HEMATOLOGICAL PROFILE OF RATS ADMINISTERED WITH PROPOLIS FOLLOWING ANTITUBERCULOSIS DRUGS INDUCED TOXICITY

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
NISHA SAHU ◽  
HEMESHWER KUMAR CHANDRA ◽  
GITA MISHRA ◽  
SATENDRA KUMAR NIRALA ◽  
MONIKA BHADAURIA
Keyword(s):  
Hematological Parameters ◽  
Blood Parameters ◽  
Positive Control ◽  
Blood Parameter ◽  
Dependent Manner ◽  
Distribution Width ◽  
Antituberculosis Drugs ◽  
Hematological Indices ◽  
Propolis Extract ◽  
Therapeutic Choice

Antituberculosis drugs (ATD) used as standard drugs for the treatment of deadly disease tuberculosis, cause blood disorders. The present study was conducted to investigate the efficacy of propolis against ATD induced alteration in blood parameters in rats. Rats were administered with ATD for 8 weeks (3 days/week) followed by propolis at three different doses (100, 200 and 400 mg/kg) conjointly for 8 weeks (3 days/week) orally. Silymarin (50 mg/kg) was used as positive control in the study. After 8 weeks, animals were euthanized; blood was collected by retro-orbital sinus method for analysis of hematological parameters. The results of this study show a decrease in red blood cells, hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width alongwith increase in the number of lymphocytes in ATD induced rats. Treatment with propolis extract encountered ATD induced blood parameter alteration which was evident by significant reversal in hematological indices towards control in a dose dependent manner. Thus, it can be concluded that propolis may be an agent of therapeutic choice in case of ATD induced hematological alterations.

scholarly journals Red Blood Cell Variables in Children and Adolescents regarding the Age and Sex

2019 ◽  
Author(s):  
Jasmina PLUNCEVIC GLIGOROSKA ◽  
Serjoza GONTAREV ◽  
Beti DEJANOVA ◽  
Lidija TODOROVSKA ◽  
Daniela SHUKOVA STOJMANOVA ◽  
...  
Keyword(s):  
Blood Cell ◽  
Children And Adolescents ◽  
Red Blood Cell ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Female Group ◽  
Distribution Width ◽  
Hematological Indices ◽  
Significant Difference ◽  
Age And Sex

Background: This study aimed to assess the basic red blood cell variables and hematological indices in children and adolescents and analyze the differences regarding age and sex. Methods: Overall, 320 young participants, age 8 to 18 yr, were enrolled at Laboratory of Sport’s Medicine, Medical Faculty, Skopje, Macedonia in 2016. Capillary blood samples were drawn and following hematologic parameters were measured: the red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit level (Hct) and hematological indexes: mean corpuscular volume (MCV), mean hemoglobin concentration (MCH), mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW). Results: RBC variables in male group showed high statistical level of significance between age different groups (P=0.001) for all studied parameters except MCHC (P=0.423) and RDW (P=0.174). ANOVA test and multivariate tests in female group showed that there was no significant difference for all hematological parameters between age different groups. Regarding the sex differences, male participants had significantly higher red blood count (P<0.001), hemoglobin content (P<0.001) and hematocrit (P<0.001). Conclusion: Hematological parameters in adolescent as inhomogeneous population are not quantified sufficiently, especially hematological indices. RBC variables, regardless of the age, differ very much between male and female examinees, in favor of the male examinees. Hematological indices were insignificantly higher in males. Regarding the age of examinees, RBC variables showed significant inter-groups differences only within male adolescents. While with girls, ages span 8 to 18 yr, we did not find significant differences for most of the hematological variables.

scholarly journals AMELIORATIVE EFFECT OF NARINGENIN AGAINST ANTITUBERCULOSIS DRUGS INDUCED ALTERATIONS IN HEMATOLOGICAL PARAMETERS OF RATS

2018 ◽  
Vol 11 (11) ◽  
pp. 253 ◽  
Author(s):  
Nisha Sahu ◽  
Gita Mishra ◽  
Hemeshwer Kumar Chandra ◽  
Satendra Kumar Nirala ◽  
Monika Bhadauria
Keyword(s):  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Hematological Parameter ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Antituberculosis Drugs ◽  
Hematological Indices ◽  
Significant Reversal ◽  
Ameliorative Effect ◽  
Conjoint Treatment

Objective: The aim of the present study was to evaluate the efficacy of naringenin against antituberculosis drugs (ATDs) induced alteration in hematological parameters in rats.Methods: Rats were administered with ATDs for 8 weeks (3 days/weeks) followed by naringenin at three different doses (10, 20, and 40 mg/kg) conjointly for 8 weeks (3 days/weeks) orally. After 8 weeks, animals were euthanized; blood was collected by retro-orbital sinus method for the analysis of hematological parameters.Results: The results of this study show decreased in red blood cells, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelets, and eosinophils along with increase in the number of lymphocytes in ATDs induced rats. Treatment with naringenin encountered ATDs induced hematological parameter alteration which was evident by significant reversal in hematological indices toward control in dose-dependent manner.Conclusion: The present study concluded that ATDs exposure caused adverse effects in various blood components and conjoint treatment of naringenin reduced hematological alterations toward control due to antioxidant activity.

