scholarly journals Genotoxic Potential of Nanoparticles: Structural and Functional Modifications in DNA

2021 ◽  
Vol 12 ◽  
Author(s):  
Ritesh K Shukla ◽  
Ashish Badiye ◽  
Kamayani Vajpayee ◽  
Neeti Kapoor
Keyword(s):  
Technological Development ◽  
Vital Role ◽  
Cellular System ◽  
Human Beings ◽  
Biomedical Sciences ◽  
Cellular Processes ◽  
Dna And Rna ◽  
Functional Modification ◽  
Damage Repair ◽  
Industrial Material

The rapid advancement of nanotechnology enhances the production of different nanoparticles that meet the demand of various fields like biomedical sciences, industrial, material sciences and biotechnology, etc. This technological development increases the chances of nanoparticles exposure to human beings, which can threaten their health. It is well known that various cellular processes (transcription, translation, and replication during cell proliferation, cell cycle, cell differentiation) in which genetic materials (DNA and RNA) are involved play a vital role to maintain any structural and functional modification into it. When nanoparticles come into the vicinity of the cellular system, chances of uptake become high due to their small size. This cellular uptake of nanoparticles enhances its interaction with DNA, leading to structural and functional modification (DNA damage/repair, DNA methylation) into the DNA. These modifications exhibit adverse effects on the cellular system, consequently showing its inadvertent effect on human health. Therefore, in the present study, an attempt has been made to elucidate the genotoxic mechanism of nanoparticles in the context of structural and functional modifications of DNA.

scholarly journals Epigenetic Methylations on N6-Adenine and N6-Adenosine with the same Input but Different Output

2019 ◽  
Vol 20 (12) ◽  
pp. 2931 ◽  
Author(s):  
Zhiqing Li ◽  
Ping Zhao ◽  
Qingyou Xia
Keyword(s):  
Genetic Information ◽  
Target Genes ◽  
Technological Development ◽  
Wide Spectrum ◽  
Functional Identification ◽  
Methyl Group ◽  
Cellular Processes ◽  
Dna And Rna ◽  
Future Challenges ◽  
Detection Strategies

Epigenetic modifications on individual bases in DNA and RNA can encode inheritable genetic information beyond the canonical bases. Among the nucleic acid modifications, DNA N6-methadenine (6mA) and RNA N6-methyladenosine (m6A) have recently been well-studied due to the technological development of detection strategies and the functional identification of modification enzymes. The current findings demonstrate a wide spectrum of 6mA and m6A distributions from prokaryotes to eukaryotes and critical roles in multiple cellular processes. It is interesting that the processes of modification in which the methyl group is added to adenine and adenosine are the same, but the outcomes of these modifications in terms of their physiological impacts in organisms are quite different. In this review, we summarize the latest progress in the study of enzymes involved in the 6mA and m6A methylation machinery, including methyltransferases and demethylases, and their functions in various biological pathways. In particular, we focus on the mechanisms by which 6mA and m6A regulate the expression of target genes, and we highlight the future challenges in epigenetic regulation.

The role of Record of Rights (Khatian) in determining title or possession: An overview

IIUC Studies ◽  
2020 ◽  
Vol 15 ◽  
pp. 33-46
Author(s):  
Kalim Ullah
Keyword(s):  
Human Life ◽  
Vital Role ◽  
Critical Element ◽  
Human Beings ◽  
Supportive Evidence ◽  
Land Administration ◽  
Holy Quran ◽  
The Holy Quran ◽  
Religious Systems

Human beings are deeply related to land. Human beings take birth on land, live on land, die on land and mixes with land ultimately. As stated in the holy Quran: ‘We (Allah) created you (human beings) from the soil, we shall make you return to the soil and We shall call you back again from the soil’ (20:55). Human life is surrounded by soil i.e. land. So, land is a highly completed issue of human life involving economic, social, political, cultural and often religious systems. Land administration is thus a critical element and often a pre-condition for peaceful society and sustainable development. In administrating land, Khatian or record of rights plays a vital role to determine the rights and interests of the respective parties as supportive evidence. In this article, discussion is mainly made on the fact that Khatian or record of rights is not a document of title solely but it may be an evidence of title as well as possession. IIUC Studies Vol.15(0) December 2018: 33-46

