scholarly journals Pharmacological and biochemical modulation of stress markers by L-NAME and L-Ascorbic acid in chronic restraint model in Wistar rats

2017 ◽  
Vol 8 (1) ◽  
pp. 15-20
Author(s):  
Giridhari Pal ◽  
Vishwajeet Rohil ◽  
Razi Akhtar ◽  
Tapan Behl ◽  
Sudha Bharati ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Chronic Stress ◽  
Vital Role ◽  
The Body ◽  
Biochemical Modulation ◽  
Stress Group ◽  
Stress Markers ◽  
Physical Stimuli ◽  
Induced Changes

Background: Stress is the psycho-physiologic reaction of the body to diverse stimuli including emotional or physical stimuli that imbalance the homeostasis and is also known to trigger various stress markers. Despite the stressors of different types, chronic stress in particular, is known to influence the physiological milieu and breakdown of adaptive mechanisms consequently aggravating the morbid states.  Aims and Objectives: The present study was designed to evaluate the modulatory role of stress marker by N-nitro-L-arginine-methyl ester (L-NAME) and L-Ascorbic acid (L-AA) in experimental model of chronic restraint stress (RSx21) in Wistar rats.Materials and Methods: MDA and GSH levels were determined by the method of Okhawa et al 1979 and Ellman 1959 respectively, the SOD and catalase levels were estimated by the method of Nandi and Chatterjee 1988 and Aebi 1984 respectively.Results: Results from our study reveal the significant enhancement of malondialdehyde (MDA) level while significant attenuation of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase levels in chronic stress group compared with vehicle (non-stress) group. The MDA level was found to be increased by L-NAME (10 and 50 mg/kg) in chronic restraint (RSx21) induced rats as compared to vehicle treated RS group. Antioxidant L-AA (100 and 200 mg/kg) significantly reduced MDA level in chronic stress situation. However, L-NAME and L-Ascorbic Acid were found to cause an increase in level of plasma SOD, GSH and catalase when compared with vehicle treated RS group. On the other hand, L-AA (100 and 200 mg/kg) reversed these RS induced changes in these oxidative parameters.Conclusions: Hence, results from the study underlined the intricate role of antioxidants as evidenced by reversal of oxidative stress markers that command a vital role in the development of morbid condition.Asian Journal of Medical Sciences Vol.8(1) 2017 15-20

scholarly journals Role of Education and Mentorship in Entrepreneurial Behavior: Mediating Role of Self-Efficacy

2021 ◽  
Vol 12 ◽  
Author(s):  
Binwu Hu ◽  
Qiang Zheng ◽  
Jie Wu ◽  
Zhibin Tang ◽  
Jianchun Zhu ◽  
...  
Keyword(s):  
Self Efficacy ◽  
Vital Role ◽  
The Body ◽  
Survey Study ◽  
Mediating Role ◽  
Farming Community ◽  
Body Of Knowledge ◽  
Behavioral Preferences ◽  
Structured Questionnaire

Farmers have been very precious for societies for ages. Their active experiments, valuable knowledge about their surroundings, environment, and crops’ requirements have been a vital part of society. However, the psychological perspectives have been a hole in the loop of farming. Hence, this study has investigated the antecedents of entrepreneurial behaviors of farmers with the mediating risk of their entrepreneurial self-efficacy (ESE). The population chosen for this study was the farming community of suburbs of China, and a sample size of 300 was selected for the data collection. This is a survey study, where a structured questionnaire was adapted on a five-point Likert scale. The data were collected from the farming community to know their psychological and behavioral preferences about their profession. This study has produced interesting results that education, training, and intrinsic motivation play a vital role in farmers’ ESE, affecting their entrepreneurial behaviors. This study will add to the body of knowledge and provide an eminent path for emerging entrepreneurs to find more mentorship opportunities to overcome the limitations in upcoming endeavors influencing education and training.

scholarly journals Role of the modulation of Nkb pathway in chronic stress induced changes in the BNST and consequences on the anxiety behavior

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S78
Author(s):  
Aurelie Menigoz ◽  
Donald Rainnie ◽  
Katie Barrett ◽  
Megan Jiang ◽  
Larry Young
Keyword(s):  
Chronic Stress ◽  
Anxiety Behavior ◽  
Induced Changes

