scholarly journals Leptin Concentrations in Maternal and Umbilical Cord Blood in Relation to Maternal Weight, Birth Weight and Weight of the Placenta

1970 ◽  
Vol 23 (1) ◽  
pp. 3-7 ◽  
Author(s):  
S Ishrat ◽  
MW Rahman ◽  
MR Rahman ◽  
MZ Hussain ◽  
S Jahan
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Fetal Growth ◽  
Leptin Receptor ◽  
Venous Blood ◽  
The Body ◽  
Placental Weight ◽  
Enzyme Linked Immunosorbent Assay ◽  
Maternal Weight ◽  
Serum Leptin

Objective: Leptin is a hormone which regulates adipose tissue mass of the body. Substantial increase of leptin during pregnancy and detection of leptin and leptin receptor in placenta have led to the speculation that leptin is a gestational hormone with a possible role in regulation of fetal growth. The study was done to find out whether maternal and cord blood leptin correlate with birthweight and weight of the placenta. Materials and methods: A prospective cross sectional study was undertaken in the Department of Obsterics and Gynecology, Bangabandhu Sheikh Mujib Medical University from January 2005 to June 2005. The study was carried out on 39 pairs of mothers and newborns. Maternal venous blood was sampled just before delivery. Cord blood was obtained, birth weight and placental weight measurements were taken just after delivery of the baby. Serum leptin levels were measured by enzyme linked immunosorbent assay. Results: Maternal serum leptin was 24.50 ng/ml (range- 13.15-45.60 ng/ml) and cord serum leptin was 6.50 ng/ml (range- 2.02-12.30 ng/ml). There was no correlation between maternal leptin and birth weight or between maternal leptin and placental weight. Cord leptin was significantly correlated with birth weight but not with placental weight. There was no correlation between maternal and cord blood leptin. There was no significant gender differences in cord blood leptin concentrations. Conclusions: There may be an important role of leptin in regulation of fetal growth and development. Placenta may not be a major source of leptin in maternal and feto-placental circulation. Maternal leptin cannot be a reliable marker of fetal growth. Keywords: Serum leptin, birth weight, placental weight   doi: 10.3329/bjog.v23i1.3049 Bangladesh J Obstet Gynaecol, 2008; Vol. 23(1) : 3-7

scholarly journals Maternal Serum and Cord Blood Leptin Concentrations at Delivery in Normal Pregnancies and in Pregnancies Complicated by Intrauterine Growth Restriction

Obesity Facts ◽  
2021 ◽  
pp. 1-8
Author(s):  
Małgorzata Stefaniak ◽  
Ewa Dmoch-Gajzlerska
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Intrauterine Growth Restriction ◽  
Maternal Serum ◽  
Serum Leptin ◽  
Intrauterine Growth ◽  
The Mean ◽  
Maternal Bmi

<b><i>Introduction:</i></b> Leptin is a polypeptide hormone, and in pregnancy, it is secreted by the placenta and maternal and fetal adipose tissues. Normal leptin production is a factor responsible for uncomplicated gestation, embryo development, and fetal growth. The study compared maternal serum and cord blood leptin concentrations at delivery in normal pregnancies and in pregnancies complicated by intrauterine growth restriction (IUGR). <b><i>Methods:</i></b> The study was performed in 25 pregnant women with isolated IUGR and in 194 pregnant women without any complications. Leptin concentrations in maternal serum and in cord blood samples collected at delivery were measured by ELISA and subsequently analyzed by maternal body mass index (BMI), mode of delivery, and infant gender and birth weight. For comparative analyses of normally distributed variables, parametric tests were used, that is, the Student <i>t</i> test and a one-way ANOVA. The nonparametric Mann-Whitney test was used when the distribution was not normal. The Pearson correlation coefficient was calculated to assess the correlation between normally distributed variables (<i>p</i> &#x3c; 0.05). <b><i>Results:</i></b> In pregnancies complicated by IUGR, the mean maternal serum leptin concentration at delivery was significantly higher (52.73 ± 30.49 ng/mL) than in normal pregnancies (37.17 ± 28.07 ng/mL) (<i>p</i> = 0.01). The mean cord blood leptin concentration in pregnancies complicated by IUGR was 7.97 ± 4.46 ng/mL and significantly lower than in normal pregnancies (14.78 ± 15.97 ng/mL) (<i>p</i> = 0.04). In normal pregnancies, but not in pregnancies complicated by IUGR, a statistically significant correlation was established between maternal serum leptin concentrations and maternal BMI at delivery (<i>r</i> = 0.22; <i>p</i> = 0.00). No statistically significant correlation was found between cord blood leptin concentrations and maternal BMI in either study subjects or controls. In normal pregnancies, but not in pregnancies complicated by IUGR, a strong correlation was observed between cord blood leptin concentrations and birth weight (<i>r</i> = 0.23; <i>p</i> = 0.00). <b><i>Conclusions:</i></b> Elevated maternal blood leptin concentrations in pregnancies complicated by IUGR may indicate a significant adverse effect of elevated leptin on fetal growth. The differences in leptin concentrations, measured in maternal serum and in cord blood, between the study subjects and controls suggest that deregulated leptin levels may increase the risk of obstetric complications associated with placental insufficiency.