MiRNA-145 and Its Direct Downstream Targets in Digestive System Cancers: A Promising Therapeutic Target

2020 ◽  
Vol 26 ◽  
Author(s):  
Yini Ma ◽  
Xiu Cao ◽  
Guojuan Shi ◽  
Tianlu Shi
Keyword(s):  
Digestive System ◽  
Target Genes ◽  
Malignant Neoplasm ◽  
Vital Role ◽  
Diagnostic Biomarkers ◽  
Cellular Processes ◽  
Promising Therapeutic Target ◽  
Direct Target ◽  
Potential Strategy

: MicroRNAs (miRNAs) play a vital role in the onset and development of many diseases, including cancers. Emerging evidence shows that numerous miRNAs have the potential to be used as diagnostic biomarkers for cancers, and miRNA-based therapy may be a promising therapy for the treatment of malignant neoplasm. MicroRNA-145 (miR-145) has been considered to play certain roles in various cellular processes, such as proliferation, differentiation and apoptosis, via modulating expression of direct target genes. Recent reports show that miR-145 participates in the progression of digestive system cancers, and plays crucial and novel roles for cancer treatment. In this review, we summarize the recent knowledge concerning the function of miR-145 and its direct targets in digestive system cancers. We discuss the potential role of miR-145 as valuable biomarkers for digestive system cancers and how miR-145 regulates these digestive system cancers via different targets to explore the potential strategy of targeting miR-145.

The applications of next-generation sequencing (NGS) in drug development for cancer therapy

2020 ◽  
Vol 16 ◽  
Author(s):  
Pelin Telkoparan-Akillilar ◽  
Dilek Cevik
Keyword(s):  
Next Generation Sequencing ◽  
Drug Discovery ◽  
Cancer Therapy ◽  
Target Identification ◽  
Rapid Development ◽  
Next Generation ◽  
Biomedical Sciences ◽  
Dna And Rna ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Background: Numerous sequencing techniques have been progressed since the 1960s with the rapid development of molecular biology studies focusing on DNA and RNA. Methods: a great number of articles, book chapters, websites are reviewed, and the studies covering NGS history, technology and applications to cancer therapy are included in the present article. Results: High throughput next-generation sequencing (NGS) technologies offer many advantages over classical Sanger sequencing with decreasing cost per base and increasing sequencing efficiency. NGS technologies are combined with bioinformatics software to sequence genomes to be used in diagnostics, transcriptomics, epidemiologic and clinical trials in biomedical sciences. The NGS technology has also been successfully used in drug discovery for the treatment of different cancer types. Conclusion: This review focuses on current and potential applications of NGS in various stages of drug discovery process, from target identification through to personalized medicine.

scholarly journals Role of Long Non-Coding RNA Polymorphisms in Cancer Chemotherapeutic Response

2021 ◽  
Vol 11 (6) ◽  
pp. 513
Author(s):  
Zheng Zhang ◽  
Meng Gu ◽  
Zhongze Gu ◽  
Yan-Ru Lou
Keyword(s):  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Cellular Processes ◽  
Dna And Rna ◽  
Chemotherapeutic Response ◽  
Non Coding Rna ◽  
Response To Chemotherapy ◽  
Personalized Oncology ◽  
Long Non Coding Rna

