scholarly journals Effects of Fasting on Body Weight, Serum Glucose and Creatinine and Histotexture of Liver and Kidney in Swiss Albino Mice

2020 ◽  
Vol 7 (3) ◽  
pp. 421-430
Author(s):  
Tithe Saha ◽  
Khaled Mahmud Sujan ◽  
Ziaul Haque ◽  
Md Kamrul Islam
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Serum Biochemistry ◽  
Serum Glucose ◽  
Swiss Albino Mice ◽  
Liver And Kidney ◽  
Group A ◽  
Albino Mice ◽  
Group B ◽  
Histopathological Studies

Fasting means remaining without foods and water from a specific period of time which is important for improving health and increasing longevity. The present study was conducted to investigate the effect of fasting on body weight, serum biochemistry and histomorphological changes of liver and kidney in mice. A total of 18 Swiss Albino Mice (Musmusculus), 28-35 days old with an average body weight of 26.2 ± 1 gm were randomly divided into three groups. Group A was considered as control (n=6) and fed on standard mice pellet and fresh drinking water. Group B was considered as 14 hours fasting group (n=6), kept fasting for 14 hrs and Group C was considered as 18 hours fasting group (n=6), kept fasting for 18 hrs. At the end of the experiment, blood and tissues were collected for biochemical and histomorphological examination. Data showed that no significant change was found in body weight, serum glucose and creatinine level in fasting groups Histopathological studies of liver and kidney revealed that fasting could initiate minor change in the normal structures of liver but no architectural change in kidney. Slight depletion of glycogen was found in hepatocytes of liver. From the present study it can be concluded that fasting may be beneficial as its decreases body weight gain and have not any significant alteration in the liver and kidney histotextures. Res. Agric., Livest. Fish.7(3): 421-430,  December 2020

scholarly journals Subacute Hepatotoxicity of Extracts of Senna occidentalis Seeds in Swiss Albino Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Egziharia Mokonen Gebrezgi ◽  
Mebrahtom Gebrelibanos Hiben ◽  
Kidanemariam Gaim Kidanu ◽  
Amanuel Tesfay Tsegay
Keyword(s):  
Body Weight ◽  
Liver Enzyme ◽  
Liver Tissue ◽  
Body Weight Gain ◽  
Treated Group ◽  
Mice Model ◽  
Water Control ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Enzyme Markers

Senna occidentalis is potentially toxic to humans and animals. Its seeds are crop contaminant weeds in some localities where liver disease is prevalent. This study assessed the subacute hepatotoxicity of S. occidentalis seeds in mice model. Three groups of female Swiss Albino mice (25–28 g, aged 8–10 weeks) received distilled water (control), 400, and 1000 mg/kg extract of S. occidentalis seed, respectively. At the end of the study, body weight and liver organ weight were recorded, and tissue and blood samples were collected and analyzed. The results indicated that the extract treated groups, at both doses, showed significant (p≤0.001) decrease in mean body weight gain in the fourth week of the experiment. Besides, the extract treated groups showed significant (p≤0.001) elevation of liver enzyme markers: alanine aminotransferase and aspartate aminotransferase. Also, histopathological examinations of liver tissue showed moderate microvesicular steatosis of hepatocytes and mild inflammation in the 400 mg/kg treated group as well as marked micro- and macrovesicular steatosis, focal area necrosis, and periportal inflammation with mononuclear cell infiltration in the 1000 mg/kg treated group. Thus, these findings show that S. occidentalis seeds exhibit hepatotoxicity in mice, characterized by changes in liver tissue architecture and liver enzyme levels.

scholarly journals Effects of edible fats and oils on the body weight gain and on weights of some selected organs in rats removing the impact of unequal feed intake

1970 ◽  
pp. 107-110
Author(s):  
N Ahmad ◽  
S Majumder ◽  
MA Miah ◽  
MJ Uddin
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Feed Intake ◽  
Body Weight Gain ◽  
Fats And Oils ◽  
Male Rats ◽  
Edible Fats ◽  
Group A ◽  
Group B ◽  
The Impact