Hematological Indicators of Moose in Domestication Process

2020 ◽  
Keyword(s):  
Hematological Parameters ◽  
Physiological State ◽  
Blood Parameters ◽  
The Body ◽  
Sex Characteristics ◽  
Hematological Indices ◽  
Blood Indices ◽  
Hematological Indicators ◽  
Age And Sex ◽  
Selection Of

Presented hematological indices for a stress-free selection of material from moose in the process of domestication depending on age and sex characteristics. Fluctuations in the blood parameters of moose have been established within various limits, taking into account the influence of various factors - the climatic, environmental, technological, physiological state of the animal, and age and sex characteristics. Considerable attention is paid to the selection of blood from moose, one of the most labor-intensive processes when working with them. Some tendency to fluctuations in hematological parameters in young moose has been recorded. This, possibly, is associated with a decrease in the action of colostral immunity, the formation of a specific defense of the body. Differences in blood indices in moose depending on gender were unreliable. However, in males, some of them - in terms of the content of erythrocytes, basophils, and monocytes - was higher than in females, and vice versa, in females - the number of leukocytes, lymphocytes, and eosinophils. It was shown that in young animals of 21-50 days of age, a neutrophilic profile prevails with increased content of segmented forms, and in adults - a lymphocytic profile. Compared with moose, which are in the process of domestication in animals living in natural conditions, expressed leukocytosis was recorded. As a result of the studies, the estimated norms of morphological parameters of the blood of moose in the process of domestication are established, depending on age and gender.

scholarly journals Reference Interval of Hemoglobin A1c and Influence of Hematological Parameters on Its Serum Concentration in Dogs

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Stephan Neumann
Keyword(s):  
Hemoglobin A1c ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Reference Interval ◽  
Blood Parameters ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Glucose Levels ◽  
Hba1c Concentration

HbA1c could be an alternative to fructosamine as a marker for glucose levels over a longer period. In this study, we calculated a reference interval for HbA1c in dogs and investigated the correlation of HbA1c with hemoglobin and different hematological parameters. In total, 110 blood samples from dogs were investigated. Significant negative correlations were found between HbA1c and erythrocyte count, hemoglobin concentration, as well as hematocrit. There was a tendency in the red cell distribution width. No significant correlation was found in the reticulocyte number and the erythrocyte indices. In conclusion, there is an association of different blood parameters with the HbA1c concentration, which have to be considered for the interpretation of HbA1c.

scholarly journals Effect of thiazolidine derivatives on heart rate variability (hrv) and blood parameters of experimental animals under hypobaric hypoxia

2015 ◽  
Vol 17 (4) ◽  
Author(s):  
O. I. Antoniv ◽  
S. M. Kovalchuk ◽  
L. V. Panina ◽  
O. R. Pinyazhko
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Hypobaric Hypoxia ◽  
Hematological Parameters ◽  
Blood Parameters ◽  
Reference Drug ◽  
Hematological Indices ◽  
Regulatory Systems ◽  
Adaptation Processes ◽  
Prior Administration

<p>Heart rate variability (HRV ) parameters and hematological indices in rats under hypobaric hypoxia during<br />treatment by a thiazolidine derivative substance Les-589 (potassium salt of 3-(5-phenylpropeniliden rhodamine-3-<br />yl)-propanoic acid) were studied. Hypobaric hypoxia was developed in altitude chamber for 1 hour under conditions<br />identical height of 6000 m above sea level, 45 minutes after injection of Les-589. Thiotriazolin was applied as a<br />reference drug.<br />After one day after exposure to hypoxia, according to blood parameters and hematological indices, adaptive<br />response develops by the type of insufficient adaptation. The effect of the prior administration of Les-589, similar to<br />the effect of a reference drug Thiotriazolin, in the time of post-hypoxic period developed reactions of an increased<br />activation, which indicates a favorable course of adaptation.<br />Considering the parameters of HRV was found that prior administration of Les-589 within studied terms of posthypoxic<br />period leads to earlier and more effective recovery of various links of regulatory systems, compared with<br />hypoxia. This is consistent with an estimated type of adaptation processes, based on hematological parameters<br />and indices.</p>