Genetic polymorphisms are defined as the presence of two or more different alleles in the same locus, with a frequency higher than 1% in the population. Since the discovery of long non-coding RNAs (lncRNAs), which refer to a non-coding RNA with a length of more than 200 nucleotides, their biological roles have been increasingly revealed in recent years. They regulate many cellular processes, from pluripotency to cancer. Interestingly, abnormal expression or dysfunction of lncRNAs is closely related to the occurrence of human diseases, including cancer and degenerative neurological diseases. Particularly, their polymorphisms have been found to be associated with altered drug response and/or drug toxicity in cancer treatment. However, molecular mechanisms are not yet fully elucidated, which are expected to be discovered by detailed studies of RNA–protein, RNA–DNA, and RNA–lipid interactions. In conclusion, lncRNAs polymorphisms may become biomarkers for predicting the response to chemotherapy in cancer patients. Here we review and discuss how gene polymorphisms of lncRNAs affect cancer chemotherapeutic response. This knowledge may pave the way to personalized oncology treatments.

scholarly journals Context-aware recommender systems and cultural heritage: a survey

2021 ◽  
Author(s):  
Mario Casillo ◽  
Francesco Colace ◽  
Dajana Conte ◽  
Marco Lombardi ◽  
Domenico Santaniello ◽  
...  
Keyword(s):  
Cultural Heritage ◽  
Recommender Systems ◽  
Context Awareness ◽  
Technological Development ◽  
Context Aware ◽  
Human Beings ◽  
Context Analysis ◽  
Analysis Techniques ◽  
The Right ◽  
Technological Improvements

AbstractIn the Big Data era, every sector has adapted to technological development to service the vast amount of information available. In this way, each field has benefited from technological improvements over the years. The cultural and artistic field was no exception, and several studies contributed to the aim of the interaction between human beings and artistic-cultural heritage. In this scenario, systems able to analyze the current situation and recommend the right services play a crucial role. In particular, in the Recommender Systems field, Context-Awareness helps to improve the recommendations provided. This article aims to present a general overview of the introduction of Context analysis techniques in Recommender Systems and discuss some challenging applications to the Cultural Heritage field.

scholarly journals The Value of Recreational Ecosystem Services in India

2020 ◽  
Vol 3 (1) ◽  
pp. 80
Author(s):  
Muniyandi Balasubramanian
Keyword(s):  
Ecosystem Services ◽  
National Park ◽  
Economic Value ◽  
Consumer Surplus ◽  
Well Being ◽  
Vital Role ◽  
Human Beings ◽  
Forest Ecosystem Services ◽  
The Individual ◽  
Mental Well Being

Forest ecosystem services have played a vital role in human well-being. Particularly, recreational ecosystem services are creating physical and mental well-being for human beings. Therefore, the main objective of the paper is to estimate the economic value of recreational ecosystem services provides by recreational sites such as Nandi Hills and Nagarhole National Park based on the individual travel cost method in Karnataka, India. This study has used a random sampling method for 300 tourist visitors to recreational sites. The present study has also estimated the consumer surplus of the visitors. The results of the study have found that (i) economic value of two creational sites has been estimated at US $323.05 million, (ii) the consumer surplus has been estimated for Nandi Hills at US $7.45 and Nagarhole National Park at US $3.16. The main implication of the study is to design the entry fees for the recreational site and sustainable utilization of recreational ecosystem services for the present and future generations.

scholarly journals Investigation of an Electrostatic Discharge Protective Biodegradable Packaging Foam in the Logistic Chain

2014 ◽  
Vol 5 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Ákos Mojzes ◽  
Barnabás Tóth ◽  
Péter Csavajda
Keyword(s):  
Electrostatic Discharge ◽  
Technological Development ◽  
Environmental Parameters ◽  
Thermoplastic Starch ◽  
Vital Role ◽  
Packaging Materials ◽  
Negative Effects ◽  
Packaging System ◽  
Product Packaging ◽  
The One

