The effect of osteopathic correction on the function of external respiration in patients after COVID -19 coronavirus pneumonia

2021 ◽  
pp. 8-17
Author(s):  
A. F. Belyaev ◽  
T. S. Kharkovskaya ◽  
O. N. Fotina ◽  
A. A. Yurchenko
Keyword(s):  
Respiratory Function ◽  
Vital Capacity ◽  
Pathological Condition ◽  
The Body ◽  
Lung Damage ◽  
External Respiration ◽  
Single Procedure ◽  
Arterial Blood ◽  
Number Of Patients ◽  
Coronavirus Infection

Introduction. The 2019 coronavirus infection (COVID-19) pandemic caused by a novel coronavirus strain (SARS-CoV-2) posed a serious threat to public health around the world. Postcoid syndrome (post-COVID-19 condition, according to ICD-10 code U09 State after COVID-19 or Postcoid state, Postcoid syndrome) is a pathological condition after a coronavirus infection, accompanied by cardio-respiratory, neurological, musculoskeletal, metabolic disorders. According to a number of studies, osteopathic methods of correction increase the lymph flow, immunological protection of the body, help to reduce pain, reduce the restriction of mobility in the chest, and therefore improve the function of external respiration. There are practically no studies that allow assessing the effect of osteopathic correction methods on the function of external respiration at the modern evidence-based level in patients who have undergone COVID pneumonia.The aim was to study the effect of a single procedure of osteopathic correction on the function of external respiration in patients during the rehabilitation period after coronavirus pneumonia.Materials and methods. On the basis of the Primorsky Institute of Vertebroneurology and Manual Medicine (Vladivostok) the rehabilitation of patients after coronavirus pneumonia was carried out using osteopathic correction. The study included 73 patients over the age of 60 years with varying degrees of lung damage and impaired respiratory function. To assess the function of external respiration, spirometry was performed and the vital capacity of the lungs was assessed; pulse oximetry was performed to measure the saturation of arterial blood hemoglobin with oxygen (SpO2). Osteopathic testing and treatment were carried out according to clinical guidelines, and the biomechanics of the chest was additionally investigated. The Statistica-10 software package was used for the statistical analysis of the obtained data.Results. Osteopathic examination revealed the presence of local somatic dysfunctions in 98,8 % of patients (spinal dysfunction, rib dysfunction, diaphragm dysfunction). 87,6 % of patients were diagnosed with regional somatic dysfunctions of thoracic region. Global somatic dysfunctions were diagnosed in 78,4 % of patients. After a single procedure of osteopathic correction, patients had a statistically significant improvement of the external respiration function, manifested in an increase in vital capacity from 78,27±2,79 to 85,36±3,38 % (p=0,0006). Also, the effectiveness of osteopathic correction is confirmed by a significant increase in the average hemoglobin saturation of arterial blood with oxygen. Thus, in patients with low SpO2 levels, the index increased from 94,21±0,21 to 95,09±0,3 % (p=0,02). After a single osteopathic correction procedure, the number of patients with local somatic dysfunctions decreased from 98,8 to 17,7 %; global somatic dysfunctions were revealed only in 16,3 % of patients. All patients noted an improvement in their general condition, a decrease in symptoms of respiratory discomfort and shortness of breath, and an increase in chest excursion.Conclusion. A single procedure of somatic dysfunctions' osteopathic correction in patients after coronavirus pneumonia leads to a statistically significant improvement in respiratory function. The vital capacity and the oxygen saturation of the blood increase in patients. This is caused by the increase of the mobility of the chest (increase in its excursion), diaphragm, ribs, spine. The obtained results allow recommend the inclusion of osteopathic correction in the rehabilitation programs for patients who have undergone coronavirus infection.

scholarly journals ANALYSIS OF DIAGNOSTIC PARAMETERS OF RESPIRATORY FAILURE IN PATIENTS WITH BRONCHIAL ASTHMA

2015 ◽  
Vol 4 (2) ◽  
pp. 10-12
Author(s):  
Dmitry Alexandrovich Anisimov ◽  
Lyudmila Nikitichna Goncharov ◽  
Anna Albertovna Dyachkova
Keyword(s):  
Respiratory Failure ◽  
Bronchial Asthma ◽  
Clinical Laboratory ◽  
Pathological Condition ◽  
External Respiration ◽  
Clinical Parameters ◽  
Arterial Blood ◽  
Criteria For Diagnosis ◽  
Invasive Techniques ◽  
Instrumental Methods