Modulation of Hematological Indices of Normal and Alloxan-Induced Diabetic Rabbits by Aqueous Extract of Pleurotus tuberregium Sclerotia

2020 ◽  
Vol 20 (3) ◽  
pp. 380-387
Author(s):  
Ifeanacho M. Onuekwuzu ◽  
Ikewuchi C. Chidinma ◽  
Ikewuchi J. Chigozie
Keyword(s):  
Aqueous Extract ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Diabetic Control ◽  
Red Cell ◽  
Distribution Width ◽  
Hematological Indices ◽  
Diabetic Rabbits ◽  
Pleurotus Tuberregium ◽  
Mean Cell Hemoglobin

Objective:: The ability of an aqueous extract of the sclerotia of Pleurotus tuberregium to modulate hematological parameters was investigated in normal and alloxan treated rabbits. Methods:: The extract was subjected to atomic absorption spectrophotometric and flame ionization detector-coupled-gas chromatographic (GC-FID) analysis. Diabetes mellitus was induced by a 120 mg/kg body weight intravenous injection of alloxan. Metformin was orally administered at 50 mg/kg, while the extract was administered (both to normal and diabetic rabbits) at 100, 200 and 300 mg/kg. Results:: Analysis of the extract showed that it had high contents of calcium, magnesium, manganese and potassium. Eleven known glycosides were detected, comprising mainly of amygdalin (37.7%), digoxin (14.4%), dhurrin (14.0%), linamarin (13.6%), prunasin (10.8%) and digitoxin (8.4%). Also detected were twelve known saponins, consisting mainly of sapogenin (40.3%) and neochlorogenin (21.8%); and twelve known lignans, consisting mainly of matairesinol (59.7%), secoisolariciresinol (20.9%) and lariciresinol (14.9%). Compared to the Diabetic control, the hematocrit, hemoglobin concentration, mean cell hemoglobin, mean cell hemoglobin concentration, mean corpuscular volume, red cell distribution width; and red cell, total white cell, lymphocytes, granulocytes and platelet counts of the treated groups were significantly (p<0.05) higher. Conclusion:: The above result showed that the extract had a positive effect on the hemopoietic system of the treated animals, at least at the doses at which it was administered in this study.

scholarly journals Ecotoxical influence of plumbum and cadmіum on gematological parameters of sylver carp (hypopthalmichtys molitrix)

2017 ◽  
Vol 19 (74) ◽  
pp. 24-28
Author(s):  
N. I. Hradovych
Keyword(s):  
Heavy Metals ◽  
Hematological Parameters ◽  
Silver Carp ◽  
Ecological Factors ◽  
Blood Parameters ◽  
The Body ◽  
Control Group ◽  
Research Station ◽  
Hematological Indices ◽  
Experimental Part

Many authors noticed the actuality of fish hematological parameters usage as indices of anthropogenic influence. Blood system reflects the reaction of the body on the action of different ecological factors. The problem of heavy metals influence on hematological parameters of silver cap (Hypopthalmichtys molitrix) needs to be investigated. The aim of the work was studying of ecotoxical Plumbum and Cadmium influence on hematological indices of silver carp (Hypopthalmichtys molitrix) during the period exposition. The results of the investigations concerning the influence of Plumbum and Cadmium on some hematological indices of silver carp (Hypopthalmichtys molitrix) for 12 days exposition up to the action of these heavy metals are given in this article. Experimental part was realized at the Lviv research station of Institute of fisheries NAAS (Lviv oblast, Horodok region, Velykyi Lyubin). Experimental groups contained 10 two-years individuals each. Fish were adopted to laboratory conditions for 5 days under the temperature 19 ± 2ºС, рН = 7.3 ± 0.2, oxygen content 7–8 mg/l. Blood parameters were measured on the sixth and twelfth days at the control group and groups which were under the influence on the level of 2 and 5 MPC of the appropriate metal. It was proved that the influence of Plumbum and Cadmium causes the lowering of erythrocytes number, hemoglobin and corpuscular volume: the effect becomes stronger when he concentration increases and in time. The effect from intoxication by Cadmium comes faster than by Plumbum.

scholarly journals Hematological parameters, liver integrity and growth of Nile tilapia fingerlings fed diets supplemented with propolis extract

2021 ◽  
Vol 19 (4) ◽  
pp. e0612-e0612
Author(s):  
Glaucia M. R. Maccari ◽  
Keyword(s):  
Growth Performance ◽  
Nile Tilapia ◽  
Hematological Parameters ◽  
Control Diet ◽  
Experimental Period ◽  
Culture Conditions ◽  
Water Volume ◽  
Alcoholic Extract ◽  
Hematological Indices ◽  
Propolis Extract