An investigation on Long Evans male rats fed with different edible fats and oils was conducted in the Department of Physiology, Bangladesh Agricultural University, Mymensingh during a period of 7 weeks (1st April to 19th May, 2005) to determine and to compare the effect of feeds on body weight gain and on weights of some selected organs (heart, liver and kidney) removing the impact of unequal feed intake. A total of 20, six-week old male rats were randomly divided into A, B, C and D groups. Each group consisted of 5 rats. Rats were fed rat pellets purchased from ICDDR,B, Dhaka supplemented with beef fat in group A, fish fat in group B and soybean oil in group C while group D was considered as control and fed only with rat pellets. The concentration of fats and oils were 7% of normal diet and fed for 7 weeks. The highest weekly mean body weight gain (19.90g) adjusted for unequal feed intake was achieved by the rats of beef fat supplemented group A, followed by the rats of soybean oil supplemented group C (19.76g) and fish fat supplemented group B (15.67g). But none of the adjusted means of weekly body weight gain differed significantly (p > 0.05) from the control. Insignificant increases in heart weight were recorded in all treated rats and the maximum weight was in fish oil treated ones. Not much differences were recorded in the kidney weights rather beef oil treated rats' kidney had the lowest mean weight. A significantly (p < 0.01) higher liver weight was recorded in group B & C compared to control (group D), though the differences between A & D were insignificant. It could be concluded that fats and oils are harmful for the rat's body especially on liver and heart. Key words: Edible fats and oils, rat, body weight, organ weight, analysis of variance, covariance DOI = 10.3329/bjvm.v5i1.1326 Bangl. J. Vet. Med. (2007). 5 (1 & 2): 107-110

How growth parameters of sexed native Aseel chickens affected when fed with selenium supplemented diets during three growth phases

2017 ◽  
Author(s):  
Waseem Muhammad Zia ◽  
Anjum Khalique ◽  
Saima Naveed ◽  
Jibran Hussain
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth Parameters ◽  
Body Weight Gain ◽  
Control Diet ◽  
Growth Phases ◽  
Feed Conversion ◽  
Treatment Groups ◽  
Group A ◽  
Group B

In total, 240 three-weeks-old sexed birds (191.06±6.01g), 120 + 120 from Lakha, Mushki, Peshaweri and Mianwali varieties of local Aseel were used to determine the influence of selenium forms on growth during three growth phases. Birds were divided into four equal groups, 60 birds/variety (30 + 30 ), further subdivided into A, B and C treatment groups, 10 bids/treatment. Each group was allocated starter, grower and finisher diets. Group A was offered the diet supplemented with 0.3 ppm Se-enriched yeast and the diet of group B included 0.3 ppm sodium selenite, while group C was fed with un-supplemented control diet. Birds were maintained individually for 18 weeks. Feed intake was decreased, while, body weight gain, feed conversion ratio (FCR) and body weight gain were improved in males and females of Lakha, while best results detected in males during all growth phases in Se-enriched yeast fed groups. In conclusion, Se-enriched yeast had the positive effect in improving growth parameters of native Aseel.

Study on effect of chitosan on body weight gain and anti-microbial activity in swiss albino mice

2016 ◽  
Vol 4 (2) ◽  
pp. 41-43
Author(s):  
D. Rani Prameela ◽  
◽  
D. Sreenivasulu ◽  
A. Ravi ◽  
M. Amaravathi ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Microbial Activity ◽  
Body Weight Gain ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Effects of growth promoter and multivitamin-mineral premix supplementation on body weight gain in broiler chickens

2013 ◽  
Vol 10 (2) ◽  
pp. 245-248 ◽  
Author(s):  
MA Rahman ◽  
MS Parvin ◽  
RR Sarker ◽  
MT Islam
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
The Body ◽  
Growth Promoter ◽  
Commercial Feed ◽  
Significant Difference ◽  
Group A ◽  
Group B

