A technique to identify core journals for neurosurgery using citation scatter analysis and the Bradford distribution across neurosurgery journals

2013 ◽  
Vol 119 (5) ◽  
pp. 1274-1287 ◽  
Author(s):  
Venkatesh S. Madhugiri ◽  
Sudheer Ambekar ◽  
Shane F. Strom ◽  
Anil Nanda
Keyword(s):  
Impact Factor ◽  
Current Knowledge ◽  
Medical Science ◽  
Medical Specialty ◽  
Current Status ◽  
The Core ◽  
Bradford’S Law ◽  
Citation Ranking ◽  
Rank List ◽  
Bradford Distribution

Object The volume of scientific literature doubles approximately every 7 years. The coverage of this literature provided by online compendia is variable and incomplete. It would hence be useful to identify “core” journals in any field and validate whether the h index and impact factor truly identify the core journals in every subject. The core journals in every medical specialty would be those that provide a current and comprehensive coverage of the science in that specialty. Identifying these journals would make it possible for individual physicians to keep abreast of research and clinical progress. Methods The top 10 neurosurgical journals (on the basis of impact factor and h index) were selected. A database of all articles cited in the reference lists of papers published in issues of these journals published in the first quarter of 2012 was generated. The journals were ranked based on the number of papers cited from each. This citation rank list was compared with the h index and impact factor rank lists. The rank list was also examined to see if the concept of core journals could be validated for neurosurgical literature using Bradford's law. Results A total of 22,850 papers spread across 2522 journals were cited in neurosurgical literature over 3 months. Although the top 10 journals were the same, irrespective of ranking criterion (h index, impact factor, citation ranking), the 3 rank lists were not congruent. The top 25% of cited articles obeyed the Bradford distribution; beyond this, there was a zone of increased scatter. Six core journals were identified for neurosurgery. Conclusions The core journals for neurosurgery were identified to be Journal of Neurosurgery, Neurosurgery, Spine, Acta Neurochirurgica, Stroke, and Journal of Neurotrauma. A list of core journals could similarly be generated for every subject. This would facilitate a focused reading to keep abreast of current knowledge. Collated across specialties, these journals could depict the current status of medical science.

scholarly journals Studying document information flow on the information safety problems

2019 ◽  
pp. 51-70
Author(s):  
V. Fedorenko ◽  
N. Mishurov ◽  
D. Demidov ◽  
Yu. Chavykin
Keyword(s):  
Impact Factor ◽  
Information Flow ◽  
Russian Science ◽  
The Core ◽  
Bradford’S Law ◽  
Russian Science Citation Index ◽  
Information Safety ◽  
Document Flow ◽  
The Impact ◽  
Information Significance

The national document flow in the area of information safety is analyzed based on the Russian Science Citation Index database for 1993–2017. Its volume makes over 18,000 entries including up to 59% articles and conference proceeding (28%). The flow dynamics demonstrates its annual growth – it is ahead of other science information flows in the number of documents. The dispersion of publications in periodicals in 2016 is characterized; the dependence of the information flow completeness from the number of sources is considered. The findings of microflow study have proved the provision of S. Bradford’s law of the periodicals division into three zones. The “core” comprises 52 journals, primarily in the related sectors rather than those specializing in the mentioned area which evidences on the vibrant interdisciplinary character of the problem. The authors characterize information significance of the most productive journals using such indicators as the 2-year impact-factor and the number of article loads. It was found that the impact-factor as a criteria of journal influence was in the range 0.040–1.435, while the number of loads was from 252 to 56,041. The accessibility of the “core” journals in the RSCI as related to the availability of full texts and the open access and their coverage by RSCI, WoS and Scopus databases are discussed.

