scholarly journals The influence of the preparation “Bendamin” on the morphological and biochemical indices of blood of rats in experimental modeling of heart failure

2020 ◽  
Vol 3 (1) ◽  
pp. 38-41
Author(s):  
I. S. Varkholiak ◽  
B. V. Gutyj
Keyword(s):  
Heart Failure ◽  
Young Male ◽  
Experimental Modeling ◽  
Male Rats ◽  
Simultaneous Increase ◽  
Control Group ◽  
State Research Institute ◽  
Hematological And Biochemical Parameters ◽  
Biochemical Indices ◽  
Experimental Group

The purpose of this work was to study the influence of “Bendamin” on the morphological and biochemical indices of rat blood in experimental modeling of heart failure. The investigation were performed on white sexually mature young  male-rats of Wistar line  weighing 180–200 g, kept at the standard ration of the institute vivarium of the State Research Institute of Veterinary Preparations and Fodder Additives. To create a model of doxorubicin-induced cardiomyopathy, 24 male rats were selected. Animals were divided into 3 groups of 6 animals in each: control group – intact animals; experimental group E1, in which animals were modeled doxorubicin-induced cardiomyopathy by intraperitoneal injected of doxorubicin at a dose of 2.5 mg/kg 3 times a week for two weeks; experimental group E2, in which animals, after injection of doxorubicin, the preparation “Bendamin” was injected in the dose 20 mg/kg intragastrically. For experimental modeling of heart a decrease in the number of red blood cells was found in the blood of rats of the first experimental group by 34.7 % and hemoglobin level – by 24.2 %, with a simultaneous increase in the average hemoglobin content in one erythrocyte by 16.2 %. Doxorubicin-induced cardiomyopathy in rats of the first experimental group was accompanied by a decrease in leukocyte count by 22.2 %, an increase in uric acid level by almost in 2 times, creatinine by 11.4 %, cholesterol by 61.1 %. In the research of the protein synthesizing function of the liver of rats in experimental modeling of heart failure, a decrease in total protein by 9.6 % was found. These changes were accompanied by a slight decrease in albumin levels and a slight increase in globulin levels. By intoxication with doxorubicin, rats of the first experimental group showed a violation of the functional state of the liver, indicating an increase in the activity of aminotransferases in their blood, namely: AlAT by 34.2 %, AsAT – by 21.7 %, accordingly. Positive action of cardio preparation “Bendamin” on rats organism under conditions of creation of a model of doxorubicin-induced cardiomyopathy was installed, manifested by the normalization of hematological and biochemical parameters, functional status and protein synthesis of the liver.

Influence of doxorubicin on lipid peroxidation and heart histology in rats

2015 ◽  
Vol 21 (31) ◽  
pp. 33-36
Author(s):  
Джиоев ◽  
Inal Dzhioev ◽  
Джанаев ◽  
Robert Dzhanaev
Keyword(s):  
Low Dose ◽  
Male Rats ◽  
Control Group ◽  
High Dose ◽  
Cardiovascular Toxicity ◽  
Anthracycline Antibiotic ◽  
Cross Striation ◽  
Group A ◽  
Sexually Mature ◽  
Experimental Group

Anthracycline antibiotic doxorubicin, which has proven cardiovascular toxicity, is often used in the treatment of cancer. The research project was carried out in 21 sexually mature Wistar male rats divided into three groups: control group, high-dose experimental group, in which rats were once injected intraperitoneally with doxorubicin hydrochloride at a dose of 10 mg/kg and low-dose experimental group, in which animals twice received intraperitoneal 2.5 mg/kg doses of doxorubicinhydrochloride at 10-day interval.An increase of malondialdehyde was revealed in the membranes of red blood cells in the high-dose experimental group, while in the low-dose experimental group a reduction in the levels of malondialdehyde and plasma hydroperoxides as well as a decreasing of catalase activity was observed. Intake of doxorubicin also causes venous hyperemia in wide areas of myocardiumalong with increasing of cardiomyocytic cross striation.