Respiratory failure (NAM)-a pathological condition in which there is provided the maintenance of normal blood gas or it is achieved through more intensive operation of external respiration and heart, resulting in decreased functional capacity of the organism [1,2]. The main method of diagnosis of DN is the study of the gas composition of the arterial blood, but because of the complexity of the analysis, which involves complex invasive techniques for obtaining arterial blood by puncture of a major artery in the therapeutic Department is not carried out [1,3]. A plurality of classifications days, the lack of clear criteria for diagnosis was to analyze assessment days by a combination of clinical, laboratory and instrumental methods patient days. As a model of acute respiratory failure were selected from patients with mild intermittent and persistent severity of asthma, which bore a slight aggravation, burdened days 1 severity, number of 30 people. SatO2 blood was the criterion for assessing the severity of DN. In the evaluation of clinical parameters, such as shortness of breath and respiratory rate, it was revealed that the values of these parameters increase is inversely proportional to the drop SatO2 blood. In assessing such clinical parameters as the rate of breathing and instrumental measure FEV1 did not find such dependence. Thus, to assess the severity of DN in patients with bronchial asthma it is necessary to conduct a comprehensive analysis of the clinical and instrumental methods.

scholarly journals CLINICAL SIGNIFICANCE OF CARDIAC AND RESPIRATORY ADJUSTMENTS IN CHRONIC ANEMIA

Blood ◽  
1948 ◽  
Vol 3 (4) ◽  
pp. 329-348 ◽  
Author(s):  
HERRMAN L. BLUMGART ◽  
MARK D. ALTSCHULE
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Carbonic Anhydrase ◽  
Carrying Capacity ◽  
Vital Capacity ◽  
The Body ◽  
Carbon Dioxide Transport ◽  
Chronic Anemia ◽  
Arterial Blood ◽  
Oxygen Carrying Capacity

Abstract The cardiac and respiratory adjustments in chronic anemia and their clinical manifestations have been reviewed. When the oxygen carrying capacity of the blood is diminished, an adequate supply of oxygen to the tissues is maintained by an increased cardiac output, an increased velocity of blood flow, and a relatively more complete abstraction of the oxygen from the blood as it passes through the capillaries. With the increased blood flow, the average peripheral resistance is decreased but the state of the small blood vessels is not uniform everywhere; the blood flow in the hands and kidneys, for instance, may be reduced, while that of other parts of the body is increased. The total oxygen consumption of the body in anemia is not strikingly altered. The blood volume generally is slightly reduced but the plasma volume is normal. The deviations from the normal values vary from patient to patient, but generally are definite when the hemoglobin values are less than 50 per cent and are greatest at the lowest levels of hemoglobin concentration. The close interrelationship between the cardiovascular and respiratory systems is exemplified by the coincident changes in the respiratory system in anemia. The rate and depth of respiration often are increased together with a lowering in the vital capacity and its subdivisions, the reserve and complemental air volumes. The resid- ual air is somewhat increased. These deviations from the normal are similar to those observed in pulmonary congestion or edema and denote a loss of elasticity and expansibility favoring the occurrence of exertional dyspnea. The arterial blood saturation is usually normal at rest but, during exertion, a significant lowering becomes apparent. The importance of hemoglobin in the transport of carbon dioxide is reviewed; the decreased availability of hemoglobin as a buffer in carbon dioxide transport in anemia is compensated by the increased ventilation of the blood in the lungs, rendering the arterial blood somewhat alkalotic. The red cells also play an important role in regard to the respiratory enzyme, carbonic anhydrase. In the anemias due to blood loss, malnutrition, chronic infection, uremia, or leukemia, the blood carbonic anhydrase activity is parallel to the decrease in hemoglobin level leading to a deficiency not only of oxygen carrying capacity but also a decreased ability to absorb carbon dioxide from the tissues and to release it in the lungs. The following factors, many of which are closely interrelated, are operative in the production of dyspnea in anemic patients: the increased respiratory minute volume, the decreased vital capacity and its subdivisions, the abnormalities in carbon dioxide transport and dissociation, the reduced arterial oxygen capacity and the decreased blood oxygen saturation during effort, and the frequently observed elevated blood lactic acid values. The symptoms and signs exhibited by anemic patients, including palpitation and breathlessness on exertion, tachycardia, cardiac dilatation and hypertrophy, are described. In addition to an apical systolic murmur, other systolic and diastolic murmurs are occasionally heard. The arterial blood pressure is frequently lowered in anemia; the venous pressure is generally within the limits of normal. Electrocardiographic abnormalities occur in approximately one-quarter of anemic patients but are minor and not specific in character. The occurrence of angina pectoris, congestive failure, and intermittent claudication in some patients with the development of anemia, and disappearance of these conditions as the anemia is alleviated, is discussed with particular reference to the underlying physiologic mechanisms.

