scholarly journals Prevention of Brain Hypoperfusion-Induced Neurodegeneration in Rat’s Hippocampus by Black Cumin Fixed Oil Treatment

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Marwan Saad Azzubaidi ◽  
Imad Matloub Al-Ani ◽  
Anil Kumar Saxena ◽  
Ghasak Ghazi Faisal
Keyword(s):  
Nigella Sativa ◽  
Pyramidal Cells ◽  
Treated Group ◽  
Neuroprotective Activity ◽  
Protective Effects ◽  
Sham Control ◽  
Vessel Occlusion ◽  
Black Cumin ◽  
Age Related ◽  
Hippocampal Pyramidal Cells

Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration following CBH. Objective: The current study was devoted to assess the protective effects of Nigella sativa (NSO) treatment on CA1 hippocampal pyramidal cells of rats subjected to chronic brain hypoperfusion (CBH) that was achieved through permanent two vessel occlusion (2VO) procedure. Methods: Twenty four rats were equally divided into three groups; sham control, untreated 2VO and NSO treated group (2VO with daily oral NSO treatment. After the 10th postoperative week coronal sections of the hippocampus were collected for histopathological and electron microscopical examinations. Results: The number of viable pyramidal cells within CA1 hippocampal region in sham control and NSO treated groups was significantly higher than that of untreated 2VO group, while the difference was not significant when comparing the viable pyramidal cells number of sham control with NSO treated groups. Furthermore, 2VO group showed marked intracellular ultrastructural distortions that were less pronounced in NSO treated group. Conclusion: NSO displayed a robust potential to protect hippocampal pyramidal cells from CBH induced neurodegeneration putting forward its prospective neuroprotective activity against age related cognitive decline of Alzheimer’s disease and vascular dementia.

scholarly journals Neuroprotective Properties of Nigella sativa (L.) Seeds Extract in Sprague Dawley Rats models

2018 ◽  
Vol 17 (1) ◽  
pp. 113-121
Author(s):  
Zahir Uddin Babar ◽  
Abul Kalam Azad ◽  
Wan Mohd Azizi Wan Sulaiman ◽  
Jalal Uddin ◽  
Zubair Khalid Labu
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Nigella Sativa ◽  
Antioxidant Properties ◽  
Treated Group ◽  
Neuroprotective Activity ◽  
Sprague Dawley ◽  
Vessel Occlusion ◽  
Sprague Dawley Rats ◽  
Healthy Control ◽  
The Brain

Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Nigella sativa (L.) seeds extract (50 mg/kg/day orally) has shown to have anti-neuroinflammatory and antioxidant properties. The brain hippocampal tissues were humanely collected at the end of 10th treatment week and preserved in Allprotect™ reagent at –80°C. Total RNA was extracted and purified by phenol/chloroform method using kits and reverse transcribed into cDNA and relatively quantified as per ΔΔCq. The NSSE treatment showed significantly (p<0.001) different relative GFAP mRNA expression in the treated group as compared to that of untreated 2VO whilst it was insignificantly (p>0.5) different to that of healthy control (HC). Prolonged or daily treatment with NSSE (Nigella sativa (L.) seeds extract) may provide moderate anti-neuroprotective activity within hippocampus.Dhaka Univ. J. Pharm. Sci. 17(1): 113-121, 2018 (June)

scholarly journals Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights

2021 ◽  
Vol 22 (16) ◽  
pp. 9078
Author(s):  
Md. Abdul Hannan ◽  
Md. Sarwar Zahan ◽  
Partha Protim Sarker ◽  
Akhi Moni ◽  
Hunjoo Ha ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Kidney Diseases ◽  
Nigella Sativa ◽  
Close Association ◽  
Kidney Injury ◽  
Antioxidant Defense System ◽  
Chemotherapeutic Agents ◽  
Environmental Chemicals ◽  
Protective Effects ◽  
Black Cumin

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and a close association between acute kidney injury (AKI) and CKD has recently been identified. Black cumin (Nigella sativa) has been shown to be effective in treating various kidney diseases. Accumulating evidence shows that black cumin and its vital compound, thymoquinone (TQ), can protect against kidney injury caused by various xenobiotics, namely chemotherapeutic agents, heavy metals, pesticides, and other environmental chemicals. Black cumin can also protect the kidneys from ischemic shock. The mechanisms underlying the kidney protective potential of black cumin and TQ include antioxidation, anti-inflammation, anti-apoptosis, and antifibrosis which are manifested in their regulatory role in the antioxidant defense system, NF-κB signaling, caspase pathways, and TGF-β signaling. In clinical trials, black seed oil was shown to normalize blood and urine parameters and improve disease outcomes in advanced CKD patients. While black cumin and its products have shown promising kidney protective effects, information on nanoparticle-guided targeted delivery into kidney is still lacking. Moreover, the clinical evidence on this natural product is not sufficient to recommend it to CKD patients. This review provides insightful information on the pharmacological benefits of black cumin and TQ against kidney damage.

