scholarly journals A review on antidepressant effect of medicinal plants

2017 ◽  
Vol 12 (1) ◽  
pp. 1 ◽  
Author(s):  
Zahra Rabiei ◽  
Sana Rabiei
Keyword(s):  
Medicinal Plants ◽  
Complete Recovery ◽  
Antidepressant Effect ◽  
Common Disease ◽  
Pubmed Central ◽  
Synaptic Regulation ◽  
Synthetic Drugs ◽  
Antidepressant Effects ◽  
Life Threatening ◽  
Anti Oxidant

<p class="Abstract">Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of patients. At the same time, medicinal plants have been reported to exert optimal pharmacological effects in treating depression in different models. In this review, the relevant articles indexed in the reliable databases PubMed, PubMed central, Scopus and Web of Science were review-ed. The review indicated that most medicinal plants exerted antidepressant effects through synaptic regulation of serotonin, noradrenaline, and dopamine, regulating activity of hypothalamic-pituitary-adrenal axis, reinfor-cing anti-oxidant defense system, and decreasing inflammatory mediators. The medicinal plants and their active compounds can relieve depression through different pathways and hence are considered a new source to produce antidepressants.</p>

New Drug Discovery from Medicinal Plants and Phytoconstituents for Depressive Disorders

2019 ◽  
Vol 18 (2) ◽  
pp. 92-102 ◽  
Author(s):  
Fatma Tuğçe Gürağaç Dereli ◽  
Mert Ilhan ◽  
Esra Küpeli Akkol
Keyword(s):  
Medicinal Plants ◽  
Depressive Disorders ◽  
Living Standards ◽  
Side Effect Profile ◽  
Active Components ◽  
Synthetic Drugs ◽  
Traditional Medicinal Plants ◽  
Antidepressant Effects ◽  
Life Threatening ◽  
Culinary Herbs

Background & Objective: Depression, a risk factor for several serious diseases, is a highly prevalent and life-threatening psychiatric disorder. It can affect the individual’s position in life and reduce the living standards. The research on the use of medicinal plants in treating this disease has increased enormously because of the possible low rehabilitation rate and side effects of available synthetic drugs, such as sexual dysfunction, nausea, fatigue, insomnia, hypersomnia, and weight gain.Conclusion:Therefore, this review aimed to draw attention to the antidepressant effects of culinary herbs and traditional medicinal plants and their active components, thereby promoting their use in the development of more potent antidepressants with improved side effect profile.

scholarly journals Medicinal herbs with anti-depressant effects

2020 ◽  
Vol 9 (4) ◽  
pp. 309-317 ◽  
Author(s):  
Mahbubeh Setorki
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
Complete Recovery ◽  
Medicinal Herbs ◽  
Double Blind ◽  
Synthetic Drugs ◽  
Positive Effects ◽  
Antidepressant Effects ◽  
Life Threatening ◽  
Echium Amoenum

Depression is a life-threatening chronic illness which affects people worldwide. Drugs used to treat this disease have multiple side effects and may cause drug-drug or drug-food interactions. Additionally, only 30% of patients respond adequately to the existing drugs and the remaining do not achieve complete recovery. Thus, finding effective treatments that have adequate efficacy, fewer side effects and lower cost seem to be necessary. The purpose of this study was to review animal and double-blind clinical studies on the anti-depressant effects of medicinal herbs. In this study, validated scientific articles indexed in PubMed, SID, Web of Science and Scopus databases were reviewed. A database search was performed using the following terms: clinical trials, depression, major depressive disorder, essential oil, extract and medicinal plant. Positive effects of a number of herbs and their active compounds such as St John’s-wort, saffron, turmeric, ginkgo, chamomile, valerian, Lavender, Echium amoenum and Rhodiola rosea L. in improvement of symptoms of mild, moderate or major depression have been shown in clinical trials. The above plants show antidepressant effects and have fewer side effects than synthetic drugs. Hence, they have the potential to treat patients with depression.

scholarly journals Depression and Treatment with Effective Herbs

2019 ◽  
Vol 25 (6) ◽  
pp. 738-745 ◽  
Author(s):  
Zohre Fathinezhad ◽  
Robert D.E Sewell ◽  
Zahra Lorigooini ◽  
Mahmoud Rafieian-Kopaei
Keyword(s):  
Nervous System ◽  
Medicinal Plants ◽  
Treatment Process ◽  
Potential Method ◽  
Psychiatric Disease ◽  
Synaptic Regulation ◽  
Synthetic Drugs ◽  
Therapeutic Benefits ◽  
Treatment Of Depression ◽  
Antidepressant Effects

