scholarly journals Quality of Different Brands of Metronidazole Benzoate Oral Suspensions Available at Jimma Town, Southwest Ethiopia: Pharmaceuticals Quality Study

2021 ◽  
Vol 2 (3) ◽  
pp. 01-06
Author(s):  
Teshome Sosengo ◽  
Fuad Adem ◽  
Jemal Abdella
Keyword(s):  
United States ◽  
Poor Quality ◽  
Microbial Count ◽  
United States Pharmacopoeia ◽  
Drug Content ◽  
Significant Difference ◽  
Assay Result ◽  
Metronidazole Benzoate ◽  
Jimma Town

Background: Poor quality drugs include substandard and counterfeit medicines. Poor quality antibiotics selectively kill the susceptible strain and leaves resistant strain to multiply. Metronidazole is a broad spectrum antibiotic whose effectiveness depends up on a dose administered to the patient. Objective: The aim of the study is to assess the quality of different brands of metronidazole Benzoate oral suspension available in Jimma town, West Ethiopia. Methods: Cross-sectional study was conducted in Jimma town, West Ethiopia from Feb 08 – Mar 28, 2018. The assay result of all the seven brands of Metronidazole Benzoate oral suspensions was entered to statistical package for social sciences software version 24.0 for windows. Then, one way analysis of variance was performed using Tukey test to determine whether there exists significant difference in assay result of the brands (p<0.05). Result: All the seven Metronidazole benzoate oral suspensions assessed in this study passed British Pharmacopoeia 2013 specification of identity test of the drug. All the brands passed the assay test and total aerobic microbial count specification United States Pharmacopoeia 2015. The highest percentage of drug content was obtained for Metrolag, 105.56%, while the least content for Mizel, 93.12%. However, statistical comparison of drug contents at 95% confidence interval indicates that there is significant difference in drug content within and among the seven brands of Metronidazole benzoate oral suspensions (p<0.05). The pH of all the brands was with in United States Pharmacopoeia 2015 specification limit.

Quality of Glucosamine Products: Is it a Potential Reason for Inconsistent Clinical Outcomes in Osteoarthritis?

2020 ◽  
Author(s):  
Chhavi Asthana ◽  
Gregory M Peterson ◽  
Madhur D Shastri ◽  
Rahul P Patel
Keyword(s):  
United States ◽  
Clinical Studies ◽  
The United States ◽  
The Other ◽  
Quality Analysis ◽  
Therapeutic Effects ◽  
Clinical Effects ◽  
United States Pharmacopoeia ◽  
Potential Reason

Abstract Background Clinical studies have reported inconsistent outcomes of glucosamine therapy in osteoarthritis patients. One possible reason could be the use of glucosamine products of varying quality. Objective Hence, this study aimed to assess the quality of glucosamine products marketed in Australia and India. This is the first study to investigate both the content and dissolution profiles of glucosamine products. Method The content and dissolution analysis of Australian (n = 25 brands) and Indian (n = 21 brands) glucosamine products was performed according to the criteria specified in the United States Pharmacopoeia (USP). Results The quality analysis revealed that 16% and 18% of Australian brands, as well as 24% and 19% of Indian brands, did not fulfil the USP content and dissolution criteria, respectively. In approximately half of these cases, the glucosamine content was only slightly below (&lt;3%) that specified by the USP and dissolution was achieved within 15 min after the duration specified by the USP. Conclusions The majority of the brands did meet both the content and dissolution analysis criteria of the USP. The extent of deviation from the specified criteria for the other brands was probably insufficient to account for the significant variability in clinical effects. Hence, the study proposed that inter-patient pharmacokinetic variations in glucosamine could be another potential reason for inconsistent therapeutic effects. Highlights

Lousy Jobs, Invisible Unions: The Mexican Retail Sector in the Age of Globalization

2006 ◽  
Vol 70 (1) ◽  
pp. 61-85 ◽  
Author(s):  
Chris Tilly ◽  
José Luis Álvarez Galván
Keyword(s):  
United States ◽  
The United States ◽  
Poor Quality ◽  
Data Sources ◽  
Retail Sector ◽  
The Poor ◽  
Union Coverage ◽  
Dominant Retailer ◽  
Retail Workers

Globalization and modernization transformed the Mexican retail sector over the last two decades. One result is that Wal-Mart has become Mexico's dominant retailer. Another is the poor quality of jobs in the Mexican retail sector. Drawing on a variety of data sources, we review changes and current patterns in the characteristics and quality of retail jobs in Mexico. Retail jobs are worse than the Mexican average. Union coverage is widespread but offers little benefit to workers. Unlike the case in the United States, Wal-Mart offers unionized jobs very similar in quality to those of other retailers; indeed, in general we find little difference between the jobs of global and domestic Mexican retailers. Globalization and modernization have left Mexican retail workers with lousy jobs and invisible unions.

