Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease

Background: The value of aspirin for primary prevention continues to be debated. Data showing whether aspirin use for primary prevention adheres to established guidelines in real world practice are sparse.Methods: A total of 13,104 patients without cardiovascular diseases (CVD) were selected from the DYS-lipidemia International Study of China, a national survey of patients with dyslipidemia in 2012. The CVD risk of the participants were calculated using the 10-year risk of Ischemic Cardiovascular Diseases model. The misuse of aspirin for primary prevention was defined as having CVD risk <10% with daily aspirin. Multivariate logistic regression models were used to explore risk factors associated with aspirin misuse.Results: The proportion of the patients categorized as low, moderate and high risk for CVD were 52.9, 21.6, and 25.4% respectively. The misuse frequency of aspirin was 31.0% (2,147/6,933) in patients with low risk. The misuse of aspirin increased with aging for both men and women. In the multivariate analysis, the independent risk factors associated with aspirin misuse were hypertension, diabetes mellitus, a family history of premature CVD, and elderly age. Level of total cholesterol is negatively associated with aspirin misuse. Patients from low level hospitals are more likely to be taking aspirin inappropriately. Results remained consistent after including 2,837 patients having 10-year risk for CVD between 10 and <20%.Conclusion: The misuse of aspirin for primary prevention is common in patients having CVD risk <10%. There are important opportunities to improve evidence-based aspirin use for the primary prevention of CVD in Chinese patients.Clinical Trial Registration:https://clinicaltrials.gov/, identifier [NCT01732952].

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Factors associated with elevated blood pressure or hypertension in Afro-Caribbean youth: a cross-sectional study

PeerJ ◽

10.7717/peerj.4385 ◽

2018 ◽

Vol 6 ◽

pp. e4385 ◽

Cited By ~ 10

Author(s):

Trevor S. Ferguson ◽

Novie O.M. Younger-Coleman ◽

Marshall K. Tulloch-Reid ◽

Nadia R. Bennett ◽

Amanda E. Rousseau ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Young Adults ◽

Regression Models ◽

Cvd Risk ◽

Cut Points ◽

Lower Odds ◽

Logistic Regression Models ◽

Factors Associated ◽

Relative Risks

Background Although several studies have identified risk factors for high blood pressure (BP), data from Afro-Caribbean populations are limited. Additionally, less is known about how putative risk factors operate in young adults and how social factors influence the risk of high BP. In this study, we estimated the relative risk for elevated BP or hypertension (EBP/HTN), defined as BP ≥ 120/80 mmHg, among young adults with putative cardiovascular disease (CVD) risk factors in Jamaica and evaluated whether relative risks differed by sex. Methods Data from 898 young adults, 18–20 years old, were analysed. BP was measured with a mercury sphygmomanometer after participants had been seated for 5 min. Anthropometric measurements were obtained, and glucose, lipids and insulin measured from a fasting venous blood sample. Data on socioeconomic status (SES) were obtained via questionnaire. CVD risk factor status was defined using standard cut-points or the upper quintile of the distribution where the numbers meeting standard cut-points were small. Relative risks were estimated using odds ratios (OR) from logistic regression models. Results Prevalence of EBP/HTN was 30% among males and 13% among females (p < 0.001 for sex difference). There was evidence for sex interaction in the relationship between EBP/HTN and some of risk factors (obesity and household possessions), therefore we report sex-specific analyses. In multivariable logistic regression models, factors independently associated with EBP/HTN among men were obesity (OR 8.48, 95% CI [2.64–27.2], p < 0.001), and high glucose (OR 2.01, CI [1.20–3.37], p = 0.008), while high HOMA-IR did not achieve statistical significance (OR 2.08, CI [0.94–4.58], p = 0.069). In similar models for women, high triglycerides (OR 1.98, CI [1.03–3.81], p = 0.040) and high HOMA-IR (OR 2.07, CI [1.03–4.12], p = 0.039) were positively associated with EBP/HTN. Lower SES was also associated with higher odds for EBP/HTN (OR 4.63, CI [1.31–16.4], p = 0.017, for moderate vs. high household possessions; OR 2.61, CI [0.70–9.77], p = 0.154 for low vs. high household possessions). Alcohol consumption was associated with lower odds of EBP/HTN among females only; OR 0.41 (CI [0.18–0.90], p = 0.026) for drinking <1 time per week vs. never drinkers, and OR 0.28 (CI [0.11–0.76], p = 0.012) for drinking ≥3 times per week vs. never drinkers. Physical activity was inversely associated with EBP/HTN in both males and females. Conclusion Factors associated with EBP/HTN among Jamaican young adults include obesity, high glucose, high triglycerides and high HOMA-IR, with some significant differences by sex. Among women lower SES was positively associated with EBP/HTN, while moderate alcohol consumption was associated lower odds of EBP/HTN.