Depression is a common psychiatric disease and one of the main causes of disability worldwide. In spite of certain developments in this field, chemical and synthetic drugs used for the treatment of depression disrupt the treatment process due to numerous side effects and high cost. Today, the goal of using a potential method for treating depression involves the use of medicinal and phytochemical plants, which have many therapeutic benefits. Studies have shown that medicinal plants affect the nervous system and exert antidepressant effects in various ways, including synaptic regulation of serotonin, noradrenaline and dopamine, and inflammatory mediators. In this study, depression as well as the factors and mechanisms involved in its development are first addressed, and then medicinal plants effective in the treatment of depression along with their mechanisms of actions are reported.

scholarly journals Review on Antidepressant Medication

2019 ◽  
pp. 580-587
Author(s):  
Sudhir R. Kaulage ◽  
Kiran T. Aldar ◽  
Rahul P. Jadhav ◽  
Prakash D. Jadhav ◽  
Vishal D. Yadhav
Keyword(s):  
Treatment Options ◽  
Antidepressant Drugs ◽  
Antidepressant Medication ◽  
Severe Depression ◽  
Complete Recovery ◽  
Common Disease ◽  
Drug Induced ◽  
Supportive Psychotherapy ◽  
Synthetic Drugs ◽  
Depressive Episodes

Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of patients. Antidepressants are effective and accessible treatment options that can reduce suffering and prevent relapse of symptoms. They are recommended as first line treatment options in moderate and severe depression or mild or sub threshold depression that has persisted despite other interventions All current antidepressants, with the exception of agomelatine, increase the transmission of the monoamines, particularly serotonin, nor adrenaline and dopamine. The antidepressants are crucial for the treatment of depressive episodes in the acute phase when untreated symptoms are at their worst. With long-term use, however, the brain sets to work compensating for the drug-induced changes with a process he calls oppositional tolerance. Antidepressant drugs are the mainstay for the treatment of depression. Usually, antidepressants are given in combination with some form of limited supportive psychotherapy.

scholarly journals Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. (Trellis-vine): a review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Devanesan Arul Ananth ◽  
Garlapati Deviram ◽  
Vijayaraghavan Mahalakshmi ◽  
V. Ratna Bharathi
Keyword(s):  
Medicinal Plants ◽  
Chronic Diseases ◽  
Molecular Mechanisms ◽  
Human Beings ◽  
Pharmacological Activities ◽  
Pubmed Central ◽  
Synthetic Drugs ◽  
Anti Cancer

Abstract Background Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Earlier to the innovation of synthetic drugs, human beings completely relied on the plants for the treatment of various ailments. Natural product extracts, particularly those derived from different plant species, provided the main source of Siddha, Ayurveda and Folk medicines. P. daemia is a perennial climber, traditionally reported for the treatment in a variety of diseases. In present review, we focused on the present status of phytochemical and pharmacological activities P. daemia. Methodology With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. Traditional knowledge information collected by Indian taxonomical books, survey from local rural and tribal peoples. Pharmacological data’s obtained from scientific journals published from 2000 to 2020. Results P. daemia extract, contains several phytochemicals, especially rich in flavonoids. These secondary metabolites synthesized from P. daemia have been reported for the treatment of various chronic diseases. In recent years, P. daemia phytoconstituents set as a key role in natural drug development as it harbours many in vitro and in vivo pharmacological activities such as anti-inflammatory, anti-cancer, anti-fertility, anti-arthritic and antimicrobial etc., Conclusion P. daemia was the less studied plant compared to other medicinal plants. In this context more emphasis has to be laid on studies that discuss on the secondary metabolite activities and molecular mechanisms that work against various chronic diseases.

scholarly journals A Review on Ethnopharmacological Applications and Pharmacological Activities of Leea macrophylla

2021 ◽  
pp. 58-61
Keyword(s):  
Medicinal Plants ◽  
Modern Medicine ◽  
In Vivo Studies ◽  
Pharmacological Activities ◽  
Plant Parts ◽  
Synthetic Drugs ◽  
Research Activities ◽  
Anti Oxidant

Plants are used as a potential source of medicines since the prehistoric period. Medicinal plants are the richest bio-resource of drugs of a number of traditional systems of medicines. Medicinal plants can also be used as nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates, and chemical entities for synthetic drugs. A good number of researches on medicinal plants have enriched the science of modern medicine over the last decades. Leea macrophylla (Leeaceae) locally known as ‘Hastikarna palasa’ is a shrub that has been used in herbal medicine as a cure for a number of disorders. Several studies have proven that the plant possesses potential antimicrobial, anti-oxidant, anti-inflammatory, analgesic, neuropharmacological and anti-diabetic activities. Tribal communities used the plant parts as a remedy for a number of ailments as well as nutritional products. Established in-vitro and in-vivo studies were conducted to get evidence of pharmacological activities of the plant parts. This review paper focuses on the phytopharmacological activities and traditional uses of the plant which may help further research activities on L. macrophylla by giving up-to-date information about the plant.

