Recent Trends on Biosurfactants With Antimicrobial Activity Produced by Bacteria Associated With Human Health: Different Perspectives on Their Properties, Challenges, and Potential Applications

The attention towards the bacteria associated with human health is growing more and more, above all regarding the bacteria that inhabit the niches offered by the human body, i.e., the gastrointestinal tract, skin, vaginal environment, and lungs. Among the secondary metabolites released by microorganisms associated with human health, little consideration is given to the biosurfactants, molecules with both hydrophobic and hydrophilic nature. Their role in the complex human environment is not only the mere biosurfactant function, but they could also control the microbiota through the quorum sensing system and the antimicrobial activity. These functions protect them and, accordingly, the human body principally from microbial and fungal pathogens. Consequently, nowadays, biosurfactants are emerging as promising bioactive molecules due to their very different structures, biological functions, low toxicity, higher biodegradability, and versatility. Therefore, this review provides a comprehensive perspective of biosurfactants with antimicrobial activity produced by bacteria associated with the human body and related to everything human beings are in contact with, e.g., food, beverages, and food-waste dumping sites. For the first time, the role of an “-omic” approach is highlighted to predict gene products for biosurfactant production, and an overview of the available gene sequences is reported. Besides, antimicrobial biosurfactants’ features, challenges, and potential applications in the biomedical, food, and nutraceutical industries are discussed.

Download Full-text

Fast, simultaneous metal reduction/deposition on electrospun a-WO3/PAN nanofiber membranes and their potential applications for water purification and noble metal recovery

Journal of Materials Chemistry A ◽

10.1039/c8ta03686a ◽

2018 ◽

Vol 6 (30) ◽

pp. 14577-14586 ◽

Cited By ~ 11

Author(s):

Jing Wei ◽

Xiuling Jiao ◽

Ting Wang ◽

Dairong Chen

Keyword(s):

Human Health ◽

Noble Metal ◽

Human Body ◽

Water Purification ◽

Metal Reduction ◽

Negative Effects ◽

Metal Pollutants ◽

Potential Applications ◽

Nanofiber Membranes ◽

Pan Nanofiber

Wastewater containing metal pollutants has raised concerns owing to their accumulation in the human body and their negative effects on human health.

Download Full-text

Bovine Colostrum and Its Potential for Human Health and Nutrition

Frontiers in Nutrition ◽

10.3389/fnut.2021.651721 ◽

2021 ◽

Vol 8 ◽

Author(s):

Ayşenur Arslan ◽

Merve Kaplan ◽

Hatice Duman ◽

Ayşe Bayraktar ◽

Melih Ertürk ◽

...

Keyword(s):

Human Health ◽

Post Partum ◽

Bovine Colostrum ◽

Bioactive Molecules ◽

Human Populations ◽

Mature Milk ◽

Processing Technologies ◽

Health And Nutrition ◽

Potential Applications ◽

History Of

Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating its potential for applications in human nutrition and health. Extensive characterization of the constituent fractions has identified a wealth of potentially bioactive molecules, their potential for shaping neonatal development, and the potential for their application beyond the neonatal period. Proteins, fats, glycans, minerals, and vitamins are abundant in colostrum, and advances in dairy processing technologies have enabled the advancement of bovine colostrum from relative limitations of a fresh and unprocessed food to a variety of potential applications. In these forms, clinical studies have examined bovine colostrum as having the substantial potential to improve human health. This review discusses the macro-and micronutrient composition of colostrum as well as describing well-characterized bioactives found in bovine colostrum and their potential for human health. Current gaps in knowledge are also identified and future directions are considered in order to elevate the potential for bovine colostrum as a component of a healthy diet for a variety of relevant human populations.

Download Full-text

Antimicrobial Activity of Silver Nanoparticles Synthesized by Streptomyces Species JF714876

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2012.5.1.7 ◽

2012 ◽

Vol 5 (1) ◽

pp. 1638-1642 ◽

Cited By ~ 2

Author(s):

Vidyasagar G M ◽

Shankaravva B ◽

R Begum ◽

Imrose ◽

Sagar R ◽

...

