scholarly journals The effect of humic substances on carbohydrate metabolism in alloxan-induced diabetes mellitus in rats

2021 ◽  
Vol 9 (2) ◽  
pp. 96-97
Author(s):  
V. A. Utkina ◽  
L. M. Stepchenko
Keyword(s):  
Diabetes Mellitus ◽  
Aqueous Solution ◽  
Carbohydrate Metabolism ◽  
Active Substance ◽  
Biologically Active ◽  
Hypoglycemic Effect ◽  
Feed Additive ◽  
Glucose Content ◽  
C Peptide ◽  
The Third

The article presents study results of the effect of humic nature biologically active additive «Humilid» on carbohydrate metabolism, namely on glucose, insulin and C-peptide in alloxan-induced diabetes mellitus in rats. The purpose of the experiment was to investigate how “Humilid” affects carbohydrate metabolism in rats; to study and analyze the effect of the humic nature biologically active substance «Humilid» on metabolic processes. In the work we used biochemical methods for studying the blood of experimental rats. Adult male white rats were taken for the experiment, from which four groups were formed. The experiment lasted three weeks, during which the animals from the first experimental group received daily in addition to the main feed an aqueous solution of feed additive «Humilid» at dose 5 mg / kg of body weight of the active substance, and had free access to water. Rats of the second and third groups were injected with alloxan as a single intraperitoneal injection. The rats of the third group additionally received an aqueous solution of feed additive «Humilid». It was identified that “Humilid” has an antioxidant activity, which may be one of the mechanisms of its antidiabetic action, as it is known that alloxan causes free radical damage to β-cells with weak antioxidant protection. The use of a biologically active feed additive of humic nature was found to have a hypoglycemic effect in both healthy animals as well as in rats with alloxan-induced diabetes mellitus. It was found that the use of “Humilid” in rats enhances energy processes in their bodies of experimental animals. There was a decrease in glucose content in rats from second group by 11.9% (P ≤ 0.001) compared with the control one. At the same time, the glucose content in animals from third and fourth groups was higher by 35.9% (P ≤ 0.001) and 20% (P ≤ 0.001) higher than in animals from the control one. The insulin concentration in the blood of rats from the second group was 7.4% higher (P ≤ 0.05) compared to the animals from first group. The concentration of C-peptide was within the reference values. The levels of insulin and C-peptide concentration in animals of the third and groups were lower by 47.8% (P ≤ 0.001) and 32.4% (P ≤ 0.001) and 55.5% (P ≤ 0.001) and 37.5% (P ≤ 0.001) in comparison with animals of first group. A pronounced hypoglycemic effect, which was due to an increase in the sensitivity of tissues to glucoregulatory hormones and an increase in the body’s tolerance to excessive intake of carbohydrates. The obtained results of the study indicate the regulatory effect of humic feed additive «Humilid» on key links in the regulation of carbohydrate metabolism, which is characterized by the decrease in blood glucose level due to activation of the synthesis and secretion of insulin and C-peptide.

scholarly journals Hypoglycemic effect of katakakhadiradi kashayam by alleviating the oxidative damage in experimentally induced diabetic rats

2021 ◽  
Vol 12 (2) ◽  
pp. 1306-1310
Author(s):  
Angelie Jessica Subbiah ◽  
Kavimani M ◽  
Mukilan Ramadoss ◽  
Prabhu K
Keyword(s):  
Diabetes Mellitus ◽  
Oxidative Damage ◽  
Good Alternative ◽  
Pancreatic Tissue ◽  
Diabetic Rats ◽  
Blood Glucose Measurement ◽  
Biologically Active ◽  
Hypoglycemic Effect ◽  
Glucose Measurement ◽  
Active Components