Rheumatoid Arthritis: History, Stages, Epidemiology, Pathogenesis, Diagnosis and Treatment

2017 ◽  
Vol 9 (02) ◽  
Author(s):  
Abeer Fauzi Al-Rubaye ◽  
Mohanad Jawad Kadhim ◽  
Imad Hadi Hameed
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Systemic Disease ◽  
Modern Medicine ◽  
Whole Body ◽  
Internal Organs ◽  
Synthetic Drugs ◽  
Relieve Pain ◽  
Medicinal Treatment ◽  
Natural Drugs

The pharmacological mechanisms of the medicinal plants traditionally used for RA in Persian medicine are discussed in the current review. Further investigations are mandatory to focus on bioefficacy of these phytochemicals for finding novel natural drugs. Rheumatoid arthritis is chronic, progressive, disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joints. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, heart and eyes. Although numbers of synthetic drugs are being used as standard treatment for rheumatoid arthritis but they have adverse effect that can compromise the therapeutic treatment. Unfortunately, there is still no effective known medicinal treatment that cures rheumatoid arthritis as the modern medicine can only treat the symptoms of this disease that means to relieve pain and inflammation of joints. It is possible to use the herbs and plants in various forms in order to relieve the pain and inflammation in the joints. There are so many medicinal plants that have shown anti rheumatoid arthritis properties. So the plants and plant product with significant advantages are used for the treatment of rheumatoid arthritis. The present review is focused on the medicinal plants having anti rheumatoid arthritis activity

In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

2020 ◽  
Vol 7 (2) ◽  
pp. 21-24
Author(s):  
Pavani C H
Keyword(s):  
Medicinal Plants ◽  
Chemical Constituents ◽  
The Body ◽  
Lipid Lowering ◽  
Medical Systems ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Anti Oxidant ◽  
And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

In-vivo anti-oxidant screening of Tectona grandis extract

2020 ◽  
Vol 9 (1) ◽  
pp. 1-4
Author(s):  
Tamilarasi G P ◽  
Sabarees G
Keyword(s):  
Biochemical Parameters ◽  
Tectona Grandis ◽  
The Body ◽  
Altered Expression ◽  
Physiological Conditions ◽  
Synthetic Drugs ◽  
Significant Difference ◽  
Anti Oxidant ◽  
Radical Generation

Oxidation is an essential reaction in the human body, which determines the expression of proteins in the body. This results in the altered expression like rapid growth resulting in cancers and other disorders. Many synthetic drugs are available in the market that is effective in limiting the free radical generation and the reaction of radicals with cells. Unfortunately, all those synthetic drugs were found to cause side effects and adverse effects in the body. But given the accuracy of the predictability of the results and administration, this research focuses on testing the anti-oxidant efficiency in rat models testing the biochemical parameters. Investigations have also been done on the anti-oxidant activity of Tectona, but every research was concentrated to prove the anti-oxidant activity only. extract had been tested for anti-oxidant activity by estimating various tissue parameters and it showed better activity. As predicted, there is a significant difference in the and results which can be explained are due to the physiological conditions that exist inside the body.

scholarly journals Immunoregulation and antidepressant effect of ketamine

2021 ◽  
Vol 12 (1) ◽  
pp. 218-236
Author(s):  
Nan Zhang ◽  
Lihua Yao ◽  
Peilin Wang ◽  
Zhongchun Liu
Keyword(s):  
Disease Burden ◽  
Severe Disease ◽  
Mental Health Disorder ◽  
Antagonistic Effect ◽  
Antidepressant Effect ◽  
Future Research ◽  
Recurrence Rates ◽  
Aspartate Receptor ◽  
Antidepressant Effects ◽  
Common Mental Health Disorder

Abstract Major depressive disorder (MDD) is a common mental health disorder that brings severe disease burden worldwide. Traditional antidepressants are mainly targeted at monoamine neurotransmitters, with low remission rates and high recurrence rates. Ketamine is a noncompetitive glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist, and its rapid and powerful antidepressant effects have come to light. Its antidepressant mechanism is still unclarified. Research found that ketamine had not only antagonistic effect on NMDAR but also strong immunomodulatory effect, both of which were closely related to the pathophysiology of MDD. Although there are many related studies, they are relatively heterogeneous. Therefore, this review mainly describes the immune mechanisms involved in MDD and how ketamine plays an antidepressant role by regulating peripheral and central immune system, including peripheral inflammatory cytokines, central microglia, and astrocytes. This review summarizes the related research, finds out the deficiencies of current research, and provides ideas for future research and the development of novel antidepressants.

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