scholarly journals Medical rehabilitation for coronavirus infection: new challenges for physical and rehabilitation medicine in Russia

2020 ◽  
Vol 97 (3) ◽  
pp. 14-21 ◽  
Author(s):  
A.A. Shmonin ◽  
M.N. Maltseva ◽  
E.V. Melnikova ◽  
I.E. Mishina ◽  
G.E. Ivanova
Keyword(s):  
Pulmonary Rehabilitation ◽  
Rehabilitation Medicine ◽  
Medical Rehabilitation ◽  
Lung Damage ◽  
Risk Of Infection ◽  
Physical And Rehabilitation Medicine ◽  
Number Of Patients ◽  
Infectious Disease Specialists ◽  
Coronavirus Infection ◽  
New Challenges

Coronavirus infection causes lung damage and leads to the development of disabling conditions. The development of the Covid-19 pandemic leads to a one-stage increase in the number of patients who need assistance not only from infectious disease specialists and intensive care specialists, but also from rehabilitation specialists. However, patients suffering from other non-infectious conditions need rehabilitation despite the pandemic. Thus, rehabilitation specialists are faced with new tasks to organize rehabilitation in the epidemic for both patients with Covid-19 and patients at high risk of infection, but without coronavirus infection, to develop specific programs for pulmonary rehabilitation, data collection on the nature of disability, organization of outpatient programs and telerehabilitation.

Features of the course of new coronaviral infection (COVID-19) in patients with acute kidney injury and end stage renal failure

2021 ◽  
Vol 25 (6) ◽  
pp. 71-75
Author(s):  
N. V. Agranovich ◽  
L. I. Tkachenko ◽  
S. A. Knyshova ◽  
M. V. Titorenko ◽  
A. P. Lichacheva
Keyword(s):  
Acute Kidney Injury ◽  
Clinical Laboratory ◽  
Kidney Injury ◽  
Kidney Damage ◽  
Lung Damage ◽  
Newly Diagnosed ◽  
Negative Effects ◽  
Arterial Blood ◽  
Coronavirus Infection ◽  
Group 2

BACKGROUND. In the modern era, COVID-19 is the biggest problem facing doctors and scientists around the world. SARSCоV-2 is a multisystem infection that is not limited to lung damage and has the immuno-mediated effect of negative effects on organs and systems, including the kidneys. To date, there is no precise understanding of the pathogenesis of nephrological disorders in patients with COVID-19. Patients with chronic kidney disease (CKD) are a group of particularly high risk of CO-VID-19 infection and high mortality in the development of the disease.THE AIM: to evaluate the features of the course of a new coronavirus infection (COVID 19) in patients with acute kidney injury and terminal renal insufficiency.PATIENTS AND METHODS. The study of clinical, laboratory and instrumental parameters was carried out in 119 patients (67 men and 52 women) diagnosed with COVID-19. The average age of the patients was 63.1±1.7 years. All patients were divided into two groups: group 1 - patients with CKD and HD, group 2 - patients with newly diagnosed kidney damage against the background of coronavirus infection (COVID-19). Statistical data analysis was carried out using the software package "IBM SPSS Statistics 21.0" (USA) (Russified version).RESULTS. As a result of the study, it was found that in the clinical picture of COVID-19 patients suffering from CKD and undergoing hemodialysis, such a symptom as myalgia was noted 2 times more often, the percentage of saturation of arterial blood hemoglobin with oxygen (SaO2,%) was significantly lower compared to patients with newly diagnosed kidney damage on the background of infection. The duration of the temperature reaction during the disease was 5 times longer than in patients without CKD. Although the incidence of lung damage in patients of both groups was identical, mortality was significantly higher in the group of patients with CKD.CONCLUSION. In the patients examined by us, proteinuria, an increase in the level of nitrogenous metabolites, as well as D-dimers in both groups, are associated with increased mortality. Mortality in patients with CKD and HD was several times higher than in those without pathology of the urinary system. The severity of the patients' condition was primarily due to the symptoms of damage to the respiratory system, but the degree of renal dysfunction is undoubtedly an important prognostic value. Thus, monitoring the state of individual nephron structures in patients with CO-VID-19 is of great importance, and emergency nephroprotective measures may be crucial in the fight against cytokine storm.