At present, herbal plants and their biologically active components have acquired importance in diabetes mellitus (DM) management, which has spread worldwide. The current study was carried out to analyse the antidiabetic action of  Katakakhadiradi kashayam in streptozotocin administered diabetic rats. The study was done in wistar rats by inducing diabetes using streptozotocin and nicotinamide. Diabetic rats were given katakakhadiradi kashayam with various doses of 100, 200 and 300 mg/kg/b.wt for 14 days, and its efficacy was compared with glibenclamide drug. The hypoglycemic effect of this katakakhadiradi kashayam was tested by taking blood glucose measurement in experimental rats. The oxidative damage caused by streptozotocin was analysed by LPO levels and the antioxidants status was assessed by GSH levels, GPx, SOD and CAT activities in pancreatic tissues. The antidiabetic study of katakakhadiradi kashayam showed reduction in hyperglycemia by reducing the oxidative damage in pancreatic tissue and improving the antioxidants. Overall, the reports of the study showed that katakakhadiradi kashayam could be used to improve management of diabetic rats. The acquired data suggest the hypoglycemic efficacy of katakakhadiradi kashayam, which is practically a safe herbal formulation and may be used as a good alternative to cure diabetes mellitus.

scholarly journals Ethological and biological features of the organism of the black-and-white bulls when using natural feed additives in the diets

2020 ◽  
Vol 17 ◽  
pp. 00237
Author(s):  
Oksana Krasnova ◽  
Ekaterina Hardina ◽  
Sergei Hramov ◽  
Michail Kudrin ◽  
Nina Konik
Keyword(s):  
Active Substance ◽  
Feed Additives ◽  
Biologically Active ◽  
Feed Additive ◽  
Biologically Active Substance ◽  
Black And White ◽  
Scientific Experiment ◽  
Biological Features ◽  
Livestock Feed ◽  
Meat Productivity

The authors studied the natural feed additive effect to the behaviour and biochemical blood composition of the black-and-white bulls. As results of the scientific experiment we came to the conclusion that using of the biologically active substance dihydroquercetin as a part of a natural feed additive in livestock feed for the metabolic processes intensity stimulation, the nutrient synthesis intensity and higher rates meat productivity formation.

scholarly journals THE EFFICIENCY OF DIHYDROQUERCETIN IN THE FEEDING OF BROILER CHICKENS

REPORTS ◽  
2021 ◽  
Vol 2 (336) ◽  
pp. 13-17
Author(s):  
N. N. Kuzmina ◽  
O. Yu. Petrov ◽  
A. K. Karynbayev ◽  
A. S. Alentayev
Keyword(s):  
Active Substance ◽  
Broiler Chickens ◽  
Live Weight ◽  
Biologically Active ◽  
Feed Additive ◽  
Control Group ◽  
Standard Diet ◽  
Biologically Active Substance ◽  
Growing Period ◽  
Experimental Group

The purpose of the research was to determine the feasibility and effectiveness of using a natural antioxidant of plant origin – dihydroquercetin (DHA), as a biologically active substance, in combination with the main standard diet of broiler chickens. Scientific and economic experience conducted in production conditions on broiler chickens of the "COBB-500" cross allowed us to objectively establish that the addition of the biologically active substance Dihydroquercetin to mixed feed contributes to the increase in meat productivity and safety of broiler chickens. Feeding of broiler chickens was carried out with full-fledged compound feeds, in accordance with the recommendations of the originator for this cross. In terms of energy nutrition and the content of nutrient active substances, they were the same and differed between the groups in the amount of the additive administered. Chickens of the 1st control group received only feed (basic diet), the 2nd experimental group – advanced antioxidant supplement Dihydroquercetin in the amount of 0.5 g per 100 g of feed, the 3rd – 0.75 g per 100 g of feed, and 4th – 1 g per 100 g of feed. The duration of the experiment was 40 days and to clarify the effectiveness of increasing the duration of the broiler fattening period, it was extended to 60 days. Broiler chickens were reared on the floor, temperature and light conditions, air humidity, feeding and watering front of the bird during the experiment corresponded to the recommended standards. As a result of the conducted studies on the effect of adding optimal levels of biologically active feed additive Dihydroquercetin to the diet of broiler chickens, it was found that during the growing period, a higher coefficient of live weight gain was established in broiler chickens of the 3rd and 4th experimental groups, whose live weight increased by 105.32 and 120.48 times by the age of 40 days, while in broiler chickens of the 2nd experimental group by 102.57 times and the lowest–in control group chickens only in 90.96 times. The selected feed additive can be considered as an alternative to the use of feed antibiotics in the feeding of broiler chickens in industrial poultry farming technology.

