scholarly journals Dynamic Spatial Responsiveness in Concert Halls

Acoustics ◽  
2019 ◽  
Vol 1 (3) ◽  
pp. 549-560 ◽  
Author(s):  
Evan Green ◽  
Eckhard Kahle
Keyword(s):  
Three Dimensional ◽  
Direction Of Arrival ◽  
Spatial Response ◽  
Musical Perception ◽  
Key Factor ◽  
Listening Levels ◽  
Concert Halls ◽  
Virtual Acoustics ◽  
The Relationship ◽  
Good Agreement

In musical perception, a proportion of the reflected sound energy arriving at the ear is not consciously perceived. Investigations by Wettschurek in the 1970s showed the detectability to be dependent on the overall loudness and direction of arrival of reflected sound. The relationship Wettschurek found between reflection detectability, listening level, and direction of arrival correlates well with the subjective progression of spatial response during a musical crescendo: from frontal at pianissimo, through increasing apparent source width, to a fully present room acoustic at forte. “Dynamic spatial responsiveness” was mentioned in some of the earliest psychoacoustics research and recent work indicates that it is a key factor in acoustical preference. This article describes measurements of perception thresholds made using a binaural virtual acoustics system—these show good agreement with Wettschurek’s results. The perception measurements indicate that the subjective effect of reflections varies with overall listening level, even when the reflection level, delay, and direction relative to the direct sound are maintained. Reflections which are perceptually fused with the source may at louder overall listening levels become allocated to the room presence. An algorithm has been developed to visualize dynamic spatial responsiveness—i.e., which aspects of a three-dimensional (3D) Room Impulse Response would be detectable at different dynamic levels—and has been applied to measured concert hall impulse responses.

A Free Energy Perturbation Approach to Estimate the Intrinsic Solubilities of Drug-like Small Molecules

2019 ◽  
Author(s):  
Sayan Mondal ◽  
Gary Tresadern ◽  
Jeremy Greenwood ◽  
Byungchan Kim ◽  
Joe Kaus ◽  
...  
Keyword(s):  
Solid State ◽  
Small Molecules ◽  
Three Dimensional ◽  
Aqueous Solubility ◽  
Computational Approach ◽  
Free Energy Perturbation ◽  
Perturbation Approach ◽  
Energy Perturbation ◽  
State Form ◽  
Good Agreement

<p>Optimizing the solubility of small molecules is important in a wide variety of contexts, including in drug discovery where the optimization of aqueous solubility is often crucial to achieve oral bioavailability. In such a context, solubility optimization cannot be successfully pursued by indiscriminate increases in polarity, which would likely reduce permeability and potency. Moreover, increasing polarity may not even improve solubility itself in many cases, if it stabilizes the solid-state form. Here we present a novel physics-based approach to predict the solubility of small molecules, that takes into account three-dimensional solid-state characteristics in addition to polarity. The calculated solubilities are in good agreement with experimental solubilities taken both from the literature as well as from several active pharmaceutical discovery projects. This computational approach enables strategies to optimize solubility by disrupting the three-dimensional solid-state packing of novel chemical matter, illustrated here for an active medicinal chemistry campaign.</p>

scholarly journals Experimental studies on the transformation from firn to ice in the wet-snow zone of temperate glaciers

1997 ◽  
Vol 24 ◽  
pp. 181-185 ◽  
Author(s):  
Katsuhisa Kawashima ◽  
Tomomi Yamada
Keyword(s):  
Experimental Studies ◽  
Ice Formation ◽  
Compression Tests ◽  
Densification Rate ◽  
Overburden Pressure ◽  
Proportionality Constant ◽  
Wet Snow ◽  
Water Saturated ◽  
The Relationship ◽  
Good Agreement

