scholarly journals COMBINED EFFECTS OF IONIZING RADIATION AND AGENTS OF BIOLOGICAL NA-TURE ON THE BODY OF ANIMALS

2021 ◽  
Vol 246 (2) ◽  
pp. 98-103
Author(s):  
A.M. Idrisov ◽  
◽  
T.R. Gaynutdinov ◽  
R.R. Timerbaeva ◽  
G.Sh. Zakirova ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Lethal Dose ◽  
The Body ◽  
Combined Effects ◽  
Pathogenic Effect ◽  
The Absolute ◽  
Living Organisms

As a result of the work carried out, proceeding from the conceptual position of radiation parasitology about a certain commonality of the mechanisms of the pathogenic effect of ionizing radiation and parasitic agents on living organisms, we determined the conditions for modeling para-sitic invasion, as well as combined radiation-helminthic damage to the body using optimal doses of agents of invasive etiology. Irradiation of rabbits at a half-lethal dose of 7.0 Gy, produced before infection with passaluros at a dose of LD50 (1500 eggs of P. ambiguus), aggravates the course of the invasive process and promotes its generalization, accelerating the death of animals. The combined radiation-helminthic lesion proceeds quickly with the absolute death of all affected animals.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

scholarly journals Dealing with PET radiometabolites

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Krishna Kanta Ghosh ◽  
Parasuraman Padmanabhan ◽  
Chang-Tong Yang ◽  
Sachin Mishra ◽  
Christer Halldin ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Distribution Patterns ◽  
The Body ◽  
Analysis Process ◽  
Pet Tracer ◽  
Positron Emission ◽  
Structural Identity ◽  
Available Technology ◽  
Living Organisms ◽  
Entire Amount

Abstract Positron emission tomography (PET) offers the study of biochemical, physiological, and pharmacological functions at a cellular and molecular level. The performance of a PET study mostly depends on the used radiotracer of interest. However, the development of a novel PET tracer is very difficult, as it is required to fulfill a lot of important criteria. PET radiotracers usually encounter different chemical modifications including redox reaction, hydrolysis, decarboxylation, and various conjugation processes within living organisms. Due to this biotransformation, different chemical entities are produced, and the amount of the parent radiotracer is declined. Consequently, the signal measured by the PET scanner indicates the entire amount of radioactivity deposited in the tissue; however, it does not offer any indication about the chemical disposition of the parent radiotracer itself. From a radiopharmaceutical perspective, it is necessary to quantify the parent radiotracer’s fraction present in the tissue. Hence, the identification of radiometabolites of the radiotracers is vital for PET imaging. There are mainly two reasons for the chemical identification of PET radiometabolites: firstly, to determine the amount of parent radiotracers in plasma, and secondly, to rule out (if a radiometabolite enters the brain) or correct any radiometabolite accumulation in peripheral tissue. Besides, radiometabolite formations of the tracer might be of concern for the PET study, as the radiometabolic products may display considerably contrasting distribution patterns inside the body when compared with the radiotracer itself. Therefore, necessary information is needed about these biochemical transformations to understand the distribution of radioactivity throughout the body. Various published review articles on PET radiometabolites mainly focus on the sample preparation techniques and recently available technology to improve the radiometabolite analysis process. This article essentially summarizes the chemical and structural identity of the radiometabolites of various radiotracers including [11C]PBB3, [11C]flumazenil, [18F]FEPE2I, [11C]PBR28, [11C]MADAM, and (+)[18F]flubatine. Besides, the importance of radiometabolite analysis in PET imaging is also briefly summarized. Moreover, this review also highlights how a slight chemical modification could reduce the formation of radiometabolites, which could interfere with the results of PET imaging. Graphical abstract

scholarly journals Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions

2021 ◽  
Vol 22 (4) ◽  
pp. 1761
Author(s):  
Ilya Lyagin ◽  
Elena Efremenko
Keyword(s):  
Phylogenetic Analysis ◽  
Future Development ◽  
Organophosphorus Compounds ◽  
The Body ◽  
Chemical Transformations ◽  
Negative Consequences ◽  
Biological Targets ◽  
Oxidation Reduction ◽  
Structural Differences ◽  
Living Organisms

Organophosphorus compounds (OPCs) are able to interact with various biological targets in living organisms, including enzymes. The binding of OPCs to enzymes does not always lead to negative consequences for the body itself, since there are a lot of natural biocatalysts that can catalyze the chemical transformations of the OPCs via hydrolysis or oxidation/reduction and thereby provide their detoxification. Some of these enzymes, their structural differences and identity, mechanisms, and specificity of catalytic action are discussed in this work, including results of computational modeling. Phylogenetic analysis of these diverse enzymes was specially realized for this review to emphasize a great area for future development(s) and applications.