Keyword(s):

Antimicrobial Activity ◽

Silver Nanoparticles ◽

Silver Ions ◽

Human Beings ◽

Streptomyces Species ◽

Force Microscopy ◽

E Coli ◽

Extracellular Synthesis ◽

Atomic Force ◽

Uv Visible

Microorganisms like fungi, actinomycetes and bacteria are considered nanofactories and are helpful in the production of nanoparticles useful in the welfare of human beings. In the present study, we investigated the production of silver nanoparticles from Streptomyces species JF714876. Extracellular synthesis of silver nanoparticles by Streptomyces species was carried out using two different media. Silver nanoparticles were examined using UV-visible, IR and atomic force microscopy. The size of silver nanoparticles was in the range of 80-100 nm. Antimicrobial activity of silver nanoparticle against bacteria such as E. coli, S. aureus, and dermatophytes like T. rubrum and T. tonsurans was determined. Thus, this study suggests that the Streptomyces sp. JF741876 can produce silver ions that can be used as an antimicrobial substance.

Download Full-text

Novel Technologıes and Nanotoxıcology of Medıcal Implants

Current Analytical Chemistry ◽

10.2174/1573411016999200507104128 ◽

2020 ◽

Vol 16 ◽

Author(s):

Ramazan Akçan ◽

Halit Canberk Aydogan ◽

Mahmut Şerif Yıldırım ◽

Burak Taştekin ◽

Necdet Sağlam

Keyword(s):

Human Health ◽

Human Body ◽

Diagnostic Procedures ◽

Toxic Effects ◽

Medical Implants ◽

Healthcare Applications ◽

Detailed Review ◽

Novel Technologies ◽

Technological Developments

Background/aim: Use of nanomaterials in the healthcare applications increases in parallel to technological developments. It is frequently utilized in diagnostic procedures, medications and in therapeutic implementations. Nanomaterials take place among key components of medical implants, which might be responsible for certain toxic effects on human health at nano-level. In this review, nanotoxicological effects, toxicity determination of nanobiomaterials used in human body and their effects on human health are discussed. Material and Method: A detailed review of related literature was performed and evaluated as per nanomaterials and medical implants. Results and Conclusion: The nanotoxic effects of the materials applied to human body and the determination of its toxicity are important. Determination of toxicity for each nanomaterial requires a detailed and multifactorial assessment considering the properties of these materials. There are limited studies in the literature regarding the toxic effects of nanomaterials used in medical implants. Although these implants are potentially biocompatible and biodegradable, it is highly important to discuss nanotoxicological characteristics of medical implant.

Download Full-text

Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies

Molecules ◽

10.3390/molecules26102930 ◽

2021 ◽

Vol 26 (10) ◽

pp. 2930

Author(s):

Jelena Šuran ◽

Ivica Cepanec ◽

Tomislav Mašek ◽

Božo Radić ◽

Saša Radić ◽

...

Keyword(s):

Antimicrobial Activity ◽

Geographical Origin ◽

Research Area ◽

Mechanisms Of Action ◽

Bioactive Molecules ◽

Erk Pathway ◽

Pharmacological Effects ◽

Propolis Extract ◽

Open Research ◽

Antioxidant Mechanisms

Propolis is a honeybee product known for its antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. It is rich in bioactive molecules whose content varies depending on the botanical and geographical origin of propolis. These bioactive molecules have been studied individually and as a part of propolis extracts, as they can be used as representative markers for propolis standardization. Here, we compare the pharmacological effects of representative polyphenols and whole propolis extracts. Based on the literature data, polyphenols and extracts act by suppressing similar targets, from pro-inflammatory TNF/NF-κB to the pro-proliferative MAPK/ERK pathway. In addition, they activate similar antioxidant mechanisms of action, like Nrf2-ARE intracellular antioxidant pathway, and they all have antimicrobial activity. These similarities do not imply that we should attribute the action of propolis solely to the most representative compounds. Moreover, its pharmacological effects will depend on the efficacy of these compounds’ extraction. Thus, we also give an overview of different propolis extraction technologies, from traditional to modern ones, which are environmentally friendlier. These technologies belong to an open research area that needs further effective solutions in terms of well-standardized liquid and solid extracts, which would be reliable in their pharmacological effects, environmentally friendly, and sustainable for production.