scholarly journals THE ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN THE FORMATION OF NEUROENDOCRINE AND IMMUNE DISORDERS DURING STRESS AND DISSTRESSE

2019 ◽  
Vol 19 (1S) ◽  
pp. 31-34
Author(s):  
Y M Pesin ◽  
V K Gabitov ◽  
A A Beisembaev ◽  
Ya I Potekhina
Keyword(s):  
Diabetes Mellitus ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Carbohydrate Metabolism ◽  
The Body ◽  
C Peptide ◽  
Functional Changes ◽  
Autonomic Nervous ◽  
Neurohumoral Regulation ◽  
Cellular And Humoral Immunity

The aim of the research was studying the features of neurohumoral regulation of carbohydrate metabolism in experimental diabetes mellitus. A model of diabetes mellitus was created by introducing 0.1% solution of epinephrine hydrochloride into animals. Biochemical parameters of carbohydrate metabolism (cortisol, C-peptide and glucose) were studied in 17 animals on day 0, 15, 21, 30, 45. On the same day morphofunctional changes formed in the pancreas and Nodi lymphatici pancreaticoduodenales were studied. With stress, there is an increase in cortisol and C-peptide and a decrease in the concentration of glucose in the blood. In distress cortisol secretion is reduced, and the production of C-peptide and glucose concentration in the blood increases. In the lymph nodes formed functional changes that led to a violation of cellular and humoral immunity in the body. Conclusion. The cause of diabetes is a failure in the work of self-regulating mechanisms of carbohydrate metabolism, which leads to dysregulation pathology of the autonomic nervous system, manifested by antagonism between adrenaline and cortisol, insulin and cortisol.

scholarly journals Minidiab test to assess the function of pancreatic beta-cells in the children of diabetics

1994 ◽  
Vol 40 (6) ◽  
pp. 7-10
Author(s):  
E. G. Gasparyan ◽  
S. A. Nersesyan ◽  
Ye. A. Volkova ◽  
Z. V. Kryuchkova ◽  
L. I. Velikanova
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Pancreatic Beta Cells ◽  
Test Group ◽  
Normal Subjects ◽  
Dependent Diabetes Mellitus ◽  
Healthy Controls ◽  
C Peptide ◽  
Insulin Dependent

The levels of glucose, insulin, and C-peptide in the blood scrum were measured in 38 subjects with normal and impaired glucose tolerance whose parents suffered from insulin-dependent and noninsulin-dependent diabetes mellitus (IDDM and NID- DM, respectively) and in 12 normal subjects without hereditary aggravation for diabetes mellitus in order to specify the pecualiaritics of development of diabetes mellitus of various types. Reliably increased levels of glucose, insulin, and C-peptide on an empty stomach and absence of adequate secretion of insulin and C-peptide in response to stimulation with 5 mg of minidiab, expressed by a later and less manifest release of insulin and C-peptide, were observed in the test group, in contrast to healthy controls. The detected changes augment with the progress of carbohydrate metabolism disorders, being more marked in the subjects whose parents suffered from IDDM. The findings permit a conclusion that function of the insular system is changed during early disorders of carbohydrate metabolism in subjects whose parents suffered from both forms of diabetes mellitus. Minidiab test is recommended to specify the function of the pancreatic insular system.

scholarly journals The effective use of biologically active substance that belongs to hydrolyse class “Lysozyme G3” in the composition of pigs premix