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Abstract P160: Contributing Factors to Prolonged Length of Hospital Stay After Readmission Among Patients With Cardiovascular Diseases in Rural Appalachia

Circulation ◽

10.1161/circ.141.suppl_1.p160 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Hadii M Mamudu ◽

Sylvester Orimaye ◽

Manul Awasthi ◽

Arsham Alamian ◽

Liang Wang ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Hospital Stay ◽

Length Of Hospital Stay ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Prolonged Length ◽

Factors Associated ◽

Study Population ◽

Rural Appalachia

Introduction: The Appalachian region has a disproportionate rate of morbidity and mortality related to cardiovascular diseases (CVD), compared to other regions in the United States. Readmission after initial hospitalization for CVD is a major health and economic burden. However, little is known about the factors that contribute to a prolonged length of hospital stay (LOS) after readmission for CVD in rural Appalachia. This study aimed to identify factors associated with prolonged LOS after readmission of patients with CVD in rural Appalachian region. Hypothesis: It is hypothesized that certain demographic and CVD risk factors would be positively and significantly associated with prolonged LOS after readmission of patients with CVD. Methods: Study population consisted of 2,063 patients from Central Appalachia who were diagnosed with ≥1 CVD-related medical comorbidities (diabetes, hypertension, hypercholesterolemia, depressive symptoms, coronary artery disease, stroke, and heart failure) and readmitted between 2010 and 2016 to a large health system. The average LOS was assessed and the Cox Proportional Hazard Ratios (HR) were calculated to identify factors associated with prolonged LOS (defined as a LOS of six or more days) after readmission among CVD patients. The median LOS and probability of prolonged LOS for different sociodemographic risk groups in the study population were calculated. Results: The average LOS was 13.44±45.77 days. A one-year increase in the age of CVD patients tended to increase the risk of prolonged LOS by 0.6% (95% CI: 1.00-1.01; p=0.04). Additionally, being male was found to be associated with increased risk of prolonged LOS (HR: 1.20; 95% CI: 1.08-1.34; p<0.001). Similarly, having at least one CVD related comorbid condition increased the risk of prolonged LOS by 23.3% (95% CI: 1.03-1.47; p=0.02). Our findings also showed that both underweight and obese CVD patients were at 58.2% (95% CI: 0.52-0.65; p<0.0001) and 53.6% (95% CI: 0.50-0.56; p<0.0001) higher risk of having a prolonged LOS, respectively. Conclusions: In conclusion, increasing age, being male, having ≥1 comorbidities of CVD, and being underweight or obese were positively associated with prolonged LOS after hospital readmission in this rural population. These findings suggest that preventing and treating comorbid conditions and CVD risk factors may lower the likelihood of a prolonged LOS after readmission.