scholarly journals Results of Open-Label non-Randomized Comparative Clinical Trial: “BromhexIne and Spironolactone for CoronаvirUs Infection requiring hospiTalization (BISCUIT)

Kardiologiia ◽  
2020 ◽  
Vol 60 (11) ◽  
pp. 4-15
Author(s):  
V. Yu. Mareev ◽  
Ya. A. Orlova ◽  
A. G. Plisyk ◽  
E. P. Pavlikova ◽  
S. T. Matskeplishvili ◽  
...  
Keyword(s):  
Thrombus Formation ◽  
Clinical Status ◽  
Randomized Study ◽  
Lung Damage ◽  
Control Group ◽  
Virus Elimination ◽  
Combine Endpoint ◽  
Positive Polymerase Chain Reaction ◽  
Number Of Patients ◽  
Coronavirus Infection

Introduction The aim of this study was to assess the efficacy and safety of a combination of bromhexine at a dose of 8 mg 4 times a day and spironolactone 50 mg per day in patients with mild and moderate COVID 19.Material and methods It was an open, prospective comparative non-randomized study. 103 patients were included (33 in the bromhexine and spironolactone group and 70 in the control group). All patients had a confirmed 2019 novel coronavirus infection (COVID 19) based on a positive polymerase chain reaction (PCR) for SARS-CoV-2 virus RNA and/or a typical pattern of viral pneumonia on multispiral computed tomography. The severity of lung damage was limited to stage I-II, the level of CRP should not exceed 60 mg / dL and SO2 in the air within 92-98%. The duration of treatment is 10 days.Results The decrease in scores on the SHOKS-COVID scale, which, in addition to assessing the clinical status, the dynamics of CRP (a marker of inflammation), D-dimer (a marker of thrombus formation), and the degree of lung damage on CT (primary endpoint) was statistically significant in both groups and differences between them was not identified. Analysis for the group as a whole revealed a statistically significant reduction in hospitalization time from 10.4 to 9.0 days (by 1.5 days, p=0.033) and fever time from 6.5 to 3.9 days (by 2.5 days, p<0.001). Given the incomplete balance of the groups, the main analysis included 66 patients who were match with using propensity score matching. In matched patients, temperature normalization in the bromhexine/spironolactone group occurred 2 days faster than in the control group (p=0.008). Virus elimination by the 10th day was recorded in all patients in the bromhexine/spironolactone group; the control group viremia continued in 23.3% (p=0.077). The number of patients who had a positive PCR to the SARS-CoV-2 virus on the 10th day of hospitalization or longer (≥10 days) hospitalization in the control group was 20/21 (95.2%), and in the group with bromhexine /spironolactone -14/24 (58.3%), p=0.012. The odds ratio of having a positive PCR or more than ten days of hospitalization was 0.07 (95% CI: 0.008 - 0.61, p=0.0161) with bromhexine and spironolactone versus controls. No side effects were reported in the study group.Conclusion The combination of bromhexine with spironolactone appeared effective in treating a new coronavirus infection by achieving a faster normalization of the clinical condition, lowering the temperature one and a half times faster, and reducing explanatory combine endpoint the viral load or long duration of hospitalization (≥ 10 days).

scholarly journals WORK EXPERIENCE BUREAU OF FORENSIC MEDICINE OF MOSCOW REGION IN THE CONTEXT OF A PANDEMIC CAUSED BY A NEW CORONAVIRUS INFECTION

2020 ◽  
Author(s):  
A. Maksimov
Keyword(s):  
Work Experience ◽  
Diffuse Alveolar Damage ◽  
Age Groups ◽  
The Body ◽  
Lung Damage ◽  
Internal Organs ◽  
Forensic Research ◽  
Qualitative Variables ◽  
Coronavirus Infection ◽  
Common Sign