The densification of water-saturated firn, which had formed just above the firn-ice transition in the wet-snow zone of temperate glaciers, was investigated by compression tests under pressures ranging from 0.036 to 0.173 MPa, with special reference to the relationship between densification rate, time and pressure. At each test, the logarithm of the densification rate was proportional to the logarithm of the time, and its proportionality constant increased exponentially with increasing pressure. The time necessary for ice formation in the firn aquifer was calculated using the empirical formula obtained from the tests. Consequently, the necessary time decreased exponentially as the pressure increased, which shows that the transformation from firn in ice can be completed within the period when the firn aquifer exists, if the overburden pressure acting on the water-saturated firn is above 0.12–0.14 MPa. This critical value of pressure was in good agreement with the overburden pressure obtained from depth–density curves of temperate glaciers. It was concluded that the depth of firn–ice transition was self-balanced by the overburden pressure to result in the concentration between 20 and 30 m.

scholarly journals Dynamics of Single Droplet Splashing on Liquid Film by Coupling FVM with VOF

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 841
Author(s):  
Yuzhen Jin ◽  
Huang Zhou ◽  
Linhang Zhu ◽  
Zeqing Li
Keyword(s):  
Liquid Film ◽  
Weber Number ◽  
Stokes Equations ◽  
Numerical Study ◽  
Three Dimensional ◽  
Navier Stokes ◽  
Single Droplet ◽  
Navier Stokes Equations ◽  
Volume Method ◽  
The Relationship

A three-dimensional numerical study of a single droplet splashing vertically on a liquid film is presented. The numerical method is based on the finite volume method (FVM) of Navier–Stokes equations coupled with the volume of fluid (VOF) method, and the adaptive local mesh refinement technology is adopted. It enables the liquid–gas interface to be tracked more accurately, and to be less computationally expensive. The relationship between the diameter of the free rim, the height of the crown with different numbers of collision Weber, and the thickness of the liquid film is explored. The results indicate that the crown height increases as the Weber number increases, and the diameter of the crown rim is inversely proportional to the collision Weber number. It can also be concluded that the dimensionless height of the crown decreases with the increase in the thickness of the dimensionless liquid film, which has little effect on the diameter of the crown rim during its growth.

scholarly journals Estimation of resistance force at steady-state sinkage for cylindrical wheel-typed lunar/planetary exploration rovers with function of push–pull locomotion

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Daisuke Fujiwara ◽  
Naoki Tsujikawa ◽  
Tetsuya Oshima ◽  
Kojiro Iizuka
Keyword(s):  
Steady State ◽  
Estimation Method ◽  
Planetary Exploration ◽  
Experimental Result ◽  
Resistance Force ◽  
Estimation Model ◽  
Loose Soil ◽  
Key Factor ◽  
The Relationship ◽  
Resistance Forces

Abstract Planetary exploration rovers have required a high traveling performance to overcome obstacles such as loose soil and rocks. Push-pull locomotion rovers is a unique scheme, like an inchworm, and it has high traveling performance on loose soil. Push-pull locomotion uses the resistance force by keeping a locked-wheel related to the ground, whereas the conventional rotational traveling uses the shear force from loose soil. The locked-wheel is a key factor for traveling in the push-pull scheme. Understanding the sinking behavior and its resistance force is useful information for estimating the rover’s performance. Previous studies have reported the soil motion under the locked-wheel, the traction, and the traveling behavior of the rover. These studies were, however, limited to the investigation of the resistance force and amount of sinkage for the particular condition depending on the rover. Additionally, the locked-wheel sinks into the soil until it obtains the required force for supporting the other wheels’ motion. How the amount of sinkage and resistance forces are generated at different wheel sizes and mass of an individual wheel has remained unclear, and its estimation method hasn’t existed. This study, therefore, addresses the relationship between the sinkage and its resistance force, and we analyze and consider this relationship via the towing experiment and theoretical consideration. The results revealed that the sinkage reached a steady-state value and depended on the contact area and mass of each wheel, and the maximum resistance force also depends on this sinkage. Additionally, the estimation model did not capture the same trend as the experimental results when the wheel width changed, whereas, the model captured a relatively the same trend as the experimental result when the wheel mass and diameter changed.

scholarly journals Simulation of Thermal and Electric Field Distribution in Packaged Sausages Heated in a Stationary Versus a Rotating Microwave Oven

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1622
Author(s):  
Wipawee Tepnatim ◽  
Witchuda Daud ◽  
Pitiya Kamonpatana
Keyword(s):  
Temperature Distribution ◽  
Electric Field ◽  
Three Dimensional ◽  
Development Stage ◽  
Microwave Oven ◽  
Computational Time ◽  
Plastic Package ◽  
Heating Uniformity ◽  
The Cost ◽  
Good Agreement