DYNAMICS OF PROTEIN METABOLISM AND ACTIVITY OF AMINOTRANSFERASES OF DOGS BY ADDING DIHYDROQUERCETIN

2016 ◽  
Vol 1 (1) ◽  
pp. 6-8
Author(s):  
Полищук ◽  
Sergey Polishchuk ◽  
Молянова ◽  
Galina Molyanova
Keyword(s):  
Body Weight ◽  
The Body ◽  
Control Group ◽  
German Shepherd ◽  
Formalin Edema ◽  
Working Dogs ◽  
Healthy Dogs ◽  
Biochemical Indices ◽  
Experimental Group ◽  
Operational Capacity

The purpose of research is to improve business and operational capacity of the body through the use of dogs dihydroquercetin. The article presents the results of experiment by the effect of dihydroquercetin dynamics of biochemical indices of the dogs blood. Dihydroquercetin – it is an active antioxidant, natural scavenger of oxygen free radicals, hepatoprotector, having anti-inflammatory action due to limitations of the formalin edema and histamine, and inhibits the formation of serous fluid, painkillers, immunocorrelation properties. Due to the high complexing properties it displays the body of heavy metals, including radionuclides, helps to restore the blood vessels tone, normalizing the lipid levels and slows the progression of atherosclerotic plaques. Investigations were carried out in zonal center of the dog expert service GU MVD of Russia in Samara region with clinically healthy dogs, German shepherd breed, age 2-4 years with an average body weight of 30 kg in the background conditions and feeding, adopted by the enterprise. The dogs of the experimental group received dose dihydroquercetin 0.001 g/kg for body weight once a day during meals. When added to the basic diet, dihydroquercetined dogs of the experimental group shown the increase in indicators such as: total protein – by 11.5% (p<0.01), albumin – to 12.8% (p<0.01), AST 13.6% (p <0.001), ALT – by 11% (p<0.05), alkaline phosphatase in the – 12% (p<0.01) relative to the control group. Based on the results, obtained during the experiment, we can conclude that the use of dietary supplements in the diet of dogs, dihydroquercetin allows biocorrection level of protein and enzymatic metabolism in the body, which improves service and working dogs potential.

scholarly journals Effects of combined plyometric and sled training on vertical jump and linear speed performance ​​in young soccer players (Efectos de la combinación de entrenamiento pliométrico y de arrastres sobre el rendimiento en salto vertical y la velocidad lineal e

Retos ◽  
2021 ◽  
Vol 42 ◽  
pp. 228-235
Author(s):  
Moisés Falces-Prieto ◽  
Javier Raya-González ◽  
Eduardo Sáez de Villarreal ◽  
Jesús Rodicio-Palma ◽  
Francisco Javier Iglesias-García ◽  
...  
Keyword(s):  
Vertical Jump ◽  
Young Male ◽  
Soccer Players ◽  
Control Group ◽  
General Development ◽  
Speed Performance ◽  
Level Of Significance ◽  
And Control ◽  
Los Grupos ◽  
Experimental Group

The objective of this study was to evaluate the effects of a combined plyometrics and sled training carried out two days a week for 8 weeks. 60 young male soccer players were distributed in 4 groups (Under U16) [Experimental Group (U16 Exp, n=15) and Control Group (U16 Cont, n=15); and (Under19) [U19 Exp, (n=15) and U19 Cont, (n=15)]. The jump with countermovement (CMJ) was evaluated with Chronojump-Boscosystem® and the time in seconds (sec) in the 10, 20, and 40 m split with FitLight Trainer®. Was calculated a level of significance of p≤0.05, the effect size (ES) and % change. Both experimental groups improved from pre-to pots-test in CMJ [U16Exp (p<0.02) and U19Exp (p<0.01)] and the 10, 20, and 40 m splits [U16Exp (p<0.02, p<0.03, and p<0.01, respectively) and U19Exp (p<0.02, p<0.02, and p<0.01, respectively)]. Therefore, the combination of football and plyometric and resisted methods can be used for a general development of the neuromuscular capacities of young soccer players. Resumen. El objetivo fue evaluar los efectos de un entrenamiento combinado de pliometría y arrastres realizado 2 días en semana durante 8 semanas. 60 jugadores jóvenes de fútbol fueron distribuidos en 4 grupos (Cadete (CAD) [Grupo Experimental (CADExp n= 15) y Grupo Control (CADCont n= 15)] y (Juvenil (JUV) [JUVExp n= 15 y JUVCont n= 15]. Se evaluó el salto con contramovimiento (CMJ) con Chronojump-Boscosystem® y el tiempo en segundos (seg) en los tramos de 10, 20, y 40 m con FitLight Trainer®. Se calculó en nivel de significación p≤0.05, tamaño del efecto (TE) y % de cambio. Los grupos experimentales mejoraron del pre al pots-test en CMJ [CADExp (p<0.02) y JUVExp (p<0.01)] y los tramos de 10, 20, y 40 m [CADExp (p<0.02, p<0.03, p<0.01, respectivamente) y JUVExp (p<0.02, p<0.02, p<0.01, respectivamente)]. Por tanto, la combinación de fútbol y métodos pliométricos y resistidos puede utilizarse para un desarrollo general de las capacidades neuromusculares de los futbolistas jóvenes.