Protective Effects of Black Cumin (Nigella sativa) Oil on TNBS-Induced Experimental Colitis in Rats

2010 ◽  
Vol 56 (3) ◽  
pp. 721-730 ◽  
Author(s):  
F. Isik ◽  
Tugba Tunali Akbay ◽  
A. Yarat ◽  
Z. Genc ◽  
R. Pisiriciler ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Experimental Colitis ◽  
Protective Effects ◽  
Black Cumin ◽  
Nigella Sativa Oil

scholarly journals Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 226
Author(s):  
Juveriya Farooq ◽  
Rokeya Sultana ◽  
Tahreen Taj ◽  
Syed Mohammed Basheeruddin Asdaq ◽  
Abdulkhaliq J. Alsalman ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Low Cost ◽  
Middle Eastern ◽  
Antioxidant Properties ◽  
Volatile Oil ◽  
Chemotherapeutic Agents ◽  
Herbal Remedies ◽  
Protective Effects ◽  
Drug Induced ◽  
Black Cumin

The drugs used to treat cancer not only kill fast-growing cancer cells, but also kill or slow the growth of healthy cells, causing systemic toxicities that lead to altered functioning of normal cells. Most chemotherapeutic agents have serious toxicities associated with their use, necessitating extreme caution and attention. There is a growing interest in herbal remedies because of their pharmacological activities, minimal side effects, and low cost. Thymoquinone, a major component of the volatile oil of Nigella sativa Linn, also known as black cumin or black seeds, is commonly used in Middle Eastern countries as a condiment. It is also utilized for medicinal purposes and possesses antidiabetic, anti-cancer, anti-inflammatory, hepatoprotective, anti-microbial, immunomodulatory, and antioxidant properties. This review attempts to compile the published literature demonstrating thymoquinone’s protective effect against chemotherapeutic drug-induced toxicities.

Nigella sativa's protective effect in acetaminophen induced liver toxicity in mice

2020 ◽  
pp. 11-18
Keyword(s):  
Protective Effect ◽  
Liver Toxicity ◽  
Nigella Sativa ◽  
Serum Levels ◽  
Oral Route ◽  
Protective Effects ◽  
Black Cumin ◽  
The Usa ◽  
Black Cumin Seed ◽  
Significant Protective Effect

Acetaminophen has contributed to acute liver failure disease in more than half of the USA and Britain but as an analgesic and antipyretic it is very effective. For many decades in Europe, Middle East and Africa, Nigella sativa has been used for various medical purposes, it is part of the botanical family Ranunculaceae of Gently sloping plants, and is called black cumin seed., Nigella sativa conjugated sterols could be used as precursors to many hydrosoluble steroids for hemisynthesis. The aim of the Study is to examine the promising hepatoprotective effects of Nigella sativa against Acetaminopheninduce hepatotoxicity in mice in this experiment Forty adult male albino mice, incorporated in the experiment and Acetaminophenwas used to induce hepatotoxicity in a dose of 1 gm /kg by the oral route. A number of biochemical and histopathological tests have been used to evaluate liver damage and Nigella sativa protective effects. The result showed a significant protective effect of Nigella sativa against acetaminophenhepatotoxic effect as Nigella sativa in this study tended to normalize the serum levels of liver enzymes, and the protective effects observed clearly by the histopathological evaluation confirming that it effectively protected mouse livers against severe damage caused by acetaminophen. Conclusion in our study it shows that Nigella sativa have a very significant protective effects against acetaminophen induced liver toxicity which is recommended to be fully investigation on human especially to people on risk of acetaminophen liver toxicity

Radiation Induced Gastrointestinal Damage and Protection: Nigella Sativa Seed Extract and Thymoquinone

2017 ◽  
Vol 2 (3) ◽  
pp. 264
Author(s):  
Nidhi Pandey ◽  
Priya Shri ◽  
Harsh Pandey ◽  
Yamini B. Tripathi
Keyword(s):  
Side Effects ◽  
Nigella Sativa ◽  
Food Supplement ◽  
Protective Effects ◽  
In Vivo Models ◽  
Black Cumin ◽  
Synthetic Drugs ◽  
Dividing Cells

<p>Ionising radiation therapy is a common treatment for different types of cancers. The side effects associated with radiation includes destruction of normal cells, especially the dividing cells. The cells in the gastrointestinal (GI) tract and bone marrow are the primary targets. The GI damage is reflected by early histological changes, functional alterations and symptoms of nausea, vomiting and diarrhea. This has been designated as the radiation syndrome. Many synthetic drugs have been used to treat GI disorders but a definite cure has not been discovered so far and these available medications also cause several side effects. The herbal extracts are being tested for long time as preventive food supplement/drug in this disease. The radio protective effects of Nigella sativa (black cumin, (Ranunculacea) is already reported but its mechanism of action is not well established. Here in this review this aspect has been explored with special reference to various in vitro and in vivo models.</p>