An experiment was conducted at the Khanpura Poultry Farm, near to the Babugonj campus of Patuakhali Science and Technology University, Patuakhali during the period from August to September, 2011 to evaluate the effect of growth promoter and multivitamin-mineral premix on the body weight gain in broiler chickens. A total of 90 ‘Cobb 500’ day-old broiler chickens were randomly divided into three equal groups (n = 30), namely Groups A, B and C. Broiler birds in groups A and B were supplemented with growth promoter and multivitamin-mineral premix, respectively in addition to commercial feed from day 4 till day 25. The dose of both the growth promoter and multivitamin-mineral premix was 2.5 g/kg of feed. Chickens of group C served as control and supplemented with commercial feed only. Body weight was recorded at three times as on day 11, 18 and 25, respectively. The mean body weight was insignificantly (p > 0.05) higher in birds of groups A (992.5±139.6g) and B (978.3±147.0g) than those of group C (926.7±133.2g). The percent increase in body weight gain compare to control was increased in both the supplemented groups (5.8% in group A and 8.8% in group B) though there was no significant difference. Based on the results, it is suggested that supplementation of growth promoter and multivitamin-mineral premix in broilers even after feeding of commercial feed has positive effect on the growth of broilers.DOI: http://dx.doi.org/10.3329/jbau.v10i2.14914 J. Bangladesh Agril. Univ. 10(2): 245-248, 2012

scholarly journals Utilization Of Soymilk As Milk Replacer For Calves

1970 ◽  
Vol 38 (1-2) ◽  
pp. 102-107 ◽  
Author(s):  
AKM Masum ◽  
MN Islam ◽  
MAS Khan
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Total Body Weight ◽  
Dairy Calves ◽  
Cow Milk ◽  
Milk Replacer ◽  
Significant Difference ◽  
Group A ◽  
Total Body ◽  
Group B

An experiment was conducted to study the utilization of soymilk as milk replacer for raising calves. Nine crossbred calves were selected and divided into three groups on the basis of their body weight and genotype. The calves of group A were reared by cow milk, group B reared by strained soymilk and group C reared by unstrained soymilk. It was found that, total body weight gain of group A, B and C were 13.933 ± 1.222, 13.800 ± 0.917 and 13.233 ± 1.537 Kg, respectively. There was no significant difference among the three groups of calves. Non-significant differences were also seen for increment in wither height (5.588 ± 0.508, 5.419 ± 0.529 and 5.080 ± 0.440 cm, respectively), length (6.096 ± 0.440, 5.927 ± 0.388 and 5.503 ± 0.388 cm, respectively) and heart-girth (5.842 ± 0.440, 5.588 ± 0.916 and 5.419 ± 0.388 cm, respectively) of calves. Economic analysis showed that soymilk was cheaper than cow milk (Tk. 8.0 vs Tk. 44.0). It can be concluded that soymilk as milk replacer could be used successfully for raising dairy calves. DOI: http://dx.doi.org/10.3329/bjas.v38i1-2.9918 BJAS 2009; 38(1-2): 102-107

scholarly journals Comparative study of the performance of buffalo calves and cow calves by feeding Urea Molasses Block with straw based diet

1970 ◽  
Vol 8 (1) ◽  
pp. 87-90
Author(s):  
S Ferdousi ◽  
AKM Masum ◽  
MAS Khan ◽  
MA Islam
Keyword(s):  
Body Weight ◽  
Body Length ◽  
Body Weight Gain ◽  
The Body ◽  
Buffalo Calves ◽  
Final Body Weight ◽  
Height Gain ◽  
Group A ◽  
Group B ◽  
Average Body