Role of ascorbic acid in chicks exposed to high environmental temperature

1985 ◽  
Vol 58 (5) ◽  
pp. 1511-1516 ◽  
Author(s):  
S. L. Pardue ◽  
J. P. Thaxton ◽  
J. Brake
Keyword(s):  
Ascorbic Acid ◽  
Environmental Temperature ◽  
Body Weight Gain ◽  
Sheep Erythrocyte ◽  
Plasma Potassium ◽  
Temperature Plasma ◽  
High Environmental Temperature ◽  
Induced Changes ◽  
And Control

This study was conducted to determine if ascorbic acid (AA) 1) increases resistance to high environmental temperature in young chickens and 2) alters heat-induced changes in several physiological responses. Groups of male chicks received either a standard ration containing 1,000 mg/kg (ppm) of AA or the ration without AA. Chicks were brooded for 3 wk and then maintained at 22 +/- 0.8 degrees C. At 4 wk of age, both AA-supplemented and control chicks were exposed to 30 min of heating (43 +/- 0.1 degrees C and 40 +/- 2% rh) on each of 3 consecutive h in an environmentally controlled chamber. Chicks were challenged with sheep erythrocytes (1 ml, 10(5) cells, iv) 12 h postheating. Heating reduced plasma potassium, body weight gain, relative bursa and spleen weights, and anti-sheep erythrocyte levels. Heating increased cloacal temperature, plasma protein, corticosteroid levels, and mortality. AA ameliorated many of these stress-related responses.

Glucocorticoid-induced changes in glucocorticoid receptor mRNA and protein expression in the human placenta as a potential factor for altering fetal growth and development

2017 ◽  
Vol 29 (5) ◽  
pp. 845 ◽  
Author(s):  
Svetlana Bivol ◽  
Suzzanne J. Owen ◽  
Roselyn B. Rose'Meyer
Keyword(s):  
Fetal Growth ◽  
Growth And Development ◽  
Glucocorticoid Receptors ◽  
Low Birthweight ◽  
Experimental Studies ◽  
Vital Role ◽  
The Body ◽  
Protein Levels ◽  
Organ Systems ◽  
Induced Changes

Glucocorticoids (GCs) control essential metabolic processes in virtually every cell in the body and play a vital role in the development of fetal tissues and organ systems. The biological actions of GCs are mediated via glucocorticoid receptors (GRs), the cytoplasmic transcription factors that regulate the transcription of genes involved in placental and fetal growth and development. Several experimental studies have demonstrated that fetal exposure to high maternal GC levels early in gestation is associated with adverse fetal outcomes, including low birthweight, intrauterine growth restriction and anatomical and structural abnormalities that may increase the risk of cardiovascular, metabolic and neuroendocrine disorders in adulthood. The response of the fetus to GCs is dependent on gender, with female fetuses becoming hypersensitive to changes in GC levels whereas male fetuses develop GC resistance in the environment of high maternal GCs. In this paper we review GR function and the physiological and pathological effects of GCs on fetal development. We propose that GC-induced changes in the placental structure and function, including alterations in the expression of GR mRNA and protein levels, may play role in inhibiting in utero fetal growth.

scholarly journals Role of Vitamin C (Ascorbic Acid) on Human Health- A Review

2005 ◽  
Vol 5 (8) ◽  
pp. 01-12
Author(s):  
Mary K Walingo ◽  
Keyword(s):  
Blood Pressure ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Human Health ◽  
The Body ◽  
Water Soluble ◽  
Plasma Vitamin ◽  
Risk Of Death ◽  
Increased Risk