Download Full-text

The Use of Essential Oils from Thyme, Sage and Peppermint against Colletotrichum acutatum

Plants ◽

10.3390/plants10010114 ◽

2021 ◽

Vol 10 (1) ◽

pp. 114

Author(s):

Armina Morkeliūnė ◽

Neringa Rasiukevičiūtė ◽

Lina Šernaitė ◽

Alma Valiuškaitė

Keyword(s):

Essential Oils ◽

Fungal Pathogens ◽

Control Plant ◽

Antimicrobial Activities ◽

Plant Diseases ◽

Colletotrichum Acutatum ◽

Low Toxicity ◽

Colletotrichum Spp ◽

Biological Protection

The Colletotrichum spp. is a significant strawberry pathogen causing yield losses of up to 50%. The most common method to control plant diseases is through the use of chemical fungicides. The findings of plants antimicrobial activities, low toxicity, and biodegradability of essential oils (EO), make them suitable for biological protection against fungal pathogens. The aim is to evaluate the inhibition of Colletotrichum acutatum by thyme, sage, and peppermint EO in vitro on detached strawberry leaves and determine EO chemical composition. Our results revealed that the dominant compound of thyme was thymol 41.35%, peppermint: menthone 44.56%, sage: α,β-thujone 34.45%, and camphor: 20.46%. Thyme EO inhibited C. acutatum completely above 200 μL L−1 concentration in vitro. Peppermint and sage EO reduced mycelial growth of C. acutatum. In addition, in vitro, results are promising for biological control. The detached strawberry leaves experiments showed that disease reduction 4 days after inoculation was 15.8% at 1000 μL L−1 of peppermint EO and 5.3% at 800 μL L−1 of thyme compared with control. Our findings could potentially help to manage C. acutatum; however, the detached strawberry leaves assay showed that EO efficacy was relatively low on tested concentrations and should be increased.

Download Full-text

Plant antimicrobial peptides: structures, functions, and applications

Botanical Studies ◽

10.1186/s40529-021-00312-x ◽

2021 ◽

Vol 62 (1) ◽

Author(s):

Junpeng Li ◽

Shuping Hu ◽

Wei Jian ◽

Chengjian Xie ◽

Xingyong Yang

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Peptides ◽

Agricultural Production ◽

Food Additives ◽

Antimicrobial Activities ◽

Gram Positive Bacteria ◽

Potential Applications ◽

Potential Applicability ◽

Bacteria And Fungi ◽

Positively Charged

AbstractAntimicrobial peptides (AMPs) are a class of short, usually positively charged polypeptides that exist in humans, animals, and plants. Considering the increasing number of drug-resistant pathogens, the antimicrobial activity of AMPs has attracted much attention. AMPs with broad-spectrum antimicrobial activity against many gram-positive bacteria, gram-negative bacteria, and fungi are an important defensive barrier against pathogens for many organisms. With continuing research, many other physiological functions of plant AMPs have been found in addition to their antimicrobial roles, such as regulating plant growth and development and treating many diseases with high efficacy. The potential applicability of plant AMPs in agricultural production, as food additives and disease treatments, has garnered much interest. This review focuses on the types of plant AMPs, their mechanisms of action, the parameters affecting the antimicrobial activities of AMPs, and their potential applications in agricultural production, the food industry, breeding industry, and medical field.

Download Full-text

Isolation of a Novel Polyketide from Neodidymelliopsis sp.

Molecules ◽

10.3390/molecules26113235 ◽

2021 ◽

Vol 26 (11) ◽

pp. 3235

Author(s):

Melissa M. Cadelis ◽

Hugo Gordon ◽

Alex Grey ◽

Soeren Geese ◽

Daniel R. Mulholland ◽

...

Keyword(s):

Antimicrobial Activity ◽

Natural Products ◽

Ambient Temperature ◽

Crude Extract ◽

Structure Elucidation ◽

Fungal Pathogens ◽

Spectroscopic Techniques ◽

Bioactive Natural Products

Fungi have become an invaluable source of bioactive natural products, with more than 5 million species of fungi spanning the globe. Fractionation of crude extract of Neodidymelliopsis sp., led to the isolation of a novel polyketide, (2Z)-cillifuranone (1) and five previously reported natural products, (2E)-cillifuranone (2), taiwapyrone (3), xylariolide D (4), pachybasin (5), and N-(5-hydroxypentyl)acetamide (6). It was discovered that (2Z)-cillifuranone (1) was particularly sensitive to ambient temperature and light resulting in isomerisation to (2E)-cillifuranone (2). Structure elucidation of all the natural products were conducted by NMR spectroscopic techniques. The antimicrobial activity of 2, 3, and 5 were evaluated against a variety of bacterial and fungal pathogens. A sodium [1-13C] acetate labelling study was conducted on Neodidymelliopsis sp. and confirmed that pachybasin is biosynthesised through the acetate polyketide pathway.