An experiment was conducted to evaluate the performance of buffalo calves and cow calves supplementing Urea Molasses Block (UMB) with straw based diet. Three cow calves (average 1 year & 8 months age and 111 kg body weight) and three buffalo calves (average 1 year & 10 months age and 89 kg body weight) were grouped into A and B, respectively and fed for 60 days. It was found that, the DMI (kg/h/d) was 5.66±1.18 and 6.10±0.99, respectively in group A and B (p>0.05). The DMI in 1st and 2nd fortnight of the experiment in group A and B were 5.77±0.31 and 6.17±0.33; 4.96±0.43 and 5.77±0.39, respectively (p<0.01). But, the DMI in 3rd and 4th fortnight differs nonsignificantly (p>0.05). At the end of the experiment, the final body weight for group A and group B were 132.6±11.96 and 113±8.19 kg, respectively (p>0.05). The body weight gain per day for both groups were 0.36±0.05 and 0.40±0.05 kg, respectively (p>0.05). The average heart girth gain per day in group A and group B were 0.24±0.02 and 0.30±0.03 cm, respectively (p>0.05). The average wither height gain per day was 0.075±0.005 and 0.059±0.005 cm in group A and B, respectively (p<0.05). The average body length gain per day for group A and group B were 0.31±0.03 and 0.36±0.04 cm, respectively (p>0.05). The growth performance of buffalo calves is better than cow calves by feeding UMB with straw based diet. Keywords: UMB; Body weight; Heart girth; Wither height; Body length DOI: 10.3329/jbau.v8i1.6404J. Bangladesh Agril. Univ. 8(1): 87-90, 2010

scholarly journals Effects of Dicalcium Phosphate (DCP) and Vitamin E on Growth Performance and Hemato-Biochemical Parameters in Broilers

2020 ◽  
Vol 2 (2) ◽  
pp. p104
Author(s):  
Tairan Ikbal ◽  
Sumitra Saha
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Vitamin E ◽  
Detrimental Effect ◽  
Body Weight Gain ◽  
Experimental Period ◽  
Group A ◽  
Group B ◽  
Vitamin E Supplementation ◽  
Blood Profiles

This study was conducted to assess the effect of DCP and vitamin E supplementation on body weight, hematological- (TEC, Hb content, PCV and ESR) and biochemical (AST and ALT) parameters of “Cobb 500” broiler. A total of 20 chicks (14 days old) were reared and randomly divided into four equal groups (n=5). Body weight was measured at each 7 days interval up to the end of the 35 days of experimental period.  Group A was considered as control, fed with commercial ration. Group B, C and D were treated with 1 gm DCP per kg feed, 1 ml vitamin E per litre of drinking water, and 1 gm DCP per kg feed plus 1 ml vitamin E per litre of drinking water with commercial ration, respectively from day 14 to day 35. It was observed that DCP and vitamin E supplementation significantly (p<0.01) increased body weight. Moreover, TEC and Hb content increased significantly (p<0.01) in the treated groups as compared to control. Besides, ESR, AST and ALT values decreased significantly (p<0.01) in the treated groups. Therefore, it may be concluded that DCP and vitamin E could be used to improve body weight gain and blood profiles without any detrimental effect to liver and muscle on broilers.

scholarly journals Phytochemical Analysis and Antiplasmodial (curative) Activities of Methanolic Leaf Extract of Morinda lucida (Ewe Oruwo) in Male Swiss Mice Infected with Plasmodium berghei NK65

2019 ◽  
pp. 1-13
Author(s):  
Momoh Johnson Oshiobugie ◽  
Damazio Olanrewaju Anthony ◽  
Ajetunmobi Asibiallau Oladipupo ◽  
Babalola Adenike Omosalewa ◽  
Adekunle Oluwasegun Michael ◽  
...  
Keyword(s):  
Body Weight ◽  
Vitamin A ◽  
Plasmodium Berghei ◽  
Leaf Extract ◽  
Liver Homogenate ◽  
Haematological Parameters ◽  
Swiss Albino Mice ◽  
Swiss Mice ◽  
Albino Mice ◽  
Group B