scholarly journals Slow Release Metformin Effect in Weight Loss and Total Calorie Intake in Obese Volunteers

2017 ◽  
Vol 3 (1) ◽  
pp. 50
Author(s):  
Cholis Abrori ◽  
Lucky Tiya ◽  
Deti Rosalina
Keyword(s):  
Weight Loss ◽  
Slow Release ◽  
Poor Quality ◽  
The Body ◽  
Calorie Intake ◽  
Measured Weight ◽  
Significant Difference ◽  
Total Calorie ◽  
Alternative Drug

Obesity can cause serious problems that will lead to poor quality of life, increased morbidity and mortality rate. Slow-release metformin will work longer in the body with a single dose everyday be an alternative drug for weight loss. The purpose of this study was to compare the effectiveness of slow-release metformin compared to metformin regular to body weight and calorie intake in volunteers with obesity. The study was conducted on 16 volunteers who were divided into two groups in pairs. Volunteers will be measured weight and calorie intake with a 24-hour food recall method, data was taken at the time before the intervention, the end of week 1st, 2nd, 3rd, and 4th. The result obtained weight loss better in the group receiving slow-release metformin by 5.08% compared to the group receiving regular metformin by 2,60%, but there was no significant difference between the groups in terms of calorie intake during the study. The conclusion of this study is a slow-release metformin is greater in weight loss than regular metformin, but does not affect the amount of calorie intake.Keywords: Metformin, slow-release, weight loss, calorie intake, obesity

scholarly journals P645 Mental health, work presenteeism and exercise in IBD patients

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S577-S577
Author(s):  
M Sciberras ◽  
C Nascimento ◽  
T Tabone ◽  
K Karmiris ◽  
P Nikolaou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Demographic Data ◽  
International Study ◽  
Poor Quality ◽  
Psychiatric Medication ◽  
Active Involvement ◽  
Significant Difference ◽  
Previous Medication ◽  
History Of

Abstract Background IBD has been shown to increase the rates of anxiety and depression amongst diagnosed individuals, with a prevalence rate of approximately 15- 20%. Chronic diseases such as IBD can have a significant impact on productivity at work (presenteeism). This can lead to emotional distress, poor quality of life and cost effects on employers. The primary aim of the study was to assess the prevalence of psychological problems, exercise levels and presenteeism at work among IBD patients. Methods This was a multicentre international study whereby IBD patients (&gt;18 years) in clinical remission over the last year, were asked to answer an anonymous questionnaire. Demographic data, type of IBD, current and previous medication, admissions to hospital, history of psychiatric referrals, Stanford Presenteeism Scale (SPS-6), Godin Score (exercise related score) were collected. Exclusion criteria included patients with IBD flares requiring corticosteroids in the previous 12 months. Results 573 patients (CD: n=318) from 8 European Centres and Israel participated in the study. The mean patient age was 39.9 years (SD+/- 13.0). 21.6% were smokers and 48.5% were non-smokers. The rest were ex-smokers. 10.9% of patients had a diagnosis of depression/anxiety prior to the diagnosis of IBD, whereas this increased to 20.6% post-IBD diagnosis, this being significantly commoner in the CD cohort (23.0%, p&lt;0.05) and in females (55.8%, p&lt;0.05). 37.7% of patients had been to a psychiatrist or a psychologist (41% of CD, p&lt;0.05) with 11.7% of patients being on psychiatric medication (14.5% of CD, p&lt;0.05). Low presenteeism at work was evident in 34.7%, with no statistically significant difference between UC and CD patients (p=0.5). 39.9% had a Godin Exercise Score being in the active range, 38.8% had a sedentary/insufficient exercise score. The rest were moderately active. Patients diagnosed with depression/anxiety had a more sedentary lifestyle. Conclusion In our study 37.7% of patients were referred for psychological help. This can have several effects including poor presenteeism at work (34.7%) and reduced efficiency. These issues are commoner in patients with CD than in UC. Active involvement of a psychologist/ psychiatrist as part of the IBD team should be routine as to improve the patient’s quality of life.

scholarly journals Evaluation of the quality of Dahi available in Sylhet Metropolitan City