The article presents the results of studying cases of deaths of individuals from a new coronavirus infection according to forensic research. Aim. Based on the study of the results of forensic research of corpses to generalize and identify patterns of damage to internal organs and body systems in cases of death from COVID-19 without medical assistance. Material and methods. We studied 198 cases of fatal outcomes from a new coronavirus infection. We determined the frequency of fatal outcomes in various age groups. The leading morphological manifestations of internal organ lesions were established. Absolute (abs) and relative (%) frequencies were calculated for qualitative variables. Conclusion. In the structure of mortality from COVID-19 outside medical organizations, the proportion of deaths of elderly (60-80 years) and senile (over 80 years) age was 74.2%. Among the internal organs, the lungs are the most susceptible to changes. in 77.8% of cases, pathological changes corresponded to the acute phase of diffuse alveolar damage. In addition to lung damage, the most common sign was the depletion of spleen parenchyma by lymphocytes, indicating an immune inflammatory response of the body. The identified characteristic morphological signs of alveolar lung damage in OT CAVID-19 can be used as a differential diagnosis of lung damage from shocks of other etiology

scholarly journals Features of glucocorticoides using for treatment of a patient with a new coronaviral infection in the conditions of the observator on the basis of students’ dormitory. Clinical case

2020 ◽  
Vol 24 (3) ◽  
pp. 27-32
Author(s):  
Olga Yu. Kuznetsova ◽  
Anna V. Lubimova ◽  
Zhanna V. Pleshanova ◽  
Olga S. Zamyatina ◽  
Nikita V. Donetskov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Treatment Regimen ◽  
Severe Disease ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Early Period ◽  
Lung Damage ◽  
Medical Monitoring ◽  
Number Of Patients ◽  
Coronavirus Infection

The article is devoted to the peculiarities of providing medical care for coronavirus infection in a university student who has been moved to an observatory organized in a hotel-type hostel of the university to prevent the spread of COVID-19 among students living in hostels. The article provides data on the positive experience of using dexamethasone in the treatment regimen for moderately severe disease, follow-up and examination data. The article considers the tactics of managing a patient with suspected COVID-19 in the presence of data for pneumonia according to computed tomography and clinical manifestations characteristic of a new coronavirus infection, which was later confirmed in the study of antibodies to SARS-CoV-2. The importance of round-the-clock medical monitoring of persons placed in the observatory, finding out the details of the epidemiological history from them, as well as determining the tactics of their treatment with limited hospitalization opportunities in a growing number of patients with severe manifestations of COVID-19 requiring inpatient treatment is emphasized. A new coronavirus infection can lead to a rapid deterioration of the condition in young patients, which is not always manifested by severe lung damage according to computed tomography data, but is characterized by persistent fever that cannot be stopped by antipyretics, as well as severe muscle pain, severe asthenia, which can be considered as clinical indicators of the development of hyperactive inflammatory syndrome. The use in the treatment regimen of intravenous dexamethasone at a dose of 0.1 mg / kg of body weight twice led to a rapid normalization of temperature, relief of all clinical symptoms and was not accompanied by any complications both in the early period of convalescence and 2 months after discharge from the observatory.

scholarly journals Practical Experience of Using Riamilovir in Treatment of Patients with Moderate COVID-19

2020 ◽  
Vol 65 (7-8) ◽  
pp. 27-30
Author(s):  
A. U. Sabitov ◽  
V. V. Belousov ◽  
A. S. Edin ◽  
E. V. Oleinichenko ◽  
E. P. Gladunova ◽  
...  
Keyword(s):  
Ct Scan ◽  
Complete Resolution ◽  
Practical Experience ◽  
The Body ◽  
Lung Damage ◽  
Pcr Analysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Number Of Patients ◽  
Time Required

The article evaluates the results of Riamilovir use in treatment of patients with a moderate form of the disease caused by a new strain of the SARS-CoV-2 virus. It was found that the average time required to complete resolution of symptoms during treatment with the drug was 6-7 days. The first negative result of PCR analysis for the SARS-CoV-2 virus was registered on the 10-11th day of therapy; two consecutive negative PCR results for the SARS-CoV-2 virus were registered in the majority of patients by day 14–19 of treatment in 63±4.28%. The body temperature of the majority of patients (75%) returned to normal by the 4th day of treatment. CT scan showed improvement in the lungs of patients: a repeated CT scan performed on average on day 19 from the start of therapy showed no lung damage or no progression in 10±3.0% of patients following therapy. The CT scan of the lungs performed in 1-2 months after the treatment showed that the number of patients with no lung damage increased to 27±4.44%. As a result of treatment, a decrease in the C-reactive protein index was observed in patients. The tolerability level of the drug was assessed as good: no adverse events or significant deviations in laboratory parameters were detected.

scholarly journals Age features of O2 mass transfer regimes in adolescents’ body at rest