Relationship between Leptin Concentration in Cord Blood and Foetal Growth and Maternal Anthropometry of GDM Mothers at Delivery

1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas
Keyword(s):  
Body Mass Index ◽  
Birth Weight ◽  
Cord Blood ◽  
Body Mass ◽  
Anthropometric Measurements ◽  
Anthropometric Parameters ◽  
Serum Leptin ◽  
C Peptide ◽  
Cord Serum ◽  
The Relationship

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)

scholarly journals Expression patterns of GHRL, GHSR, LEP, LEPR, SST and CCK genes in the gastrointestinal tissues of Tibetan and Yorkshire pigs

2019 ◽  
Vol 64 (No. 6) ◽  
pp. 239-247
Author(s):  
Wen-Kui Sun ◽  
Chi Cheng ◽  
Rui Liu ◽  
Yi-Hui Chen ◽  
Kai Zeng ◽  
...  
Keyword(s):  
Feed Intake ◽  
Plasma Levels ◽  
Target Genes ◽  
Leptin Receptor ◽  
Expression Patterns ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mrna Levels ◽  
Growth Difference ◽  
Yorkshire Pigs

The aim was to characterize the expression patterns of several genes in the gastrointestinal tracts of Tibetan pigs (TP) and Yorkshire pigs (YP) and to explore their correlation with digestion and growth difference of the two breeds. The body weights and growth of YP and TP were studied at 6, 12 and 24 weeks of age, and their plasma levels of ghrelin (GHRL), leptin (LEP), somatostatin (SST) and cholecystokinin (CCK) were determined by enzyme linked immunosorbent assay (ELISA). Blood and gastrointestinal sections (stomach, duodenum, jejunum, ileum, caecum and colon) were collected and assayed for mRNA expression of the six genes (GHRL, ghrelin receptor (GHSR), LEP, leptin receptor (LEPR), SST and CCK) by reverse transcription-qPCR (RT-qPCR). TP generally had higher mRNA expressions of GHSR, LEP, LEPR, SST and CCK genes compared to YP, and expressed lower levels of the GHRL gene in most tissues of the digestive tract. In both breeds, plasma levels of the expressed proteins were more closely correlated with the feed intake and growth than with mRNA levels of the target genes. Our data indicate that TP possess special gene expression patterns in the gastrointestinal tract compared to YP, which is consistent with its unique feed intake and adaptation to harsh environment.

scholarly journals Fetal Thyroid Hormone Level at Birth Is Associated with Fetal Growth

2011 ◽  
Vol 96 (6) ◽  
pp. E934-E938 ◽  
Author(s):  
Beverley M. Shields ◽  
Beatrice A. Knight ◽  
Anita Hill ◽  
Andrew T. Hattersley ◽  
Bijay Vaidya
Keyword(s):  
Birth Weight ◽  
Thyroid Hormone ◽  
Cord Blood ◽  
Thyroid Function ◽  
Fetal Growth ◽  
Late Gestation ◽  
Third Trimester ◽  
Free T4 ◽  
Skeletal Size ◽  
Fetal Thyroid

Context: Thyroid function is known to play an important role in fetal neurological development, but its role in regulating fetal growth is not well established. Overt maternal and fetal thyroid disorders are associated with reduced birth weight. We hypothesized that, even in the absence of overt thyroid dysfunction, maternal and fetal thyroid function influence fetal growth. Aim: In normal, healthy pregnancies, we aimed to assess whether fetal thyroid hormone at birth (as measured in cord blood) is associated with fetal growth. We also aimed to study whether fetal thyroid hormone at birth is associated with maternal thyroid hormone in the third trimester. Methods: In 616 healthy mother-child pairs, TSH, free T4 (FT4), and free T3 (FT3) were measured in mothers at 28 wk gestation and in umbilical cord blood at birth. Birth weight, length, head circumference, and tricep and bicep skinfold thicknesses were measured on the babies. Results: Cord FT4 was associated with birth weight (r = 0.25; P &lt; 0.001), length (r = 0.17; P &lt; 0.001), and sum of skinfolds (r = 0.19; P &lt; 0.001). There were no associations between birth measurements and either cord TSH or cord FT3. Maternal FT4 and cord FT4 were correlated (r = 0.14; P = 0.0004), and there were weaker negative associations between maternal TSH and cord FT4 (r = −0.08; P = 0.04) and FT3 (r = −0.10; P = 0.01). Conclusion: Associations between cord FT4 and birth size suggest that fetal thyroid function may be important in regulating fetal growth, both of skeletal size and fat. The correlation between third-trimester maternal FT4 and cord FT4 supports the belief that maternal T4 crosses the placenta even in late gestation.

scholarly journals Fetal growth and ratio of placental weight to birth weight.