Aim of study: To assess the effects of propolis extract supplementation in diets for Nile tilapia (Oreochromis niloticus) fingerlings on growth performance, hematological and histological parameters. Area of study: The study was carried out in Paraná (Brazil). Material and methods: The experimental design was based on six treatments including the control diet and propolis supplementation (2%, 4%, 6%, 8% and 10% in the diet). Three hundred Nile tilapia fingerlings, with an initial weight of 0.61± 0.02 g, were distributed in 30 plastic mesh hapas (0.15 m3 each) arranged in a concrete tank of 25 m3 of water volume. The duration of the experimental period was 90 days. Main results: The increasing levels of propolis did not influence the growth performance and proximate composition of fishes. Red blood cells and hematological indices were not affected by propolis supplementation. However, total leukocytes and thrombocytes were higher in fish fed on propolis diets, being significant in fish fed 2% and 8%, and 6% and 8% supplemented diets groups, respectively. Research highlights: The supplementation of propolis alcoholic extract in the range of 2, 4, 6 and 8% in the diet for Nile tilapia fingerlings promote healthier fish with increased immunity in the evaluated culture conditions.

scholarly journals Carcass traits, blood parameters and meat composition of quail and pigeon available in Bangladesh

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
ABM Rubayet Bostami ◽  
CJ Yang ◽  
MD Hossain ◽  
MR Islam ◽  
MKH Ajoy ◽  
...  
Keyword(s):  
Meat Quality ◽  
Hematological Parameters ◽  
Carcass Traits ◽  
Blood Parameters ◽  
Quality Parameters ◽  
Blood Parameter ◽  
Promising Alternative ◽  
Meat Composition ◽  
Intestinal Microbiology ◽  
Preliminary Study

Common poultry birds like chicken, duck, quail and pigeon meat is gaining interest due to their genetic potentiality and management factors as well as special characters of their meat and egg. With a view to considers consumers demand, promising alternative bird farming and meat quality research, an attempt was undertaken to conduct a preliminary study to compare carcass characteristics, blood parameter, intestinal microbiology and meat composition of quail and pigeon of Bangladesh. The result revealed that, carcass traits, hematological parameters and intestinal microbiology did differ between quail and pigeon (P<0.05). The meat proximate composition data indicated that moisture and ether extract content did differ (P<0.05), however, crude protein and ash content did not differ between quail and pigeon (P>0.05). Thus, the preliminary study suggested that farmers can easily rear quail and pigeon for consumption of meat, however, further detail study can ensure detail physiological aspects and meat quality parameters of quail and pigeon.

Attenuation of oxidative stress and hepatic damage by white butterfly (Clerodendrum volubile) leaves in streptozotocin-induced diabetes in rats

2018 ◽  
Vol 30 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Olorunfemi R. Molehin ◽  
Omotade I. Oloyede
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Negative Impact ◽  
Hematological Parameters ◽  
Diabetic Control ◽  
Positive Control ◽  
Diabetic Rats ◽  
Total Protein Content ◽  
Hematological Indices

Abstract Background The negative impact of diabetes on the liver is well documented. The white butterfly (Clerodendrum volubile) leaf has been used in traditional practices for the treatment of various diseases, such as hypertension, diabetes, and rheumatism, but without scientific validation. This work was designed to evaluate the hepatoprotective properties of Clerodendrum volubile leaves on oxidative stress in streptozotocin (STZ)-induced diabetes in rats. Methods The rats were divided into ten groups of five rats each. Diabetes was induced by a single injection of STZ (65 mg/kg body weight; i.p), while the C. volubile extract (at the respective doses of 50, 100 and 200 mg/kg body weight) was given to diabetic and non-diabetic rats orally for 14 days. Metformin (100 mg/kg body weight) served as the positive control. Biochemical assays were conducted on the plasma for hematological parameters, along with hepatic marker damages and antioxidant enzyme determination in vivo to assess hepatic injury. Results The diabetic control rats showed significant increase (p<0.05) in marker enzymes: aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and malondiadehyde with reduction in reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase activities and plasma total protein content. Likewise, there were alterations in hematological indices in the diabetic control rats when compared with the normal control. However, treatment with C. volubile caused a reversal of the above parameters towards normal levels, thereby suggesting the modulating effect of the extract on oxidative stress, which may be a result of the high polyphenolic content and antioxidant capacity. Conclusions The protection of the liver tissues and the modulation of oxidative stress in STZ diabetic rats compare favorably to metformin, a standard antidiabetic drug.

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