2019 ◽  
Vol 21 (90) ◽  
pp. 93-97 ◽  
Author(s):  
A. Y. Karunskiy ◽  
I. V. Nikolenko
Keyword(s):  
Active Substance ◽  
Live Weight ◽  
Biologically Active ◽  
Feed Consumption ◽  
Control Group ◽  
Biologically Active Substance ◽  
The Third ◽  
Effective Use ◽  
Experimental Group ◽  
Fattening Pigs

This article presents the results of the effective use of biologically active substance that belongs to hydrolyse class “Lysozyme G3” in the composition of pigs premix. New premix that can balance the main grains in pigs feeding has been developed. The main grains are wheat, corn, barley. These compounds are included into pigs feeding ration and they are the main crops in the South of Ukraine. The effect of using this new premix that contains the enzyme preparation “Lysozyme G3” for fattening pigs was also investigated. The productive effect of enzyme preparation in the rations with the same nutritional value for fattening pigs and its effect on the nutrients digestibility were studied. Experimental research activities were conducted at the agricultural enterprise “Avangard-D” LLC, Ovidiopol District, Odessa Oblast. The changes in live weight, as well as gains of fattening pigs at the age of 4, 5, 6 and 7 months were studied in the scientific and economical experience. During the main period (120 days), the increase in pigs live weight was observed in all groups. Thus, in the control group, this indicator changed from 27.8 to 107 kg; in II experimental group – from 28.1 to 109.2; in III experimental group – from 28.0 to 111.7 kg. When removing animals from fattening, the difference in live weight between the III experimental and control groups was 4.4% and it was statistically significant (P > 0.95). The average daily gains in piglets of II and III experimental groups significantly exceeded the indices of control one by 2.4% and 5.7%, respectively. The nutrients digestibility in animals of all experimental groups was studied to analyze more carefully. The analysis of digestibility indices in pigs rations during experiment (when pigs are fed with premix that contains biologically active substance Lysozyme G3), and its content in the ration indicated that nutrient digestibility indices had changed into the direction of increase. Feed consumption was calculated after analyzing these indices. Thus, the smallest feed consumption per unit of live weight gain was established in the third experimental group, where it was 3.2 feed units and was less in comparison with animals of the control group by 3.4%. During scientific and economical researches, blood samples were taken from animals of the first control group and the third experimental one for morphological and biochemical studies. It was found that the blood parameters of experimental animals during the entire period of fattening were within the physiological norm. The amount of protein in the blood indicates that animals of experimental group have higher growth rate by 10.9%. The economic indicators directly reflected above mentioned facts when the calculation of the economic part of the research were carried out. Thus, we got 1870.5 UAH from the first group, 1934.3 UAH from the second group, 1989.4 UAH from the third group, selling products from one head. Accordingly, the level of profitability of pork production was: in the first group (control) – 13.5; in the second (1 kg/ton of premix) – 16.5%; in the third (2 kg/ton of premix) – 19.8%.

scholarly journals Assessment of the influence of the mineral complex of rutin on the degree of expression of anti-diabetic activity

2021 ◽  
Vol 10 (4) ◽  
pp. 197-205
Author(s):  
V. I. Toporkova ◽  
E. V. Vishnyakov ◽  
K. O. Sidorov ◽  
I. I. Terninko ◽  
D. Yu. Ivkin
Keyword(s):  
Diabetes Mellitus ◽  
Aqueous Solution ◽  
Phenolic Compounds ◽  
Zinc Chloride ◽  
Biologically Active ◽  
Molar Ratio ◽  
Antidiabetic Effect ◽  
Mineral Complex ◽  
Active Substances