Download Full-text

Concept of Mental Education: A Perspective of Ibn Qayyim Al-Jawziyyah

Jurnal Dirosah Islamiyah ◽

10.47467/jdi.v3i3.533 ◽

2021 ◽

Vol 3 (3) ◽

pp. 407-419

Author(s):

Makmudi Makmudi

Keyword(s):

Mental Health ◽

Human Body ◽

Natural Environment ◽

Integrated Curriculum ◽

Educational Process ◽

Sexual Education ◽

Human Beings ◽

The Will ◽

Life Education ◽

The Mind

Man consists of two elements, namely body and spirit, so that human beings are jasiman and ruhiyah at once. Hummans are also part of one element of the elements that exist in an educational process. Three element include the soul, the mind, the heart, and the human body. Humman and education, can not be separated from each other. Both are an interconnected entity, human as the perpetrator and education as a syistem in the process to achieve the goal of education itself. Mental health education requires alignment and harmony in various stages and sectors as well as attention to the three elements that exist in the human self that is the physical element (psychomotor) which includes body building, skill (skill) and sexual education, the spiritual element (affective) which includes the formation of faith, and iradah (the will), the element of reason (cognitive) which includes the coaching of intelligence and the provision of knowledge. The purpose of writing this research is to know and analyze thoughts about the concept of life education perspective Ibn Qayyim al-Jauziyyah. Soul education is considered successful, if one's soul has reached the degree of nafs muthmainnah, which has three main characteristics that mutually reinforce one another, namely; (1) a faithful soul to God, (2) a patient soul, (3) a soul that is self-serving to Allah (tawakal). Through the process of mental education which includes: the foundation of theology, the purpose of mental education, integrated curriculum / manhaj at-takamul, appropriate methods and applicable according to its stages, such as: takhliyah stages, tahliyah stages, muhasabah an-nafs, dzikrullah, and tahqiq 'ubudiyah. So that from the process will give birth ihsan attitude, and will increase the piety in worship, both related to God and those related to humans and the surrounding natural environment. Because, the essence of ihsan attitude itself is upholding 'ubudiyah.

Download Full-text

Interventions for Improving Health Care Workers’ Retention in Epidemics – a Scoping Review

10.21203/rs.3.rs-951428/v1 ◽

2021 ◽

Author(s):

Zahra Zarei Jelyani ◽

Sadra Valiee ◽

Mohammad Kia ◽

Ali jajarmizadeh ◽

Sajad Delavari

Keyword(s):

Health Care ◽

Human Resources ◽

Health System ◽

Human Health ◽

Scoping Review ◽

Health Care Workers ◽

Health Resources ◽

The United States ◽

Human Beings ◽

Care Workers

Abstract Introduction: Generally, in Epidemics, such as COVID-19, health care workers (HCWs) faces many problems which lead to a shortage and weakening of human resources in the health system. Therefore, using effective strategies to retain human resources is one of the most important issues during outbreaks. This study aims to collect and classify the proposed interventions to strengthen human health resources and their sustainability during epidemics through scoping review.Methods: In this scoping review study, 2300 studies were retrieved through searching international databases –PubMed, Embase, Scopus and Web of Science. The retrieved studies were screened, and finally, 50 studies were included for analysis. The strategies were classified using inductive qualitative content analysis.Results: Most of the studies were conducted in the United States and the United Kingdom. The target population in 39 studies was all health workers; five studies were on physicians, five studies on nurses, and only one study on dentists. The proposed interventions were classified into five categories: preparation, protection, support, treatment, and feedback. Discussion: Most studies focused on providing interventions in one or two dimensions of human resources, but these interventions were summarized and categorized in this review. Therefore, this study has a holistic view of various dimensions of strengthening and maintaining human health resources during epidemics by providing a thematic map. Considering that human beings are multidimensional, policymakers and managers of the health system should use a set of interventions that simultaneously cover different aspects of their needs to strengthen and maintain HCWs.

Download Full-text