scholarly journals Changes in the sizes of the kidney after contralateral nephrectomy in the experiment

2018 ◽  
Vol 24 (3) ◽  
pp. 52-57
Author(s):  
V.M. Monastyrskyi
Keyword(s):  
Postoperative Period ◽  
Left Kidney ◽  
Abdominal Cavity ◽  
White Male ◽  
Male Rats ◽  
Control Group ◽  
Close Relationship ◽  
Length Width ◽  
Sexually Mature ◽  
Experimental Group

The evaluation of renal measurements such as length, width and thickness, volume is important in the diagnosis and treatment of many renal disorders, since there is a close relationship between the sizes of the kidneys and its function. The purpose of the study was to establish and compare during the postoperative period changes in the mass and sizes of the kidney left after nephrectomy in the sexually mature male rats. An experimental study was carried out on 84 sexually mature white male rats weighing 178-194 grams. Animals were divided into two groups: control (42 rats) and experimental (42 rats). In the control group, the animals under ketamine anesthesia were followed by an abdominal cavity dilution, after which the abdominal wall was applied in a row. All animals of the experimental group performed surgical intervention – nephrectomy of the left kidney. The animals were withdrawn from the trial by intra-pleural administration of thiopental-sodium 50 mg/kg after 7, 14, 21, 30, 90 days after nephrectomy. Macroscopic evaluation and description of the kidneys of animals was performed after their removal. Their weight was determined on the laboratory scale of HLR-200 up to 0.1 mg, and the length, width and thickness of the organ were measured with the help of a caliper to an accuracy of 0.05 mm. Calculated the volume of the kidney. The statistical analysis of the obtained results was carried out using the program STATISTICA 5.5 using parametric methods for evaluating the results. It was established that the mass, length, width, thickness and volume of the kidney of animals in the experimental group, as compared with the control group, were statistically significantly higher in all terms of observation. The fraction of the growth of the width and thickness of the single kidney of animals in the experimental group compared with the control animals in the animals was statistically significantly greater than the proportion of kidney growth during the postoperative period. It was found that the largest increase in the mass and thickness of the kidney, as compared with the control group, was observed after 30 days of the postoperative period, and the greatest increase in the length and width of the kidney, as compared with the control group, was observed after 14 days of the postoperative period.

scholarly journals Effects of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Dan Zhang ◽  
Hongli Li ◽  
Xiang Tian ◽  
Sujuan Zhang
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Enteral Nutrition ◽  
Elderly Patients ◽  
Immune Function ◽  
Inflammatory Markers ◽  
Heart Function ◽  
Inflammatory Factors ◽  
Control Group ◽  
Experimental Group