The microwave oven has become a standard appliance to reheat or cook meals in households and convenience stores. However, the main problem of microwave heating is the non-uniform temperature distribution, which may affect food quality and health safety. A three-dimensional mathematical model was developed to simulate the temperature distribution of four ready-to-eat sausages in a plastic package in a stationary versus a rotating microwave oven, and the model was validated experimentally. COMSOL software was applied to predict sausage temperatures at different orientations for the stationary microwave model, whereas COMSOL and COMSOL in combination with MATLAB software were used for a rotating microwave model. A sausage orientation at 135° with the waveguide was similar to that using the rotating microwave model regarding uniform thermal and electric field distributions. Both rotating models provided good agreement between the predicted and actual values and had greater precision than the stationary model. In addition, the computational time using COMSOL in combination with MATLAB was reduced by 60% compared to COMSOL alone. Consequently, the models could assist food producers and associations in designing packaging materials to prevent leakage of the packaging compound, developing new products and applications to improve product heating uniformity, and reducing the cost and time of the research and development stage.

scholarly journals 3D-Volume Rendering of the Pelvis with Emphasis on Paraurethral Structures Based on MRI Scans and Comparisons between 3D Slicer and OsiriX®

2021 ◽  
Vol 45 (3) ◽  
Author(s):  
C. M. Durnea ◽  
S. Siddiqi ◽  
D. Nazarian ◽  
G. Munneke ◽  
P. M. Sedgwick ◽  
...  
Keyword(s):  
Image Processing ◽  
Secondary Analysis ◽  
Three Dimensional ◽  
3D Models ◽  
Clinical Role ◽  
Cross Sectional ◽  
3D Slicer ◽  
Mri Scans ◽  
3D Volume ◽  
Good Agreement

AbstractThe feasibility of rendering three dimensional (3D) pelvic models of vaginal, urethral and paraurethral lesions from 2D MRI has been demonstrated previously. To quantitatively compare 3D models using two different image processing applications: 3D Slicer and OsiriX. Secondary analysis and processing of five MRI scan based image sets from female patients aged 29–43 years old with vaginal or paraurethral lesions. Cross sectional image sets were used to create 3D models of the pelvic structures with 3D Slicer and OsiriX image processing applications. The linear dimensions of the models created using the two different methods were compared using Bland-Altman plots. The comparisons demonstrated good agreement between measurements from the two applications. The two data sets obtained from different image processing methods demonstrated good agreement. Both 3D Slicer and OsiriX can be used interchangeably and produce almost similar results. The clinical role of this investigation modality remains to be further evaluated.

scholarly journals A Field Measurement Based Wind Characteristics Analysis of a Typhoon in Near-Ground Boundary Layer

Atmosphere ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 873
Author(s):  
Dandan Xia ◽  
Liming Dai ◽  
Li Lin ◽  
Huaifeng Wang ◽  
Haitao Hu
Keyword(s):  
Turbulence Intensity ◽  
Field Measurement ◽  
Three Dimensional ◽  
Wind Data ◽  
Statistical Characteristics ◽  
Gust Factor ◽  
Characteristics Analysis ◽  
Wind Characteristics ◽  
The Mean ◽  
The Relationship

The field measurement was conducted to observe the wind field data of West Pacific typhoon “Maria” in this research. With the application of ultrasonic anemometers installed in different heights (10 m, 80 m, 100 m) of the tower, the three dimensional wind speed data of typhoon “Maria” was acquired. In addition, vane-type anemometers were installed to validate the accuracy of the wind data from ultrasonic anemometers. Wind characteristics such as the mean wind profile, turbulence intensity, integral length scale, and wind spectrum are studied in detail using the collected wind data. The relationship between the gust factor and turbulence intensity was also studied and compared with the existing literature to demonstrate the characteristics of Maria. The statistical characteristics of the turbulence intensity and gust factor are presented. The corresponding conclusion remarks are expected to provide a useful reference for designing wind-resistant buildings and structures.