Aim: Medicinal plants have been used for the treatment of many infections and diseases including malaria. The study was conducted to determine the effect of in vivo anti-plasmodial and antioxidant properties of the methanolic leaf extract of Morinda lucida in male Swiss albino mice infected with Plasmodium Berghei NK65. Study Design and Methodology: Phytochemical, GC-MS and AAS analyses were determined in the plant. Swiss albino mice were inoculated intraperitoneally with Plasmodium berghei NK65. Thirty-five (35) mice were grouped into seven groups, five per group. Group A were not infected with P.berghei NK65. Group B, C and D served as the negative and positive control groups while Group E, F and G mice were treated with 400, 600 and 800 mg/kg body weight of methanolic leaf extract of M. lucida. Haematological parameters were determined in the whole blood using BC-3200 Auto Hematology Analyzer. TP, MDA, CAT, SOD % inhibition, SOD unit and vitamin A were all determined in the liver homogenate using standard procedures. Results: The GC-MS result of the M. lucida shows the presence of five bioactive compounds. It was also observed that the plant contains the following minerals: iron, magnesium, potassium, phosphorus and copper. Acute toxicity shows that the LD50 >000mg/Kg b.wt. The extract caused 30.96%, 32.93% and 67.23% reduction in parasitemia at 400, 600 and 800 mg/kg body weight respectively while chloroquine exerted 96.53% and artesunate exerted 92.03% reduction at 10 mg/kg body weight respectively. The Haematological parameters showed that the plant extract is not haematotoxic since it significantly (P<0.05) reduced WBC count, and increase RBC, HGB, and HCT values in the treated mice compared to the infected untreated mice. This study shows that the mean lipid peroxidation (MDA) level was significantly decreased in the malaria treated mice (group C, D, E, F and G) compared to the untreated mice (group B). There was also a significant increase in the total protein, catalase, SOD % inhibition, SOD unit and Vitamin A levels in the liver homogenate of animals treated with chloroquine, artesunate and extract of M. lucida compared to the untreated mice. Conclusions: The study shows that Morinda lucida possess antiplasmodial activity in male Swiss mice infected with Plasmodium berghei NK 65.

Chloroquine Induced Hepatotoxicity in Male Albino Mice: RCT

2021 ◽  
Vol 15 (10) ◽  
pp. 3070-3071
Author(s):  
Sumbal Khalid ◽  
Hamid Javaid Qureshi ◽  
Talha Laique
Keyword(s):  
Body Weight ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Controlled Study ◽  
Control Group ◽  
Trial Methodology ◽  
Clinical Trial Methodology ◽  
Group A ◽  
Albino Mice ◽  
Group B

Many drugs have been found to induce hepatotoxicity and acute liver failure. Chloroquine is one of those drugs, which can induce hepatotoxicity when it is given at higher dose Purpose: To find the effect of chloroquine on liver function tests (LFTs) Study Design: Randomized clinical trial Methodology: Sixty male albino mice were taken into this randomized controlled study. Those were divided into two groups of 30 each. Group A was the control group while group B mice were given single oral dose of 970 mg/kg of body weight of chloroquine on 9th day of experiment. Terminal intracardiac blood sample was obtained on 17th day of experiment Statistical analysis: SPSS version 23 was used for data analysis Results: When results of group B were compared with those of group A, they depicted highly significant (p=0.000) rise in serum ALP. Serum albumin decreased significantly (p= 0.007). Serum AST increased significantly (p=0.005). Serum ALT, however, did not rise significantly (p=0.285) in group B. Similarly, serum total proteins did not decrease significantly ( p=0.530) in group B Conclusion: It was concluded that chloroquine induced mild hepatotoxicity in male albino mice when a single oral dose of 970 mg/kg of body weight of it is given Key Words: Chloroquine, Hepatotoxicity and Alkaline Phosphatase.

Sign in / Sign up

Export Citation Format

Share Document