The Value of Neuroimaging Techniques in the Translation and Transdiagnostic Validation of Psychiatric Diagnoses - Selective Review

2020 ◽  
Vol 20 (7) ◽  
pp. 540-553 ◽  
Author(s):  
Anna Todeva-Radneva ◽  
Rositsa Paunova ◽  
Sevdalina Kandilarova ◽  
Drozdstoy St. Stoyanov
Keyword(s):  
Psychiatric Disorders ◽  
Psychiatric Symptoms ◽  
Medical Science ◽  
Self Report ◽  
Current Status ◽  
Diagnostic Tools ◽  
Main Concept ◽  
Directional Change ◽  
The Mind ◽  
Neuroimaging Techniques

: Psychiatric diagnosis has long been perceived as more of an art than a science since its foundations lie within the observation, and the self-report of the patients themselves and objective diagnostic biomarkers are lacking. Furthermore, the diagnostic tools in use not only stray away from the conventional medical framework but also remain invalidated with evidence-based concepts. However, neuroscience, as a source of valid objective knowledge has initiated the process of a paradigm shift underlined by the main concept of psychiatric disorders being “brain disorders”. It is also a bridge closing the explanatory gap among the different fields of medicine via the translation of the knowledge within a multidisciplinary framework. : The contemporary neuroimaging methods, such as fMRI provide researchers with an entirely new set of tools to reform the current status quo by creating an opportunity to define and validate objective biomarkers that can be translated into clinical practice. Combining multiple neuroimaging techniques with the knowledge of the role of genetic factors, neurochemical imbalance and neuroinflammatory processes in the etiopathophysiology of psychiatric disorders is a step towards a comprehensive biological explanation of psychiatric disorders and a final differentiation of psychiatry as a well-founded medical science. : In addition, the neuroscientific knowledge gained thus far suggests a necessity for directional change to exploring multidisciplinary concepts, such as multiple causality and dimensionality of psychiatric symptoms and disorders. A concomitant viewpoint transition of the notion of validity in psychiatry with a focus on an integrative validatory approach may facilitate the building of a collaborative bridge above the wall existing between the scientific fields analyzing the mind and those studying the brain.

Current Status of Knowledge and Awareness of Diabetes Mellitus in Saudi Arabia

2020 ◽  
Vol 16 ◽  
Author(s):  
Asirvatham Alwin Robert ◽  
Ahmad Dakeel Al Awad ◽  
Mohamed Abdulaziz Al Dawish
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Disease Risk ◽  
Current Knowledge ◽  
Adult Population ◽  
Management Training ◽  
Control Measures ◽  
Current Status ◽  
Treatment Modalities ◽  
The Government

Abstract: Diabetes mellitus (DM) is a chronic disease, and the complications may be life-threatening; however, with proper treatment and control measures, it can be very well-managed. Self-management training and education of diabetes are critical in diabetes care and management. It is essential that patients with diabetes must have a comprehensive understanding of the nature of the disease, risk factors, complications, and possible treatment modalities to attenuate the complications. Over the last few years, DM in Saudi Arabia has been rapidly growing at an alarming rate. It has affected around one-fifth of the adult population, and by 2030, the numbers are predicted to rise further and exceed more than double the present number. An estimated tenfold increase has been reported over the past three decades in Saudi Arabia. However, there has not been much research focusing on understanding the knowledge and awareness of DM in Saudi Arabia as compared to developed nations. This review aims to present an overview of the current knowledge and awareness level of DM among the population of Saudi Arabia through an extensive review of the currently available literature. The review findings could be of immense assistance to the government, healthcare systems, educational institutions, and researchers to develop evidence-based programs, policies, and guidelines towards increasing the knowledge and awareness about diabetes and its management, so that early detection and management can be ensured to control the escalating burden of diabetes, in Saudi Arabia.

scholarly journals Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Mija Marinković ◽  
Matilda Šprung ◽  
Maja Buljubašić ◽  
Ivana Novak
Keyword(s):  
Therapeutic Strategy ◽  
Current Knowledge ◽  
Therapeutic Agents ◽  
Therapeutic Strategies ◽  
Human Diseases ◽  
The Core ◽  
Future Drug ◽  
Autophagic Activity ◽  
Tumor Types ◽  
Catabolic Process

In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation. Identification of the key autophagy targets is essential for the development of new therapeutic agents. Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation. Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose. Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases. Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy. Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer.