Introduction. Type 2 diabetes mellitus is currently considered one of the most common non-communicable diseases. For the prevention and concomitant treatment of this pathology, various herbal remedies are successfully used, such as, for example, blueberry shoots. The plant contains phenolic compounds (anthocyanins, flavonoids, phenolcarboxylic and organic acids), which have antioxidant and hypoglycemic effects, and also accumulates macro- and microelements (Ca, Mg, Zn, Mn), which in turn can affect the course of diabetes mellitus. Complexes of elements with phenolic biological active substances (BAS) can affect the formation of a pharmacological response or change its severity. Therefore, it is possible to put forward a hypothesis about the potentiation of the antidiabetic action of phenolic compounds when they exist in the form of mineral complexes.Aim. To carry out a comparative assessment of the antidiabetic activity of the mineral complex rutin with zinc in comparison with precursor substances and extraction from blueberry shoots to predict the effect of elements on the course of this pathology.Materials and methods. The objects of the study were an aqueous solution (C = 0.18 mg/ml) of a model complex of rutin with zinc with a molar ratio of components of 1 : 1 and blueberry shoots purchased from a pharmacy in St. Petersburg. According to the information on the packaging, the region of raw material procurement is Altai Territory, Barnaul, the period for harvesting blueberries is July 2020. The complex of rutin with zinc was obtained according to the method described in the literature from the pharmaceutical substance rutin (Rutin, batch 332, valid until 26.03.2023, Sichuan Guangsong Pharmaceutical Co., Ltd., China, FS 000569-060514) and an aqueous solution (С = 0.13 mg/ml) zinc chloride (Zinc chloride, batch 39/G 4, valid until 09.10.2021, Neva Reaktiv, Russia, STP TU COMP 1-533-2012). The optimal ratio of components 1 : 1 for the formation of a mineral complex was established by us earlier experimentally using the Job's method. The mass of zinc chloride, which must be added to the extraction, and the mass of the complex for the preparation of its aqueous solution were calculated on the basis of the quantitative content of biologically active substances in blueberry shoots and the molar ratio of the components involved in the formation of the complex compound determined by the spectral method. The quantitative content of the main groups of biologically active substances (flavonoids, hydroxycinnamic acids, organic acids) was determined spectrophotometrically on SF-2000 instrument (Russia) and titrimetrically using the methods presented in Russian Pharmacopoeia XIV FS.2.5.0093.18 and FS.2.5.0012.15. The antidiabetic effect of the complex of rutin with zinc was evaluated in comparison with an aqueous extract from the shoots of common blueberries (the ratio of raw materials: extractant – 1 : 80), an aqueous solution of zinc chloride (concentration – 0.36 mg/ml) and their mixture (ratio 1 : 1) on a model of dexamethasone-induced type 2 diabetes mellitus in laboratory animals. Determination of blood glucose concentration was carried out using a portable glucometer "AccuChek Active" (Roche Diabetes Care, Germany). The presence of glucosuria and ketonuria was established using Ketoglyuk-1 test strips (Biosensor AN, Russia). Statistical processing of the results was carried out using the Microsoft Excel program according to OFS.1.1.0013.15.Results and discussion. The results of the content of glucose and ketones in urine showed that in the process of modeling diabetes mellitus, glucosuria and ketonuria are characteristic for all groups of animals, which confirmed the formation of a pathological process in rats. A lower content of glucose and ketones in urine was found in a group of animals that received a complex of rutin with zinc (glucose concentration – less than 2.3 mmol/l, ketone concentration – less than 0.2 mmol/l). Measurement of the concentration of glucose in the blood showed that the complex of rutin with zinc has the most pronounced hypoglycemic effect, while the water extract from blueberry shoots and an aqueous solution of zinc chloride have a minimal antidiabetic effect (blood glucose is 6.9 mmol/l versus 8,1 mmol/l and 7.9 mmol/l, respectively).Conclusion. The study of the influence of elements in the composition of phenolic complexes on the course of diabetes mellitus showed that the introduction of minerals has a positive effect on the severity of the pharmacological effect, which can serve as confirmation of the hypothesis about the potentiation of the antidiabetic effect of phenolic compounds when they exist in the form of mineral complexes. Thus, the complex of rutin with zinc showed the maximum activity in comparison with the solution of zinc chloride, extraction from blueberry shoots and their mixture, which suggests that the form of existence of natural phenolic compounds in the composition of mineral complexes is optimal both from the point of view of accumulation and from the side manifestations of a pharmacological response. The results of the study create the preconditions for further study of the effect of various elements in combination with marker phenolic components of antidiabetic herbal preparations on the course of diabetes mellitus, and also make it possible to conclude that natural mineral complexes have a prophylactic effect against this pathology.