BMJ ◽  
1992 ◽  
Vol 304 (6827) ◽  
pp. 638-638 ◽  
Author(s):  
R. De Courcy-Wheeler ◽  
C. Wolfe
Keyword(s):  
Birth Weight ◽  
Fetal Growth ◽  
Placental Weight

scholarly journals The content of gas transmitters in umbilical cord blood and blood of newborns born to mothers with preeclampsia

2021 ◽  
Vol 66 (4) ◽  
pp. 53-57
Author(s):  
I. G. Popova ◽  
O. G. Sitnikova ◽  
S. B. Nazarov ◽  
G. N. Kuzmenko ◽  
M. M. Klychevа ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Life Support ◽  
Venous Blood ◽  
The Body ◽  
Control Group ◽  
Control Groups ◽  
And Control

To assess endothelial function in the newborns born to mothers with preeclampsia and without preeclampsia the scientists assessed the content of nitricoxide and hydrogen sulfide in the umbilical and venous blood of these children. The main group consisted of 80 women with moderate preeclampsia and their80 newborns; the control group included 50 children born to women without preeclampsia. The authors studied the content of nitric oxide by determining the totalnitrates and nitrites (NOx), hydrogen sulfide in mixed cord blood collected within 30 minutes after delivery, and venous blood taken from newborns on the 1-3rd day of life. Umbilical cord blood demonstrated no significant differences in the content of NO xand hydrogen sulfide in newborns of the main and control groups. However, in general, the study of umbilical cord blood revealed a relationship between the concentration of hydrogen sulfide and the possibility of developing intraventricular hemorrhagein a newborn of the main and control groups. In the venous blood there was a significant increase in the content of NOx and hydrogen sulfide in newborns born to mothers with preeclampsia. It may cause vasodilation asa compensatory reaction of the body during the period of postnatal adaptation of the child’s body, aimed at life support.

scholarly journals Umbilical Cord Blood Culture in General in the Diagnosis of Sageis Newborns

2020 ◽  
pp. 126-131
Author(s):  
Naredra P. Porval ◽  
Kanvikar Reshmi ◽  
D. B. Potdar ◽  
S. B. Karanjkar
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
High Risk ◽  
Blood Culture ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Neonatal Sepsis ◽  
Venous Blood ◽  
Peripheral Venous Blood

Worldwide neonatal sepsis is among the most frequent causes of neonatal death. Various studies have tried to establish the relationship between prevalence of neonatal septicemia risk factors and bacteriological profiling, low birth weight, prematurity, etc. Current study was aimed to compare early onset of neonatal sepsis (EONS) among primigravida and multigravida mothers using umbilical cord blood (UCB) and peripheral venous blood (PVB) samples. It was also aimed to establish the utilization of umbilical cord blood culture (UCBC) in comparison to peripheral venous blood culture (PVBC) in identifying EONS. In present study the blood samples were collected from high risk neonates for the clinical blood culture and screening. Among the 75 neonates in the study, 24 (32.0%) were observed to have sepsis screen positive. Study of high risk neonates umbilical cord blood culture (UCBC) positivity was 17.3% while Peripheral Venous blood culture positivity was 5.3%. Moreover,  in this study all risk factors like Prematurity, Low birth weights, Premature rupture of membrane, and birth asphyxia were significantly (p<0.05) associated with UCBC growth/positivity. Low birth weight (86%) was mostly reported in the high risk neonates with other associated sepsis factors. Similarly maternal fever and prolonged rupture of membrane was highly significantly (p<0.01) associated with UCBC positivity. Gram negative bacterias  were  more  commonly found,  such as Pseudomonas (5.3%), followed by E. coli (4%), and Klebsiella (2.7%) and gram positive Streptococcus sp. (2.7%), etc. From our analysis it can be said that the UCBC has strong diagnostic outcomes as compared to the PVBC for etiological evaluation of bacterial sepsis in neonates at high risk.

scholarly journals Korelasi persentase lemak tubuh dengan kadar adipsin pada premenopause

2018 ◽  
Vol 14 (3) ◽  
pp. 99
Author(s):  
Rahmani Welan ◽  
Gusti Revilla ◽  
Desmawati Desmawati
Keyword(s):  
Body Fat ◽  
Venous Blood ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Cross Sectional ◽  
The Mean