Trinity Metaphysics

2021 ◽  
pp. 107-116
Author(s):  
Nikita A. Solovyev ◽  
Keyword(s):  
The Body ◽  
Quantum Object ◽  
Material Body ◽  
Modern Cosmology ◽  
Ontological Model ◽  
Mental Space ◽  
The Absolute ◽  
Other World ◽  
The Universe ◽  
Living Being

A ternary ontological model in which the living being is a triad of I – form – substrate is described. I is an intangible subject, contemplating the content of consciousness and controlling the material body, which is the unity of the form and the substrate. The contents of consciousness are connected both with the form of the body, which I contemplate in the inner “mental space” in the form of in­formation, and with the substrate, which embodies the forms of the body and is responsible for sensations and intentions. The problem of control of the material body by the non-material self is solved under the assumption that the human brain is a quantum object. The ternary model of a living being is inscribed in an absolute ontology, in which the Absolute also has a threefold structure and is the unstitched unity of the absolute I, the absolute Form and the absolute Sub­strate. The Absolute creates the other world with its threefold energies, which provides the threefold structure of a living being. The created world arises from the timeless world of the potential possibilities of the Universe, which modern cosmology associates with its wave function. Created entities arise in the process of alienation from the Absolute, resulting in free will.

The Neuronal Crisis: Meditate to Comprehend the Nature of Psychosomatic Epidemic

2021 ◽  
Vol 64 (2) ◽  
pp. 110-127
Author(s):  
Henri Hude
Keyword(s):  
Major Part ◽  
The Body ◽  
Human Being ◽  
The West ◽  
The Unconscious ◽  
Experimental Knowledge ◽  
The World ◽  
The Absolute ◽  
Rational Consideration ◽  
Existential Problem

This articles describes the “neuronal crisis,” the epidemic of psychosomatic illnesses observed all over the world, particularly in the West. The paper looks into the deeper real causes and seeks the most effective kind of cure for this malady. This leads to rational consideration of the metaphysical dimension of the human being and the fundamental problems (those of evil, of freedom, of God, of the soul, and of the body), where lack of sufficiency plays a major part in the etiology of these pathologies, as the desire for the Absolute is the basis of the unconscious. This approach presumes the Freudian model but denies its purely libidinal interpretation that substitutes desire for the Absolute with libido. Hence, an explanatory system applied to increasingly serious pathologies: ailments, neuroses, depressions, and psychoses. Frustration of one’s desire for the Good gives rise to a sublimation of finite goodness. The inevitable desublimation, caused by anguish because of the Evil, intense guilt, and the dramatization of evils, causes neuroses as awkward but inevitable solutions to the existential problem that is still unresolved, due to lack of functional and experimental knowledge. Psychiatry and even medicine must take into account the metaphysical layer, and, therefore, operate within an existential dynamic, aiming to progress in wisdom and to discover man, man’s brain and body, as these are structured around the axis of his desire.

RADIO FREQUENCY RADIATION DEVICES AND ANTENNAS MAY VIOLATE THE RIGHT TO LIFE PRINCIPLE

2021 ◽  
pp. 27-35
Author(s):  
Herman Kelting
Keyword(s):  
Ionizing Radiation ◽  
Review Literature ◽  
Base Stations ◽  
Right To Life ◽  
Radio Frequency Radiation ◽  
Macro Cell ◽  
Natural Birth ◽  
Survival And Development ◽  
Living Organisms ◽  
The Right

This article proposesthat the Right to Life Principle, dened as “every person hasthe right to a natural birth and legitimate survival and development into adulthoodwithout environmental or othersystematic injury to theirwell-being,”may be violated byRFRemissionsfromcell phones,Wi-Fi,macro cell phone base stations (MCPBSs), 5G/4G small cell antennas (SCAs), etc. in excess of the standards set by the Building Biology Institute. BBI standardsset1000µW/m2as anextreme anomaly;theprecisedivisionpointofharm/noharmbelow1000µW/m2is unknown. I review literature describing (1) the Right to Life Principle, (2) the attributes of non-ionizing radiation, and (3) proven injury from cell phones, WiFi, MCPBSs, 5G/4G SCAs, etc. to living organisms with 20 categories of illnesses and 58 references. Non-ionizing radiation isshown to place a force eld on negatively charged particles including electrons, neurons, and DNA, and exciting/energizing electrons with shifts to outer orbits with energy emission when they return to ground orbit thereby destabilizing atoms, molecules, cells and organs in the process of orbital shifts. RFR induced illnesses include sperm damage, fetus injury, irreversibility infertility, emotional and hyperactive disorders, cancer, damage to DNA, the immune system, blood brain barrier, and stem cells, increasesin oxidative stress and free radicals, and harm to those living lessthan 500 metersfrom MCPBSs. My recommendationsto reduce injury from RFR are based upon review of the literature, experience in metering residential property and MCPBSsfor RFR, avoiding the use of RFR emitting devices and accessto line-of-sight antennas, and legislative proposalsto show the dangers of RFR devices and antennas by,for example,requiringnotice tobuyers andlessees ofresidentialpropertyof powerdensitieswithinhousingunits.