scholarly journals Morphological and biochemical blood values of fattening young rabbits

2016 ◽  
Vol 18 (2) ◽  
Author(s):  
V. P. Kucheriavyi ◽  
O. B. Shtenska ◽  
Y. I. Vanzhula
Keyword(s):  
Feed Additives ◽  
Blood Analysis ◽  
Feed Additive ◽  
Control Group ◽  
Glucose Content ◽  
The Third ◽  
Nitrogenous Substances ◽  
Calcium Magnesium ◽  
Complete Protein ◽  
Different Doses

Meat of rabbits is considered to be a valuable dietary product. It is a source of complete protein, minerals and vitamins. It is second only to meat of turkey by the content of nitrogenous substances. It is known the blood composition is a symptomatic reflection of the intensity of metabolic processes that take place in the animal’s body under the influence of certain feeding factors. Testing of new feed additives in animal diets should be accompanied by in–depth blood analysis. Thus, the purpose of this research is to investigate, along with the performance, the effect of feeding different doses of Prebiolact–Cr on the morphological and biochemical blood values of fattening young rabbits. The research was conducted in four groups of young rabbits selected by the principle of analogues. The basic period of the experiment lasted for 42 days; it was divided into six sub–periods lasting for seven days. Animals of the second group, together with complete granulated mixed feed, received Prebiolact–Cr in the amount of 1.5 g, the third – 2.0 g and fourth – 2.5 g per rabbit daily. During this scientific experiment, young rabbits were kept in two–high cage batteries with five animals in each rabbit hutch, females and males were kept separately. Morphological and biochemical blood values were within their physiological norm when prebiotic preparation Prebiolact–Cr was introduced into the diet of young rabbits at the doses of 1.5, 2.0 and 2.5 g per rabbit daily. Prebiolact–Cr dose of 2.0 and 2.5 g per rabbit daily leads to haemoglobin increase by 4.63% in the third group and 9.5% in the fourth group. Studied feed additive at the dose of 1.5 g per head daily causes the increase of segmented neutrophils by 6.1%, reduction of monocytes by 0.9%, compared to the control group. Glucose content in the blood of experimental rabbits increased by 5.9%, 10.3% and 7.4% when the dose of the preparation became higher. Prebiotic preparation facilitates the increase of iron, potassium, calcium, magnesium and phosphorus content in blood and maintains the immune system of rabbits.

scholarly journals Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity

2016 ◽  
Vol 19 (6) ◽  
pp. 457-463 ◽  
Author(s):  
Daria S. Skuratovskaia ◽  
Maria A. Vasilenko ◽  
Nikolai S. Fattakhov ◽  
Elena V. Kirienkova ◽  
Natalia I. Mironyuk ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Abdominal Obesity ◽  
Serum Insulin ◽  
Control Group ◽  
C Peptide ◽  
Increased Risk