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Association of major cardiovascular risk factors, risk factor clustering with cardiovascular diseases from eastern China A population-based cross-sectional study

10.21203/rs.2.19393/v1 ◽

2019 ◽

Author(s):

Hua-Feng Yang ◽

Xin Hong ◽

Wei-Wei Wang ◽

Qing Ye ◽

Zhi-Yong Wang ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Cardiovascular Diseases ◽

Regression Models ◽

Eastern China ◽

Population Based ◽

Cvd Risk ◽

Cross Sectional ◽

Logistic Regression Models ◽

Weighted Prevalence

Abstract Background: Cardiovascular diseases (CVDs) are serious public health issues and the burden of CVDs is at alarmingly high level in China. The aim of the current study was to estimate the prevalence of CVDs and modifiable risk factors, and explore the association of risk factors, risk factor clustering with CVDs among Nanjing adults from eastern China. Methods: A population-based cross-sectional survey was conducted by a stratified clustered sampling between June and November 2011. A representative sample of 40,896 residents aged over 18 years was interviewed by face-to-face questionnaire survey, anthropometric measurements and laboratory examinations. The prevalence of CVDs including coronary heart disease (CHD) and stroke was determined according to a participant’s self-report. Multivariable logistic regression models were used to estimate the relationship between relevant risk factors, their clustering and CVDs. Results: The weighted prevalence of self-reported in the entire population was 1.1% for CHD; and 1.4% for stroke. The weighted prevalence of hypertension, diabetes, dyslipidemia, overweight or obesity, and current smoking was 25.0%, 6.7%, 29.6%, 35.9% and 24.5%, respectively. In multivariable-adjusted models, higher levels of body mass index, systolic blood pressure and fasting plasma glucose could be associated with increased risks of CHD and stroke, whereas higher level of high-density lipoprotein cholesterol could be related to lower risks of CHD. Hypertension, diabetes and dyslipidemia were likely to be positively associated with self-reported CVDs regardless of genders in multivariable logistic regression models. Participants with CVDs had significant higher proportion of at least two of CVD risk factors than their counterparts without CVDs. Compared to those having no risk factor; adults with one, two, three or more CVD risk factors had possibly gradually increased risks of CHD and stroke in both genders. Conclusion: Higher regional prevalence of CVDs was likely to be synergistic effects of risk factors aggregation. Therefore, multifactorial intervention strategies based on associated risk factors may be available for prevention and control of CVDs in Chinese population. Keywords: Cardiovascular diseases, Risk Factors, Prevalence, Coronary heart disease, Stroke, China

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Does HbA1cc Play a Role in the Development of Cardiovascular Diseases?

Current Pharmaceutical Design ◽

10.2174/1381612824666180903121957 ◽

2018 ◽

Vol 24 (24) ◽

pp. 2876-2882 ◽

Cited By ~ 4

Author(s):

Kailash Prasad

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Cardiovascular System ◽

Half Life ◽

Serum Levels ◽

Serum Glucose ◽

Cvd Risk ◽

Factors Affecting ◽

Diagnosis And Management ◽

Coronary Artery Atherosclerosis

Cardiovascular diseases (CVD) may be mediated through increases in the cardiovascular risk factors. Hemoglobin A1c (HbA1c) also called glycated hemoglobin is presently used for the diagnosis and management of diabetes. It has adverse effects on cardiovascular system. This review deals with its synthesis and effects on the cardiovascular system. The serum levels of HbA1c have been reported to be affected by various factors including, the lifespan of erythrocytes, factors affecting erythropoiesis, agents interfering glycation of Hb, destruction of erythrocytes, drugs that shift the formation of Hb, statins, and drugs interfering the HbA1c assay. Levels of HbA1c are positively correlated with serum glucose and advanced glycation end products ( AGE), but no correlation between AGE and serum glucose. AGE cannot replace HbA1c for the diagnosis and management of diabetes because there is no correlation of AGE with serum glucose, and because the half-life of protein with which glucose combines is only 14-20 days as compared to erythrocytes which have a half-life of 90-120 days. HbA1c is positively associated with CVD such as the carotid and coronary artery atherosclerosis, ischemic heart disease, ischemic stroke and hypertension.HbA1c induces dyslipidemia, hyperhomocysteinemia, and hypertension, and increases C-reactive protein, oxidative stress and blood viscosity that would contribute to the development of cardiovascular diseases. In conclusion, HbA1c serves as a useful marker for the diagnosis and management of diabetes. AGE cannot replace HbA1c in the diagnosis and management of diabetes. There is an association of HbA1c with CVD which be mediated through modulation of CVD risk factors.