Background: One of the conditions on premenopausal period is the increase in body fat, among which are caused by levels of the fluctuating estrogen hormone. Increase fat affects the body fat percentage and adipsin levels. Adipsin plays a role in the stimulation of insulin secretion by producing C3a, in which C3AR1 (C3a Receptor 1) fragments interact with beta cells to secrete insulin.Objective: The purpose of this study is to determine correlation of body fat percentage with adipsin levels on premenopause.Design: This was an analytical study with cross-sectional design. Body fat percentage was obtained by examination using Bioelectrical Impedance Analysis (BIA). Venous blood was taken at the mediana cubiti area used for serum adipsin levels. Adipsin levels were analyzed by Enzyme-linked Immunosorbent Assay (ELISA) technique.Results: The mean of body fat percentage on premenopausal was 36,18 ± 8,35%. The mean of adipsin levels on premenopausal was 117,05 ± 87,93 ng/ml. Result of Pearson test analysis got value r = 0,632 and value p = 0.0005 (p <0,05).Conclusions: There is a positive significant correlation between the percentage of body fat with adipsin levels on premenopause.

scholarly journals Pengaruh berat badan induk terhadap berat lahir dan pertambahan bobot badan pedet pada sapi bali yang dipelihara secara semi-intensif di kabupaten belu

2019 ◽  
Vol 7 (1) ◽  
pp. 62-69
Author(s):  
Jenitha Verawati Fallo ◽  
Enike Dwi Kusumawati ◽  
Aju Tjatur Nugroho Krisnaningsih
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Birth Weight ◽  
Body Weight Gain ◽  
Parent Body ◽  
The Body ◽  
Maternal Weight ◽  
Weight Group ◽  
Maintenance System ◽  
Daily Body Weight

Abstrak Tujuan penelitian ini untuk mengetahui pengaruh berat badan induk terhadap berat lahir dan pertambahan bobot badan pedet pada sapi Bali yang dipelihara secara semi-intensif. Materi yang digunakan dalam penelitian ini adalah 30 ekor induk sapi Bali dengan umur 3-5 tahun dan 30 ekor pedet sapi Bali dari tahun 2015 sampai 2017. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan analisis data dari data recording, dengan 3 perlakuan yaitu P1 bobot badan 151-200 Kg, P2 bobot badan 201-250 Kg, P3 bobot badan 251-300 Kg dengan masing-masing perlakuan di ulangan 10 kali. Variabel yang diukur adalah berat lahir sapi Bali dan pertambahan bobot badan harian, data dianalisa menggunakan analisa varian.Hasil dari penelitian ini menunjukkan bahwa berat badan induk tidak memberikan pengaruh yang nyata terhadap berat lahir dan pertambahan bobot badan pedet pada sapi Bali yang dipelihara secara semi-intensif (P>0,05), dengan berat lahir pedet tertinggi 20 Kg pada kelompok bobot badan induk 251 – 300 Kg, demikian pula pada kelompok bobot badan induk 251-300 Kg pertambahan bobot badan pedet tertimggi adalah 0,87 Kg. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa berat lahir dan pertambahan bobot badan pedet pada sapi Bali tidak dipengaruhi oleh berat badan induk pada sistem pemeliharaan semi-intensif.   Abstract The purpose of this study was to determine the effect of maternal weight on birth weight and calf weight gain in semi-intensive Balinese cattle.The material used in this study were 30 Balinese cows with 3-5 years of age and 30 Balinese calves from 2015 to 2017. The method used in this study was a quantitative method by analyzing data from recording data, with 3 treatments namely P1 body weight 151-200 Kg, P2 body weight 201-250 Kg, P3 body weight 251-300 Kg with replication is not the same, namely 10 replications. The variables measured were Bali cattle birth weight and daily body weight gain and analyzed the data using a completely randomized design.The results of this study indicate that maternal body weight did not have a significant effect on birth weight and calf weight gain in semi-intensive Balinese cattle (P> 0.05), with the highest calf birth weight 20 Kg in the body weight group the main 251 - 300 Kg, as well as the parent body weight 251-300 Kg the highest increase in calf body weight was 0.87 Kg. Based on the results of this study it can be concluded that birth weight and calf weight gain in Balinese cattle are not influenced by the body weight of the semi-intensive maintenance system.

scholarly journals Fetal growth and ratio of placental weight to birth weight.

BMJ ◽  
1992 ◽  
Vol 304 (6833) ◽  
pp. 1052-1052
Author(s):  
D. G. Altman ◽  
J. M. Bland ◽  
L. Meyer
Keyword(s):  
Birth Weight ◽  
Fetal Growth ◽  
Placental Weight
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