Abstract Since the beginning of the 20th century, logistics has undergone a huge technological development, which has, however, resulted in many negative effects as well. The industry, particularly in the packaging industry has been a massive waste producer, although recently it has forced the use of new materials and it started to focus on environmentally friendly technologies. During the transportation of finished and semi-finished Electrostatic Discharge (ESD) sensitive products, the product packaging system has a vital role. These kind of packaging materials must be suitable to both logistic (protection against mechanical and environmental stresses) and special ESD protection requirements. During the transportation of printed-circuit electronic products, ESD defense is then of primary significance. However there is a huge disadvantage for the use of various shield bags. Namely, this kind of associated packaging is particularly pollutant, it causes a lot of inconvenience in the form of waste. In order to rule out these materials from the packaging system, new innovative solutions have to be found. The investigated TPS (thermoplastic starch biodegradable foam) is subjected to a validation, a long process to certify that this material unites properties of two types of packaging materials at the same time. On the one hand, this packaging foam has to meet the requirements product defense. On the other hand, the material must be anti-static under the logistic stress effects. In case it is found suitable, it can be an alternative of the conventional materials. In this article, we investigate the ESD characteristic of TPS foam. As this material sensitive for environmental parameters during transportation, we make the relevant Surface Resistance (Rs) tests on different temperature and humidity conditions. Based on result, the decision of the application can be done, as an ESD packaging material.

scholarly journals Reading Habits of Users of Sardar Patel University: A Study

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Dr. Shishir H. Mandalia
Keyword(s):  
Data Collection ◽  
Vital Role ◽  
Human Beings ◽  
Reading Habits ◽  
Knowledge And Skills ◽  
Continued Education ◽  
New Knowledge ◽  
The World ◽  
The Individual ◽  
The University

Reading plays a vital role in life of a human. Reading provides experience through which the individual may expand his horizons of knowledge, identify, extend and intensify his interest and gains deeper understanding of himself, of other human beings and of the world. The study carried out to assess the reading habits of user of Sardar Patel University, VallabhVidyanagar, Anand, Gujarat. As a research tool; questionnaire was used for the data collection. Collected data were analyzed and tables were used to present the results of findings. Reading especially is a resource for continued education, for the acquisition of new knowledge and skills, for gaining information through media, especially newspapers, books, radio, television, and the computers. In this article investigator attempts to investigate the reading habits of users of the university.

scholarly journals Counterfactuality as a Polyphonic Assemblage. Entangled Human and Nonhuman Stories of Early Modern Sciences in Neal Stephenson’s The Baroque Cycle

2018 ◽  
Vol 14 (1) ◽  
pp. 110-121
Author(s):  
Mateusz Chaberski
Keyword(s):  
Science Fiction ◽  
Technological Development ◽  
Vital Role ◽  
Multispecies Ethnography ◽  
The Past ◽  
Political Effects ◽  
Neal Stephenson ◽  
History Of ◽  
Ways Of Being ◽  
Point Of Departure

Summary In recent science-fiction literature, we can witness a proliferation of new counterfactual narratives which take the 17th century as their point of departure. Unlike steampunk narratives, however, their aim is not to criticise the socio-political effects caused by contemporary technological development. Such authors as Neal Stephenson or Ian Tregillis, among others, are interested in revisiting the model of development in Western societies, routing around the logic of progress. Moreover, they demonstrate that modernity is but an effect of manifold contingent and indeterminate encounters of humans and nonhumans and their distinct temporalities. Even the slightest modification of their ways of being could have changed Western societies and cultures. Thus, they necessitate a rather non-anthropocentric model of counterfactuality which is not tantamount to the traditional alternative histories which depart from official narratives of the past. By drawing on contemporary multispecies ethnography, I put forward a new understanding of counter-factuality which aims to reveal multiple entangled human and nonhuman stories already embedded in the seemingly unified history of the West. In this context, the concept of “polyphonic assemblage” (Lowenhaupt-Tsing) is employed to conceptualize the contingent and open-ended encounters of human and nonhuman historical actors which cut across different discourses and practices. I analyse Stephenson’s The Baroque Cycle to show the entangled stories of humans and nonhumans in 17th century sciences, hardly present in traditional historiographies. In particular, Stephenson’s depiction of quicksilver and coffeehouse as nonhuman historical actors is scrutinized to show their vital role in the production of knowledge at the dawn of modernity.

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