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POS0486 FACTORS ASSOCIATED WITH CHRONOTROPIC RESPONSE IN PEOPLE WITH RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3050 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 475.2-476

Author(s):

A. Osailan

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Cardiorespiratory Fitness ◽

Inflammatory Markers ◽

Exercise Intolerance ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Chronotropic Response ◽

Factors Associated ◽

The University

Background:People with rheumatoid arthritis (RA) are at high risk for cardiovascular diseases (CVD) and CVD mortality. Reduced Chronotropic response (CR), which produces exercise intolerance, is known as a contributing factor to CVD and mortality. Studies have shown that people with RA have reduced CR. However, knowledge about the factors associated with CR in people with RA is limited.Objectives:To explore the factors associated with CR including CVD risk factors, inflammatory markers and cardiorespiratory fitness (VO2 peak).Methods:106 people with RA completed a treadmill exercise tolerance test while heart rate (HR) was monitored via 12 leads ECG. CR was defined as the percentage of [(achieved peak HR minus resting HR) divided by (age-predicted maximum HR minus resting HR)]. Serological CVD risk factors and inflammatory markers including lipids profile, markers of insulin resistance and sensitivity (HOMA, QUICKi), high sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), fibrinogen and white blood cells (WBC) were examined via a fasted blood sample. VO2 peak was assessed via breath-by-breath gas analysis.Results:34% had reduced CR based on the cut-off value (≤ 80%) and the average CR was 86.2 ± 21%. Body mass index (r=-0.33, p=.001), HOMA (r=-0.26, p=.009), hsCRP (r=-0.23, p=.02), ESR (r=-0.21, p=.04), fibrinogen (r=-0.2, p=.05), WBC (r=-0.21, p=.04) were inversely associated with CR, whereas, high density lipoprotein (HDL) (r=0.43, p<.001), QUICKi (r=0.31, p=.002), and VO2 peak (r=0.4, p<.001) were positively associated with CR. When all the variables were entered into a stepwise linear regression, HDL (p<.001) and VO2 peak (p=.009) were independently associated with CR.Conclusion:The current findings suggest that CR in RA was associated with many CVD risk factors, inflammatory markers, and cardiorespiratory fitness. Among all the varibales, HDL and cardiorespiratory fitness were moderately and independently associated with CR. Future studies should investigate the effect of improving these associated variables on CR in people with RA via exercise training programes.Acknowledgements:Thanks to physical activity in Rheumatoid arthritis research team and Research department in Dudley Hospital. Sincere appreciation and gratitude to Dr Jet Veldhuizen van Zanten, Prof. Joan Duda, and Prof. George Kitas from the University of Birmingham and Prof. George Metsios from the University of Wolverhampton.Disclosure of Interests:None declared

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Comparative risk assessment for the development of cardiovascular diseases in the Hungarian general and Roma population

Scientific Reports ◽

10.1038/s41598-021-82689-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Peter Piko ◽

Zsigmond Kosa ◽

Janos Sandor ◽

Roza Adany

Keyword(s):