Vitamin C, also known as ascorbic acid, abounds in nature and is highly labile. It is a water-soluble vitamin that is lost in large amounts during food processing. It is a vitamin whose prescribed requirement across cultures is not uniform. For example , the prescribed requirement of vitamin C in Great Britain is 30mg/day, while in the U.S.A., it is 60mg/day and 100mg/day in Japan. These variations are unusual and point to the need for further research to establish the acceptable RDAs for diverse populations. The RDA for vitamin C should be more than the amount needed to prevent the occurrence of disease. Vitamin C plays significant functions in the body that enhance its role in the health status of the human body. The biochemical functions of vitamin C include: stimulation of certain enzymes, collagen biosynthesis, hormonal activation, antioxidant, detoxification of histamine, phagocytic functions of leukocytes, formation of nitrosamine, and proline hydroxylation amongst others. These functions are related to the health effects of vitamin C status in an individual. In human health, vitamin C has been associated with reduction of incidence of cancer, blood pressure, immunity, and drug metabolism and urinary hydroxyproline excretion, tissue regeneration. This vitamin is needed for the proper metabolism of drugs in the body through adequate hepatic mixed function oxidase system. Epidemiological data have revealed the preventive and curative role of vitamin C on certain disease conditions in the body though controversies still persist. Vitamin C is effective in protecting against oxidative damage in tissues and also suppresses formation of carcinogens like nitrosamines. There is an inverse relationship with blood pressure and both plasma vitamin C and Vitamin C. Vitamin C has a lowering effect on blood pressure, especially on systolic pressure more than a diastolic pressure. Low levels of plasma vitamin C are associated with stroke and with an increased risk of all cause mortality. Increased consumption of ascorbic acid raises serum ascorbic levels and could decrease the risk of death.

scholarly journals Removing Trigger Point and Balancing Metabolic Reactions Are the Keys to Fatigue, Nerve Pain, Chronic Illness, Diabetes, Fibromyalgia, Alzheimer’s Diseases, Vestibular Disorder, and Neurodegenerative Diseases

2019 ◽  
Vol 4 (6) ◽  
Keyword(s):  
Chronic Illness ◽  
Neurodegenerative Diseases ◽  
Blood Circulation ◽  
Trigger Point ◽  
Vital Role ◽  
The Body ◽  
Vestibular Disorder ◽  
Metabolic Reactions ◽  
Alzheimer’S Diseases

When we talk about the vital role of oxygen, we forget that the vital role of oxygen is to interact with glucose in the cells catalyzed by many enzymes to generate energy. The main source to generate energy in cells is from glucose, enough glucose is as vital as enough oxygen. Poor blood circulation may come from the blocking points in the vessels or from low blood pressure or low blood glucose. In the body, all the billions of cells of all body systems need the energy to have normal functions; which is mainly generated from metabolizing glucose. When the cells hunger for glucose, it can start to use structure stored glucose or stored lipids or polysaccharides or structure lipid or structure protein. To take stored glucose, the body needs good blood circulation and right body temperature. The people with chronic illness often have hormonal imbalanced – which need glucose as the main source of energy also, and poor blood circulation and disorder of thermoregulation. If we do not stop these disorders, these people may have metabolic disorders or metabolic diseases. The main energy source for the cells is from the catabolism of glucose. So any problem for glycemia and oxygen saturation will make the billions of cells of the body are out of balance. During practice Vietnamese Qi gong combining with traditional medicine, the author realizes that in just ten minutes, just by removing trigger point and balancing metabolic reactions, we can deal easily most of the symptoms of fatigue, nerve pain, chronic illness, diabetes, fibromyalgia, Alzheimer’s diseases, Vestibular disorder, and Neurodegenerative Diseases.

Role of BCL-2 Family Proteins in Apoptosis and its Regulation by Nutrients

2020 ◽  
Vol 21 (8) ◽  
pp. 799-806 ◽  
Author(s):  
Chen Zheng ◽  
Ting Liu ◽  
Huihui Liu ◽  
Jing Wang
Keyword(s):  
Cell Death ◽  
Normal Function ◽  
Vital Role ◽  
The Body ◽  
Cell Leukemia ◽  
Nutritional Factors ◽  
Antiapoptotic Proteins ◽  
B Cell Leukemia ◽  
Growth Development

In the body, millions of cells die and proliferate each day to maintain normal function and cooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical to sustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2) family proteins in apoptosis has been identified. The BCL-2 family includes both pro- and antiapoptotic proteins, which are structurally and functionally related, containing up to four BCL-2 homology (BH) motifs (BH1-4). There are also some nutritional factors that regulate apoptosis via the BCL-2 family proteins. In this review, the BCL-2 family proteins and their apoptosis-inducing mechanism have been discussed, along with the nutrient factors that regulate apoptosis through the BCL-2 family proteins.