2021 ◽  
Vol 11 (12) ◽  
pp. 344-349
Author(s):  
D. Komolafe ◽  
M. Filippov ◽  
V. Ilyin ◽  
A. Klimenko
Keyword(s):  
Mass Transfer ◽  
Quantitative Relationship ◽  
The Body ◽  
External Respiration ◽  
Oxygen Utilization ◽  
Cardiorespiratory System ◽  
Arterial Blood ◽  
Age Related ◽  
System Functioning ◽  
Age Features

The results of complex studies of the quantitative relationship between the stage-by-stage mass transfer of O2 and the efficiency of cardiorespiratory system functioning in relation to its consumption in adolescents’ body under conditions of relative rest are presented. The results obtained show that in adolescents, the modes of mass transfer of O2 in the body and the nature of the respiratory and circulatory systems functioning in relation to its consumption have a number of age-related differences compared with adult men. So, in adolescents, the external respiration system at rest functions less economically than in adults. Each liter of O2 consumed by adolescents is extracted from almost 3 liters more than in adults the amount of air ventilated per minute through the lungs. The volumetric indicators of blood circulation are also higher in adolescents, which may indicate the influence of neuro-humoral rearrangements in the body during the pubertal period. The coefficient of oxygen utilization by tissues from arterial blood in adolescents turned out to be significantly higher, which may characterize a higher tension of tissue metabolic processes.

STEROID RECEPTOR PHENOTYPE, EXPRESSION OF HER-2/NEU, PD-1, PD-L1 AND LYMPHOCYTIC-MACROPHAGAL INFILTRATION OF ENDOMETRIAL CARCINOMAS: COMPARISON OF MODERN MOLECULAR BIOLOGICAL TYPES OF THE DISEASE (THE ROLE OF BODY MASS INDEX)

2020 ◽  
Vol 66 (1) ◽  
pp. 71-78
Author(s):  
Lev Bershteyn ◽  
Aleksandr Ivantsov ◽  
Aglaya Ievleva ◽  
A. Venina ◽  
I. Berlev
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Tumor Tissue ◽  
Immunohistochemical Analysis ◽  
The Body ◽  
Molecular Profile ◽  
Total N ◽  
Number Of Patients ◽  
Her 2

The aim of this study was to evaluate steroid receptors’ status of tumor tissue in different molecular biological types of endometrial cancer (EC), subdivided according to the current classification, and their colonization by lymphocytic and macrophage cells, taking into account body mass index of the patients. Materials and methods: Material from treatment-naive patients with EC (total n = 229) was included; the number of sick persons varied depending on the method used. The average age of patients was close to 60 years, and about 90% of them were postmenopausal. It was possible to divide the results of the work into two main subgroups: a) depending on the molecular biological type of the tumor (determined on the basis of genetic and immunohistochemical analysis), and b) depending on the value of the body mass index (BMI). The latter approach was used in patients with EC type demonstrating a defective mismatch repair of the incorrectly paired nucleotides (MMR-D) and with a type without characteristic molecular profile signs (WCMP), but was not applied (due to the smaller number of patients) in EC types with a POLE gene mutation or with expression of the oncoprotein p53. According to the data obtained, when comparing various types of EC, the lowest values of Allred ER and PR scores were revealed for POLE-mutant and p53 types, while the “triple-negative” variant of the tumor (ER-, PR-, HER2/neu-) was most common in POLE-mutant (45.5% of cases) and WCMP (19.4%) types of EC. The p53+ type of EC is characterized by inclination to the higher expression of the macrophage marker CD68 and lymphocytic Foxp3, as well as mRNA of PD-1 and SALL4. In addition to the said above, for WCMP type of EC is peculiar, on the contrary, a decrease in the expression of lymphocytic markers CD8 (protein) and PD-L1 (mRNA). When assessing the role of BMI, its value of >30.0 (characteristic for obesity) was combined with an inclination to the increase of HER-2/neu expression in the case of MMR-D EC type and to the decrease of HER-2 /neu, FOXp3 and ER expression in WCMP type. Conclusions: The accumulated information (mainly describing here hormonal sensitivity of the tumor tissue and its lymphocytic-macrophage infiltration) additionally confirms our earlier expressed opinion that the differences between women with EC are determined by both the affiliation of the neoplasm to one or another molecular biological type (subdivided according to the contemporary classification), as well as by body mass value and (very likely) the associated hormonal and metabolic attributes.

Sign in / Sign up

Export Citation Format

Share Document