Risk Factors ◽

Risk Assessment ◽

Cardiovascular Risk ◽

Cardiovascular Diseases ◽

High Risk ◽

Risk Group ◽

High Risk Group ◽

Average Risk ◽

Cvd Risk ◽

Roma Population

AbstractCardiovascular diseases (CVDs) are the number one cause of death globally, and the early identification of high risk is crucial to prevent the disease and to reduce healthcare costs. Short life expectancy and increased mortality among the Roma are generally accepted (although not indeed proven by mortality analyses) which can be partially explained by the high prevalence of cardiovascular risk factors (CVRF) among them. This study aims to elaborate on the prevalence of the most important CVD risk factors, assess the estimation of a 10-year risk of development of fatal and nonfatal CVDs based on the most used risk assessment scoring models, and to compare the Hungarian general (HG) and Roma (HR) populations. In 2018 a complex health survey was accomplished on the HG (n = 380) and HR (n = 347) populations. The prevalence of CVRS was defined and 10-year cardiovascular risk was estimated for both study populations using the following systems: Framingham Risk Score for hard coronary heart disease (FRSCHD) and for cardiovascular disease (FRSCVD), Systematic COronary Risk Evaluation (SCORE), ACC/AHA Pooled Cohort Equations (PCE) and Revised Pooled Cohort Equations (RPCE). After the risk scores had been calculated, the populations were divided into risk categories and all subjects were classified. For all CVD risk estimation scores, the average of the estimated risk was higher among Roma compared to the HG independently of the gender. The proportion of high-risk group in the Hungarian Roma males population was on average 1.5–3 times higher than in the general one. Among Roma females, the average risk value was higher than in the HG one. The proportion of high-risk group in the Hungarian Roma females population was on average 2–3 times higher compared to the distribution of females in the general population. Our results show that both genders in the Hungarian Roma population have a significantly higher risk for a 10-year development of cardiovascular diseases and dying from them compared to the HG one. Therefore, cardiovascular interventions should be focusing not only on reducing smoking among Roma but on improving health literacy and service provision regarding prevention, early recognition, and treatment of lipid disorders and diabetes among them.

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ROLE OF VARIOUS RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASES

International Research Journal of Pharmacy ◽

10.7897/2230-8407.04511 ◽

2013 ◽

Vol 4 (5) ◽

pp. 44-50

Author(s):

Pranay Wal ◽

Ankita Wal ◽

Nikita Saraswat ◽

Shalini Singh ◽

Shikha Bajpai

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Factors Associated

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PARAMETERS OF ECG DISPERSION MAPPING AMONG STUDENTS OF NORTHERN UNIVERSITY

Bulletin of Nizhnevartovsk State University ◽

10.36906/2311-4444/19-2/12 ◽

2019 ◽

pp. 98-104 ◽

Cited By ~ 1

Author(s):

I. A Pogonysheva ◽

D. A Pogonyshev ◽

I. I Lunyak

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

High Risk ◽

Questionnaire Survey ◽

Cardiac Activity ◽

State University ◽

Men And Women ◽

Factors Associated ◽

Far North ◽

Pathological Characteristics

The cardiac activity of students who have been born and live in the territory equated to regions of Far North was assessed. In total, 132 students of Nizhnevartovsk State University were examined using the CardioVisor-06c analyser that helps to diagnose dysfunctions of the cardiovascular system at preclinical level. The authors conducted a questionnaire survey to identify risk factors associated with cardiovascular diseases in students and analyzed the results of ECG dispersion mapping. The deterioration of the functional state of the myocardium was more pronounced among students with a high risk of developing cardiovascular diseases. The young men and women with pre-pathological characteristics of electrophysiological indicators were referred for additional examination and cardiology consultation.

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Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases

Clinical Science ◽

10.1042/cs20171574 ◽

2018 ◽

Vol 132 (6) ◽

pp. 615-626 ◽

Cited By ~ 10

Author(s):

Asokan Devarajan

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Diseases ◽

Kidney Stone ◽

Arterial Wall ◽

Stone Formation ◽

Crystal Nucleation ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Kidney Stone Formation

The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed a positive association between nephrolithiasis and CVDs. Based on preclinical and clinical evidences, this review discusses: (i) stone forming risk factors, crystal nucleation, aggregation, injury-induced crystal retention, and stone formation, (ii) CVD risk factors such as dyslipidemia, perturbation of gut microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk factors, such as cholesterol, phospholipids, and uric acid, contribute to kidney stone formation are described.

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