Abstract P457: Systems Analysis To Understand The Impact Of The CDK Module On Cardiomyocyte Proliferation

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Bryana N Harris ◽  
Laura Woo ◽  
Jeffrey J Saucerman
Keyword(s):  
Experimental Data ◽  
Cell Cycle ◽  
Transcription Factor ◽  
Dna Synthesis ◽  
Current Knowledge ◽  
Cycle Phase ◽  
Cyclin D ◽  
Cardiomyocyte Proliferation ◽  
The Core ◽  
The Impact

Rationale: Heart failure is caused by the inability of adult mammalian hearts to overcome the loss of cardiomyocytes (CMs). This is due partly to the limited proliferative capacity of CMs, which exit the cell cycle and do not undergo cell division. Current knowledge in cardiac regeneration lacks an understanding of the molecular regulatory networks that determine whether CMs will progress through the cell cycle to proliferate. Our goal is to use computational modeling to understand the expression and activation levels of the core cell cycle network, specifically cyclins and cyclin-cyclin-dependent kinase (CDK) complexes. Methods: A model of core cell cycle dynamics was curated using previously published studies of CM proliferation regulators. This model incorporates those regulators known to stimulate G1/S and G2/M transitions through the core CDKs. The activity of each of the 22 network nodes (22 reactions) was predicted using a logic-based differential equation approach. The CDK model was then coupled with a minimal ODE model of cell cycle phase distributions and validated based on descriptions and experimental data from the literature. To prioritize key nodes for experimental validation, we performed a sensitivity analysis by stimulating individual knockdown for every node in the network, measuring the fractional activity of all nodes. Results: Our model confirmed that the knockdown of p21 and Rb protein and the overexpression of E2F transcription factor and cyclinD-cdk4 showed an increase in cells going through DNA synthesis and entering mitosis. A combined knockdown of p21 and p27 showed an increase of cells entering mitosis. Cyclin D-cdk4 and p21 overexpression showed a decrease and increase of Rb expression, respectively. Of the 14 model predictions, 12 agreed with experimental data in the literature. A comprehensive knockdown of the model nodes suggests that E2F (a key transcription factor driving DNA synthesis) is positively regulated by cyclin D while negatively regulated by GSK3B, SMAD3, and pRB. Conclusion: This model enables us to predict how cardiomyocytes respond to stimuli in the CDK network and identify potential therapeutic regulators that induce cardiomyocyte proliferation.

scholarly journals The core software framework for the LHCb Upgrade

2019 ◽  
Vol 214 ◽  
pp. 05040
Author(s):  
Concezio Bozzi ◽  
Sébastien Ponce ◽  
Stefan Roiser
Keyword(s):  
Critical Points ◽  
Inelastic Collision ◽  
Current Status ◽  
Software Framework ◽  
Collision Rate ◽  
Proton Proton ◽  
Work Program ◽  
The Core ◽  
Lhcb Detector ◽  
Many Core

The LHCb detector will be upgraded for the LHC Run 3. The new, full software trigger must be able to sustain the 30MHz proton-proton inelastic collision rate. The Gaudi framework currently used in LHCb has been re-engineered in order to enable the efficient usage of vector registers and of multi-and many-core architectures. This contribution presents the critical points that had to be tackled, the current status of the core software framework and an outlook of the work program that will address the challenges of the software trigger.

scholarly journals Current Status of- and Future Perspectives in- Bacterial Degradation of Benzo[a]pyrene