1970 ◽  
Vol 9 (1) ◽  
pp. 79-84 ◽  
Author(s):  
S Dey ◽  
A Iqbal ◽  
A Ara ◽  
MH Rashid
Keyword(s):  
Protein Content ◽  
Viable Count ◽  
Coliform Bacteria ◽  
Microbial Count ◽  
Total Viable Count ◽  
Total Solids ◽  
Metropolitan City ◽  
Significant Difference ◽  
Solids Content

The study was undertaken to evaluate the quality of Dahi available in Sylhet Metropolitan City. Dahi samples from five different Sweetmeat Shops namely Fulkoli, Banaful, Mohanlal, Modhuban and Shad were collected and analyzed. Significant difference in chemical (protein, fat, total solids, ash, acidity and pH) and microbiological status was found among different Dahi samples. Of the five Dahi Brands examined, Fulkoli Brand Dhai had the highest protein content (4.58 ± 0.24) and Shad Brand Dahi had the lowest protein content (4.01 ± 0.17). Fat content was highest in Fulkoli Brand (4.02 ± 0.13) and lowest in Shad Brand (2.10 ± 0.21). The highest total solids content was found in Dahi of Shad Brand (38.00 ± 2.23) and lowest total solids content was found in Banaful Brand Dahi (32.02 ±1.50). Highest Total Viable Count (log cfu/ml.) was recorded in the Dahi of Shad Brand (5.92±0.09) and lowest Total Viable Count was recorded in Mohanlal Brand Dahi (5.84±0.06). Coliform bacteria, Yeast and Mould were present in all the samples. From this experiment, it was found that Fulkoli Brand Dahi was the best in quality . Dahi of Banaful and Mohanlal were in 2nd and 3rd position in quality. Keywords: Fermented milk; Evaluation; Chemical analysis; Microbial count; Total viable count DOI: http://dx.doi.org/10.3329/jbau.v9i1.8748 JBAU 2011; 9(1): 79-83

scholarly journals Comparison of two doses of eCG for obtaining embryos in llama

SPERMOVA ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 173-178
Author(s):  
Cesar A Olaguivel ◽  
◽  
Jaime Ruiz ◽  
Pedro Coila
Keyword(s):  
Statistical Difference ◽  
Poor Quality ◽  
Dominant Follicle ◽  
Linear Transducer ◽  
Significant Difference ◽  
National University ◽  
Applied Dose ◽  
T1 And T2 ◽  
Ovulatory Follicles

The study was developed at the Pampa del Arco Experimental Center of the National University of San Cristóbal de Huamanga, the objective was to evaluate doses of 800 IU (T1) and doses of 1000 IU (T2) of eCG to obtain embryos. Eight adult female llamas were used, distributed four in each treatment (T1 and T2), with a body condition of 2.5, these were evaluated by ultrasound with a 7.5 MHz rectal linear transducer. Hormonal treatments began when the animals had a follicle> 7 mm. The application of eCG was 72 hours after the induction of ovulation of the dominant follicle with GnRH, on day 7 PGF2α was applied, natural mounting was performed plus GnRH (1ml), on day 15 the collection and evaluation of embryos was performed. The results obtained were the pre-ovarian stimulation follicular diameter of 8.3 mm and 9.1 mm for T1 and T2 respectively, the number of pre-ovulatory follicles was 6.33 and 5.50 for T1 and T2 respectively, the diameter of follicles pre-ovulatory was 11.2mm and 10.6 mm for T1 and T2 respectively, average of embryos recovered per donor was 4.66 ± 0.81 and 3.50 ± 0.54 embryos for T1 and T2 respectively, with a significant difference (p <0.05) and the quality of embryos had 35.7% and 38.1% of embryos of excellent quality, 28.6% and 33.3% of good quality, 10.7% and 9 , 5% of regular quality, 10.7% and 0% of poor quality, for T1 and T2 respectively and 14.3% and 19.0% of non-transferable embryos for T1 and T2 respectively, with no statistical difference (p≥0, 05). It is concluded that the number of embryos recovered with a dose of 800 IU of eCG is higher compared to the dose of 1000 IU of eCG (p <0.05) and that there is no association between the applied dose of eCG and the quality of the llama embryos (p≥0.05)

scholarly journals Psychiatric morbidity, quality of life and marital satisfaction among spouse of men with opioid dependence syndrome: a study from North India

2017 ◽  
Vol 4 (2) ◽  
pp. 556
Author(s):  
Ruchi Soni ◽  
Ritesh Upadhyay ◽  
Parth Singh Meena ◽  
Mahendra Jain
Keyword(s):  
Quality Of Life ◽  
Marital Satisfaction ◽  
Psychiatric Disorder ◽  
Opioid Dependence ◽  
Short Form ◽  
Psychiatric Morbidity ◽  
Poor Quality ◽  
North India ◽  
Significant Difference