Objectives: To evaluate the effect of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure and its clinical significance. Methods: Eighty patients with moderate and severe heart failure admitted to the Cardiology Intensive Care Unit (CCU) of Baoding First Central Hospital from May 2019 to May 2020 were included in this study and randomly divided into two groups: the experimental group and the control group, with 40 patients in each group. The experimental group was given enteral nutrition support therapy on the basis of conventional therapy for one month, while the control group was given restricted salt and water intake on the basis of conventional therapy, and patients were given free diet according to their wishes. The changes in heart function before and after treatment, changes in inflammatory factors such as TNF-a, CRP, IL-6, changes in levels of immunoglobulins such as IgA, IgM, and IgG, and the improvement of the performance status of the two groups were compared and analyzed. Results: After treatment, indicators such as BNP, LVEDD, LVEF and 6min walking distance in the experimental group were significantly improved compared with the control group, with statistically significant differences (p<0.05), and the levels of inflammatory factors such as TNF-a, CRP and IL-6 in the experimental group were significantly reduced compared with those in the control group (p=0.00). The levels of IgG, IgA, IgM and other immunoglobulins in the experimental group improved more significantly after treatment than those in the control group, with statistically significant differences (IgG, IgA, p=0.00; IgM, p=0.01). Moreover, the experimental group was significantly superior to the control group in the improvement rate of performance status score (ECOG) after treatment (p=0.04); The incidence of gastrointestinal adverse reactions in the experimental group was 20%, and that in the control group was 15%. No statistically significant difference can be observed in the gastrointestinal tolerance of both groups (p=0.56). Conclusions: Reasonable enteral nutrition boasts a variety of benefits for the recovery of elderly patients with chronic heart failure. With reasonable enteral nutrition, the heart function of elderly patients with chronic heart failure can be significantly improved, inflammatory factors can be reduced, immunity and performance status can be enhanced, and gastrointestinal tolerance can be ameliorated without obvious gastrointestinal reactions. doi: https://doi.org/10.12669/pjms.38.1.4451 How to cite this:Zhang D, Li H, Tian X, Zhang S. Effects of enteral nutrition on heart function, inflammatory markers and immune function in elderly patients with chronic heart failure. Pak J Med Sci. 2022;38(1):---------.  doi: https://doi.org/10.12669/pjms.38.1.4451 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Dynamics of the functional activity changes in rats testicles under conditions of dosage spermatic cord stenosis

2019 ◽  
Vol 23 (3) ◽  
pp. 479-485
Author(s):  
M.Ya. Stravska ◽  
A.V. Hantimurov ◽  
T.Ya. Stravskyy ◽  
A.S. Sverstiuk ◽  
O.Ya. Halytska-Kharkhalis
Keyword(s):  
Male Infertility ◽  
Functional Activity ◽  
Spermatic Cord ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Standard Diet ◽  
The Third ◽  
Reperfusion Period ◽  
Experimental Group

Infertility in marriage is an important medical, biological, social and demographic problem. Inguinal hernioplasty is objectively considered as a factor of male infertility in 9.8% of cases. Under these pathological conditions, the structural elements of the spermatic cord are compressed those appears the circulatory disturbances in testicle. Disorders of reproductive function often occur precisely because of hemodynamic disorders, which are considered one of the leading pathogenetic factors in the development of male infertility. Purpose — to establish peculiarities of testicles vessels and tissues remodeling under dosed spermatic cord stenosis conditions and during the reperfusion period. The experiments have been carried out on 78 non-linear white male rats, weighting 180–200 grams which were fed due to a standard diet of vivarium. All the animals were divided into four groups: one control group and three experimental ones. The control group included six intact animals. All the other comprised the experimental group which was divided into three series six animals per each depending on the terms of observation. The animals with the model of dosed stenosis of funiculus comprised first experimental group; the animals with the model of dosed stenosis and one-moment decompression, starting from the third day of the experiment comprised the second group; to the third group we referred the animals with the model of dosed stenosis of the funiculus which have undergone decompression with the correction of reperfusion changes due to the method proposed by us, starting from the third day. During the experiment it was established that after one-time decompression of the spermatic cord that was under the experimental stenosis conditions, apereas destructive changes in testicles parenchyma and decreases the functional activity of the organ. Despite that the compression factor has been removed and the blood flow in arteries and veins has been fully restored, there was no improvement in the hemodynamics of the testicle. The use of the dosage decompression method of the spermatic cord helps to improve the hemodynamic conditions of the organ during the reperfusion period. In this case, the detected changes of the testicle’s parenchyma and its intra-organ vessels were less pronounced than during stenosis of the spermatic cord and its one-time decompression. The functional activity of the testicles with use of the reperfusion changes correction, was slightly violated, the spermatogenesis index has been increased and the mature forms of spermatozoa were present in the seminiferous tubules. Thus, the usage of the proposed method of the spermatic cord decompression allows us to obtain positive dynamics in testicles blood vessels remodeling in reperfusion period.