Iron Homeostasis and Disorders in Dogs and Cats: A Review

2011 ◽  
Vol 47 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Jennifer L. McCown ◽  
Andrew J. Specht
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Homeostasis ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Essential Element ◽  
The Body ◽  
Deficiency Anemia ◽  
Enzyme Systems ◽  
Living Organisms

Iron is an essential element for nearly all living organisms and disruption of iron homeostasis can lead to a number of clinical manifestations. Iron is used in the formation of both hemoglobin and myoglobin, as well as numerous enzyme systems of the body. Disorders of iron in the body include iron deficiency anemia, anemia of inflammatory disease, and iron overload. This article reviews normal iron metabolism, disease syndromes of iron imbalance, diagnostic testing, and treatment of either iron deficiency or excess. Recent advances in diagnosing iron deficiency using reticulocyte indices are reviewed.

scholarly journals TOXICOLOGICAL EVALUATION OF INDOMETHACIN AS A RISK FACTOR FOR WORKERS’ HEALTH

2019 ◽  
Vol 98 (5) ◽  
pp. 503-508
Author(s):  
N. A. Martynova ◽  
Larisa G. Gorokhova ◽  
V. A. Shtaiger
Keyword(s):  
Blood Serum ◽  
Guinea Pigs ◽  
Muscle Relaxation ◽  
Lethal Dose ◽  
The Body ◽  
Male Rats ◽  
Hazard Class ◽  
Toxicological Evaluation ◽  
Mucous Membranes ◽  
Ulcerogenic Effect

Introduction. The toxicity of indomethacin was studied for its hygienic regulation. Material and methods. The toxic properties of indomethacin in the experiments on out-bred and linear mice, rats, Guinea pigs and rabbits contained in standard vivarium conditions and quarantined have been studied. In the experiments, various modes (single, repeated, chronic) and ways of exposure (intragastric, inhalation, epicutaneous) were modeled. The average lethal dose (LD50) of Indomethacin and the threshold of a single acute action (Limac) were determined; irritant effect on the skin and mucous membranes, cumulative and allergenic activity were revealed. In subacute and chronic intake to the body, the main target organs were determined on the based of the results of biochemical and hematological studies. Results. DL50 for male rats, females and male mice, when introduced into the stomach, were have been established to be 20, 15 and 25.6 mg/kg respectively. It refers to the substances of hazard class 2. DL50 in the intraperitoneal introduction for the rats accounted for 13.8 mg/kg, for Guinea pigs - 500 mg/kg. The clinical picture of acute poisoning in mice and rats was characterized by low mobility, decreasing breathing, ataxia, muscle relaxation, anorexia, diarrhea, ulceration with the perforation of the intestines, and the death on the 2-4th days after the poisoning. In the experiments on Guinea pigs, the ulcerogenic effect was not detected. Local irritant effect on the skin and mucous membranes of the eyes was not revealed. It has a marked skin-resorptive action causing ulcerogenic effect and the death of the animals after 6 applications. The introduction of verospiron to the rats in a dose of 25 mg/kg simultaneously with the application of indomethacin ointment on the skin prevented the ulcer development in the gastrointestinal tract and the death of the animals. No sensitizing effect was detected. It has an average cumulative ability: the cumulation coefficient amounted to 2.6. In a subacute experiment, there was a decrease in the body temperature and summation-threshold index, an increase in the vertical motor activity and a threshold of pain sensitivity. During the study of blood serum an increase in AcAt activity, a rise of chlorides in the blood serum and their decrease in the urine, and an increase in the number of erythrocytes and hemoglobin in peripheral blood were revealed. In the pathomorphological study, there was an increase in the coefficients of liver mass and ulceration of the stomach and intestines. The threshold of acute inhalation action accounted for 0.52 mg/m3 (by the reduction of the summation-threshold index and the content of sodium and chlorides in the urine). Conclusion. The maximum permissible concentration of indomethacin in the air of the working area was of 0.05 mg/m3 with the mark “special protection of the skin and eyes”, hazard class 1, aerosol.

scholarly journals Hegelian Phenomenology of Spirit and Boxing Fight

2018 ◽  
Vol 77 (1) ◽  
pp. 48-54
Author(s):  
Jerzy Kosiewicz
Keyword(s):  
The Body ◽  
Special Role ◽  
Collective Consciousness ◽  
Phenomenology Of Spirit ◽  
Human Individual ◽  
The Subject ◽  
The Absolute ◽  
Low Culture ◽  
The Individual ◽  
Absolute Synthesis