scholarly journals ATTITUDE TOWARDS HANDLING OF EMPTYPACKAGED DRINKING WATER BOTTLE

2016 ◽  
Vol 4 (9(SE)) ◽  
pp. 9-17
Author(s):  
S. Vanitha
Keyword(s):  
Drinking Water ◽  
Vital Role ◽  
The Body ◽  
Water Bottle ◽  
Environment Pollution ◽  
Industrial Growth ◽  
Green Management ◽  
Pollution Problem ◽  
The World

Water is one of most essential product for our life. Without water any living beings cannot live for a longer period of time. Water is one of the important top five sources for all. Role of water cannot be measured. Such the vital role is done by water in the body. It gives strength, clear all unnecessary contains from our body, refresh our flesh, and maintain correct temperature and so on. It is very much important that drinking a good water. These days, water is highly polluted due to the industrial growth. Therefore, water is sold in the packet. As it is little difficult to bring water wherever we go, people prefer to buy this packaged water. After drinking the water, people simply throw the packet in the dustbin. It creates the environment pollution problem. Now, green management has very important to protect the world from pollution. It urges the scholar to study about the importance of the packet water and how can be protected our environment from these waste. It also deals with giving suggestion to use packet water without pollute the environment.

scholarly journals Harnessing immunological targets for COVID-19 immunotherapy

2021 ◽  
Author(s):  
Abhishesh Kumar Mehata ◽  
Matte Kasi Viswanadh ◽  
Vishnu Priya ◽  
Vikas ◽  
Madaswamy S Muthu
Keyword(s):  
Immune Responses ◽  
Protective Immunity ◽  
Vital Role ◽  
The Body ◽  
Innate Immune ◽  
Host Immune System ◽  
Molecular Alteration ◽  
Microbial Infections ◽  
Permanent Cure

COVID-19 is an infectious and highly contagious disease caused by SARS-CoV-2. The immunotherapy strategy has a great potential to develop a permanent cure against COVID-19. Innate immune cells are in constant motion to scan molecular alteration to cells led by microbial infections throughout the body and helps in clearing invading viruses. Harnessing immunological targets for removing viral infection, generally based on the principle of enhancing the T-cell and protective immune responses. Currently-approved COVID-19 vaccines are mRNA encapsulated in liposomes that stimulate the host immune system to produce antibodies. Given the vital role of innate immunity, harnessing these immune responses opens up new hope for the generation of long-lasting and protective immunity against COVID-19.

scholarly journals Comparative study for some antioxidants in correction of oxidative stress markers for experimental induced diabetic rabbits

2012 ◽  
Vol 11 (2) ◽  
pp. 25
Author(s):  
A. J. Abd
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Body Weight Gain ◽  
Stress Markers ◽  
Diabetic Rabbit ◽  
New Zealand White Rabbits ◽  
Diabetic Rabbits ◽  
Histopathological Lesion

Determination of reliable biochemical parameters of experimental diabetic rabbit by alloxane monohydrates and role of diatery antioxidants (ascorbic acid, vit. A, and α-tocopherole) supplementation were investigated. Body weight gain, blood (plasma) chemistries, antioxidant enzymes and histopathological lesion were determined over 10 week in new Zealand white rabbits: control T1 group, diabetic T2 group, diabetic and ascorbic acid T3 group, diabetic and Vit. A T4 group, diabetic and α-tocopherole T5 animals group . each of dietary ascorbic acid, vit. A and α-tocopherole that given to animals of T3, T4 and T5 respectively were significantly (P≤0.01) reduced glucose level in blood than T2 diabetic group, also these antioxidants improve levels of cholesterol and triglyceride. Enzymatic activity of liver glutathione peroxidase and superoxide dismutase were significantly increasd more than of diabetic animals T2. histopathological structures of liver and pancrease confirm these results which indicate mild congestion and less degenerative signs in hepatocytes with mild degeneration of langerhans islets, generally oxidative stress resulted from diabetes and may diminished by administration of antioxidant ascorbic acid, Vit. A and α-tocopherole supplementation, and α-tocopherole group was the best group

Sign in / Sign up

Export Citation Format

Share Document