Aim. To investigate the association of the GIPR gene polymorphisms rs2302382 and rs8111428 with increased risk of type 2 diabetes mellitus and abdominal obesity.Materials and methods. The study involved 163 patients with abdominal obesity (BMI, 39.5 ± 8.3 kg/m2; age, 44.7 ± 8.9 years; men, 61; women, 102), 72 with type 2 diabetes mellitus (BMI, 43.70 ± 9.32 kg/m2; age, 46.5 ± 10.1 years; men, 29; women, 43) and 91 patients without carbohydrate metabolism disorders (BMI, 36.13 ± 6.72 kg/m2; age, 43.93 ± 8.35 years; men, 32; women 59). The control group comprised 109 relatively healthy volunteers (BMI, 22.6 ± 2.7 kg/m2; age, 39.5 ± 7.6 years; men, 66; women, 43). Genotypes were analysed by real-time PCR and serum insulin and C-peptide levels were evaluated by ELISA.Results. The AA genotype in the rs2302382 polymorphism of GIPR was associated with an increased risk for type 2 diabetes mellitus in abdominal obesity and the CA genotype was associated with a reduced risk. In individuals with abdominal obesity and type 2 diabetes mellitus carrying the CA genotype in rs2302382 polymorphism of GIPR, serum insulin and C-peptide levels were elevated to 56.27 mU/L (55.49–58.41 mU/L) and 2.04 ng/ml (1.37–2.85 ng/ml), respectively (p 0.05). In obese patients with the same genotype and without type 2 diabetes, serum insulin levels and C-peptide levels were 22.73 mU/L (19.07–25.76 mU/L) and 0.73 ng/ml (0.53–1.03 ng/ml), respectively (p 0.05). The GIPR rs8111428 polymorphism was not associated with increased risk of type 2 diabetes mellitus in obesity for any of the groups examined.Conclusion. Serum insulin and C-peptide levels were increased in patients with abdominal obesity who were carriers of the CA genotype in the rs2302382 polymorphism of GIPR, which is associated with a decreased risk of type 2 diabetes mellitus in obesity compared with the CC genotype.

scholarly journals Prognostic factors for the carbohydrate metabolism normalization in patients with type 2 diabetes mellitus and obesity using liraglutide 3.0 mg per day

2021 ◽  
Vol 93 (10) ◽  
pp. 1203-1208
Author(s):  
Igor A. Sklyanik ◽  
Marina V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Fasting Blood Glucose ◽  
The Body ◽  
Hypoglycemic Effect ◽  
Antihyperglycemic Therapy

Background. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are innovative drugs that effectively reduce glycemic levels and overweight in patients with type 2 diabetes mellitus (T2DM). However, the criteria for predicting the hypoglycemic effect of this group of drugs have not been practically defined. Aim. To assess the factors contributing to the achievement the glycemia normalization in patients with diabetes mellitus and obesity by adding to antihyperglycemic therapy (AT) a drug from the GLP-1 RA group liraglutide 3.0 mg per day. Materials and methods. A single-center, prospective, non-randomized study was provided. The objects of the study were patients with T2DM and obesity (n=22). Liraglutide 3.0 mg per day was added to the current AT of patients. Initially, the parameters of carbohydrate metabolism, hormones of the incretin system on an empty stomach and during the mixed-meal test, insulin resistance using the euglycemic hyperinsulinemic clamp test, and body composition were studied. After 9 months of therapy, all studies were repeated and a search for possible predictors of the carbohydrate metabolism normalization was made. Results. The body mass index of patients decreased from 42.4 [37.7; 45.0] to 35.9 [33.0; 40.9] kg/m2. Fasting blood glucose and glycated hemoglobin levels decreased from 9.02 [7.40; 11.37] mmol/L and 7.85 [7.43; 8.65]% up to 5.90 [5.12; 6.18] mmol/L and 6.40 [5.90; 6.60]%, respectively. 14 (63.6%) patients reached normoglycemia. Insulin resistance according to the clamp test did not change over the study. Basal concentrations of oxyntomodulin, glycentin and the area under the GLP-1, oxyntomodulin, glycentin curve significantly decreased 9 months after liraglutide administration. The prognostic marker of the achievement of normoglycemia during therapy with liraglutide 3.0 mg/day is the level of endogenous GLP-15.5 pmol/L before the appointment of arGPP-1 therapy. Conclusion. The concentration of endogenous GLP-1 before the appointment of liraglutide therapy at a dose of 3.0 mg per day can be used for prediction the drug hypoglycemic effect and achieving normoglycemia possibility.

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