2020 ◽  
Author(s):  
Alexis Nzila ◽  
Musa M. Musa
Keyword(s):  
Molecular Weight ◽  
Current Knowledge ◽  
Bacterial Degradation ◽  
Current Status ◽  
Low Molecular Weight ◽  
Future Perspectives ◽  
Aromatic Rings ◽  
Compound A ◽  
Current Review ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs), which consist of low-molecular-weight PAHs (LMW-PAHs) and high-molecular-weight PAHs (HMW-PAHs), form an important class of pollutants. Pyrene and benzo[a]pyrene (BaP) are the main pollutants belonging to HMW-PAHs, and their degradation by microorganisms remains an important strategy for their removal from the environments. Extensive studies have been carried out on the isolation and characterisation of microorganisms that actively degrade LMW-PAHs, and to a certain extent, the HMW-PAH pyrene. However, so far, limited work has been carried out on BaP biodegradation. BaP consists of five fused aromatic rings, which confers this compound a high stability, rendering it less amenable to biodegradation. The current review summarizes the emerging reports on BaP biodegradation. More specifically, work carried out on BaP bacterial degradation and current knowledge gaps that limit our understanding of BaP degradation are highlighted. Moreover, new avenues of research on BaP degradation are proposed, specifically in the context of the development of “omics” approaches

scholarly journals Application of Artificial Intelligence Technology in Mechanical Electrical Control System

2021 ◽  
Vol 2066 (1) ◽  
pp. 012057
Author(s):  
Nan Li
Keyword(s):  
Artificial Intelligence ◽  
Control System ◽  
Control Systems ◽  
Current Status ◽  
Work Efficiency ◽  
Electrical Control ◽  
Existing Problems ◽  
The Core ◽  
Core Technology ◽  
Artificial Intelligence Technology

Abstract Artificial intelligence technology (A I T) has also been widely used in society. Combining A I T with mechanical and electrical control systems will bring huge profits to the corporate sector and greatly improve work efficiency. It can save a lot of money in the electrical control operations of all walks of life in the country, and fill the gap in this technology in the country. The purpose of this article is to study the application of A I T in mechanical electrical control systems (M E C S). This article first introduces the basic theories and concepts of A I T, extends the core technology of A I T, and combines the current status of the electrical control system of modern enterprises in our country to discuss its existing problems, and finally studies and analyzes A I T and machinery. Combination of electrical control systems, and discuss the application of A I T in mechanical electrical orifice subsystems. Experiments show that, compared with the existing M E C S, the M E C S using A I T can better complete the work and improve work efficiency.

scholarly journals Posthumanism and the New Ethics of Medical Practice—Epidemiology as the New Deontological Paradigm

2021 ◽  
Vol 3 (1) ◽  
pp. 106-118
Author(s):  
Timea Vitan ◽  
Keyword(s):  
Medical Practice ◽  
Medical Science ◽  
Medical Specialty ◽  
Medical Doctors ◽  
Public Attention ◽  
Short Introduction ◽  
Starting Point ◽  
History Of ◽  
The Individual ◽  
Vantage Points

In the context of the COVID19 pandemic, during last year all public attention has been focused on Medicine. Epidemiology is no longer just one medical specialty among many others, but became the main paradigm and the unique background of medical science. The individual pacient has turned into the collective pacient. Medical policies are not centered on the pacient anymore, but on its social group. In this article I will try to show how the characteristics of medical practice changed since the pandemic began and which are the deontological implications of such changes. With a short introduction on the medical policies proposed by the WHO during the last decades, I wish to underline the recent history of medical practice and its obvious turning point occasioned by the pandemic. Once the new bioethical vantage points are set, I wonder to which extent posthumanist philosophy foresaw this new deontological paradigm. Having Rosi Braidotti`s “The Posthuman” as my starting point, I maintain that medical doctors no longer practice on a humanist background, but with a sort of commitment that goes beyond the individual. However, this is not an antihumansit pledge, because contemporary medical doctors still adhere to certain humanist principles. As it so often happens, we will be left with even more questions. If the pacient is no longer the individual, but the group of individuals, which is the nature of a symptom and how should we decipher its meaning? How would a new medical science look like if we are to build it not on a human but on a posthuman biology?

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