Abstract In the presented text the author points out to anthropological as well as axiological foundations of the boxing fight from the viewpoint of Hegel’s philosophy. In the genial idealist’s views it is possible to perceive the appreciation of the body, which constitutes a necessary basis for the man’s physical activity, for his work oriented towards the self-transformation and the transformation of the external world, as well as for rivalry and the hand-to-hand fight. While focusing our attention on the issue of rivalry and on the situation of the fight - and regarding it from the viewpoint of the master - slave theory (included in the phenomenology of spirit), it is possible to proclaim that even a conventionalised boxing fight - that is, restricted by cultural and sports rules of the game - has features of the fight to the death between two Hegelian forms of selfknowledge striving for self-affirmation and self-realisation. In the boxing fight, similarly as in the above mentioned Hegelian theory, a problem of work and of the development of the human individual (that is, of the subject, self-knowledge, the participant of the fight) appears. There appears also a prospect of death as a possible end of merciless rivalry. The fight revalues the human way in an important way, whereas the prospect for death, the awareness of its proximity, the feeling that its close and possible, saturates the life with additional values. It places the boxer, just like every subject fighting in a similar or a different way, on the path towards absolute abstraction - that is, it brings him closer to his self-fulfilment in the Absolute, to the absolute synthesis. The Hegelian viewpoint enables also to appreciate the boxing fight as a manifestation of low culture (being in contrast with high culture), to turn attention to the relations which - according to Hegel - take place between the Absolute and the man, as well as to show which place is occupied by the subject both in the process of the Absolute’s self-realisation and in the German thinker’s philosophical system. Independently of the dialectical, simultaneously pessimistic and optimistic overtone of considerations connected with the very boxing fight (regarding destruction and spiritualisation on a higher level), it is possible to perceive farreaching appreciation of the human individual in Hegel’s philosophy since the Absolute cannot make its own self-affirmation without the individual, without the human body, without the fight aimed at the destruction of the enemy and without the subjective consciousness and the collective consciousness which appear thanks to this fight. Thus, it is justified to suppose that the foundation of the whole Hegel’s philosophy is constituted by anthropology and that in the framework of this anthropology a special role is played by the fight and by work, which changes the subject and his(her) environment. Admittedly Hegel does not emphasise it explicitly, nevertheless his views (with their centre, which, according to Hegel himself and his interpreters, is constituted by the Absolute) have, as a matter of fact, an anthropocentric character and the main source of the subject’s development is the struggle which, irrespectively of its result, always primarily leads to the destruction or even to the death of one of the sides, just like in the boxing fight. However, it is also a germ of the positive re-orientation of the subject, the beginning and a continuation of that what the phenomenology of the spirit describes as a movement towards absolute abstraction.

Acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii (Miq.) Miq. stem bark in rats

2021 ◽  
Vol 10 (2) ◽  
pp. 89-97
Author(s):  
EL Lappa ◽  
◽  
C Bogning Zangueu ◽  
EL Nguemfo ◽  
JJ Kojom Wanche ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Chronic Toxicity ◽  
Hematological Parameters ◽  
Lethal Dose ◽  
Relative Weight ◽  
Stem Bark ◽  
The Body ◽  
Female Rats ◽  
Male Rats

Ficus vogelii is a medicinal plant mainly found in tropical Africa and reported to treat inflammatory complaints. This study aims to evaluate the acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii stem bark in wistar rats. For acute study, aqueous extract at a single dose of 5000 mg/kg body weight was administered to female rats and observed for 14 days. In the sub-chronic study, the extract was administered daily to both sex rats at the doses of 100, 200, 400, and 600 mg/kg body weight for 28 consecutive days. Body weight was measured weekly, while hematological, biochemical, and histopathological parameters were analyzed after euthanize. Aqueous extract of Ficus vogelii at all tested doses didn’t produced any mortality or significant change on the body weight and relative weight of rats on acute and sub-chronic studies. The lethal dose 50 was estimated greater than 5000 mg/kg (DL50˃5000 mg/kg). Hematological parameters were recorded non-significant in all treated rats. Aqueous extract at 600 mg/kg significantly changed transaminases and alkaline phosphatase activities, these changes were reversible in satellites. The concentrations of bilirubin was increased at 200 and 600 mg/kg in male rats, at 100, 400 mg/kg in female rats. The levels of lipids markers didn’t changed, except the significant decrease of LDL-cholesterol. Histological examination didn’t showed any change in the architecture of the liver and kidney of rats treated compared to control. Thus aqueous extract of Ficus vogelii stem bark didn’t produced adverse effects in rats after oral acute and sub-chronic treatment.

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