Background: Opioid dependence syndrome has deleterious consequences not only on addict but also on the members of family especially his spouse who is most vulnerable to develop significant psychiatric disorder given the intimate nature of their relationship. Addressing these issues will be beneficial as spouses are important source of moral support and assistance to the substance user’s quest toward abstinence.Methods: For psychiatric morbidity, 100 spouses of men with opioid dependence syndrome were evaluated. Severity of opioid dependence in the husbands was assessed using severity of opioid dependence questioner (SODQ). Quality of life and marital satisfaction was assessed using short form health survey 36 (SF 36) and marital satisfaction scale (MSS) respectively.Results: Data analysis reveals that 33% of spouses had a psychiatric disorder. Primarily mood and anxiety disorder was present in 22% and 9% of subjects respectively. Highly significant difference existed between cases and controls in terms of marital satisfaction (p = 0.0001) and quality of life (p≤0.05) indicating low marital satisfaction and poor quality of life in spouses of opioid dependent individuals.Conclusions: Psychological distress and psychiatric morbidity in spouses of opioid dependent men is high, with poor quality of marital life and marital satisfaction being low. Hence, interventions that aim at allaying their distress and improving their mental health can improve the condition of the substance user and contribute to a better outcome of substance abuse treatment.

scholarly journals Quality assessment of selected co-trimoxazole suspension brands marketed in Nairobi County, Kenya

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257625
Author(s):  
Beatrice Njeri Irungu ◽  
Lilian C. Koech ◽  
Joyce M. Ondicho ◽  
Lucia K. Keter
Keyword(s):  
Public Health ◽  
United States ◽  
High Performance ◽  
Opportunistic Infections ◽  
Poor Quality ◽  
United States Pharmacopeia ◽  
Health Concern ◽  
Fixed Dose ◽  
States Pharmacopeia

Introduction Quality of medicines in both developed and developing countries is sometimes compromised due to infiltration of counterfeit, substandard or degraded medicines into the markets. It is a public health concern as poor quality medicines endanger public health where patients are exposed to chemical toxins and/or sub-therapeutic doses. This could lead to reduced treatment efficacy and promote development of drug resistance. Co-trimoxazole, a fixed dose combination of sulfamethoxazole and trimethoprim, is a broad spectrum for bacterial diseases and is also used as a prophylaxis for opportunistic infections in HIV infected individuals. This study evaluated quality of selected co-trimoxazole suspension brands marketed in Nairobi County, Kenya. Methods A total of 106 samples were collected, categorized into 15 brands and evaluated for active pharmaceutical ingredient content (API) and pH following United States Pharmacopeia. Assay for API was conducted using High Performance Liquid Chromatography. Results were compared with pharmacopeia references. Visual examination of labels and confirmation of retention status of the brands with Pharmacy and Poisons Board retention register was carried out. Results The samples were primarily of local origin (86.7%). On October 23, 2019, retention status of six of the fifteen brands documented were no longer listed in the Pharmacy and Poisons Board retention register. Of the 106 samples tested 70.6% and 86.8% were compliant with United States Pharmacopeia (USP) specifications for pH and API respectively while 84.0% adhered to packaging and labelling requirements. Conclusion This study has demonstrated that majority of co-trimoxazole suspensions tested were compliant with USP requirements. Additionally, it has provided evidence of poor quality co-trimoxazole medicines that could compromise treatment of infectious diseases in children. This emphasizes the need for regular quality assurance tests to ensure only quality medicines are in the market.

Improving Learning and Reducing Costs for Online Learning

2011 ◽  
pp. 1054-1060 ◽  
Author(s):  
Carol A. Twigg
Keyword(s):  
United States ◽  
Information Technology ◽  
Black Hole ◽  
Teaching And Learning ◽  
New Technologies ◽  
The United States ◽  
College And University ◽  
Significant Difference ◽  
Reducing Costs

Every college and university in the United States (US) is discovering exciting new ways of using information technology to enhance the process of teaching and learning, and to extend access to new populations of students. For most institutions, however, new technologies represent a black hole of additional expense. Most campuses have simply bolted new technologies onto a fixed plant, a fixed faculty and a fixed notion of classroom instruction. Under these circumstances, technology becomes part of the problem of rising costs rather than part of the solution. In addition, comparative research studies show that rather than improving quality, most technology-based courses produce learning outcomes that are simply “as good as” their traditional counterparts — what often is referred to as the “no significant difference” phenomenon. By and large, colleges and universities have not yet begun to realize the promise of technology to improve the quality of student learning and reduce the costs of instruction.

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