A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases

2018 ◽  
Vol 17 (6) ◽  
pp. 412-420 ◽  
Author(s):  
Saeed Samarghandian ◽  
Tahereh Farkhondeh ◽  
Fariborz Samini
Keyword(s):  
Medicinal Plants ◽  
Neurodegenerative Diseases ◽  
Nigella Sativa ◽  
Neurological Diseases ◽  
Volatile Oil ◽  
Protective Effects ◽  
Active Components ◽  
Neuroprotective Effects ◽  
Black Cumin ◽  
Main Components

Background & Objective: Medicinal plants have attracted great attention in the recent years and is increasingly applied instead of the chemical drugs. Several documents showed that herbal medicine traditionally and clinically applied in the cure and prevention of several diseases. In the recent years, different medicinal plants and their main components have been chosen in neurological therapy. The less toxic effects, availability, and lower price of medicinal plants versus synthetic substances make them as excellent and simple selection in the treatment of nervous diseases. Nigella sativa (N. Sativa) L. (Ranunculaceae), well recognized as black cumin, has been utilized as a medicinal plant that has a strong traditional background. Thymoquinone (TQ) is one of the main active components of the volatile oil of N. sativa seeds and most effects and actions of N. Sativa are mainly related to TQ. The several pharmacological properties of N. sativa and TQ have been found, for example; anti-tumor, anti-microbial, anti-histaminic, immunomodulatory, anti-inflammatory, and anti-oxidant effects. Many reviews have investigated this valuable plant and its components, but none of them focused on their neuroprotective effects. Therefore, the aim of the present review was to show comprehensive and neuropharmacological properties of N. sativa and TQ. In this review, various studies on scientific databases regarding the effects of N. sativa and TQ in neurological diseases have been introduced. Studies on the neuroprotective effects of N. sativa and TQ which were published between1979 and 2018, were searched using various databases. The results of these studies showed that N. sativa and TQ have the protective effects against neurodegenerative diseases, including; Alzheimer, depression, encephalomyelitis, epilepsy, ischemia, Parkinson, and traumatic brain injury have been discussed in the cell lines and experimental animal models. Although there are many studies indicating the beneficial actions of this plant in the nervous system, the number of research projects relating to the human reports is rare. Conclusion: Therefore, better designed clinical trials in humans are needed to confirm these effects.

scholarly journals EVALUATION OF THE PROTECTIVE EFFECT OF NIGELLA SATIVA (BLACK CUMIN) OIL AGAINST VANCOMYCIN-INDUCED NEPHROTOXICITY IN RATS

2019 ◽  
pp. 332-336
Author(s):  
SARAH T OMRAN ◽  
JAWAD H AHMED
Keyword(s):  
Protective Effect ◽  
Normal Saline ◽  
Histopathological Examination ◽  
Nigella Sativa ◽  
Statistical Significance ◽  
Treated Group ◽  
Renal Tissue ◽  
Albino Rats ◽  
Black Cumin ◽  
Group I

Objective: The study was designed to investigate a possible protective effect of Nigella sativa (NS) against vancomycin (VAN)-induced nephrotoxicity in rats. Methods: Twenty-eight adult male Albino rats were randomly divided into four groups; seven rats in each. Group I (control): The animals were treated with normal saline (2 ml/kg/day) given orally and intraperitoneally (IP); Group II: VAN was given at a dose of 400 mg/kg/day for 7 days IP and normal saline orally; Group III: NS oil was given at a dose of 2 ml/kg/day for seven days orally and normal saline IP; and Group IV: VAN 400 mg/kg/day IP in combination with NS oil 2 ml/kg/day orally for 7 days. Twenty-four hours after the last dose, the animals were sacrificed, and serum was collected to estimate urea and creatinine. Then, both kidneys were excised, one for homogenate preparation to estimate renal tissue malondialdehyde (MDA), glutathione (GSH) and neutrophil gelatinase-associated lipocalin (NGAL) and the other for histopathological examination. Results: NS significantly decreased serum urea and creatinine compared to VAN treated group, p<0.001. NS significantly increased renal tissue GSH compared to VAN treated group p<0.001. NS lowered MDA and NGAL levels in the homogenate of renal tissues compared to their elevated levels in rats treated with VAN, but this did not achieve statistical significance. NS also ameliorated renal histopathological changes induced by VAN. Conclusion: NS has a protective effect against VAN-induced nephrotoxicity.

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