scholarly journals CHANGES OF STRESS HORMONES LEVELS AND SERUM LIPID SPECTRUM INDICATORS OF RATS IN ACUTE CEREBRAL ISCHEMIA

2015 ◽  
pp. 102-107
Author(s):  
T. N. Chubukova ◽  
T. S. Ugolnick
Keyword(s):  
Cerebral Ischemia ◽  
Serum Lipid ◽  
Stress Hormones ◽  
Male Rats ◽  
Control Group ◽  
Low Density ◽  
Acute Cerebral Ischemia ◽  
Experimental Group ◽  
Lipid Spectrum ◽  
Wistar Male Rats

Objective: to study the changes of stress hormones levels and serum lipid spectrum indicators of Wistar male rats in acute cerebral ischemia (ACI). Material and methods . The study was performed on 40 mature Wistar male rats weighing 220-300 g. ACI simulation was performed by means of 3-hour chronic occlusion of bilateral common carotid arteries (n = 23). The control group consisted of intact animals (n = 17). The levels of total cholesterol (TC, mmol/l), triglyceride (TG, mmol/l), high density lipoproteins (HDL, mmol/l), low density lipoprotein (LDL, mmol/l), lipoproteins of very low density (VLDL mmol/l), adrenocorticotropic hormone (ACTH nmol/l), and cortisol (nmol/l) were assessed in the serum of the rats. Atherogenic index (AI) was calculated according to the formula: AI = (TC-HDL) / HDL. Results. TC concentration in the serum of the rats of the experimental group was 1.1 times as high (p = 0.03), the concentration of TG - 1.2 times as high (p = 0.012), the concentration of VLDL - 2 times as high (p = 0.01), cortisol concentration - 1.4 times as high (p = 0.02) compared with the control group. The rats of the experimental group revealed a moderate inverse correlation between the levels of cortisol and index AI (p = 0.025). The group of ACI rats observed a tendency of direct relation of ACTH with TG and LDL serum, p > 0.05. The correlation of ACTH and serum triglycerides in the rats of the control group was statistically significant (p = 0.012). Conclusion: ACI during the period «therapeutic window» in rats is accompanied by a complex set of compensatory and adaptive reactions which may be characteristic of a generalized stress response.

scholarly journals Morphometric features of rat pinealocytes in conditions of chronic ethanol intoxication

2021 ◽  
Vol 27 (1) ◽  
pp. 17-22
Author(s):  
V.V. Pshychenko ◽  
V.S. Cherno
Keyword(s):  
Pineal Gland ◽  
Morphological Changes ◽  
Alcohol Intoxication ◽  
Morphometric Parameters ◽  
Chronic Ethanol ◽  
Male Rats ◽  
Control Group ◽  
Ethanol Intoxication ◽  
Chronic Ethanol Intoxication ◽  
Experimental Group

Ethanol has chronobiological effects, which are associated with inhibition of melatonin synthesis and secretion and disruption of the sleep-wake cycle. Ethanol is known to cause sleep fragmentation due to frequent awakenings, prolong wakefulness, and reduce the duration of the slow sleep phase. At the same time, changes in the morphology of the pineal gland under chronic exposure to ethanol remain poorly studied. Of particular interest are changes in the basic morphometric parameters of pinealocytes, because they are a marker of the functional state of the pineal gland. The aim of the study was to morphometrically study the features of morphological changes in rat pinealocytes in the physiological norm and in chronic ethanol intoxication. To achieve this goal, we used 20 laboratory male rats: a control group and an experimental group. The control group was under standard vivarium conditions. For the experimental group, alcohol intoxication was modeled by injecting a 40% ethanol solution at the rate of 12 mg/kg of body weight intragastric 4 times a day. The morphometric parameters of pinealocytes were studied on day 30 from the start of the study. According to the results of morphometric measurements, a significant increase in the parameters of light pinealocytes and a decrease in the parameters of dark cells were established. It was determined that the average values of the cytoplasm area of light pinealocytes increase by 54.55% (p<0.05), the area of the nucleus increases by 61.32% (p<0.05), and the area of the nucleolus by 32.84% (p<0.05) compared with the control group. The area of the cytoplasm of dark pinealocytes decreases by 27.2% (p<0.05), and the area of the nucleus by 37.33% (p<0.05). Changes in the ratio of light and dark pinealocytes were also noted. An increase in the number of active light cells by 8.17% was found. The detected morphometric changes indicate high functional activity of cells, which has a compensatory nature in response to apoptosis of pinealocytes.