scholarly journals Experimental and Numerical Investigation about Small Clearance Journal Bearings under Static Load Conditions

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Carlo Alberto Niccolini Marmont Du Haut Champ ◽  
Fabrizio Stefani ◽  
Paolo Silvestri
Keyword(s):  
Three Dimensional ◽  
Journal Bearings ◽  
Radial Clearance ◽  
Small Scale ◽  
Test Rig ◽  
Small Clearance ◽  
Dimensional Simulation ◽  
Dynamic Loading Conditions ◽  
Static And Dynamic Loading ◽  
Good Agreement

The aim of the present research is to characterize both experimentally and numerically journal bearings with low radial clearances for rotors in small-scale applications (e.g., microgas turbines); their diameter is in the order of ten millimetres, leading to very small dimensional clearances when the typical relative ones (order of 1/1000) are employed; investigating this particular class of journal bearings under static and dynamic loading conditions represents something unexplored. To this goal, a suitable test rig was designed and the performance of its bearings was investigated under steady load. For the sake of comparison, numerical simulations of the lubrication were also performed by means of a simplified model. The original test rig adopted is a commercial rotor kit (RK), but substantial modifications were carried out in order to allow significant measurements. Indeed, the relative radial clearance of RK4 RK bearings is about 2/100, while it is around 1/1000 in industrial bearings. Therefore, the same original RK bearings are employed in this new test rig, but a new shaft was designed to reduce their original clearance. The new custom shaft allows to study bearing behaviour for different clearances, since it is equipped with interchangeable journals. Experimental data obtained by this test rig are then compared with further results of more sophisticated simulations. They were carried out by means of an in-house developed finite element (FEM) code, suitable for thermoelasto-hydrodynamic (TEHD) analysis of journal bearings both in static and dynamic conditions. In this paper, bearing static performances are studied to assess the reliability of the experimental journal location predictions by comparing them with the ones coming from already validated numerical codes. Such comparisons are presented both for large and small clearance bearings of original and modified RKs, respectively. Good agreement is found only for the modified RK equipped with small clearance bearings (relative radial clearance 8/1000), as expected. In comparison with two-dimensional lubrication analysis, three-dimensional simulation improves prediction of journal location and correlation with experimental results.

scholarly journals Three-dimensional relationships between tumor cells and microcirculation with double cyanine immunolabeling, laser scanning confocal microscopy, and computer-assisted reconstruction: an alternative to cast corrosion preparations.

1994 ◽  
Vol 42 (5) ◽  
pp. 681-686 ◽  
Author(s):  
V Rummelt ◽  
L M Gardner ◽  
R Folberg ◽  
S Beck ◽  
B Knosp ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Blood Vessels ◽  
Tumor Cells ◽  
Laser Scanning ◽  
Three Dimensional ◽  
Melanoma Cells ◽  
Tumor Blood Vessels ◽  
The Relationship ◽  
Scanning Electron

The morphology of the microcirculation of uveal melanomas is a reliable market of tumor progression. Scanning electron microscopy of cast corrosion preparations can generate three-dimensional views of these vascular patterns, but this technique sacrifices the tumor parenchyma. Formalin-fixed wet tissue sections 100-150 microns thick from uveal melanomas were stained with the lectin Ulex europaeus agglutinin I (UEAI) and proliferating cell nuclear antigen (PCNA) to demonstrate simultaneously the tumor blood vessels and proliferating tumor cells. Indocarbocyanine (Cy3) was used as a fluorophore for UEAI and indodicarbocyanine (Cy5) was used for PCNA. Double labeled sections were examined with a laser scanning confocal microscope. Images of both stains were digitized at the same 5-microns intervals and each of the two images per interval was combined digitally to form one image. These combined images were visualized through voxel processing to study the relationship between melanoma cells expressing PCNA and various microcirculatory patterns. This technique produces images comparable to scanning electron microscopy of cast corrosion preparations while permitting simultaneous localization of melanoma cells expressing PCNA. The microcirculatory tree can be viewed from any perspective and the relationship between tumor cells and the tumor blood vessels can be studied concurrently in three dimensions. This technique is an alternative to cast corrosion preparations.

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