australian Coroners’ Cases Exploring Similarities and Lessons Learnt

Pharmacy ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 101
Author(s):  
Nicholas Smoker ◽  
Ben Kirsopp ◽  
Jacinta Lee Johnson
Keyword(s):  
Pain Management ◽  
Service Delivery ◽  
Health Service Delivery ◽  
Opioid Therapy ◽  
Individual Characteristics ◽  
Respiratory Impairment ◽  
Risk Of Death ◽  
Increased Risk ◽  
Hospital Deaths ◽  
The Individual

Although opioids are the cornerstone of moderate-to-severe acute pain management they are appropriately recognised as high-risk medicines. Patient and health service delivery factors can contribute to an increased risk of death associated with excessive sedation and respiratory impairment. Despite increasing awareness of opioid-induced ventilation impairment (OIVI), no reliable method consistently identifies individual characteristics and factors that increase mortality risk due to respiratory depression events. This study assessed similarities in available coronial inquest cases reviewing opioid-related deaths in Australian hospitals from 2010 to 2020. Cases included for review were in-hospital deaths that identified patient factors, clinical errors and service delivery factors that resulted in opioid therapy contributing to the death. Of the 2879 coroner’s inquest reports reviewed across six Australian states, 15 met the criteria for inclusion. Coroner’s inquest reports were analysed qualitatively to identify common themes, contributing patient and service delivery factors and recommendations. Descriptive statistics were used to summarise shared features between cases. All cases included had at least one, but often more, service delivery factors contributing to the death, including insufficient observations, prescribing/administration error, poor escalation and reduced communication. Wider awareness of the individual characteristics that pose increased risk of OIVI, greater uptake of formal, evidence-based pain management guidelines and improved documentation and observations may reduce OIVI mortality rates.

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