scholarly journals Pisciculture, biological and physiological indicators of age–1+ carp while adding naked oats into main feeding

2021 ◽  
Author(s):  
N. Syrovatka ◽  
Keyword(s):  
Control Group ◽  
Feed Mixture ◽  
Physiological Indicators ◽  
Total Fish ◽  
Feed Costs ◽  
Hematological And Biochemical Parameters ◽  
Naked Oats ◽  
Fish Productivity ◽  
Carp Serum ◽  
Experimental Group

The influence of naked oats on pisciculture, biological, hematological and biochemical parameters of commercial carp groups, as one of the components of the feed mixture in different ratios has been studied in the article. The aim of the experiment was to increase the fish productivity of ponds and to reduce feed costs for cultivation by meeting the physiological needs of commercial carp groups when using naked oats in carp feeding. The object of the study was age–1+ carps of Lubin scaly and framed intra-breed type of Ukrainian carp breed. For this purpose, three experimental groups of fish were formed by the method of analogues. Fish of the first experimental group (from July 1) were additionally introduced 30% of naked oats into the main diet, the fish of the second experimental group - 50% of naked oats, the third group was fed a feed mixture without added oats. As a result of the research done, it is proved that the addition of a mixture of naked oats has a positive effect on fish biological and physiological parameters of commercial carp. It was found out that the most effective is the additional feeding of naked oats in the amount of 30%. In particular, when the very amount of naked oats is added to the basic diet, the total fish productivity indicator increases by 7.7% relative to the control pond indicators, and feed costs are lower by 16.7%. The amount of hemoglobin in the blood of the first experimental group was higher relative to the control group, and the number of erythrocytes was significantly higher (P> 0.01). However, in the carp serum of the first experimental group the level of superoxide dismutase (P> 0.02) significantly increased while the level of catalase decreased.

Influence of enzyme feed additive on the quality of eggs on the example of PJSC “Poultry plant Chelyabinskaya”

2020 ◽  
pp. 52-59
Author(s):  
S. Ermolov ◽  
V. Kosilov ◽  
Yu. Barabanova
Keyword(s):  
Egg Production ◽  
Laying Hens ◽  
Labour Productivity ◽  
Feed Additives ◽  
Poultry Meat ◽  
Feed Additive ◽  
Simultaneous Increase ◽  
Control Group ◽  
Experimental Group

Poultry farming is one of the major branches of animal husbandry, which develops through concentration, specialization and intensification on the basis of poultry plants and poultry farms. The increase in production of eggs and poultry meat is based on a significant increase in the productivity of poultry with a simultaneous increase in its population with a high payment of feed by production and the increase in labour productivity. The purpose of the work was to study the influence of enzyme feed additives in the diets of laying hens on the quality of eggs. The researches have been carried out in PJSC “Poultry plant Chelyabinskaya”, which produces high-quality chicken eggs obtained from the poultry cross “Loman LSL-classic”. The object of study was enzyme drugs produced by Sunzyme – a multi-enzyme drug that includes xylanase, cellulase and mannase activities. The dosage of enzyme drugs in the feed mixture of laying hens was: Sunfyze 5000 – 80 g/t, Sunzyme – 100 g/t. The results of researches show that in the groups that received enzyme drugs in their diet, egg production was higher than in the control group. So, for the entire period of researches the hens of the experimental groups were significantly superior to the control group in terms of egg production per average laying hen. The largest difference was in hens of the 1st experimental group (enzyme drug Sunfyze) – 10,8 eggs; the smallest in hens of the 3rd group (enzyme drugs Sunfyze and Sunzyme) – 5,7 eggs. In hens of the 2nd experimental group compared with hens of the control group egg production was higher by 7,9 eggs. The best indicators of production efficiency have been obtained in the 1st experimental group of laying hens, which were fed with the enzyme feed additive Sunfyze to reduce the nutritional value of the diet according to the matrix.

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